GcL
@grosscol.bsky.social
Programming and human genetics. Working with TOPMED data and providing a view into human variation via BRAVO (bravo.sph.umich.edu)
@leftistlawyer.com you changed your profile picture. This new one is great too.
November 5, 2025 at 6:38 PM
@leftistlawyer.com you changed your profile picture. This new one is great too.
𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 𝚖𝚎𝚛𝚐𝚎 doesn't have an option to write to stdout. It just has a –𝚘 arg to specify output file. Named pipes to the rescue.
𝚖𝚔𝚏𝚒𝚏𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍
𝚋𝚊𝚖𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 𝚖𝚎𝚛𝚐𝚎 –𝚏 \
–𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 "${𝙸𝙽𝙿𝚄𝚃_𝙿𝙸𝙿𝙴𝚂[@]}" &
𝚌𝚛𝚊𝚖_𝚜𝚞𝚖𝚖𝚊𝚛𝚒𝚣𝚎𝚛 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 > \
𝚜𝚟_𝚜𝚞𝚖𝚖𝚊𝚛𝚢.𝚓𝚜𝚘𝚗
𝚖𝚔𝚏𝚒𝚏𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍
𝚋𝚊𝚖𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 𝚖𝚎𝚛𝚐𝚎 –𝚏 \
–𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 "${𝙸𝙽𝙿𝚄𝚃_𝙿𝙸𝙿𝙴𝚂[@]}" &
𝚌𝚛𝚊𝚖_𝚜𝚞𝚖𝚖𝚊𝚛𝚒𝚣𝚎𝚛 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 > \
𝚜𝚟_𝚜𝚞𝚖𝚖𝚊𝚛𝚢.𝚓𝚜𝚘𝚗
November 4, 2025 at 9:13 PM
𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 𝚖𝚎𝚛𝚐𝚎 doesn't have an option to write to stdout. It just has a –𝚘 arg to specify output file. Named pipes to the rescue.
𝚖𝚔𝚏𝚒𝚏𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍
𝚋𝚊𝚖𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 𝚖𝚎𝚛𝚐𝚎 –𝚏 \
–𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 "${𝙸𝙽𝙿𝚄𝚃_𝙿𝙸𝙿𝙴𝚂[@]}" &
𝚌𝚛𝚊𝚖_𝚜𝚞𝚖𝚖𝚊𝚛𝚒𝚣𝚎𝚛 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 > \
𝚜𝚟_𝚜𝚞𝚖𝚖𝚊𝚛𝚢.𝚓𝚜𝚘𝚗
𝚖𝚔𝚏𝚒𝚏𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍
𝚋𝚊𝚖𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 𝚖𝚎𝚛𝚐𝚎 –𝚏 \
–𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 "${𝙸𝙽𝙿𝚄𝚃_𝙿𝙸𝙿𝙴𝚂[@]}" &
𝚌𝚛𝚊𝚖_𝚜𝚞𝚖𝚖𝚊𝚛𝚒𝚣𝚎𝚛 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 > \
𝚜𝚟_𝚜𝚞𝚖𝚖𝚊𝚛𝚢.𝚓𝚜𝚘𝚗
For the first time, I'm glad I don't work with the Ruby ecosystem anymore.
October 30, 2025 at 8:48 PM
For the first time, I'm glad I don't work with the Ruby ecosystem anymore.
This was a useful list. Nice that this platform facilitates blocking lists of bad actors.
October 20, 2025 at 3:03 PM
This was a useful list. Nice that this platform facilitates blocking lists of bad actors.
If you rip off my post without liking it, you owe me two dollars.
October 16, 2025 at 8:44 PM
If you rip off my post without liking it, you owe me two dollars.
@katmabu.bsky.social keep it up. Good luck!
October 4, 2025 at 4:49 PM
@katmabu.bsky.social keep it up. Good luck!
@bcdreyer.social how do you edit copy? I thought paste took care of that?! /S
October 4, 2025 at 1:18 AM
@bcdreyer.social how do you edit copy? I thought paste took care of that?! /S
@@cherylrofer.bsky.social I came across a post of yours, checked your profile, and found that I liked both.
I have heard a lot about thorium reactors in recent years. What are your thoughts on thorium and thorium reactors?
I have heard a lot about thorium reactors in recent years. What are your thoughts on thorium and thorium reactors?
October 3, 2025 at 5:05 PM
@@cherylrofer.bsky.social I came across a post of yours, checked your profile, and found that I liked both.
I have heard a lot about thorium reactors in recent years. What are your thoughts on thorium and thorium reactors?
I have heard a lot about thorium reactors in recent years. What are your thoughts on thorium and thorium reactors?
Those that know history are done to watch everyone else repeat it.
September 20, 2025 at 3:56 AM
Those that know history are done to watch everyone else repeat it.
Reposted by GcL
If you want something written about the human genome that is not complex science, then this is a good place to start. 🧪
September 13, 2025 at 7:30 PM
If you want something written about the human genome that is not complex science, then this is a good place to start. 🧪
Reposted by GcL
If you run a life science lab where research has either significantly slowed or shut down completely due to Trump administration policies, I’d like to hear your story. I'm a biotech and life sciences reporter for @statnews.com, and you can reach me at [email protected] #journorequest
September 13, 2025 at 1:58 PM
Reposted by GcL
"The unsettling feeling that your device is spying on you is real — but the culprit isn't a secret microphone. It's the data broker industry," EFF’s @evacide.bsky.social tells @CNET.com. www.cnet.com/tech/servic...
No, Your iPhone Isn't Listening to You. Here's What's Really Happening
There are lots of reasons an ad pops up on your phone, but none involve a microphone listening.
www.cnet.com
September 4, 2025 at 5:04 PM
"The unsettling feeling that your device is spying on you is real — but the culprit isn't a secret microphone. It's the data broker industry," EFF’s @evacide.bsky.social tells @CNET.com. www.cnet.com/tech/servic...
Reposted by GcL
The 100 lowest-paying US corporations spent $644B on stock buybacks from 2019 to 2024.
Buybacks artificially boost share prices and inflate CEO pay.
The typical worker at these companies earned $35k last year.
Meanwhile, the average CEO was paid $17.2M
See the problem?
Buybacks artificially boost share prices and inflate CEO pay.
The typical worker at these companies earned $35k last year.
Meanwhile, the average CEO was paid $17.2M
See the problem?
September 3, 2025 at 10:15 PM
The 100 lowest-paying US corporations spent $644B on stock buybacks from 2019 to 2024.
Buybacks artificially boost share prices and inflate CEO pay.
The typical worker at these companies earned $35k last year.
Meanwhile, the average CEO was paid $17.2M
See the problem?
Buybacks artificially boost share prices and inflate CEO pay.
The typical worker at these companies earned $35k last year.
Meanwhile, the average CEO was paid $17.2M
See the problem?
Reposted by GcL
Vinay Prasad, a former adult oncologist, has moved to disrupt the childhood vaccine schedule by asserting - against all evidence - that administering multiple vaccines at the same time “could blunt their efficacy.” The added burden/delay of separating shots would sharply reduce US vaccination rates.
FDA quietly positions itself to disrupt childhood vaccine schedule
While CDC turmoil grabbed the media spotlight, a quieter but potentially more consequential drama unfolded last week at FDA. The agency has positioned itse...
www.biocentury.com
September 3, 2025 at 11:38 AM
Vinay Prasad, a former adult oncologist, has moved to disrupt the childhood vaccine schedule by asserting - against all evidence - that administering multiple vaccines at the same time “could blunt their efficacy.” The added burden/delay of separating shots would sharply reduce US vaccination rates.
Reposted by GcL
Digital Rights Bytes is a place for you to get clear answers to the frequently asked questions that bug you about technology in short, easily digestible bites. www.digitalrightsbytes.org/
Welcome to Digital Rights Bytes
Digital Rights Bytes
www.digitalrightsbytes.org
September 1, 2025 at 5:58 PM
Digital Rights Bytes is a place for you to get clear answers to the frequently asked questions that bug you about technology in short, easily digestible bites. www.digitalrightsbytes.org/
Reposted by GcL
Weekend project: writing a simple search engine. Part 2 is about document ranking: www.redblobgames.com/blog/2025-08...
September 1, 2025 at 10:30 PM
Weekend project: writing a simple search engine. Part 2 is about document ranking: www.redblobgames.com/blog/2025-08...
Reposted by GcL
Blaft with the true cure for modern malaise www.blaft.com/blogs/news/a...
September 2, 2025 at 12:01 PM
Blaft with the true cure for modern malaise www.blaft.com/blogs/news/a...
Reposted by GcL
House Republicans Want To Doxx Wikipedia Editors Over Bogus ‘Bias’ Complaints
Congress has absolutely zero constitutional authority to investigate a private website for its editorial decisions. Zero. None. This is First Amendment 101. Yet House Oversight Committee Chairman James Comer and…
Congress has absolutely zero constitutional authority to investigate a private website for its editorial decisions. Zero. None. This is First Amendment 101. Yet House Oversight Committee Chairman James Comer and…
House Republicans Want To Doxx Wikipedia Editors Over Bogus ‘Bias’ Complaints
Congress has absolutely zero constitutional authority to investigate a private website for its editorial decisions. Zero. None. This is First Amendment 101. Yet House Oversight Committee Chairman James Comer and Cybersecurity Subcommittee Chairwoman Nancy Mace have decided otherwise. In a letter to Wikimedia Foundation CEO Maryana Iskander, these two Republicans are demanding that Wikipedia hand over editor identities, internal communications, and arbitration records because some studies suggest there might be bias in Wikipedia articles about Israel-Palestine issues.
www.techdirt.com
August 29, 2025 at 6:00 PM
House Republicans Want To Doxx Wikipedia Editors Over Bogus ‘Bias’ Complaints
Congress has absolutely zero constitutional authority to investigate a private website for its editorial decisions. Zero. None. This is First Amendment 101. Yet House Oversight Committee Chairman James Comer and…
Congress has absolutely zero constitutional authority to investigate a private website for its editorial decisions. Zero. None. This is First Amendment 101. Yet House Oversight Committee Chairman James Comer and…
Reposted by GcL
The best marketing "Socialism" ever had.
August 30, 2025 at 6:41 PM
The best marketing "Socialism" ever had.
Reposted by GcL
REFINERY BUSTER: Ukraine's ship-killing R-360 Neptune has been modified into the 'Long Neptune' for use as a Tactical Land Attack Missile (TLAM). With a 1000 Km (600 mi) range the Long Neptune can deliver precision strikes in adverse Electronic Warfare (EW) environments.
x.com/chuckpfarrer...
x.com/chuckpfarrer...
August 31, 2025 at 5:26 AM
REFINERY BUSTER: Ukraine's ship-killing R-360 Neptune has been modified into the 'Long Neptune' for use as a Tactical Land Attack Missile (TLAM). With a 1000 Km (600 mi) range the Long Neptune can deliver precision strikes in adverse Electronic Warfare (EW) environments.
x.com/chuckpfarrer...
x.com/chuckpfarrer...
Reposted by GcL
A cradle-to-grave analysis from the University of Michigan has shown that battery electric vehicles have lower lifetime greenhouse gas emissions than internal combustion engine vehicles, hybrids and plug-in hybrids in every county in the contiguous U.S.
news.umich.edu/evs-reduce-c...
news.umich.edu/evs-reduce-c...
EVs reduce climate pollution, but by how much? New U-M research has the answer
Choosing a more electrified vehicle will reduce drivers' greenhouse gas emissions, regardless of where they live in the contiguous United States, according to a new study from the University of Michig...
news.umich.edu
August 31, 2025 at 5:40 AM
A cradle-to-grave analysis from the University of Michigan has shown that battery electric vehicles have lower lifetime greenhouse gas emissions than internal combustion engine vehicles, hybrids and plug-in hybrids in every county in the contiguous U.S.
news.umich.edu/evs-reduce-c...
news.umich.edu/evs-reduce-c...
Reposted by GcL
Without our own users, I have no idea when I would have learned about this extremely subtle limitation of the minimap2 serialized index github.com/COMBINE-lab/... (reference names > 255 bytes don't roundtrip). Users push your software in ways you might not even think to!
August 30, 2025 at 1:53 PM
Without our own users, I have no idea when I would have learned about this extremely subtle limitation of the minimap2 serialized index github.com/COMBINE-lab/... (reference names > 255 bytes don't roundtrip). Users push your software in ways you might not even think to!
Reposted by GcL
While defending the luddite argument in Discord, I stumbled into this IMO succinct explanation for opposing generative AI:
At every step in the process, it impoverishes us.
At every step in the process, it impoverishes us.
August 28, 2025 at 7:05 PM
While defending the luddite argument in Discord, I stumbled into this IMO succinct explanation for opposing generative AI:
At every step in the process, it impoverishes us.
At every step in the process, it impoverishes us.
Reposted by GcL
There’s a persistent myth that new solar farms don’t really help tackle climate change because panels are “made with coal” and “never pay back” their carbon debt.
This is simply false.
- UN: solar ~8x cleaner than gas, ~19x than coal per kWh
- panels repay CO2 in 4 months; save 57x over life
This is simply false.
- UN: solar ~8x cleaner than gas, ~19x than coal per kWh
- panels repay CO2 in 4 months; save 57x over life
August 30, 2025 at 8:46 AM
There’s a persistent myth that new solar farms don’t really help tackle climate change because panels are “made with coal” and “never pay back” their carbon debt.
This is simply false.
- UN: solar ~8x cleaner than gas, ~19x than coal per kWh
- panels repay CO2 in 4 months; save 57x over life
This is simply false.
- UN: solar ~8x cleaner than gas, ~19x than coal per kWh
- panels repay CO2 in 4 months; save 57x over life
Reposted by GcL
You hit the nail on the head! There's actually a paper on this: "ChatGPT is bullshit."
link.springer.com/article/10.1...
link.springer.com/article/10.1...
ChatGPT is bullshit - Ethics and Information Technology
Recently, there has been considerable interest in large language models: machine learning systems which produce human-like text and dialogue. Applications of these systems have been plagued by persist...
link.springer.com
August 30, 2025 at 1:03 AM
You hit the nail on the head! There's actually a paper on this: "ChatGPT is bullshit."
link.springer.com/article/10.1...
link.springer.com/article/10.1...