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Reposted by Ellen Foxman

Victor Tatarskiy @greenrat.bsky.social · 13d

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky

On the left - western blot of B16F10 cells wt and KO for CDK8. Our in house produced antibodies give a lot of unspecific bands. On the right same probes with antibodies preincubated with fixed CDK8 KO cells - there is a specific band and faint unspecific bands, which can be probably eliminated with increase of amount of KO cells.

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Reposted by Ellen Foxman

Marc Veldhoen @marcveld.bsky.social · 5d

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging

Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.

www.science.org/doi/...
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A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that naked mole-rat cyclic guanosine monophosphate–adenosine ...

www.science.org

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Ellen Foxman @ellenfoxman.bsky.social · 2d

Happy to share this review just out in Current Opinion in Immunology on innate immunity in the respiratory tract - also check out the other reviews in this collection on Intrinsic Immunity edited by John MacMicking #ImmunoSky #IDSky #pulmsky #MedSky www.sciencedirect.com/science/arti...

Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity

A central challenge in defending mucosal barriers is protecting against pathogens while also limiting excessive inflammation. Respiratory viruses are …

www.sciencedirect.com

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Ellen Foxman @ellenfoxman.bsky.social · Jun 23

#COVID19 revealed the urgent need for better ways to screen for & rule out respiratory virus infection. We present a nasal biomarker screening strategy to prevent & manage outbreaks @eBiomedicine.bsky.social #IDSky #MedSky #lungs @yaleschoolofmed.bsky.social www.thelancet.com/journals/ebi...

Nasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance study

These results demonstrate the utility of a nasopharyngeal biomarker to rule out respiratory infection, with potential applications in outbreak management and/or routine screening in high-risk settings...

www.thelancet.com

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Reposted by Ellen Foxman

Jeremy Berg @jeremymberg.bsky.social · May 31

ASSIGNMENT: COMMENT ON SCHEDULE F

1 week left to comment about Schedule F, potentially making NIH institute and center director essentially political appointees.

www.regulations.gov/commenton/OP...

1/n

Regulations.gov

www.regulations.gov

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Reposted by Ellen Foxman

Hensley Lab @scottehensley.bsky.social · May 30

Nice coverage of our H5 mRNA work by Jon LaPook tonight on @cbseveningnews.bsky.social

www.cbsnews.com/video/the-sc...

The scientists aiming to stay ahead of bird flu on dairy farms and prevent a human pandemic

So far, the only people to come down with bird flu got it from animals. Dr. Jon LaPook reports on how research is underway to keep bird flu from mutating into a form that could spread from person to p...

www.cbsnews.com

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Reposted by Ellen Foxman

David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · May 28

Are you a scientist and not sure what to do to help with all the awfulness all around us? Inspired by Vietnam era activism, @standupforscience.bsky.social is hosting a series of "teach ins," in which scientists share a bit about their area of expertise and why it's important with the public. 🧪🦑🌎

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Reposted by Ellen Foxman

Hensley Lab @scottehensley.bsky.social · May 21

Check out this news story that @nature.com wrote describing our recent preprint where we tested our H5 mRNA vaccine in calves.

The data look good and we are currently testing the vaccine in lactating cattle...more to come!

Nature @nature.com · May 20

As bird flu sweeps across US poultry and cattle farms, researchers are racing to find ways to contain the outbreaks before they ignite a human pandemic. Now, a team of scientists has developed a fresh approach: the first mRNA bird-flu vaccine for cattle.

https://go.nature.com/4kbOvTe

Bird flu vaccine for cattle aces early test

Vaccines for livestock could reduce the risk of human outbreaks, but hurdles remain.

go.nature.com

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Reposted by Ellen Foxman

Caroleeena @caroleeena.bsky.social · May 18

The Nile from the International Space Station:

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Jonathan Slater @jonathanslater.bsky.social · May 19

Once in a while. Good morning Blue Sky

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Ellen Foxman @ellenfoxman.bsky.social · May 19

Congratulations!

Reposted by Ellen Foxman

Dr. Lucky Tran @luckytran.com · Apr 5

Spectacular view of 100,000 people attending the #HandsOff march in NYC

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Reposted by Ellen Foxman

Dr. Sunny Shin @sunnyshinlab.bsky.social · Apr 2

Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)

elifesciences.org

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Reposted by Ellen Foxman

Carl Zimmer @carlzimmer.com · Mar 29

Top F.D.A. Vaccine Official Resigns, Citing Kennedy’s ‘Misinformation and Lies’ Gift link: nyti.ms/3DTuvVr

Top FDA Vaccine Official Resigns, Citing Kennedy’s ‘Misinformation and Lies’ (Gift Article)

Dr. Peter Marks, a veteran of the agency, wrote that undermining confidence in vaccines is irresponsible and a danger to public health.

nyti.ms

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Reposted by Ellen Foxman

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Mar 27

We are seeking to hire a lab tech, this is an HHMI funded position, please share the job posting:

hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Lab Administration Research Technician- Bertozzi Lab

Primary Work Address: Beckman Center, Stanford, CA, 94305-5323 Current HHMI Employees, click here to apply via your Workday account. We are currently looking for a highly motivated Lab Administration ...

hhmi.wd1.myworkdayjobs.com

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Reposted by Ellen Foxman

Nikolai Slavov @slavov-n.bsky.social · Mar 22

The difference between Accuracy & Precision.

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Reposted by Ellen Foxman

Maureen Barr @barrlab.bsky.social · Mar 20

In a science round table discussion yesterday, my NJ senator @kim.senate.gov suggested a strong argument for NIH and federal funding is global competitiveness. We US-based scientists should start weaving this into our narratives.

Don Moynihan @donmoyn.bsky.social · Mar 20

NIH spending more than pays for itself. It generates about $2.5 for every $1 spent. In terms of research productivity, NIH funding dwarfs the rest of the world. The only long-term potential rival is China. Politicizing the NIH's scientific processes will hand China a huge strategic advantage.

graph showing publication of NIH funded publications, relative to other funders. China is catching up.

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Reposted by Ellen Foxman

Thiago Carvalho @cyrilpedia.bsky.social · Mar 20

'Neutrophils expressed notably low levels of STING, whereas forced expression led to uncontrolled systemic inflammation. During development in the thymus, Tcells dynamically & epigenetically restricted STING expression through DNMT1–mediated transcriptional silencing'
#Immunology

Dynamic STING repression orchestrates immune cell development and function

Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

www.science.org

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Reposted by Ellen Foxman

Waggoner Lab @labwaggoner.bsky.social · Mar 19

@cp-trendsimmuno.bsky.social Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities
www.cell.com/trends/immun...

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Reposted by Ellen Foxman

Sam Wang @samwang.bsky.social · Mar 19

Today I'm filled with admiration for my university's president, Chris Eisgruber. He's standing up for Columbia and for universities as a home for freedom of ideas, debate, and thought - free of government attack. www.theatlantic.com/ideas/archiv...

The Cost of the Government’s Attack on Columbia

American universities have given the country prosperity and security. The Trump administration’s attack on academic freedom endangers all of that.

www.theatlantic.com

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Reposted by Ellen Foxman

Kalev Freeman @uvmtraumalab.bsky.social · Mar 19

My privilege to team up with FASEB President-elect Eric Kelley today. We visited the W. Virginia and #Vermont offices together to explain how science research saves lives, creates jobs and keeps the USA competitive.

#FASEBonTheHill #FundScience #NIH #MedSky #AcademicSky #UVMLarnerMed🧪

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Reposted by Ellen Foxman

Andrei Goga @andreigoga.bsky.social · Mar 20

UCSF, like all UC campuses, announced an immediate hiring freeze today. UCSF is the second largest employer in the city. There will be wide ripple effects in the Bay Area and beyond, including the future of biotech and pharma in the area. 🧪

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Reposted by Ellen Foxman

Nicole Bedera @nbedera.bsky.social · Mar 18

If there's one thing that domestic violence research has taught me, it's that abusers set up no-win scenarios. They punish you whether you cooperate with them or whether you push back.

The only way out is to strengthen ties with people outside of the relationship who can create new, better options.

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gamera obscura @ohrobin.bsky.social · Mar 19

My dear friend’s niece, who in October developed sepsis when a Georgia hospital refused her a D&C after a miscarriage, will be taken off life support tomorrow.

I don’t know the names of the countless others who have suffered and will suffered because of anti-abortion laws.

But her name was Haley.

A school photo of a gently smiling teenage girl. She has long brown hair and a black cardigan.

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Harmit Singh Malik @harmitmalik.bsky.social · Mar 19

Please consider nominating deserving colleagues (including yourselves) who would be excellent candidates for five open positions on the Council, including Nominations for President-elect, Secretary, Treasurer, and 2 Councilors.

Please share widely!

@official-smbe.bsky.social

Dear SMBE Members,

I am writing to solicit nominations for SMBE President-Elect, Secretary, Treasurer and 2 Councilors whose terms will begin on January 1, 2026. Each of these positions is for a duration of three years.

Council members play important roles in guiding the development of the society, soliciting and implementing programs that support our members, while enriching opportunities for young scientists from around the world. They also have a role in overseeing our two excellent journals (MBE and GBE) as well as our annual meeting, regional meetings, and satellite meetings.

Nominations will be reviewed by the nominations committee who will then put forward a slate of two candidates for each position for vote by the SMBE membership. Past and current council members are listed HERE.

Nominations (self-nominations are welcome) should consist of a brief statement in support of your suggestion (why this nomination, what the nominee can bring to SMBE, work subject, other biographical information). For Presidential nominees please include previous involvement with SMBE.

We ask the nominators to confirm explicitly that the person they are nominating has already confirmed their willingness to run for office.

Please send your nominations to Harmit Malik <hsmalik@fredhutch.org> AND to Emmanuelle Lerat <secretary.smbe@gmail.com> by April 18, 2025.

We look forward to hearing from you!

Sincerely yours,
Emmanuelle Lerat
Secretary of SMBE, on behalf of the Nominations Committee*

*The Nominations Committee is composed as follows:
Harmit S Malik (Chair) USA.
Xuming Zhou, China.
Mary O'Connell, UK.
Nicolas Galtier, France.
Deepa Agashe, India.
Emmanuelle Lerat (ex officio), France.

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