Christine Cucinotta
@chrstne.bsky.social
Assistant prof at OSU|epigenomics of cellular reawakening in yeast & neural stem cells|views mine!|she/her
Diversity, Equity, & Inclusion are values essential to an ethical and modern society|Black lives matter|Trans rights are human rights
Diversity, Equity, & Inclusion are values essential to an ethical and modern society|Black lives matter|Trans rights are human rights
Reposted by Christine Cucinotta
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
coming up for air after long periods of major depression feels like whiplash. late to the horrible news of our loss of Zara Weinberg.
at a loss for words but she was one of the most amazing people i’ve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
at a loss for words but she was one of the most amazing people i’ve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
December 2, 2025 at 7:32 PM
coming up for air after long periods of major depression feels like whiplash. late to the horrible news of our loss of Zara Weinberg.
at a loss for words but she was one of the most amazing people i’ve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
at a loss for words but she was one of the most amazing people i’ve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
Reposted by Christine Cucinotta
Get bedder v0.1.8 and r𝗲𝗮𝗱 𝘁𝗵𝗲 𝗱𝗼𝗰𝘂𝗺𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻 here: github.com/quinlan-lab/...
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
Release Release v0.1.8 · quinlan-lab/bedder-rs
Changes in v0.1.8
Downloads
bedder-static-linux-x86_64: Static binary for Linux x86_64 (no dependencies required)
bedder-static-macos-x86_64-python3.13: macOS x86_64 binary built with Python 3.13
...
github.com
December 2, 2025 at 2:28 AM
Get bedder v0.1.8 and r𝗲𝗮𝗱 𝘁𝗵𝗲 𝗱𝗼𝗰𝘂𝗺𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻 here: github.com/quinlan-lab/...
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
Reposted by Christine Cucinotta
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
1/n
1/n
Intro to Bedder – The Quinlan Lab
quinlanlab.org
December 2, 2025 at 2:28 AM
Reposted by Christine Cucinotta
Truly enjoyed writing this piece about recent discoveries by @bloodgenes.bsky.social and colleagues about how we can improve HSC expansion & gene editing by blocking ferroptosis!
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Blocking ferroptosis to expand human HSCs
Nature Cell Biology - Haematopoietic stem cells (HSCs) are used in a variety of cellular therapies, but our ability to support these cells ex vivo remains technically challenging. A new study...
rdcu.be
December 1, 2025 at 4:57 PM
Truly enjoyed writing this piece about recent discoveries by @bloodgenes.bsky.social and colleagues about how we can improve HSC expansion & gene editing by blocking ferroptosis!
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Reposted by Christine Cucinotta
AI is good at needling people, had me in stitches following this thread!
say what now?
AI has been infiltrating knitting and crochet spaces, filling them with useless patterns. Here's why that's happening and what can be done about it.
www.plagiarismtoday.com/2025/11/24/t...
#AI #Knitting #Crochet #FiberArt #Copyright
www.plagiarismtoday.com/2025/11/24/t...
#AI #Knitting #Crochet #FiberArt #Copyright
November 24, 2025 at 9:48 PM
AI is good at needling people, had me in stitches following this thread!
the best thing ever is when the person you are writing a letter for makes calendar invites for you for the deadlines
November 17, 2025 at 4:24 PM
the best thing ever is when the person you are writing a letter for makes calendar invites for you for the deadlines
Reposted by Christine Cucinotta
The lab published a nice paper, so we celebrated at our Friday lab meeting 🎉
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
November 14, 2025 at 7:34 PM
The lab published a nice paper, so we celebrated at our Friday lab meeting 🎉
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
i hate it here.
this is awful in so many ways i dont even have the words
this is awful in so many ways i dont even have the words
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 12:28 PM
i hate it here.
this is awful in so many ways i dont even have the words
this is awful in so many ways i dont even have the words
Reposted by Christine Cucinotta
Congrats again, everyone
November 13, 2025 at 2:27 PM
Congrats again, everyone
Reposted by Christine Cucinotta
Had an amazing time at the CSHL Genome Informatics 2025 conference!
Presented my poster: “Investigating quiescence-specific roles of FUN30 in chromatin compaction” 🧬
@chrstne.bsky.social
#GI2025 #Chromatin #Genomics #Quiescence
Presented my poster: “Investigating quiescence-specific roles of FUN30 in chromatin compaction” 🧬
@chrstne.bsky.social
#GI2025 #Chromatin #Genomics #Quiescence
November 12, 2025 at 6:32 PM
Had an amazing time at the CSHL Genome Informatics 2025 conference!
Presented my poster: “Investigating quiescence-specific roles of FUN30 in chromatin compaction” 🧬
@chrstne.bsky.social
#GI2025 #Chromatin #Genomics #Quiescence
Presented my poster: “Investigating quiescence-specific roles of FUN30 in chromatin compaction” 🧬
@chrstne.bsky.social
#GI2025 #Chromatin #Genomics #Quiescence
Reposted by Christine Cucinotta
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
October 14, 2025 at 5:57 AM
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Reposted by Christine Cucinotta
Roughly 900 PIs who will not be getting their award in FY2025. But also they will not have that money for FY2026, FY2027, FY2028 or FY2029. and *next* year, we will be adding some more applicants to this list even if by some miracle the NIH budget is the same.
November 5, 2025 at 5:42 PM
Roughly 900 PIs who will not be getting their award in FY2025. But also they will not have that money for FY2026, FY2027, FY2028 or FY2029. and *next* year, we will be adding some more applicants to this list even if by some miracle the NIH budget is the same.
Reposted by Christine Cucinotta
and there it is. the absolutely massive change in R01s funded multi-year. our perceptions that the new mandate, sorry strong suggestion, has had a dramatic effect on forward funding and therefore success rates is validated.
2025
Here the largest fraction is for R01 awards, followed by RF1s, and R21s.
In most cases, these were R01s that had not particularly reason to be forward funded except that NIH had put itself in a situation when large amounts of funding needed to be committed by the end of the fiscal year
21/25
Here the largest fraction is for R01 awards, followed by RF1s, and R21s.
In most cases, these were R01s that had not particularly reason to be forward funded except that NIH had put itself in a situation when large amounts of funding needed to be committed by the end of the fiscal year
21/25
November 5, 2025 at 4:45 PM
and there it is. the absolutely massive change in R01s funded multi-year. our perceptions that the new mandate, sorry strong suggestion, has had a dramatic effect on forward funding and therefore success rates is validated.
Reposted by Christine Cucinotta
And importantly, while a few years to settle out might seem no biggie, it sure as heck is a big deal to those PIs who have been on the job for just a few years and are looking at the tenure decision looming ahead.
November 5, 2025 at 5:46 PM
And importantly, while a few years to settle out might seem no biggie, it sure as heck is a big deal to those PIs who have been on the job for just a few years and are looking at the tenure decision looming ahead.
Reposted by Christine Cucinotta
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
www.nature.com
November 4, 2025 at 1:17 PM
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
Reposted by Christine Cucinotta
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
October 30, 2025 at 10:07 PM
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Reposted by Christine Cucinotta
Really positive sign that open source projects are standing up to do the right thing. Kudos to the Python folks: www.theregister.com/2025/10/27/p...
Python Foundation rejects $1.5M grant with no-DEI strings
: Foundation says it won't compromise policy of inclusivity even if that cash would've really helped
www.theregister.com
October 28, 2025 at 3:17 PM
Really positive sign that open source projects are standing up to do the right thing. Kudos to the Python folks: www.theregister.com/2025/10/27/p...
Reposted by Christine Cucinotta
👀Next Wednesday, Oct 22nd, at #FragileNucleosome seminar, we are excited to host @alicelaigle.bsky.social and @seungsookim.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
October 14, 2025 at 6:34 AM
👀Next Wednesday, Oct 22nd, at #FragileNucleosome seminar, we are excited to host @alicelaigle.bsky.social and @seungsookim.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Reposted by Christine Cucinotta
I am seeing a lot of people reposting Lakota Man today bc it's Indigenous Peoples Day. A reminder that he is not well liked amongst many (most?) Natives on social media. Many of us blocked him a long time ago. Some of the reasons why are in this article.
www.dailydot.com/irl/lakotama...
www.dailydot.com/irl/lakotama...
Who is LakotaMan, the user behind one of the most popular Native American accounts on X?
John Martin is adored by white X users—but infamous among Native and Indigenous communities.
www.dailydot.com
October 13, 2025 at 2:06 PM
I am seeing a lot of people reposting Lakota Man today bc it's Indigenous Peoples Day. A reminder that he is not well liked amongst many (most?) Natives on social media. Many of us blocked him a long time ago. Some of the reasons why are in this article.
www.dailydot.com/irl/lakotama...
www.dailydot.com/irl/lakotama...
Reposted by Christine Cucinotta
Beautiful, layered argument for the use of model organisms, especially small ones, in research. A must read!
October 10, 2025 at 10:15 PM
Beautiful, layered argument for the use of model organisms, especially small ones, in research. A must read!
Reposted by Christine Cucinotta
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
October 10, 2025 at 4:47 PM
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
Reposted by Christine Cucinotta
Nobel Peace Prize 2025: "The committee commended Machado as a “brave and committed champion of peace” who had kept “the flame of democracy burning during a growing darkness”. 🔥
www.theguardian.com/world/2025/o...
www.theguardian.com/world/2025/o...
Venezuelan politician María Corina Machado wins Nobel peace prize
Leader of country’s opposition receives award after scrutiny surrounding committee and comments by Donald Trump
www.theguardian.com
October 10, 2025 at 12:03 PM
Nobel Peace Prize 2025: "The committee commended Machado as a “brave and committed champion of peace” who had kept “the flame of democracy burning during a growing darkness”. 🔥
www.theguardian.com/world/2025/o...
www.theguardian.com/world/2025/o...
Reposted by Christine Cucinotta
This is nothing more than a continuation of the president’s desperate weaponization of our justice system.
I am not fearful — I am fearless.
We will fight these baseless charges aggressively, and my office will continue to fiercely protect New Yorkers and their rights..
I am not fearful — I am fearless.
We will fight these baseless charges aggressively, and my office will continue to fiercely protect New Yorkers and their rights..
October 9, 2025 at 9:36 PM
This is nothing more than a continuation of the president’s desperate weaponization of our justice system.
I am not fearful — I am fearless.
We will fight these baseless charges aggressively, and my office will continue to fiercely protect New Yorkers and their rights..
I am not fearful — I am fearless.
We will fight these baseless charges aggressively, and my office will continue to fiercely protect New Yorkers and their rights..
Reposted by Christine Cucinotta
Friendly reminder: 🎉 Pre-register today & get ready to join our FREE online celebration. Everyone is welcome. To keep #BlackInMicro alive Donate: tinyurl.com/GiveBiM and Register to attend: linktr.ee/BlackInMicro (see links in bio) #BiMWeek2025
October 9, 2025 at 5:54 PM
Friendly reminder: 🎉 Pre-register today & get ready to join our FREE online celebration. Everyone is welcome. To keep #BlackInMicro alive Donate: tinyurl.com/GiveBiM and Register to attend: linktr.ee/BlackInMicro (see links in bio) #BiMWeek2025