Alex Shackman
@ajshackman.bsky.social
Laboratory for Affective & Translational Neuroscience, University of Maryland | shackmanlab.org | affective neuroscience | "pessimism of the intellect, optimism of the will.”
Reposted by Alex Shackman
Nature research paper: Building compositional tasks with shared neural subspaces
go.nature.com/4ocRj3n
go.nature.com/4ocRj3n
Building compositional tasks with shared neural subspaces - Nature
The brain can flexibly perform multiple tasks by compositionally combining task-relevant neural representations.
go.nature.com
November 27, 2025 at 11:37 AM
Nature research paper: Building compositional tasks with shared neural subspaces
go.nature.com/4ocRj3n
go.nature.com/4ocRj3n
Reposted by Alex Shackman
New Sci Adv paper shows that dopamine in SNr does not directly act via D1/D2 receptors but gates striatonigral output indirectly, by boosting serotonin that activates presynaptic 5-HT1BRs to suppress low-frequency D1-MSN GABA release. #RewardSignals #neuroskyence pubmed.ncbi.nlm.nih.gov/41191762/
Dopamine and serotonin cotransmission filters striatonigral synaptic activity via 5-HT1B receptor activation - PubMed
The substantia nigra pars reticulata (SNr), a key basal ganglia output nucleus, is modulated by dopamine (DA) believed to be released locally from midbrain DA neurons. Although DA has been proposed to regulate γ-aminobutyric acid (GABA) release from medium spiny neuron (MSN) terminals via presynapti …
pubmed.ncbi.nlm.nih.gov
November 27, 2025 at 11:53 AM
New Sci Adv paper shows that dopamine in SNr does not directly act via D1/D2 receptors but gates striatonigral output indirectly, by boosting serotonin that activates presynaptic 5-HT1BRs to suppress low-frequency D1-MSN GABA release. #RewardSignals #neuroskyence pubmed.ncbi.nlm.nih.gov/41191762/
Reposted by Alex Shackman
A lot of people work on Thanksgiving. Patients don’t magically heal for a few days, so hospital staff and nurses never stop. A lot retail workers. Military stay deployed. But there’s one group who are also away from home and are rarely thanked: truck drivers and transportation workers. Thank you.
November 27, 2025 at 7:21 AM
A lot of people work on Thanksgiving. Patients don’t magically heal for a few days, so hospital staff and nurses never stop. A lot retail workers. Military stay deployed. But there’s one group who are also away from home and are rarely thanked: truck drivers and transportation workers. Thank you.
i've never looked for the habenula til NOW
November 26, 2025 at 9:57 PM
i've never looked for the habenula til NOW
should i read Greg/stats, this DA/Rew paper, or go make the deviled eggs for tomorrow....?
November 26, 2025 at 9:01 PM
should i read Greg/stats, this DA/Rew paper, or go make the deviled eggs for tomorrow....?
Nmax and the quest to restore caution, integrity, and practicality to the sample size planning process. Hancock, G. R., & Feng, Y. (2025). Psychological Methods. doi.org/10.1037/met0...
APA PsycNet
doi.org
November 26, 2025 at 8:59 PM
Nmax and the quest to restore caution, integrity, and practicality to the sample size planning process. Hancock, G. R., & Feng, Y. (2025). Psychological Methods. doi.org/10.1037/met0...
Reposted by Alex Shackman
On this day 49 years ago, #SexPistols released their debut single, "Anarchy in the U.K."
Released as 7″ only, and originally in a plain black sleeve, before being reissued in a standard #EMI sleeve after initial copies mis-credited production of the b-side to Chris Thomas instead of Dave Goodman.
Released as 7″ only, and originally in a plain black sleeve, before being reissued in a standard #EMI sleeve after initial copies mis-credited production of the b-side to Chris Thomas instead of Dave Goodman.
November 26, 2025 at 8:24 AM
On this day 49 years ago, #SexPistols released their debut single, "Anarchy in the U.K."
Released as 7″ only, and originally in a plain black sleeve, before being reissued in a standard #EMI sleeve after initial copies mis-credited production of the b-side to Chris Thomas instead of Dave Goodman.
Released as 7″ only, and originally in a plain black sleeve, before being reissued in a standard #EMI sleeve after initial copies mis-credited production of the b-side to Chris Thomas instead of Dave Goodman.
Reposted by Alex Shackman
“The articles in AMPPS offer, month in and month out, the invitation to practice aligning your values, intentions, and actions to do less scientific harm and reach for the methodological ceiling”
Grateful to @dsbarra.bsky.social for continuing what @profsimons.bsky.social & co started at AMPPS!
Grateful to @dsbarra.bsky.social for continuing what @profsimons.bsky.social & co started at AMPPS!
My time as Editor of AMPPS is coming to an end-- here are some parting thoughts. journals.sagepub.com/doi/full/10.... .
Taking Stock of Advances in Methods and Practices in Psychological Science at the End of the Beginning - David A. Sbarra, 2025
journals.sagepub.com
November 26, 2025 at 7:38 PM
“The articles in AMPPS offer, month in and month out, the invitation to practice aligning your values, intentions, and actions to do less scientific harm and reach for the methodological ceiling”
Grateful to @dsbarra.bsky.social for continuing what @profsimons.bsky.social & co started at AMPPS!
Grateful to @dsbarra.bsky.social for continuing what @profsimons.bsky.social & co started at AMPPS!
Reposted by Alex Shackman
My time as Editor of AMPPS is coming to an end-- here are some parting thoughts. journals.sagepub.com/doi/full/10.... .
Taking Stock of Advances in Methods and Practices in Psychological Science at the End of the Beginning - David A. Sbarra, 2025
journals.sagepub.com
November 26, 2025 at 7:10 PM
My time as Editor of AMPPS is coming to an end-- here are some parting thoughts. journals.sagepub.com/doi/full/10.... .
#CTRI_FTW Betts et al. (2025). Expanding the scope of the withdrawal syndrome: Anhedonia as a core nicotine withdrawal symptom. Journal of Psychopathology and Clinical Science, 134(5), 540–553. doi.org/10.1037/abn0...
APA PsycNet
doi.org
November 26, 2025 at 8:42 PM
#CTRI_FTW Betts et al. (2025). Expanding the scope of the withdrawal syndrome: Anhedonia as a core nicotine withdrawal symptom. Journal of Psychopathology and Clinical Science, 134(5), 540–553. doi.org/10.1037/abn0...
Reposted by Alex Shackman
Out now: Favila, Capece Marsico et al. 2025, Nature Communications: Using longitudinal deep-brain imaging, we report that amygdala interneurons exhibit complex and heterogeneous plasticity during associative learning, at both the single-cell and population level.
👉 www.nature.com/articles/s41...
👉 www.nature.com/articles/s41...
Heterogeneous plasticity of amygdala interneurons in associative learning and extinction - Nature Communications
In this study, the authors uncover how diverse inhibitory interneurons in the amygdala flexibly contribute to fear and safety learning, revealing a key role for inhibition in emotional memory and adap...
www.nature.com
November 12, 2025 at 6:55 PM
Out now: Favila, Capece Marsico et al. 2025, Nature Communications: Using longitudinal deep-brain imaging, we report that amygdala interneurons exhibit complex and heterogeneous plasticity during associative learning, at both the single-cell and population level.
👉 www.nature.com/articles/s41...
👉 www.nature.com/articles/s41...
Reposted by Alex Shackman
This Thanksgiving, I am grateful for my LETTER WRITERS. The academic job market is relentless and demands so much of applicants AND the people who champion them. I am so thankful for the time, care, and support that my letter writers have given me through the ups and downs of my academic journey.
November 26, 2025 at 3:14 PM
This Thanksgiving, I am grateful for my LETTER WRITERS. The academic job market is relentless and demands so much of applicants AND the people who champion them. I am so thankful for the time, care, and support that my letter writers have given me through the ups and downs of my academic journey.
Reposted by Alex Shackman
Attn MRI enthusiasts! 📣
Just in time for Thanksgiving, I’m thankful to share this opportunity to join us as MRI Center Director! ✨ Couldn’t speak more highly of my time here so far—such a supportive & collaborative place to build a lab—and I’m more than happy to share more with anyone interested
Just in time for Thanksgiving, I’m thankful to share this opportunity to join us as MRI Center Director! ✨ Couldn’t speak more highly of my time here so far—such a supportive & collaborative place to build a lab—and I’m more than happy to share more with anyone interested
🚨 THRILLED to share Northeastern University is hiring a new Director for our human Siemens Prisma 3T MRI Center (Associate or Full Professor levels) who will join us as faculty in our Institute for Cognitive and Brain Health! Please share widely!
northeastern.wd1.myworkdayjobs.com/careers/job/...
northeastern.wd1.myworkdayjobs.com/careers/job/...
Associate Professor/Professor and Director, Northeastern University Biomedical Imaging Center
About the Opportunity About Northeastern: Founded in 1898, Northeastern is a global research (R1) university and the recognized leader in experience-driven lifelong learning. Our world-renowned experi...
northeastern.wd1.myworkdayjobs.com
November 26, 2025 at 3:41 PM
Attn MRI enthusiasts! 📣
Just in time for Thanksgiving, I’m thankful to share this opportunity to join us as MRI Center Director! ✨ Couldn’t speak more highly of my time here so far—such a supportive & collaborative place to build a lab—and I’m more than happy to share more with anyone interested
Just in time for Thanksgiving, I’m thankful to share this opportunity to join us as MRI Center Director! ✨ Couldn’t speak more highly of my time here so far—such a supportive & collaborative place to build a lab—and I’m more than happy to share more with anyone interested
Reposted by Alex Shackman
🚨 THRILLED to share Northeastern University is hiring a new Director for our human Siemens Prisma 3T MRI Center (Associate or Full Professor levels) who will join us as faculty in our Institute for Cognitive and Brain Health! Please share widely!
northeastern.wd1.myworkdayjobs.com/careers/job/...
northeastern.wd1.myworkdayjobs.com/careers/job/...
Associate Professor/Professor and Director, Northeastern University Biomedical Imaging Center
About the Opportunity About Northeastern: Founded in 1898, Northeastern is a global research (R1) university and the recognized leader in experience-driven lifelong learning. Our world-renowned experi...
northeastern.wd1.myworkdayjobs.com
November 25, 2025 at 2:02 AM
🚨 THRILLED to share Northeastern University is hiring a new Director for our human Siemens Prisma 3T MRI Center (Associate or Full Professor levels) who will join us as faculty in our Institute for Cognitive and Brain Health! Please share widely!
northeastern.wd1.myworkdayjobs.com/careers/job/...
northeastern.wd1.myworkdayjobs.com/careers/job/...
BAT is superduper scalable, which is fab, but psychotherapy requires proper supervision for more complex and acute cases. Lightly trained mental health "hygenists" need to be supervised by dentists (MSW/MFT/PhD/PsyD/MD) and, ideally, embedded w/in multi-talented teams
New Nature Medicine study: doulas with a few weeks of training delivered therapy as effectively as PhD clinicians. Same outcomes. If that's true, what exactly requires 5-7 years of grad school? And what does it mean for AI therapy? The therapy elite won't like this.
The Therapy Elite Won’t Like This
I feel shook.
open.substack.com
November 26, 2025 at 2:55 PM
BAT is superduper scalable, which is fab, but psychotherapy requires proper supervision for more complex and acute cases. Lightly trained mental health "hygenists" need to be supervised by dentists (MSW/MFT/PhD/PsyD/MD) and, ideally, embedded w/in multi-talented teams
journals.sagepub.com/doi/full/10.... Really lovely closing lecture from Dave aka @dsbarra.bsky.social. Very nice bibliography (tasting menu?) of some of the cool methodological articles you've missed over the past several years.
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
November 26, 2025 at 2:49 PM
journals.sagepub.com/doi/full/10.... Really lovely closing lecture from Dave aka @dsbarra.bsky.social. Very nice bibliography (tasting menu?) of some of the cool methodological articles you've missed over the past several years.
Reposted by Alex Shackman
Reposted by Alex Shackman
HUGE win for @uam-umd.bsky.social this week!
We @uam-umd.bsky.social won. Faculty packed town halls, talked to their colleagues and collected hundreds of petition signatures. Now UMD is coughing up $8.75m, during a deficit, to fund faculty whose research is under attack. Not enough, but a helluva thing for a union the state calls illegal.
$8.75M Investment Supports ‘Research Resilience’… | Maryland Today
UMD, MPower Funds Combine to Help Preserve Institutional Capabilities, Lab Operations and More
today.umd.edu
November 26, 2025 at 2:37 PM
HUGE win for @uam-umd.bsky.social this week!
Reposted by Alex Shackman
Some additional updates to deadlines have been released for grant submissions that fell during the shutdown
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 25, 2025 at 3:16 AM
Some additional updates to deadlines have been released for grant submissions that fell during the shutdown
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Reposted by Alex Shackman
Not only that, but there is a Nobel prize (or 2 or 3 or 4) behind most of those fundamental discoveries.
Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
November 25, 2025 at 11:38 AM
Not only that, but there is a Nobel prize (or 2 or 3 or 4) behind most of those fundamental discoveries.
Reposted by Alex Shackman
#PenNLINC is recruiting a clinical coordinator / lab manager!!! Looking for someone who is good with both people + code, wants to learn to acquire + analyze imaging data. Alumni in this role have written 1st author papers + gone to top grad programs.
Website: www.pennlinc.io
Job: bit.ly/4ojvCir
Website: www.pennlinc.io
Job: bit.ly/4ojvCir
neuroimaging | Satterthwaite Lab | UPenn
www.satterthwaitelab.com
Homepage for Satterthwaite lab
neuroimaging | neurodevelopment | adolescence | psychiatry | machine learning | network science
www.pennlinc.io
November 24, 2025 at 9:59 PM
#PenNLINC is recruiting a clinical coordinator / lab manager!!! Looking for someone who is good with both people + code, wants to learn to acquire + analyze imaging data. Alumni in this role have written 1st author papers + gone to top grad programs.
Website: www.pennlinc.io
Job: bit.ly/4ojvCir
Website: www.pennlinc.io
Job: bit.ly/4ojvCir
Adding to my classroom slides Wenzel...(2025). Unraveling the link between neuroticism and well-being in daily life: The role of event occurrence, event appraisals, affective reactivity, and affective recovery. Jpsp. doi.org/10.1037/pspp...
APA PsycNet
doi.org
November 25, 2025 at 11:54 AM
Adding to my classroom slides Wenzel...(2025). Unraveling the link between neuroticism and well-being in daily life: The role of event occurrence, event appraisals, affective reactivity, and affective recovery. Jpsp. doi.org/10.1037/pspp...