#GLP/glucagon
Lilly announced phase 3 RCT TRIUMPH-4, where Retatrutide, a new GIP, GLP-1 & glucagon recpt agonist, was given to obese (BMI >35), knee osteoarthritis pts *without diabetes*. Wt loss at 68 wks was 28.7% with reduced WOMAC pain scores of -4.5 points (75.8%) investor.lilly.com/news-release...
investor.lilly.com
December 15, 2025 at 7:02 PM
Tracking GLP-1 Use in Breast Cancer Care

https://www.newsbeep.com/nz/183928/

Obesity is a well-known risk factor for breast cancer development and recurrence, and glucagon-like peptide 1 (GLP-1) receptor…
Tracking GLP-1 Use in Breast Cancer Care - New Zealand News Beep
Obesity is a well-known risk factor for breast cancer development and recurrence, and glucagon-like peptide 1 (GLP-1) receptor agonists have emerged as
www.newsbeep.com
December 14, 2025 at 11:00 PM
.@who.int published a guideline in JAMA on the use and indications of #GLP-1 therapies for the management of #obesity in adults. The guideline offers two conditional recommendations to inform clinical practice and health policy.

Read the guideline: ja.ma/4oNCLHN
December 14, 2025 at 2:00 PM
Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan...
#incretins

#MedSky #EndoSky
December 13, 2025 at 2:09 PM
Ophthopedia Update: Bariatric Surgery May Outperform GLP-1 RAs in Longer-Term Weight Loss Benefits: In patients with obesity, a retrospective study found greater weight loss and lower costs over 2 years after metabolic bariatric surgery than with glucagon-like peptide-1… #Ophthalmology #News
Bariatric Surgery May Outperform GLP-1 RAs in Longer-Term Weight Loss Benefits
In patients with obesity, a retrospective study found greater weight loss and lower costs over 2 years after metabolic bariatric surgery than with glucagon-like peptide-1 receptor agonist (GLP-1 RA) treatment.
dlvr.it
December 12, 2025 at 4:56 PM
Retatrutide

Triple agonist for GLP-1, GIP, and glucagon (GCG) receptors.

One peptide, three hormonal pathways.

This is peptide engineering at its peak.

Fine tuning sequence → multi-receptor binding → selective activation/inhibition.
December 12, 2025 at 4:31 AM
Mendelian randomization and mediation analysis study shows that GLP-1RAs reduce the risk of myocardial infarction mainly via metabolic improvements (HbA1c, BMI, lipids, BP), with no direct effect.

Read here ➡️ doi.org/10.2337/dc25-1822
December 11, 2025 at 3:47 PM
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used for type 2 diabetes mellitus (T2DM) and overweight or obesity, but their association with cancer is unclear.
December 10, 2025 at 11:54 AM
Hidden Dangers of GLP‑1 Weight‑Loss Drugs You Need to Know

What if the race to get thin was quietly putting health at risk? That question is becoming harder to ignore as glucagon‑like peptide‑1 receptor agonists (GLP‑1 RAs) such as semaglutide and tirzepatide move from specialist prescriptions for…
Hidden Dangers of GLP‑1 Weight‑Loss Drugs You Need to Know
What if the race to get thin was quietly putting health at risk? That question is becoming harder to ignore as glucagon‑like peptide‑1 receptor agonists (GLP‑1 RAs) such as semaglutide and tirzepatide move from specialist prescriptions for diabetes into mainstream use for rapid weight loss. Once hailed as breakthroughs, these drugs are now linked to a growing list of medical and psychological consequences that many users never anticipated.
wellbeingwhisper.net
December 8, 2025 at 11:05 AM
Weight-loss drugs have surged in popularity in recent years, with as many as 12% of Americans having tried a glucagon-like peptide-1 (GLP-1) medication. https://ow.ly/MKCY50XFvWI
GLP-1s: What you need to know about weight loss drugs
Just this week, the World Health Organization released new guidelines recommending GLP-1 therapies as a long-term treatment for adults with obesity.
ow.ly
December 8, 2025 at 4:15 AM
The Mental Health Effects of Ozempic and GLP-1 Drugs

https://www.europesays.com/uk/615990/

As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States…#uk #news #uknews
The Mental Health Effects of Ozempic and GLP-1 Drugs - United Kingdom
As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States and Canada, how those drugs influence
www.europesays.com
December 6, 2025 at 1:30 PM
The Mental Health Effects of Ozempic and GLP-1 Drugs

https://www.europesays.com/uk/615990/

As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States…
The Mental Health Effects of Ozempic and GLP-1 Drugs - United Kingdom
As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States and Canada, how those drugs influence
www.europesays.com
December 6, 2025 at 1:20 PM
The Mental Health Effects of Ozempic and GLP-1 Drugs

https://www.newsbeep.com/au/331075/

As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States…
The Mental Health Effects of Ozempic and GLP-1 Drugs - Australia News Beep
As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States and Canada, how those drugs influence
www.newsbeep.com
December 6, 2025 at 11:40 AM
The Mental Health Effects of Ozempic and GLP-1 Drugs

https://www.europesays.com/us/428457/

As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States…#us #news #usnews
The Mental Health Effects of Ozempic and GLP-1 Drugs - United States
As researchers decipher how GLP-1s affect mental health, experts worry access is outpacing the scientific investigation
www.europesays.com
December 6, 2025 at 9:20 AM
The Mental Health Effects of Ozempic and GLP-1 Drugs

https://www.newsbeep.com/us/333170/

As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States…
The Mental Health Effects of Ozempic and GLP-1 Drugs - United States News Beep
As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States and Canada, how those drugs influence
www.newsbeep.com
December 6, 2025 at 3:00 AM
The Mental Health Effects of Ozempic and GLP-1 Drugs

https://www.newsbeep.com/ca/328280/

As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States…
The Mental Health Effects of Ozempic and GLP-1 Drugs - Canada News Beep
As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States and Canada, how those drugs influence
www.newsbeep.com
December 6, 2025 at 2:50 AM
The Mental Health Effects of Ozempic and GLP-1 Drugs

https://www.newsbeep.com/uk/301467/

As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States…
The Mental Health Effects of Ozempic and GLP-1 Drugs - United Kingdom News Beep
As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States and Canada, how those drugs influence
www.newsbeep.com
December 6, 2025 at 2:42 AM
The Mental Health Effects of Ozempic and GLP-1 Drugs

https://www.europesays.com/ie/216744/

As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States…
The Mental Health Effects of Ozempic and GLP-1 Drugs - Ireland
As the reach of glucagon-like peptide-1 (GLP-1) medications such as Ozempic continue to expand in the United States and Canada, how those drugs influence
www.europesays.com
December 5, 2025 at 12:15 PM
WHO guideline on the use of glucagon-like peptide-1 (GLP-1) therapies for the treatment of obesity in adults

World Health Organization Guideline includes conditional recommendation for their use for the long-term treatment of obesity, as part of a comprehensive approach, and calls for urgent…
WHO guideline on the use of glucagon-like peptide-1 (GLP-1) therapies for the treatment of obesity in adults
World Health Organization Guideline includes conditional recommendation for their use for the long-term treatment of obesity, as part of a comprehensive approach, and calls for urgent action on manufacturing, affordability, and system readiness to meet global needs. WHO guideline on the use of glucagon-like peptide-1 (GLP-1) therapies for the treatment of obesity in adults
trfthealthweeklydigest.wordpress.com
December 5, 2025 at 8:42 AM
Another G-force molecule
GLP + glucagon agonist #pemvidutide in MASH

Resolution of MASH, fibrosis impact not seen at this time

www.thelancet.com/journals/lan... in @thelancet.com

How long till someone (?Pfizer) gobbles up Altimmune? @rnflex.bsky.social
December 5, 2025 at 12:31 AM
Introducing Retatrutide 20mg from Propep Sciences, a next-generation investigational peptide designed as a triple agonist of GLP-1, GIP, and glucagon receptors. Ideal for laboratory research. Get more info www.propepsciences.com/shop/Retatru...
#retatrutide #laboratoryresearchpeptide #propepsciences
December 4, 2025 at 9:01 AM
Use of glucagon-like peptide-1 receptor agonists (#GLP1RA) in adults with type 2 #diabetes was associated with an increased risk of new chronic cough compared with other second-line diabetes medications.

ja.ma/3LZtgrs
December 3, 2025 at 3:00 PM
WHO says GLP-1 medicines alone won’t reverse obesity or improve metabolic health; issues its first guidelines for use

https://www.newsbeep.com/us/327925/

The World Health Organization (WHO) has for the first time issued guidelines on the use of Glucagon-Like Peptide-1…
WHO says GLP-1 medicines alone won’t reverse obesity or improve metabolic health; issues its first guidelines for use - United States News Beep
The World Health Organization (WHO) has for the first time issued guidelines on the use of Glucagon-Like Peptide-1 or GLP-1 therapies for treating obesity.
www.newsbeep.com
December 3, 2025 at 12:13 PM
WHO calls obesity a chronic disease, endorses GLP-1 drugs with behavioural therapy in fresh guidelines

https://www.newsbeep.com/ca/322603/

The World Health Organization (WHO) has come out with the first-ever guidelines on the global use of Glucagon-Like…
WHO calls obesity a chronic disease, endorses GLP-1 drugs with behavioural therapy in fresh guidelines - Canada News Beep
The World Health Organization (WHO) has come out with the first-ever guidelines on the global use of Glucagon-Like Peptide-1 (GLP-1) medicines for "treating
www.newsbeep.com
December 3, 2025 at 12:11 PM