Typas Lab
@typaslab.bsky.social
Systems Microbiology @EMBL, combining high-throughput approaches & mechanism in bacteria, antibiotics, microbiome, infection, species diversity, cell envelope
https://www.embl.org/groups/typas/
https://www.embl.org/groups/typas/
Pinned
Typas Lab
@typaslab.bsky.social
· Oct 13
Excited to share our preprint led by Carlos Voogdt et al
We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
Reposted by Typas Lab
Super excited to share our new selection-free CRISPR-Cas9 editing protocol for Dictyostelids, generating 80% KO and 30% KI efficiencies without selection in D. discoideum, and being effective in Dictyostelid species that diverged millions of years ago! www.biorxiv.org/content/10.1...
March 25, 2025 at 8:34 PM
Super excited to share our new selection-free CRISPR-Cas9 editing protocol for Dictyostelids, generating 80% KO and 30% KI efficiencies without selection in D. discoideum, and being effective in Dictyostelid species that diverged millions of years ago! www.biorxiv.org/content/10.1...
Reposted by Typas Lab
HT-PELSA, a new proteomics tool by EMBL researchers, processes samples 100x faster and works directly with complex crude cell, tissue, and bacterial lysates – developments which could accelerate drug discovery and basic biological research 💊
🔗 www.embl.org/news/science...
🔗 www.embl.org/news/science...
November 5, 2025 at 10:09 AM
HT-PELSA, a new proteomics tool by EMBL researchers, processes samples 100x faster and works directly with complex crude cell, tissue, and bacterial lysates – developments which could accelerate drug discovery and basic biological research 💊
🔗 www.embl.org/news/science...
🔗 www.embl.org/news/science...
Reposted by Typas Lab
Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️
November 5, 2025 at 10:15 AM
Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️
Reposted by Typas Lab
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
Isolation, engineering and ecology of temperate phages from the human gut - Nature
Human host-associated cellular products may act as induction agents for bacteriophages.
nature.com
October 15, 2025 at 9:41 PM
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
Reposted by Typas Lab
#Perspective
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
How nutrient starvation impacts the gut microbiome - Nature Microbiology
In this Perspective, Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
www.nature.com
October 1, 2025 at 5:56 PM
#Perspective
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
#MicroSky #MicrobiomeSky 🦠
www.nature.com/articles/s41...
Reposted by Typas Lab
Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology
Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.
doi.org
October 2, 2025 at 6:20 AM
Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.
doi.org/10.1038/s415...
Reposted by Typas Lab
Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
E15 Groups
The Helmholtz Institute for RNA-based Infection Researchopens a call for
www.helmholtz-hiri.de
October 13, 2025 at 1:30 PM
Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Excited to share our preprint led by Carlos Voogdt et al
We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
October 13, 2025 at 7:48 AM
Excited to share our preprint led by Carlos Voogdt et al
We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...
Reposted by Typas Lab
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by Typas Lab
Precisely calling mutations across hundreds of bacterial isolates has been hard, requiring manual filtering and expertise.
Until now, using AccuSNV.
Herui Liao trained an ML model based on our previous meticulously called SNVs.
www.biorxiv.org/content/10.1...
Until now, using AccuSNV.
Herui Liao trained an ML model based on our previous meticulously called SNVs.
www.biorxiv.org/content/10.1...
High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV
Accurate detection of mutations within bacterial species is critical for fundamental studies of microbial evolution, reconstructing transmission events, and identifying antimicrobial resistance mutati...
www.biorxiv.org
September 29, 2025 at 7:45 PM
Precisely calling mutations across hundreds of bacterial isolates has been hard, requiring manual filtering and expertise.
Until now, using AccuSNV.
Herui Liao trained an ML model based on our previous meticulously called SNVs.
www.biorxiv.org/content/10.1...
Until now, using AccuSNV.
Herui Liao trained an ML model based on our previous meticulously called SNVs.
www.biorxiv.org/content/10.1...
Reposted by Typas Lab
📣The 2026 ERC Consolidator Grant competition is now open! 📣
Already preparing your proposal? Info links ⬇️
Info for applicants 👉 buff.ly/PSbeUxX
Application portal 👉 buff.ly/mauZoqo
Deadline: 13/01/26
General info on #ERCCoG 👉 buff.ly/KCN6GTh
Already preparing your proposal? Info links ⬇️
Info for applicants 👉 buff.ly/PSbeUxX
Application portal 👉 buff.ly/mauZoqo
Deadline: 13/01/26
General info on #ERCCoG 👉 buff.ly/KCN6GTh
September 26, 2025 at 2:30 PM
📣The 2026 ERC Consolidator Grant competition is now open! 📣
Already preparing your proposal? Info links ⬇️
Info for applicants 👉 buff.ly/PSbeUxX
Application portal 👉 buff.ly/mauZoqo
Deadline: 13/01/26
General info on #ERCCoG 👉 buff.ly/KCN6GTh
Already preparing your proposal? Info links ⬇️
Info for applicants 👉 buff.ly/PSbeUxX
Application portal 👉 buff.ly/mauZoqo
Deadline: 13/01/26
General info on #ERCCoG 👉 buff.ly/KCN6GTh
Reposted by Typas Lab
🏆 Fighting the Gender Award Gap: Microbiologist Prof Dr Lisa Maier from @unituebingen.bsky.social received the main award of the German Association for #Microbiology and Hygiene at the #DGHM meeting in Jena. Congratulations to @lisamaierlab.bsky.social we are proud of you! 💜
📸 Gabriele Pradel
📸 Gabriele Pradel
September 23, 2025 at 8:39 AM
🏆 Fighting the Gender Award Gap: Microbiologist Prof Dr Lisa Maier from @unituebingen.bsky.social received the main award of the German Association for #Microbiology and Hygiene at the #DGHM meeting in Jena. Congratulations to @lisamaierlab.bsky.social we are proud of you! 💜
📸 Gabriele Pradel
📸 Gabriele Pradel
Reposted by Typas Lab
Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors
Directors
The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.
www.mpg.de
September 17, 2025 at 3:25 PM
Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors
Reposted by Typas Lab
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
September 15, 2025 at 9:27 AM
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
Reposted by Typas Lab
Join EMBL AI!
We have ambitious plans to transform life sciences research through AI.
Interested in using ML/AI to solve complex interdisciplinary challenges?
We’re looking for two senior leaders based at EMBL Heidelberg👇
We have ambitious plans to transform life sciences research through AI.
Interested in using ML/AI to solve complex interdisciplinary challenges?
We’re looking for two senior leaders based at EMBL Heidelberg👇
September 11, 2025 at 7:24 AM
Join EMBL AI!
We have ambitious plans to transform life sciences research through AI.
Interested in using ML/AI to solve complex interdisciplinary challenges?
We’re looking for two senior leaders based at EMBL Heidelberg👇
We have ambitious plans to transform life sciences research through AI.
Interested in using ML/AI to solve complex interdisciplinary challenges?
We’re looking for two senior leaders based at EMBL Heidelberg👇
Reposted by Typas Lab
New academic faculty posts available at Imperial College London! Assistant/Associate Professors in Life Sciences. Please apply and/or circulate details!
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
August 18, 2025 at 8:25 AM
New academic faculty posts available at Imperial College London! Assistant/Associate Professors in Life Sciences. Please apply and/or circulate details!
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Reposted by Typas Lab
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
September 10, 2025 at 3:40 PM
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
Reposted by Typas Lab
🚨 We’re hiring! Oxford Biology is recruiting 3 new Associate Professors in:
🌱 Plant Sciences
🦉 Animal Behaviour
🔬 Molecular Cell Biology
Join us as we move into our new building with world-class research & teaching facilities.
Vacancies 👉 bit.ly/488CNW3
View our video here: youtu.be/TZa1x0oyqA0
🌱 Plant Sciences
🦉 Animal Behaviour
🔬 Molecular Cell Biology
Join us as we move into our new building with world-class research & teaching facilities.
Vacancies 👉 bit.ly/488CNW3
View our video here: youtu.be/TZa1x0oyqA0
Oxford Biology in the LaMB
YouTube video by Oxford Biology
youtu.be
September 8, 2025 at 3:13 PM
🚨 We’re hiring! Oxford Biology is recruiting 3 new Associate Professors in:
🌱 Plant Sciences
🦉 Animal Behaviour
🔬 Molecular Cell Biology
Join us as we move into our new building with world-class research & teaching facilities.
Vacancies 👉 bit.ly/488CNW3
View our video here: youtu.be/TZa1x0oyqA0
🌱 Plant Sciences
🦉 Animal Behaviour
🔬 Molecular Cell Biology
Join us as we move into our new building with world-class research & teaching facilities.
Vacancies 👉 bit.ly/488CNW3
View our video here: youtu.be/TZa1x0oyqA0
Reposted by Typas Lab
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer
September 9, 2025 at 12:10 PM
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer
Reposted by Typas Lab
In a new #ScienceReview, researchers investigate how the recent application of single-cell RNA sequencing technology has helped to evaluate function in microbial populations. https://scim.ag/3V2kc6l
Dissecting microbial communities with single-cell transcriptome analysis
Revealing insights into the function of microbial communities requires moving beyond measuring bulk taxonomic composition to detecting interactions between subpopulations. Following the transformative...
www.science.org
September 9, 2025 at 1:55 PM
In a new #ScienceReview, researchers investigate how the recent application of single-cell RNA sequencing technology has helped to evaluate function in microbial populations. https://scim.ag/3V2kc6l
Reposted by Typas Lab
A call for W 3 (full) professorship in Molecular and Evolutionary Zoology is now open at our department. Join our community of evolutionary biologists! Excellent facilities and scientific environment!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
W 3 professorship in Molecular and Evolutionary Zoology - Kiel, Schleswig-Holstein (DE) job with Christian-Albrechts-Universität zu Kiel | 12844416
Kiel University aims to attract more qualified women to professorship positions. The Institute of Zoology at the Faculty of Mathematics and Natural...
www.nature.com
September 5, 2025 at 8:31 AM
A call for W 3 (full) professorship in Molecular and Evolutionary Zoology is now open at our department. Join our community of evolutionary biologists! Excellent facilities and scientific environment!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Typas Lab
Bacterial cell widening alters periplasmic size and activates envelope stress responses
Kerwyn Huang, @typaslab.bsky.social et al find that E. coli outer-membrane protein RcsF senses reduced periplasm thickness due to increased cell width, & activates Rcs signaling
www.embopress.org/doi/full/10....
Kerwyn Huang, @typaslab.bsky.social et al find that E. coli outer-membrane protein RcsF senses reduced periplasm thickness due to increased cell width, & activates Rcs signaling
www.embopress.org/doi/full/10....
September 4, 2025 at 9:39 AM
Bacterial cell widening alters periplasmic size and activates envelope stress responses
Kerwyn Huang, @typaslab.bsky.social et al find that E. coli outer-membrane protein RcsF senses reduced periplasm thickness due to increased cell width, & activates Rcs signaling
www.embopress.org/doi/full/10....
Kerwyn Huang, @typaslab.bsky.social et al find that E. coli outer-membrane protein RcsF senses reduced periplasm thickness due to increased cell width, & activates Rcs signaling
www.embopress.org/doi/full/10....
Reposted by Typas Lab
Delighted to see @sakshikhaiwal.bsky.social work in print www.embopress.org/doi/full/10....
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social
Predicting natural variation in the yeast phenotypic landscape with machine learning | Molecular Systems Biology
imageimageAn ensemble of phenotypes measured in the genome-sequenced 1,011 S. cerevisiae collection were coupled with genomics and molecular-level data to benchmark machine learning models for quantitative phenotypic predictions at scale. Large-...
www.embopress.org
September 1, 2025 at 9:13 AM
Delighted to see @sakshikhaiwal.bsky.social work in print www.embopress.org/doi/full/10....
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social
Reposted by Typas Lab
Come join the Baker Heart and Diabetes Institute @bakerresearchau.bsky.social as a Lab Head in Biomedical Data Science 📣 www.baker.edu.au/career/head-...
There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!
There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!
Career opportunities at the Baker Heart and Diabetes Institute
The Baker Heart and Diabetes Institute is an independent, internationally renowned medical research facility. We have a long and distinguished history, spanning more than 97 years with our work critic...
www.baker.edu.au
August 30, 2025 at 2:41 PM
Come join the Baker Heart and Diabetes Institute @bakerresearchau.bsky.social as a Lab Head in Biomedical Data Science 📣 www.baker.edu.au/career/head-...
There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!
There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!
Reposted by Typas Lab
Time to accelerate! ⏱️4 weeks left to apply for EMBL ARISE2 fellowship programme.
Are you interested in developing or improving technologies for life science research? #ARISE2 trains you to become a future research infrastructure leader. 🧪
Apply now! www.embl.org/training/ari...
#careers
Are you interested in developing or improving technologies for life science research? #ARISE2 trains you to become a future research infrastructure leader. 🧪
Apply now! www.embl.org/training/ari...
#careers
September 2, 2025 at 8:14 AM
Time to accelerate! ⏱️4 weeks left to apply for EMBL ARISE2 fellowship programme.
Are you interested in developing or improving technologies for life science research? #ARISE2 trains you to become a future research infrastructure leader. 🧪
Apply now! www.embl.org/training/ari...
#careers
Are you interested in developing or improving technologies for life science research? #ARISE2 trains you to become a future research infrastructure leader. 🧪
Apply now! www.embl.org/training/ari...
#careers