Nature Microbiology
banner
natmicrobiol.nature.com
Nature Microbiology
@natmicrobiol.nature.com
Nature Microbiology publishes the latest research and commentary in all areas of microbiology.

https://www.nature.com/nmicrobiol/
Pinned
Our final issue of 2025 has gone live!

🫁pertussis prevention
🏭pollutants and gut bacteria
🕳️porins and resistance in E. coli
🧬many flavours of CRISPR
🦟fatal fungal attraction

...and more 👇
www.nature.com/nmicrobiol/v...
Our final issue of 2025 has gone live!

🫁pertussis prevention
🏭pollutants and gut bacteria
🕳️porins and resistance in E. coli
🧬many flavours of CRISPR
🦟fatal fungal attraction

...and more 👇
www.nature.com/nmicrobiol/v...
December 1, 2025 at 6:34 PM
Reposted by Nature Microbiology
Nature Methods is hiring! We are looking for candidates with expertise in genetics, genomics and/or molecular biology to join our editorial team in the US (NYC/Jersey City) or China (Shanghai/Beijing). Apply by December 12!

springernature.wd3.myworkdayjobs.com/SpringerNatu...
a sign that says we 're hiring in orange on a white background
ALT: a sign that says we 're hiring in orange on a white background
media.tenor.com
November 18, 2025 at 6:30 PM
Reposted by Nature Microbiology
🔬MGI doctoral student Julia Kelliher served as lead author on a global effort involving 248 experts from 28 countries to write guidelines standardizing environmental microbiome research. Published today in Nature Microbiology. @natmicrobiol.nature.com

🔗https://tinyurl.com/yh3dzc72
December 1, 2025 at 4:52 PM
Reposted by Nature Microbiology
Bacteria can control what enters their cells, balancing energy and blocking antibiotics.

New study in @natmicrobiol.nature.com uncovers this hidden mechanism of drug resistance: buff.ly/s3YIwyK

@andresfloto.bsky.social @vpd-hlri.bsky.social @unibas.ch
December 1, 2025 at 3:46 PM
#NatMicroPicks

Editing gut microbiota in vivo! 🔧🧬🦠

MetaEdit enables precise in vivo CRISPR-based editing of native gut bacteria, integrating new pathways at single-nucleotide resolution

#MicroSky #SynBio

www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 28, 2025 at 1:52 PM
#NatMicroPicks

A new protist with remnants of ancient mitochondrial DNA 🧬🦠

The eukaryotic tree of life grows with the addition Solarion arienae - a unique and peculiar protist species

#MicroSky

www.nature.com/articles/s41...
Rare microbial relict sheds light on an ancient eukaryotic supergroup - Nature
The discovery of an unusual protist named Solarion arienae, which has a mitochondrial genome with some intriguing features, provides insight into the early radiation of eukaryotic groups.
www.nature.com
November 28, 2025 at 1:49 PM
#NatMicroPicks

New insights into plasmid evolution 🧬⭕

Experimental measurements reveal that plasmid evolution is shaped by both within-cell competition and host-level selection

#MicroSky 🦠

www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 28, 2025 at 1:44 PM
#NatMicroPicks

AI to design therapeutic antibodies! 🧪⚕️

AI-driven monoclonal antibody generator designs novel antibodies without templates, targeting SARS-CoV-2, H5N1, and RSV-A

#MicroSky

www.cell.com/cell/fulltex...
Generation of antigen-specific paired-chain antibodies using large language models
MAGE is a sequence-based protein language model designed to generate diverse human antibody sequences targeting various pathogens, including SARS-CoV-2, H5N1, and RSV-A. This AI-driven approach addres...
www.cell.com
November 28, 2025 at 1:41 PM
#NatMicroPicks

How drugs reshape the gut microbiome? 💊🦠

Screening 707 drugs in gut microbial communities reveals nutrient competition as the key driver of compositional and metabolic shifts.

#MicroSky #MicrobiomeSky 🦠

www.cell.com/cell/fulltex...
Nutrient competition predicts gut microbiome restructuring under drug perturbations
Systematic profiling of 707 drugs on their impact on stool-derived microbial communities shows that nutrient competition explains and predicts species shifts under drug treatment and that post-drug re...
www.cell.com
November 28, 2025 at 1:39 PM
#NatMicroPicks

A microbial metabolite drives stress and emotional eating! 😣🍦

Gut-derived imidazole propionate (ImP) enters the brain, disrupting hypothalamic signaling and driving stress-related behaviors in metabolic disease

#MicroSky #MicrobiomeSky 🦠

www.cell.com/cell-host-mi...
The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors
Agirman et al. find that imidazole propionate, a microbiome-derived metabolite, reaches the brain, dampens hypothalamic activity, and promotes stress-related behaviors. Human data show that higher ImP...
www.cell.com
November 28, 2025 at 1:35 PM
#NatMicroPicks

Peptibody mRNA therapy for AMR infections! 💉🧬

mRNA-delivered peptibody AMPs eradicate MDR pneumonia and outperform FDA-approved antibiotics while reducing inflammation

#SynBio #MicroSky 🦠 @natbiotech.nature.com

www.nature.com/articles/s41...
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - Nature Biotechnology
Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.
www.nature.com
November 28, 2025 at 1:31 PM
#NatMicroPicks

IScream phages in gut 🧬🦠

Long-read metagenomics reveals dynamic prophage integration, cross-family host jumps, and IS30-driven phage mobilization in the human gut

#MicroSky #MicrobiomeSky

www.nature.com/articles/s41...
Long-read metagenomics reveals phage dynamics in the human gut microbiome - Nature
Complex prophage integration dynamics, including low-level induction, cross-family host range and transposase-mediated mobilization, challenge existing paradigms and deepen our understanding of phage–...
www.nature.com
November 28, 2025 at 1:29 PM
#NatMicroPicks

Virus outsmarting fever response! 🤒

Avian-origin polymerase can enable influenza virus replication at higher temperatures, limiting fever’s antiviral effect

#MicroSky 🦠

www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 28, 2025 at 1:25 PM
#NewResearch

MAP-X is used to map protein complexes in P. falciparum, identifying previously undescribed interactions, revealing stage-specific dynamics and predicting moonlighting behaviour of subunits.

#MicroSky 🦠 @pazickysamuel.bsky.social

www.nature.com/articles/s41...
MAP-X reveals distinct protein complex dynamics across Plasmodium falciparum blood stages - Nature Microbiology
MAP-X is used to map protein complexes in P. falciparum, identifying previously undescribed interactions, revealing stage-specific dynamics and predicting moonlighting behaviour of subunits.
www.nature.com
November 28, 2025 at 1:19 PM
#NewResearch

Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.

#MicroSky 🦠

www.nature.com/articles/s41...
Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
www.nature.com
November 28, 2025 at 1:17 PM
Reposted by Nature Microbiology
We're at 735 registrants and counting! 🎉🦠

If you haven't registered yet, don't miss out on this exciting (free) symposium on gut microbial metabolites and their impacts on host health.

Please share with your networks. 🔗👇

isbscience.org/events/2025-...
November 26, 2025 at 5:19 PM
Reposted by Nature Microbiology
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - @yizhoudonglab.bsky.social @icahngenomics.bsky.social go.nature.com/3LZS6HD
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - Nature Biotechnology
Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.
go.nature.com
November 26, 2025 at 3:11 PM
#NewResearch

A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.

#MicroSky 🦠

www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 26, 2025 at 3:59 PM
#NewResearch

Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearance.

#MicroSky 🦠 #ImmunoSky

www.nature.com/articles/s41...
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice - Nature Microbiology
Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice through CCL11-driven recruitment and MBP-dependent modulation of macrophage polarization and bacterial clearan...
www.nature.com
November 26, 2025 at 3:58 PM
#NewResearch

Mathematical representations of overflow metabolism, mixotrophy, exoenzymes and reactive oxygen species detoxification recapitulate dynamics in co-cultures of Prochlorococcus and eight heterotrophic bacteria.

#MicroSky 🦠

www.nature.com/articles/s41...
Models and co-culture experiments assess four mechanisms of phytoplankton–bacteria interactions - Nature Microbiology
Mathematical representations of overflow metabolism, mixotrophy, exoenzymes and reactive oxygen species detoxification recapitulate dynamics in co-cultures of Prochlorococcus and eight heterotrophic b...
www.nature.com
November 26, 2025 at 3:55 PM
#NewResearch

The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.

#MicroSky #AMR 🦠 @andresfloto.bsky.social

www.nature.com/articles/s41...
Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli - Nature Microbiology
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
www.nature.com
November 26, 2025 at 3:54 PM
#NewResearch

Iron‒sulfur nanozymes catalyse the production of an indole derivative in Lactobacillus, leading to a synergistic antibacterial activity that protects mice and weaned pigs against Salmonella infection.

#MicroSky 🦠 #NanoSky

www.nature.com/articles/s41...
Nanozymes modulate probiotic tryptophan metabolism to prevent Salmonella infection in mammalian models - Nature Microbiology
Iron‒sulfur nanozymes catalyse the production of an indole derivative, 2-indolecarboxylic acid, in Lactobacillus vaginalis, leading to a synergistic antibacterial activity that protects mice and weane...
www.nature.com
November 26, 2025 at 3:53 PM
#NewResearch

The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.

#MicroSky 🦠

www.nature.com/articles/s41...
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
www.nature.com
November 26, 2025 at 3:51 PM
Reposted by Nature Microbiology
Our paper mapping the effects of hundreds of pesticides and industrial chemicals on gut bacteria is out in @natmicrobiol.nature.com today!
Turns out many such chemicals, although labelled as 'fungicides' or similar, can inadvertently inhibit friendly gut bacteria.
www.nature.com/articles/s41...
November 26, 2025 at 11:07 AM