Lightnews — Scholar-powered news

Reposted by Mike Inouye

Sheryl Gay Stolberg @sherylnyt.bsky.social · 1d

OOOPS! UPDATE: Two HHS officials tell me that disease detectives, measles response officers, global health officials and the MMWR staff were laid off by mistake and will be reinstated. But Washington office is still RIFed

Sheryl Gay Stolberg @sherylnyt.bsky.social · 2d

BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

33 250 700

Reposted by Mike Inouye

Zornitza Stark @zornitza.bsky.social · 3d

🤗 Out now @naturemedicine.bsky.social results of our genomic NBS study BabyScreen+ 👶🧬

👉 www.nature.com/articles/s41...

1,000 babies
WGS using existing cards
600+ conditions
13 day TAT
16 diagnoses (vs 1 in std NBS)
High clinical impact
High parental acceptability

9 17

Reposted by Mike Inouye

Sheryl Gay Stolberg @sherylnyt.bsky.social · 2d

BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

860 8.5K 15K

Mike Inouye @mikeinouye.bsky.social · 3d

Totally agree, had an actual LOL when seeing the news

1

Reposted by Mike Inouye

Ewan Birney @ewanbirney.bsky.social · 3d

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Staff Scientist

About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

embl.wd103.myworkdayjobs.com

1 78 72

Reposted by Mike Inouye

Prof Anna Watts @profannawatts.bsky.social · 3d

Lol the Nobels can't even acknowledge women's contribution to discovery. But sure let's acknowledge The Machines.

Headline from an article in Nature this week that states "Prizes must recognize machine contributions to discovery. The future of science will be written by humans and machines together. Awards should reflect that reality."

86 770 3.4K

Reposted by Mike Inouye

BHF Cardiovascular Epidemiology Unit at Cambridge @cambridge-ceu.bsky.social · 4d

🚨 Exciting new PhD Opportunity 🚨

Applications are open for 3-year non-clinical PhD studentships with the BHF Cambridge Centre of Research Excellence

📅 Apply by 23 Nov 2025
🌍 Open to UK & international applicants

Find out how to apply here: tinyurl.com/3t59uwbn

The Relationship Between Genetic Factors and Heart Function - Conceptual Illustration

1 1 1

Reposted by Mike Inouye

Burcu Darst @burcudarst.bsky.social · 4d

Excited to share our recent work characterizing a type 2 diabetes (T2D) polygenic risk score (PRS) in a collaboration that included 244,637 T2D cases and 637,891 controls, led by @boyaguo.bsky.social! (1/3)

www.nature.com/articles/s41...

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations - Nature Communications

Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

www.nature.com

1 3 9

Reposted by Mike Inouye

Matthew Neville @mattneville.bsky.social · 4d

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

www.nature.com

3 48 81

Reposted by Mike Inouye

Nature @nature.com · 5d

Antimicrobial resistance is projected to cause 39 million deaths worldwide over the next 25 years

go.nature.com/42x5KHD

The rise of ‘nightmare bacteria’: antimicrobial resistance in six charts

Data reveal how the global challenge to reduce deaths and infections from drug-resistant bacteria is not going according to plan.

go.nature.com

3 47 77

Reposted by Mike Inouye

University of Cambridge @cam.ac.uk · 5d

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social

Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

43 71

Reposted by Mike Inouye

Megan Ranney MD MPH @meganranney.bsky.social · 6d

I know the news is tough right now.

So take a moment and soak in the gorgeousness & promise of the science that led to this year’s Nobel Prize in Medicine & Physiology.

WOW.

www.nytimes.com/2025/10/06/h...

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems

www.nytimes.com

5 110 540

Reposted by Mike Inouye

Gen Wojcik @genandgenes.bsky.social · 6d

Are you going to #ASHG2025 next week in Boston? Interested in getting some mentorship from leading figures in the field (and me)?

Check out our speed mentoring event on Thursday! Sign-ups are online so reserve a spot ASAP.

site.pheedloop.com/event/ASHG25...

PheedLoop

PheedLoop: Hybrid, In-Person & Virtual Event Software

site.pheedloop.com

1 5 12

Reposted by Mike Inouye

samuel mehr @mehr.nz · 7d

"the quickest way to get a collaborator to return edits on your manuscript is to write down their affiliation wrong" (ancient academic proverb)

2 28 180

Mike Inouye @mikeinouye.bsky.social · 7d

Reading through the headlines these days can be a bit depressing. Having had dozens of students and staff from all over the world, there are indeed oceans of insight within Sofia Vergara's immortal words "Do you even know how smart I am in Spanish?"

1 3

Reposted by Mike Inouye

Harmit Singh Malik @harmitmalik.bsky.social · 7d

I am leaving Rochester NY after attending the retirement fest of four giants in the field of evolutionary biology including my PhD advisor. This visit gave me a chance to revisit old haunts and reflect on my own somewhat unlikely origin story. 1/n

2 20 110

Mike Inouye @mikeinouye.bsky.social · 7d

For me, figures 5 and 6 were really exciting.

CAD PRS could both improve early identification of future CVD cases *AND* improve fairness on top of QRISK3. www.medrxiv.org/content/10.1...

4

Mike Inouye @mikeinouye.bsky.social · 7d

ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1...

Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)

h\t @iamslambert.bsky.social @clairecoffey.bsky.social

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critical...

www.medrxiv.org

1 4 8

Mike Inouye @mikeinouye.bsky.social · 7d

Wow, didn't realise it was that bad in the US (nor that the UK was that good) www.bbc.co.uk/news/article...

Reposted by Mike Inouye

Mike Inouye @mikeinouye.bsky.social · 9d

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research

and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

Inouye Lab - Research

Background Technological advances have continued to drive the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels ...

www.inouyelab.org

6 11

Mike Inouye @mikeinouye.bsky.social · 9d

Now published @nataging.nature.com: A rare sole author paper on "Refining the generation, interpretation and application of multi-organ, multi-omics biological aging clocks" www.nature.com/articles/s43...

4

Mike Inouye @mikeinouye.bsky.social · 9d

Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities www.nature.com/articles/s41...

Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)

1 5

Mike Inouye @mikeinouye.bsky.social · 9d

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research

and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

Inouye Lab - Research

Background Technological advances have continued to drive the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels ...

www.inouyelab.org

6 11

Reposted by Mike Inouye

Varun Warrier @vw1234.bsky.social · 11d

It is now clear that more people are being diagnosed as autistic in their teens and as adults than in childhood. A prevailing theory is that those diagnosed later have "milder" form of autism, and later diagnosis entirely due to social factors.

1 8 32

Reposted by Mike Inouye

Hilary Martin @hilarycmartin.bsky.social · 10d

Pleased to have contributed to this paper out at @nature.com today from @vw1234.bsky.social and Yira (Xinhe) Zhang showing that the common variant contribution to autism varies substantially by age of diagnosis www.nature.com/articles/s41.... Critical for understanding heterogeneity in autism.

Polygenic and developmental profiles of autism differ by age at diagnosis - Nature

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

www.nature.com

8 33