Mike Inouye
@mikeinouye.bsky.social
Computational biologist. Geriatric Millennial. Professor, University of Cambridge. Director of Data Sciences, Baker Heart & Diabetes Institute. British | Australian | American.
www.inouyelab.org | Cambridge, UK
www.inouyelab.org | Cambridge, UK
Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social
November 22, 2025 at 11:47 AM
Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
November 22, 2025 at 11:42 AM
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
Very cool work this.
November 19, 2025 at 2:02 AM
Very cool work this.
Nice work from Iftikhar Kullo and co on incorporating polygenic, monogenic and family history risk into the Pooled Cohort Equations for coronary heart disease risk. Assessed across spectrums of age and ethnic diversity using All of Us and eMERGE IV. www.medrxiv.org/content/10.1...
November 18, 2025 at 12:33 PM
Nice work from Iftikhar Kullo and co on incorporating polygenic, monogenic and family history risk into the Pooled Cohort Equations for coronary heart disease risk. Assessed across spectrums of age and ethnic diversity using All of Us and eMERGE IV. www.medrxiv.org/content/10.1...
Feeling much better
November 17, 2025 at 9:12 PM
Feeling much better
Wow, a whole new way to 'see' our Milky Way! Radiowave light (top) as compared to visual light (bottom).
h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...
h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...
November 7, 2025 at 5:52 PM
Wow, a whole new way to 'see' our Milky Way! Radiowave light (top) as compared to visual light (bottom).
h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...
h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...
For me, figures 5 and 6 were really exciting.
CAD PRS could both improve early identification of future CVD cases *AND* improve fairness on top of QRISK3. www.medrxiv.org/content/10.1...
CAD PRS could both improve early identification of future CVD cases *AND* improve fairness on top of QRISK3. www.medrxiv.org/content/10.1...
October 5, 2025 at 2:55 PM
For me, figures 5 and 6 were really exciting.
CAD PRS could both improve early identification of future CVD cases *AND* improve fairness on top of QRISK3. www.medrxiv.org/content/10.1...
CAD PRS could both improve early identification of future CVD cases *AND* improve fairness on top of QRISK3. www.medrxiv.org/content/10.1...
Wow, didn't realise it was that bad in the US (nor that the UK was that good) www.bbc.co.uk/news/article...
October 5, 2025 at 2:38 PM
Wow, didn't realise it was that bad in the US (nor that the UK was that good) www.bbc.co.uk/news/article...
Now published @nataging.nature.com: A rare sole author paper on "Refining the generation, interpretation and application of multi-organ, multi-omics biological aging clocks" www.nature.com/articles/s43...
October 4, 2025 at 10:22 AM
Now published @nataging.nature.com: A rare sole author paper on "Refining the generation, interpretation and application of multi-organ, multi-omics biological aging clocks" www.nature.com/articles/s43...
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities www.nature.com/articles/s41...
Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)
Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)
October 4, 2025 at 10:18 AM
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities www.nature.com/articles/s41...
Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)
Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
September 19, 2025 at 3:31 PM
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
Spotify. Worst app ever.
September 10, 2025 at 7:03 PM
Spotify. Worst app ever.
Can't live without The Onion's take on back to school
September 7, 2025 at 11:23 AM
Can't live without The Onion's take on back to school
📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1...
Very cool results: Accumulating E with age reduces heritability & PGS effects
Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
Very cool results: Accumulating E with age reduces heritability & PGS effects
Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
September 3, 2025 at 9:39 AM
📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1...
Very cool results: Accumulating E with age reduces heritability & PGS effects
Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
Very cool results: Accumulating E with age reduces heritability & PGS effects
Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
This original penicillin
August 29, 2025 at 6:51 PM
This original penicillin
"+ Franklin" The old plaque outside the Eagle pub commemorating the discovery of DNA's structure... now an artefact on display at the Whipple museum around the corner
August 29, 2025 at 12:41 PM
"+ Franklin" The old plaque outside the Eagle pub commemorating the discovery of DNA's structure... now an artefact on display at the Whipple museum around the corner
😂😂😂 ... and of course Gen X 🫥
August 21, 2025 at 10:45 PM
😂😂😂 ... and of course Gen X 🫥
OMFG why are we not doing more to lower our carbon footprint?! www.theguardian.com/uk-news/2025...
August 10, 2025 at 8:31 PM
OMFG why are we not doing more to lower our carbon footprint?! www.theguardian.com/uk-news/2025...
Part 4, lightly fried edition
August 7, 2025 at 12:03 AM
Part 4, lightly fried edition
Sad but all is not lost.
"... science itself, in the global sense, will be fine. The deep human curiosities that drive it do not belong to any nation-state..." www.theatlantic.com/science/arch...
"... science itself, in the global sense, will be fine. The deep human curiosities that drive it do not belong to any nation-state..." www.theatlantic.com/science/arch...
July 31, 2025 at 2:35 PM
Sad but all is not lost.
"... science itself, in the global sense, will be fine. The deep human curiosities that drive it do not belong to any nation-state..." www.theatlantic.com/science/arch...
"... science itself, in the global sense, will be fine. The deep human curiosities that drive it do not belong to any nation-state..." www.theatlantic.com/science/arch...
