John Tsang
@tsanglab.bsky.social
Systems immunologist at Yale, @yalecsei.bsky.social, @czbiohub.bsky.social
Me: https://medicine.yale.edu/profile/john-tsang/
Lab: https://www.tsanglab.org
Center: https://medicine.yale.edu/systems-engineering-immunology/
Me: https://medicine.yale.edu/profile/john-tsang/
Lab: https://www.tsanglab.org
Center: https://medicine.yale.edu/systems-engineering-immunology/
Pinned
John Tsang
@tsanglab.bsky.social
· Nov 17
I created a starter pack for systems immunology - let me know if you would like to be added. Excited to be here on
@bsky.app
go.bsky.app/PjH2Fuj
@bsky.app
go.bsky.app/PjH2Fuj
Reposted by John Tsang
#CancerImmuno speaker list is live!📢
Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research.
Early Bird Deadline: 15 Jan 2026
👉 Click here to register: bit.ly/4qZVqmd
#FusionImmunology #FusionCancerResearch
Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research.
Early Bird Deadline: 15 Jan 2026
👉 Click here to register: bit.ly/4qZVqmd
#FusionImmunology #FusionCancerResearch
November 17, 2025 at 3:55 PM
#CancerImmuno speaker list is live!📢
Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research.
Early Bird Deadline: 15 Jan 2026
👉 Click here to register: bit.ly/4qZVqmd
#FusionImmunology #FusionCancerResearch
Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research.
Early Bird Deadline: 15 Jan 2026
👉 Click here to register: bit.ly/4qZVqmd
#FusionImmunology #FusionCancerResearch
Reposted by John Tsang
Notes on a compelling discussion with @tsanglab.bsky.social
Genome = blueprint.
Immunome = real-time sensor.
The "curse of dimensionality" (millions of data points per sample!) meets AI compression.
Result? We can finally map the human immune system at scale.
@humanimmunomeproject 🚀
Genome = blueprint.
Immunome = real-time sensor.
The "curse of dimensionality" (millions of data points per sample!) meets AI compression.
Result? We can finally map the human immune system at scale.
@humanimmunomeproject 🚀
October 14, 2025 at 11:14 PM
Notes on a compelling discussion with @tsanglab.bsky.social
Genome = blueprint.
Immunome = real-time sensor.
The "curse of dimensionality" (millions of data points per sample!) meets AI compression.
Result? We can finally map the human immune system at scale.
@humanimmunomeproject 🚀
Genome = blueprint.
Immunome = real-time sensor.
The "curse of dimensionality" (millions of data points per sample!) meets AI compression.
Result? We can finally map the human immune system at scale.
@humanimmunomeproject 🚀
Reposted by John Tsang
Just saw a post which misspelled 'Machine learning' as 'Machine earning', and I wondered if that was a Freudian slip.
October 9, 2025 at 8:17 PM
Just saw a post which misspelled 'Machine learning' as 'Machine earning', and I wondered if that was a Freudian slip.
woohoo! well done Toronto - brings back childhood memories of the back-to-back world series won by the Jays...
October 9, 2025 at 3:12 AM
woohoo! well done Toronto - brings back childhood memories of the back-to-back world series won by the Jays...
Reposted by John Tsang
Big news: We've announced the largest #systemsimmunology collaboration in history! Ten world-class research institutes are joining @immunome.bsky.social in a pioneering plan to understand human immune response variability.
www.humanimmunomeproject.org/news/human-i...
@tsanglab.bsky.social
www.humanimmunomeproject.org/news/human-i...
@tsanglab.bsky.social
October 6, 2025 at 12:05 PM
Big news: We've announced the largest #systemsimmunology collaboration in history! Ten world-class research institutes are joining @immunome.bsky.social in a pioneering plan to understand human immune response variability.
www.humanimmunomeproject.org/news/human-i...
@tsanglab.bsky.social
www.humanimmunomeproject.org/news/human-i...
@tsanglab.bsky.social
Reposted by John Tsang
Thank you #CZBiohubNY Mini Workshop presenters and attendees! Great talks by @czbiohub.bsky.social and @yaleschoolofmed.bsky.social scientists. Grateful to #CZI and @tsanglab.bsky.social for bringing us together. Thank you Susan Rosenthal, Elizabeth Ferris and Lital Manor for superb event logistics.
July 10, 2025 at 4:00 AM
Thank you #CZBiohubNY Mini Workshop presenters and attendees! Great talks by @czbiohub.bsky.social and @yaleschoolofmed.bsky.social scientists. Grateful to #CZI and @tsanglab.bsky.social for bringing us together. Thank you Susan Rosenthal, Elizabeth Ferris and Lital Manor for superb event logistics.
Reposted by John Tsang
Exciting lineup at today's #CZBiohubNY Mini Workshop hosted by @yalemedicine.bsky.social, @tsanglab.bsky.social and @yalecsei.bsky.social. Thrilled to welcome @czbiohub.bsky.social and @chanzuckerberg.bsky.social investigators and team members to Yale for this day of science and interaction.
July 9, 2025 at 2:57 PM
Exciting lineup at today's #CZBiohubNY Mini Workshop hosted by @yalemedicine.bsky.social, @tsanglab.bsky.social and @yalecsei.bsky.social. Thrilled to welcome @czbiohub.bsky.social and @chanzuckerberg.bsky.social investigators and team members to Yale for this day of science and interaction.
Reposted by John Tsang
What an amazing work @iannaconelab.bsky.social &friends just out @natimmunol.nature.com, it was really cool to have a preview of this fantastic work at the 2025 ENII EFIS EJI Summer School! Many congrats Matteo &co! Check it out here 👉 www.nature.com/articles/s41... & here 😉 👇👇👇
July 1, 2025 at 12:08 AM
What an amazing work @iannaconelab.bsky.social &friends just out @natimmunol.nature.com, it was really cool to have a preview of this fantastic work at the 2025 ENII EFIS EJI Summer School! Many congrats Matteo &co! Check it out here 👉 www.nature.com/articles/s41... & here 😉 👇👇👇
Reposted by John Tsang
So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!
As Robert Kuttner writes, the NIH will need support from Republican Senators to avoid draconian cuts to its FY2026 budget.
prospect.org/politics/202...
prospect.org/politics/202...
Will the Senate Save NIH?
Rescuing biomedical research is every bit as important as saving Medicaid.
prospect.org
June 25, 2025 at 1:01 AM
So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!
Added a bunch of new folks. Let me know if anyone wants to be added.
I created a starter pack for systems immunology - let me know if you would like to be added. Excited to be here on
@bsky.app
go.bsky.app/PjH2Fuj
@bsky.app
go.bsky.app/PjH2Fuj
June 22, 2025 at 8:32 PM
Added a bunch of new folks. Let me know if anyone wants to be added.
Reposted by John Tsang
Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation
Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...
www.medrxiv.org
June 21, 2025 at 11:29 AM
Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
www.medrxiv.org/content/10.1...
Reposted by John Tsang
Atul Butte’s talk introduced me to systems biology—I was presynapse scientist and opened my horizon to "biomedical moments, thawing frozen discoveries in data". Ideas that changed my career. Thank you for the science, the spirit, and the inspiration. You will be remembered.
June 15, 2025 at 10:01 AM
Atul Butte’s talk introduced me to systems biology—I was presynapse scientist and opened my horizon to "biomedical moments, thawing frozen discoveries in data". Ideas that changed my career. Thank you for the science, the spirit, and the inspiration. You will be remembered.
Atul has been a constant inspiring force. He is perpetually optimistic and never stops to empower the world with more data and motivate all of us to dig deeper and be more innovative with data. I miss his energy and our conversations. RIP - May memories of Atul continue to inspire us all.
Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
June 15, 2025 at 1:44 PM
Atul has been a constant inspiring force. He is perpetually optimistic and never stops to empower the world with more data and motivate all of us to dig deeper and be more innovative with data. I miss his energy and our conversations. RIP - May memories of Atul continue to inspire us all.
Reposted by John Tsang
Senate hearing on the FY26 NIH budget with Jay Bhattacharya
June 10, 10am ET
www.appropriations.senate.gov/hearings/a-r...
June 10, 10am ET
www.appropriations.senate.gov/hearings/a-r...
A Review of the President’s Fiscal Year 2026 Budget Request for the National Institutes of Health | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
www.appropriations.senate.gov
June 5, 2025 at 1:37 AM
Senate hearing on the FY26 NIH budget with Jay Bhattacharya
June 10, 10am ET
www.appropriations.senate.gov/hearings/a-r...
June 10, 10am ET
www.appropriations.senate.gov/hearings/a-r...
Reposted by John Tsang
FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social
FlyBase funding squashed amid Harvard grant terminations
The team behind the Drosophila genetics database is now requesting donations from labs to keep the resource afloat.
www.thetransmitter.org
June 4, 2025 at 9:11 PM
FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social
Reposted by John Tsang
My colleague and friend @scripps.edu, @ardemp.bskyverified.social, on the NYT front page today
June 4, 2025 at 2:47 PM
My colleague and friend @scripps.edu, @ardemp.bskyverified.social, on the NYT front page today
Reposted by John Tsang
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
May 24, 2025 at 5:47 PM
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
Reposted by John Tsang
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Reposted by John Tsang
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
May 23, 2025 at 5:56 PM
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
Reposted by John Tsang
7/10 In a combined analysis of infants and previously sequenced adults (generated by @tsanglab.bsky.social lab; PMID:33713619), infants display a similar ISG signature in monocytes but a markedly enhanced ISG signature in T and B cells, which is consistent with infant specific immune features.
May 16, 2025 at 6:00 PM
7/10 In a combined analysis of infants and previously sequenced adults (generated by @tsanglab.bsky.social lab; PMID:33713619), infants display a similar ISG signature in monocytes but a markedly enhanced ISG signature in T and B cells, which is consistent with infant specific immune features.
Exciting study on infant immune responses to sars-cov-2 and how they compare to adults.
1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa
May 16, 2025 at 7:25 PM
Exciting study on infant immune responses to sars-cov-2 and how they compare to adults.
Reposted by John Tsang
1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa
May 16, 2025 at 6:00 PM
1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa
Reposted by John Tsang
So let me get this straight: masks are bad and un-American if worn to fight a pandemic, but good if worn by people claiming to be government agents when they kidnap people off the street
May 10, 2025 at 3:06 PM
So let me get this straight: masks are bad and un-American if worn to fight a pandemic, but good if worn by people claiming to be government agents when they kidnap people off the street
Wonderful to catch up with friends and colleagues at #aai2025. Ofer Levy, Mercy Prabhudas, Donna Farber, me, and Bali Pulendran. Adding @lucasite-lab.bsky.social in the second one!
May 5, 2025 at 10:44 PM
Wonderful to catch up with friends and colleagues at #aai2025. Ofer Levy, Mercy Prabhudas, Donna Farber, me, and Bali Pulendran. Adding @lucasite-lab.bsky.social in the second one!
Thanks for the highlight! Yes we are live still great talks to come - come on over to hang out with systems immunologists this morning at #aai2025!
A major highlight #AAI2025: the Systems Immunology symposium with @CatherineBlish and @tsanglab.bsky.social, featuring amazing national and international systems immunology speakers @aai.org
May 4, 2025 at 6:47 PM
Thanks for the highlight! Yes we are live still great talks to come - come on over to hang out with systems immunologists this morning at #aai2025!