Vincent Gureghian
@tes-and-others.bsky.social
About TEs, IFN, senescence with a zest of ML
Reposted by Vincent Gureghian
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Scripps Research team identifies sugar molecules that trigger placental formation
ow.ly
November 8, 2025 at 12:25 AM
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Reposted by Vincent Gureghian
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 5:58 PM
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
Reposted by Vincent Gureghian
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells.
The Human Silencing Hub (HUSH) complex safeguards genome integrity in human somatic cells by repressing transposable elements and regulating type I interferon (IFN-I) induction. In early development, ...
www.biorxiv.org
October 29, 2025 at 6:03 PM
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
Reposted by Vincent Gureghian
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
October 20, 2025 at 8:00 PM
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Reposted by Vincent Gureghian
#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Recognition of exogenous RNA by Toll-like receptors (TLRs) is central to pathogen defense. Using two distinct binding pockets, TLR7 and TLR8 recognize…
www.sciencedirect.com
October 19, 2025 at 3:03 PM
#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!
Reposted by Vincent Gureghian
Want to help shaping the future of #Snakemake? Then participate in the Snakemake hackathon 2026 in Munich! There's still room as the maximum number of participants is not yet reached. You can register here: indico.cern.ch/e/snakemake-...
#sciworkflows #reproducibility
#sciworkflows #reproducibility
Snakemake Hackathon March 2026
We are excited to announce the Snakemake Hackathon 2026, to be held 9-13 March, 2026 at the Technical University Munich. This event will bring together passionate developers and data scientists to col...
indico.cern.ch
October 17, 2025 at 4:49 PM
Want to help shaping the future of #Snakemake? Then participate in the Snakemake hackathon 2026 in Munich! There's still room as the maximum number of participants is not yet reached. You can register here: indico.cern.ch/e/snakemake-...
#sciworkflows #reproducibility
#sciworkflows #reproducibility
Reposted by Vincent Gureghian
Your immune system remembers skin inflammation long after it resolves because of #interferon alpha!
Check out our new paper describing these findings just published at
@jimmunol.bsky.social 👇👇👇
It was amazing working on this with my role model @drshrutinaik.bsky.social
Check out our new paper describing these findings just published at
@jimmunol.bsky.social 👇👇👇
It was amazing working on this with my role model @drshrutinaik.bsky.social
Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity
Abstract. Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions syst
academic.oup.com
October 14, 2025 at 1:04 PM
Your immune system remembers skin inflammation long after it resolves because of #interferon alpha!
Check out our new paper describing these findings just published at
@jimmunol.bsky.social 👇👇👇
It was amazing working on this with my role model @drshrutinaik.bsky.social
Check out our new paper describing these findings just published at
@jimmunol.bsky.social 👇👇👇
It was amazing working on this with my role model @drshrutinaik.bsky.social
Reposted by Vincent Gureghian
Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
October 13, 2025 at 2:03 AM
Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
Reposted by Vincent Gureghian
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
October 10, 2025 at 12:57 PM
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
Reposted by Vincent Gureghian
#LiveForever! Chen, Mao &co show @science.org that not all #cGAS are equals & that naked mole-rats one bears a 4 amino acid mutation which enhances DNA repair & when transferred in aged mice dampens frailty, hair graying, inflammatory & senescence markers! www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 9, 2025 at 10:49 PM
#LiveForever! Chen, Mao &co show @science.org that not all #cGAS are equals & that naked mole-rats one bears a 4 amino acid mutation which enhances DNA repair & when transferred in aged mice dampens frailty, hair graying, inflammatory & senescence markers! www.science.org/doi/10.1126/...
Reposted by Vincent Gureghian
#TEsky RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation doi.org/10.1073/pnas...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
October 7, 2025 at 12:10 PM
#TEsky RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation doi.org/10.1073/pnas...
Reposted by Vincent Gureghian
Sometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.
sites.stat.columbia.edu
October 4, 2025 at 5:35 PM
Sometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.
Reposted by Vincent Gureghian
🎨 Theming got a huge overhaul with the latest #ggplot2 release. In honour of that @teunbrand.bsky.social has written a comprehensive deep-dive into styling your plots, covering both old and new functionality. Grab a coffee and dive in!
#rstats
#rstats
ggplot2 styling
This post discusses one function in ggplot2: `theme()`. Find out about the glamour of graphics in this deep-dive article.
www.tidyverse.org
October 1, 2025 at 8:10 AM
🎨 Theming got a huge overhaul with the latest #ggplot2 release. In honour of that @teunbrand.bsky.social has written a comprehensive deep-dive into styling your plots, covering both old and new functionality. Grab a coffee and dive in!
#rstats
#rstats
Reposted by Vincent Gureghian
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 1, 2025 at 6:08 PM
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Reposted by Vincent Gureghian
This is my 1st time catching my pet archer fish, Legolas, spitting on camera. Archerfish use modified jaw and tongue bones to fire a jet of water to knock down bugs from over hanging vegetation. Here Legolas is shooting down a fruit fly 🪰 🐠🧪
September 30, 2025 at 8:34 PM
This is my 1st time catching my pet archer fish, Legolas, spitting on camera. Archerfish use modified jaw and tongue bones to fire a jet of water to knock down bugs from over hanging vegetation. Here Legolas is shooting down a fruit fly 🪰 🐠🧪
Reposted by Vincent Gureghian
Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
AussiERV 2025
AussiERV: Australia’s first symposium dedicated to endogenous retroviruses. Join us for this one-day virtual event on November 7th!
events.humanitix.com
September 27, 2025 at 7:28 AM
Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️
Abstracts due 1st October!
events.humanitix.com/aussierv-2025
#ERV #retrovirus
Reposted by Vincent Gureghian
This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
Collective homeostasis of condensation-prone proteins via their mRNAs - Nature
The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.
www.nature.com
September 25, 2025 at 8:24 PM
This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
Reposted by Vincent Gureghian
snkmt 0.2.0 is out! New features:
1. Multi-database support - switch between dbs via ctrl+p (like VSCode)
2. Workflow filtering - hide/filter by snakefile, status, or date for cleaner navigation
github.com/cademirch/sn...
#snakemake #bioinformatics #workflow #opensource #python #cli #tui
1. Multi-database support - switch between dbs via ctrl+p (like VSCode)
2. Workflow filtering - hide/filter by snakefile, status, or date for cleaner navigation
github.com/cademirch/sn...
#snakemake #bioinformatics #workflow #opensource #python #cli #tui
GitHub - cademirch/snkmt: A TUI for monitoring Snakemake workflows in real-time.
A TUI for monitoring Snakemake workflows in real-time. - cademirch/snkmt
github.com
September 22, 2025 at 7:46 PM
snkmt 0.2.0 is out! New features:
1. Multi-database support - switch between dbs via ctrl+p (like VSCode)
2. Workflow filtering - hide/filter by snakefile, status, or date for cleaner navigation
github.com/cademirch/sn...
#snakemake #bioinformatics #workflow #opensource #python #cli #tui
1. Multi-database support - switch between dbs via ctrl+p (like VSCode)
2. Workflow filtering - hide/filter by snakefile, status, or date for cleaner navigation
github.com/cademirch/sn...
#snakemake #bioinformatics #workflow #opensource #python #cli #tui
Reposted by Vincent Gureghian
Got into #TidyTuesday after picking up R this year. Just submitted my first dataset to the challenge—and turned it into my first R package: {tastyR}! 🍽️ Super excited to see what the #rstats community cooks up with the data this week! 😀👀
Glad to have made y'all's Tuesday a lil...tastyR. 🏃🏿♂️
Glad to have made y'all's Tuesday a lil...tastyR. 🏃🏿♂️
a cartoon character is walking through a tunnel with a sword .
Alt: a cartoon character is running through a tunnel with a sword .
media.tenor.com
September 15, 2025 at 1:05 PM
Got into #TidyTuesday after picking up R this year. Just submitted my first dataset to the challenge—and turned it into my first R package: {tastyR}! 🍽️ Super excited to see what the #rstats community cooks up with the data this week! 😀👀
Glad to have made y'all's Tuesday a lil...tastyR. 🏃🏿♂️
Glad to have made y'all's Tuesday a lil...tastyR. 🏃🏿♂️
Reposted by Vincent Gureghian
New blog post!
Ever wonder what geom_histogram is actually doing? How about geom_boxplot?
In celebration of the release of #ggplot2 4.0.0 (ggplot8?), I explore the relationships between the “geoms” and “stats” offered by the core {ggplot2} functions.
#rstats
Ever wonder what geom_histogram is actually doing? How about geom_boxplot?
In celebration of the release of #ggplot2 4.0.0 (ggplot8?), I explore the relationships between the “geoms” and “stats” offered by the core {ggplot2} functions.
#rstats
Exploring {ggplot2}’s Geoms and Stats – Stat’s What It’s All About
blog.msbstats.info
September 15, 2025 at 7:04 PM
Reposted by Vincent Gureghian
A study published in Genome Biology explores the role of transposable elements in antiviral resistance to HIV. The findings open new avenues for understanding the molecular mechanisms of viral control and developing targeted interventions for HIV-1 treatment.
#Epigenetics
#Epigenetics
Transposable elements may enhance antiviral resistance in HIV-1 elite controllers
Genome Biology
bit.ly
September 15, 2025 at 5:30 PM
A study published in Genome Biology explores the role of transposable elements in antiviral resistance to HIV. The findings open new avenues for understanding the molecular mechanisms of viral control and developing targeted interventions for HIV-1 treatment.
#Epigenetics
#Epigenetics
Reposted by Vincent Gureghian
The paper
"N-glycans conceal the hypermodified uracil base acp3U, which we identified as immunostimulatory when exposed in RNA. Consistent with this, genetic deletion of an enzyme (DTWD2) that synthesizes acp3U abrogated innate immune activation by de-N-glycosylated small RNAs and apoptotic cells"
"N-glycans conceal the hypermodified uracil base acp3U, which we identified as immunostimulatory when exposed in RNA. Consistent with this, genetic deletion of an enzyme (DTWD2) that synthesizes acp3U abrogated innate immune activation by de-N-glycosylated small RNAs and apoptotic cells"
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
September 12, 2025 at 5:36 PM
The paper
"N-glycans conceal the hypermodified uracil base acp3U, which we identified as immunostimulatory when exposed in RNA. Consistent with this, genetic deletion of an enzyme (DTWD2) that synthesizes acp3U abrogated innate immune activation by de-N-glycosylated small RNAs and apoptotic cells"
"N-glycans conceal the hypermodified uracil base acp3U, which we identified as immunostimulatory when exposed in RNA. Consistent with this, genetic deletion of an enzyme (DTWD2) that synthesizes acp3U abrogated innate immune activation by de-N-glycosylated small RNAs and apoptotic cells"
Reposted by Vincent Gureghian
I've written a short blog post introducing "The Art of Visualization with ggplot2"!
This book is all about the end-to-end process of creating charts with #ggplot2 📊 including data wrangling, sketching, and styling your plots!
nrennie.rbind.io/blog/art-of-...
#RStats #DataViz #TidyTuesday
This book is all about the end-to-end process of creating charts with #ggplot2 📊 including data wrangling, sketching, and styling your plots!
nrennie.rbind.io/blog/art-of-...
#RStats #DataViz #TidyTuesday
Introducing The Art of Visualization with ggplot2 – Nicola Rennie
I’ve written a book! This blog post gives a brief introduction to The Art of Visualization with ggplot2, a book of data visualization case studies showing the end-to-end process of building charts, st...
nrennie.rbind.io
September 11, 2025 at 2:32 PM
I've written a short blog post introducing "The Art of Visualization with ggplot2"!
This book is all about the end-to-end process of creating charts with #ggplot2 📊 including data wrangling, sketching, and styling your plots!
nrennie.rbind.io/blog/art-of-...
#RStats #DataViz #TidyTuesday
This book is all about the end-to-end process of creating charts with #ggplot2 📊 including data wrangling, sketching, and styling your plots!
nrennie.rbind.io/blog/art-of-...
#RStats #DataViz #TidyTuesday
Reposted by Vincent Gureghian
Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!
www.molbiolcell.org/doi/full/10....
Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social
And huge thank you @ascbiology.bsky.social
www.molbiolcell.org/doi/full/10....
Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social
And huge thank you @ascbiology.bsky.social
Interplay of condensation and chromatin binding underlies BRD4 targeting | Molecular Biology of the Cell
Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific ...
www.molbiolcell.org
September 13, 2025 at 12:20 AM
Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!
www.molbiolcell.org/doi/full/10....
Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social
And huge thank you @ascbiology.bsky.social
www.molbiolcell.org/doi/full/10....
Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social
And huge thank you @ascbiology.bsky.social
Reposted by Vincent Gureghian
My work today is sponsored by...
September 10, 2025 at 7:31 PM
My work today is sponsored by...