Science Says
@sciencesays.bsky.social
🧪 Scientist | Machine learning 🐍 | Bioinformatics 🧬 | Demystifying science/debunking misconceptions | me: @manifestingchaos.bsky.social ✨
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Science Says
@sciencesays.bsky.social
· Jan 25
Scientist says, annotate your code because six months is plenty of time to forget your own logic.
Reposted by Science Says
Potential long-term effects of measles infection in kids:
- Immune amnesia
- Permanent neurological disorder
- Brain damage
- Autoimmune disorder
- Hearing and vision loss
- Immune amnesia
- Permanent neurological disorder
- Brain damage
- Autoimmune disorder
- Hearing and vision loss
March 8, 2025 at 10:59 PM
Potential long-term effects of measles infection in kids:
- Immune amnesia
- Permanent neurological disorder
- Brain damage
- Autoimmune disorder
- Hearing and vision loss
- Immune amnesia
- Permanent neurological disorder
- Brain damage
- Autoimmune disorder
- Hearing and vision loss
Reposted by Science Says
Early-onset colorectal cancer is expected to become the leading cause of #cancer death in ages 20 to 49 in the U.S. by 2030.
Research is urgently needed to better detect and treat patients, argues this #SciencePerspective: scim.ag/4h1TYcQ #ColorectalCancerAwarenessMonth
Research is urgently needed to better detect and treat patients, argues this #SciencePerspective: scim.ag/4h1TYcQ #ColorectalCancerAwarenessMonth
A common cancer at an uncommon age
The etiology of early-onset colorectal cancer needs to be understood to tackle rising incidence
scim.ag
March 1, 2025 at 3:07 PM
Early-onset colorectal cancer is expected to become the leading cause of #cancer death in ages 20 to 49 in the U.S. by 2030.
Research is urgently needed to better detect and treat patients, argues this #SciencePerspective: scim.ag/4h1TYcQ #ColorectalCancerAwarenessMonth
Research is urgently needed to better detect and treat patients, argues this #SciencePerspective: scim.ag/4h1TYcQ #ColorectalCancerAwarenessMonth
Reposted by Science Says
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
March 1, 2025 at 6:07 PM
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
Reposted by Science Says
AI model deciphers the code in proteins that tells them where to go
"Whitehead Institute and CSAIL researchers created a machine-learning model to predict and generate protein localization, with implications for understanding and remedying disease."
www.science.org/doi/10.1126/...
"Whitehead Institute and CSAIL researchers created a machine-learning model to predict and generate protein localization, with implications for understanding and remedying disease."
www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 20, 2025 at 8:05 AM
AI model deciphers the code in proteins that tells them where to go
"Whitehead Institute and CSAIL researchers created a machine-learning model to predict and generate protein localization, with implications for understanding and remedying disease."
www.science.org/doi/10.1126/...
"Whitehead Institute and CSAIL researchers created a machine-learning model to predict and generate protein localization, with implications for understanding and remedying disease."
www.science.org/doi/10.1126/...
Reposted by Science Says
scPRINT: pre-training on 50 million cells allows robust gene network predictions | bioRxiv
www.biorxiv.org/content/10....
www.biorxiv.org/content/10....
February 19, 2025 at 3:15 PM
scPRINT: pre-training on 50 million cells allows robust gene network predictions | bioRxiv
www.biorxiv.org/content/10....
www.biorxiv.org/content/10....
Reposted by Science Says
A new finding of dysfunctional memory B cells that can underly a person's immune response to cancer and represent a target for immunotherapy
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Dysfunctional CD11c−CD21− extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer
Tumor-associated extrafollicular B cells are phenotypically, locationally, and functionally distinct from germinal center–dependent memory B cells.
www.science.org
February 19, 2025 at 11:41 PM
A new finding of dysfunctional memory B cells that can underly a person's immune response to cancer and represent a target for immunotherapy
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Science Says
This might be the best paper on applying sparse autoencoders to protein language models. The authors identify how neural networks trained on amino acid sequences "discover" different features, some specific to individual protein families, other for substructures
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 10, 2025 at 12:15 PM
This might be the best paper on applying sparse autoencoders to protein language models. The authors identify how neural networks trained on amino acid sequences "discover" different features, some specific to individual protein families, other for substructures
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Science Says
This study identifies inconsistent evaluation practices of large language models (LLMs) in health care, finding a lack of standardized frameworks and limited use of real patient data.
ja.ma/40WLHSt
#MedSky
ja.ma/40WLHSt
#MedSky
February 2, 2025 at 5:32 PM
This study identifies inconsistent evaluation practices of large language models (LLMs) in health care, finding a lack of standardized frameworks and limited use of real patient data.
ja.ma/40WLHSt
#MedSky
ja.ma/40WLHSt
#MedSky
Reposted by Science Says
AlphaFold (the archetype): genAI to predict 3D protein structure from amino acid sequence
New ChromoGen: genAI to predict 3D genome structure from DNA sequence
www.science.org/doi/10.1126/...
New ChromoGen: genAI to predict 3D genome structure from DNA sequence
www.science.org/doi/10.1126/...
ChromoGen: Diffusion model predicts single-cell chromatin conformations
The generative AI technique dubbed ChromoGen predicts chromatin structures from DNA sequence and its accessibility.
www.science.org
February 1, 2025 at 6:47 PM
AlphaFold (the archetype): genAI to predict 3D protein structure from amino acid sequence
New ChromoGen: genAI to predict 3D genome structure from DNA sequence
www.science.org/doi/10.1126/...
New ChromoGen: genAI to predict 3D genome structure from DNA sequence
www.science.org/doi/10.1126/...
Our local library system uses CloudLibrary. It’s free; all you need is a digital library card, which can be obtained online.
Hey while megaretailers profiting one of the richest men in world are out here doing this shit www.advocate.com/news/amazon-...
maybe it's a fun time to switch to @librofm.bsky.social for audiobooks. Select the indie bookstore you'd like to support, listen away. Comp prices to aforementioned jerks
maybe it's a fun time to switch to @librofm.bsky.social for audiobooks. Select the indie bookstore you'd like to support, listen away. Comp prices to aforementioned jerks
Amazon removes 'equity for Black people' and 'LGBTQ+ rights' from company policies
Amazon has quietly removed protections for Black and LGBTQ+ workers from its company policies.
www.advocate.com
January 25, 2025 at 6:08 AM
Our local library system uses CloudLibrary. It’s free; all you need is a digital library card, which can be obtained online.
DYK only 6% of scientists identify as Republican (55% D, 32% Ind)
<3% of scientists deny human-caused climate change
51% believe in god/higher power
5% are vaccine skeptics
2% believe in creationism/intelligent design
35% oppose nuclear energy
7% oppose stem cell research
Where do you stand?
<3% of scientists deny human-caused climate change
51% believe in god/higher power
5% are vaccine skeptics
2% believe in creationism/intelligent design
35% oppose nuclear energy
7% oppose stem cell research
Where do you stand?
January 24, 2025 at 4:44 PM
DYK only 6% of scientists identify as Republican (55% D, 32% Ind)
<3% of scientists deny human-caused climate change
51% believe in god/higher power
5% are vaccine skeptics
2% believe in creationism/intelligent design
35% oppose nuclear energy
7% oppose stem cell research
Where do you stand?
<3% of scientists deny human-caused climate change
51% believe in god/higher power
5% are vaccine skeptics
2% believe in creationism/intelligent design
35% oppose nuclear energy
7% oppose stem cell research
Where do you stand?
Reposted by Science Says
Bioinformatics Methods for Transcriptomics -- looks like a great course https://www.coursera.org/learn/bioinformatics-methods-for-transcriptomics
January 15, 2025 at 4:30 PM
Bioinformatics Methods for Transcriptomics -- looks like a great course https://www.coursera.org/learn/bioinformatics-methods-for-transcriptomics
Super late Women in Science Wednesday!
Dorothy Hodgkin: British chemist who won the Nobel Prize in Chemistry in 1964 for her work in determining the structures of important biochemical substances using X-ray crystallography, including penicillin, vitamin B12, and insulin
Dorothy Hodgkin: British chemist who won the Nobel Prize in Chemistry in 1964 for her work in determining the structures of important biochemical substances using X-ray crystallography, including penicillin, vitamin B12, and insulin
January 23, 2025 at 6:02 AM
Super late Women in Science Wednesday!
Dorothy Hodgkin: British chemist who won the Nobel Prize in Chemistry in 1964 for her work in determining the structures of important biochemical substances using X-ray crystallography, including penicillin, vitamin B12, and insulin
Dorothy Hodgkin: British chemist who won the Nobel Prize in Chemistry in 1964 for her work in determining the structures of important biochemical substances using X-ray crystallography, including penicillin, vitamin B12, and insulin
Research idea: Cognitive Benefits of Prolonged Rage Posting
Individuals engage in continuous, high-frequency rage-posting for 4 yrs
Hypothesis: Sustained rage-posting for extended periods enhances verbal creativity, emotional resilience, problem-solving skills. Also improves thumb dexterity
Individuals engage in continuous, high-frequency rage-posting for 4 yrs
Hypothesis: Sustained rage-posting for extended periods enhances verbal creativity, emotional resilience, problem-solving skills. Also improves thumb dexterity
Remember to log off sometimes. You can't rage post for four years straight without losing your mind
January 21, 2025 at 5:57 AM
Research idea: Cognitive Benefits of Prolonged Rage Posting
Individuals engage in continuous, high-frequency rage-posting for 4 yrs
Hypothesis: Sustained rage-posting for extended periods enhances verbal creativity, emotional resilience, problem-solving skills. Also improves thumb dexterity
Individuals engage in continuous, high-frequency rage-posting for 4 yrs
Hypothesis: Sustained rage-posting for extended periods enhances verbal creativity, emotional resilience, problem-solving skills. Also improves thumb dexterity
Feelings of inadequacy, low self-esteem, or alienation can push individuals to seek validation from extremist groups. The ideology provides them with a sense of purpose & superiority.
Education, exposure to diversity, and addressing underlying insecurities can be key in reducing extremist beliefs.
Education, exposure to diversity, and addressing underlying insecurities can be key in reducing extremist beliefs.
January 21, 2025 at 5:34 AM
Feelings of inadequacy, low self-esteem, or alienation can push individuals to seek validation from extremist groups. The ideology provides them with a sense of purpose & superiority.
Education, exposure to diversity, and addressing underlying insecurities can be key in reducing extremist beliefs.
Education, exposure to diversity, and addressing underlying insecurities can be key in reducing extremist beliefs.
January 20, 2025 at 8:01 PM
One of my main goals for this account is to make science accessible to everyone. I aim to break down primary research & explain it in ways that are easy to understand, without clickbait headlines or biased interpretations.
So let’s get started with this…
#sciencemadeclear #scienceforeveryone
Associations of dietary factors with risk of colorectal cancer
"Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK"
Open Access
www.nature.com/articles/s41...
"Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK"
Open Access
www.nature.com/articles/s41...
January 20, 2025 at 6:15 PM
One of my main goals for this account is to make science accessible to everyone. I aim to break down primary research & explain it in ways that are easy to understand, without clickbait headlines or biased interpretations.
So let’s get started with this…
#sciencemadeclear #scienceforeveryone
Cancer immunotherapy: Researchers combined CAR-T cell treatment with vaccines designed to stimulate the immune system. By enhancing the immune response, the vaccines help CAR-T cells persist longer and become more effective at targeting tumors, especially solid cancers.
Boosting CAR-T cell therapy through vaccine synergy
Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment landscape
for hematological cancers. However, achieving comparable success in solid tumors remains
challenging. Factors con...
www.cell.com
January 19, 2025 at 9:52 PM
Cancer immunotherapy: Researchers combined CAR-T cell treatment with vaccines designed to stimulate the immune system. By enhancing the immune response, the vaccines help CAR-T cells persist longer and become more effective at targeting tumors, especially solid cancers.
Reposted by Science Says
Higher green tea consumption was associated with fewer cerebral white matter lesions, suggesting that it may be useful in preventing dementia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 18, 2025 at 5:34 AM
Higher green tea consumption was associated with fewer cerebral white matter lesions, suggesting that it may be useful in preventing dementia.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Science Says, think critically.
January 19, 2025 at 8:51 PM
Science Says, think critically.