Sam Connell
@samuelconnell.bsky.social
Scientist and Global Sales Director at 3i (@the.3i.social), foodie, family man. Tai Chi and meditation matter. Compassion Heals. Microscopes Rock. https://www.intelligent-imaging.com
Reposted by Sam Connell
In a new blog (uniconq.substack.com), Denisa Lepǎdatu and I propose a playful, and perhaps useful, framing of fundamental science that goes for the ground truth - namely, as universe conquering, the confrontation of the foundational unknowns and challenges of existence.
Universe Conquering | Substack
A blog about how to overcome the limits of human existence, through ground truth-oriented understanding. Click to read Universe Conquering, a Substack publication. Launched 12 days ago.
uniconq.substack.com
January 17, 2026 at 9:05 PM
In a new blog (uniconq.substack.com), Denisa Lepǎdatu and I propose a playful, and perhaps useful, framing of fundamental science that goes for the ground truth - namely, as universe conquering, the confrontation of the foundational unknowns and challenges of existence.
Reposted by Sam Connell
The new Rancho Gordo store on Main St in Napa will be a reality! Looks like 1/26. How this took a year I DO NOT KNOW! Can you imagine opening lots of stores? We can't wait to see you there.
#beansky #heirloombeans #napa
#beansky #heirloombeans #napa
January 17, 2026 at 12:01 AM
The new Rancho Gordo store on Main St in Napa will be a reality! Looks like 1/26. How this took a year I DO NOT KNOW! Can you imagine opening lots of stores? We can't wait to see you there.
#beansky #heirloombeans #napa
#beansky #heirloombeans #napa
Reposted by Sam Connell
Apply by Feb. 3 to become a Janelia Group Leader!
Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader 🧪
Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader 🧪
December 15, 2025 at 3:10 PM
Apply by Feb. 3 to become a Janelia Group Leader!
Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader 🧪
Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader 🧪
Reposted by Sam Connell
Great news! The unethical hepatitis B vaccine trial planned for Guinea-Bissau has been cancelled.
Public pressure and insisting that clinical trials pass ethics analysis worked.
www.theguardian.com/us-news/2026...
1/2
Public pressure and insisting that clinical trials pass ethics analysis worked.
www.theguardian.com/us-news/2026...
1/2
Controversial US study on hepatitis B vaccines in Africa is cancelled
$1.6m project drew outrage over ethical questions about withholding vaccines proven to prevent disease
www.theguardian.com
January 15, 2026 at 4:48 PM
Great news! The unethical hepatitis B vaccine trial planned for Guinea-Bissau has been cancelled.
Public pressure and insisting that clinical trials pass ethics analysis worked.
www.theguardian.com/us-news/2026...
1/2
Public pressure and insisting that clinical trials pass ethics analysis worked.
www.theguardian.com/us-news/2026...
1/2
Reposted by Sam Connell
I am giving a talk this Jan 22 in the Bioengineering Dept at the University of Pittsburgh.
I will talk about our 3D tissue mapping platform (CODA) and our new CAR T therapies for solid tumors (CAR TV).
Thursday, Jan 22, 4 pm, Benedum Hall, 157, 3700 O'Hara Street, Pittsburgh, PA 15261
I will talk about our 3D tissue mapping platform (CODA) and our new CAR T therapies for solid tumors (CAR TV).
Thursday, Jan 22, 4 pm, Benedum Hall, 157, 3700 O'Hara Street, Pittsburgh, PA 15261
January 15, 2026 at 5:56 PM
I am giving a talk this Jan 22 in the Bioengineering Dept at the University of Pittsburgh.
I will talk about our 3D tissue mapping platform (CODA) and our new CAR T therapies for solid tumors (CAR TV).
Thursday, Jan 22, 4 pm, Benedum Hall, 157, 3700 O'Hara Street, Pittsburgh, PA 15261
I will talk about our 3D tissue mapping platform (CODA) and our new CAR T therapies for solid tumors (CAR TV).
Thursday, Jan 22, 4 pm, Benedum Hall, 157, 3700 O'Hara Street, Pittsburgh, PA 15261
Reposted by Sam Connell
Reposted by Sam Connell
This seems like it is going to be a classic Mitochondrial Transfer paper 👇🔥
Note: The original MitoTag mice expressing GFP-OMM via insertion in the Rosa26 locus are available from JAX Labs (www.jax.org/strain/032675) and the original paper describing them is here: www.nature.com/articles/s41...
Note: The original MitoTag mice expressing GFP-OMM via insertion in the Rosa26 locus are available from JAX Labs (www.jax.org/strain/032675) and the original paper describing them is here: www.nature.com/articles/s41...
January 13, 2026 at 12:11 AM
This seems like it is going to be a classic Mitochondrial Transfer paper 👇🔥
Note: The original MitoTag mice expressing GFP-OMM via insertion in the Rosa26 locus are available from JAX Labs (www.jax.org/strain/032675) and the original paper describing them is here: www.nature.com/articles/s41...
Note: The original MitoTag mice expressing GFP-OMM via insertion in the Rosa26 locus are available from JAX Labs (www.jax.org/strain/032675) and the original paper describing them is here: www.nature.com/articles/s41...
Reposted by Sam Connell
for the big dorks, it's this plasmid:
www.addgene.org/174007/
We find that ChRimson, while not as strong as other opsins, is very stable in the cortex.
www.addgene.org/174007/
We find that ChRimson, while not as strong as other opsins, is very stable in the cortex.
Addgene: pAAV-hSyn-DIO-jGCaMP8s-P2A-ChrimsonR-ST
Plasmid pAAV-hSyn-DIO-jGCaMP8s-P2A-ChrimsonR-ST from Dr. Mark Histed's lab contains the insert jGCaMP8s-P2A-ChrimsonR-ST and is published in eNeuro. 2023 Mar 29;10(3):ENEURO.0378-22.2023. doi: 10.1523...
www.addgene.org
January 12, 2026 at 11:44 PM
for the big dorks, it's this plasmid:
www.addgene.org/174007/
We find that ChRimson, while not as strong as other opsins, is very stable in the cortex.
www.addgene.org/174007/
We find that ChRimson, while not as strong as other opsins, is very stable in the cortex.
Reposted by Sam Connell
A short Bluetorial about indirect cost rates and indirect cost recovery.
1/14
1/14
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
January 12, 2026 at 7:49 PM
A short Bluetorial about indirect cost rates and indirect cost recovery.
1/14
1/14
Reposted by Sam Connell
The hardest hit would not be universities that the administration seems to be believe use indirect costs to run programs they find objectionable, but children's hospitals and cancer research institutes.
Talk about making America healthy...
14/14
Talk about making America healthy...
14/14
a cartoon character from south park is in the snow and says " are you sure this is a good idea "
ALT: a cartoon character from south park is in the snow and says " are you sure this is a good idea "
media.tenor.com
January 12, 2026 at 7:49 PM
The hardest hit would not be universities that the administration seems to be believe use indirect costs to run programs they find objectionable, but children's hospitals and cancer research institutes.
Talk about making America healthy...
14/14
Talk about making America healthy...
14/14
Reposted by Sam Connell
An important milestone for the lab: our first work looking at microtubules, and at the emergence of polarity in neurons. The PhD work of Ciarán, with invaluable help from @harrisonyork.bsky.social and researcher Pascal Verdier-Pinard who joined the team last year. We hope you'll like it! 🧵 9/9
Direct labeling of microtubule turnover reveals in-lattice repair and stabilization patterns in developing neurons
The microtubule cytoskeleton is the backbone of neuronal morphogenesis, driving the development of the dendrites and axon, and supporting trafficking to distant compartments. How neuronal microtubules...
www.biorxiv.org
January 12, 2026 at 7:14 PM
An important milestone for the lab: our first work looking at microtubules, and at the emergence of polarity in neurons. The PhD work of Ciarán, with invaluable help from @harrisonyork.bsky.social and researcher Pascal Verdier-Pinard who joined the team last year. We hope you'll like it! 🧵 9/9
Reposted by Sam Connell
But none of our existing imaging methods (SoRa, STORM…) could really visualize integration within the bundled microtubules in neurites. So Ciarán set up U-ExM expansion microscopy, then performed it on microinjected neurons - now we could see plus-end growth and in-lattice renewal everywhere! 🧵 7/9
January 12, 2026 at 7:14 PM
But none of our existing imaging methods (SoRa, STORM…) could really visualize integration within the bundled microtubules in neurites. So Ciarán set up U-ExM expansion microscopy, then performed it on microinjected neurons - now we could see plus-end growth and in-lattice renewal everywhere! 🧵 7/9
Reposted by Sam Connell
Please sign. If you can. I did.
It's been just one month and we have the momentum. We're fighting to impeach and remove RFK Jr, whose negligence and anti-science is killing Americans. There are articles of impeachment in the house as we speak — we need our reps to act on them!
Take action with us: standupforscience.net/impeac...
Take action with us: standupforscience.net/impeac...
January 12, 2026 at 7:04 PM
Please sign. If you can. I did.
Reposted by Sam Connell
Please sign this petition, it only takes a minute.
Dorks, I know more than 7.2k of you think RFK Jr. needs to go!
I’m headed to DC tomorrow to meet with members of Congress about our articles of Impeachment.
The more people sign, the louder we can yell.
SHARE SHARE SHARE!
Standupforscience.net/impeach-rfkjr
I’m headed to DC tomorrow to meet with members of Congress about our articles of Impeachment.
The more people sign, the louder we can yell.
SHARE SHARE SHARE!
Standupforscience.net/impeach-rfkjr
It's been just one month and we have the momentum. We're fighting to impeach and remove RFK Jr, whose negligence and anti-science is killing Americans. There are articles of impeachment in the house as we speak — we need our reps to act on them!
Take action with us: standupforscience.net/impeac...
Take action with us: standupforscience.net/impeac...
January 12, 2026 at 7:05 PM
Please sign this petition, it only takes a minute.
Reposted by Sam Connell
we’re in the vet’s office waiting room and they just called for Agamemnon. we all looked at the Great Dane but it turns out Agamemnon is an orange kitten in a backpack that makes him look like an astronaut cheese puff
January 11, 2026 at 5:27 PM
we’re in the vet’s office waiting room and they just called for Agamemnon. we all looked at the Great Dane but it turns out Agamemnon is an orange kitten in a backpack that makes him look like an astronaut cheese puff
Reposted by Sam Connell
One day our first interaction with colleagues at scientific meetings will not be “how is your lab doing under these disastrous circumstances?”.
Today is not that day.
Today is not that day.
January 12, 2026 at 3:25 PM
One day our first interaction with colleagues at scientific meetings will not be “how is your lab doing under these disastrous circumstances?”.
Today is not that day.
Today is not that day.
Reposted by Sam Connell
Cool new fourier framework mapping the 3D chirality of supramolecular systems - from nanoparticles to DNA and proteins! #Chemsky #Chirality
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 12, 2026 at 5:34 PM
Cool new fourier framework mapping the 3D chirality of supramolecular systems - from nanoparticles to DNA and proteins! #Chemsky #Chirality
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Sam Connell
Why yes, as a matter of Fact, sir you are a Monster. You are aware that one should ask that question - now pause & await the answer. Having kids is SUPPOSED to create real change in your experience of Reality. It is intended to shape you into a more selfless human who delights in the joy of others.
January 10, 2026 at 6:39 PM
Why yes, as a matter of Fact, sir you are a Monster. You are aware that one should ask that question - now pause & await the answer. Having kids is SUPPOSED to create real change in your experience of Reality. It is intended to shape you into a more selfless human who delights in the joy of others.
Reposted by Sam Connell
Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.
January 10, 2026 at 5:39 PM
Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.
Reposted by Sam Connell
I'll tell you what I do like though...
Kindness.
People who practice kindness in every aspect of their lives are the ones who hold this world together, making it better, safer, healthier, happier, and more peaceful.
I look for those kind people in this world, and abhor those who reject kindness.
Kindness.
People who practice kindness in every aspect of their lives are the ones who hold this world together, making it better, safer, healthier, happier, and more peaceful.
I look for those kind people in this world, and abhor those who reject kindness.
January 11, 2026 at 7:13 PM
I'll tell you what I do like though...
Kindness.
People who practice kindness in every aspect of their lives are the ones who hold this world together, making it better, safer, healthier, happier, and more peaceful.
I look for those kind people in this world, and abhor those who reject kindness.
Kindness.
People who practice kindness in every aspect of their lives are the ones who hold this world together, making it better, safer, healthier, happier, and more peaceful.
I look for those kind people in this world, and abhor those who reject kindness.
Reposted by Sam Connell
LETTERMAN: “.. CBS News is a wreck. It’s just gone. .. The integrity of CBS News .. has been trampled on, pissed on and eviscerated by these idiots that have taken it over.”
@letterman.bsky.social $PSKY
youtu.be/CHYksa07oQA?...
@letterman.bsky.social $PSKY
youtu.be/CHYksa07oQA?...
January 10, 2026 at 8:26 PM
LETTERMAN: “.. CBS News is a wreck. It’s just gone. .. The integrity of CBS News .. has been trampled on, pissed on and eviscerated by these idiots that have taken it over.”
@letterman.bsky.social $PSKY
youtu.be/CHYksa07oQA?...
@letterman.bsky.social $PSKY
youtu.be/CHYksa07oQA?...
Reposted by Sam Connell
Greenlanders express their feelings towards Trump to Sky News. Their message could not be clearer. They want to live peacefully on their land with no foreign interference. They are not for sale nor will they ever be.
January 10, 2026 at 4:01 PM
Greenlanders express their feelings towards Trump to Sky News. Their message could not be clearer. They want to live peacefully on their land with no foreign interference. They are not for sale nor will they ever be.
Reposted by Sam Connell
My last visit to Beijing, I was stunned at how many wind powered generators were going in in the mountains surrounding Beijing. And that was... in 2017.
China was leading the world in wind power back then and certainly is now. Oh, and India leads in stored energy.
China was leading the world in wind power back then and certainly is now. Oh, and India leads in stored energy.
Trump: "All you have to do is say to China, how many windmill areas do you have in China? So far they're not able to find any."
China:
China:
January 9, 2026 at 10:13 PM
My last visit to Beijing, I was stunned at how many wind powered generators were going in in the mountains surrounding Beijing. And that was... in 2017.
China was leading the world in wind power back then and certainly is now. Oh, and India leads in stored energy.
China was leading the world in wind power back then and certainly is now. Oh, and India leads in stored energy.
Reposted by Sam Connell
Palate cleanser after a shitty news week.
January 9, 2026 at 9:31 PM
Palate cleanser after a shitty news week.
Reposted by Sam Connell
Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...
The Microscopists | Uri Manor (UC San Diego School of Biological Sciences)
In this episode of The Microscopists, Uri Manor, Assistant Professor of UCSD, opens up about growing up with profound hearing loss and how, despite wanting nothing to do with becoming a scientist, ...
bit.ly
January 9, 2026 at 11:42 AM
Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...