Roland Dunbrack 🏳️🌈
@rolanddunbrack.bsky.social
Computational structural biologist @Fox Chase Cancer Center. Gay, out & proud since 1986. I support transgender & nonbinary people. Living with CLL/SLL. Video about my LGBTQ+ life in science: https://tinyurl.com/45srzjdw. Views my own, not my employer's.
Reposted by Roland Dunbrack 🏳️🌈
A new paper out this weekend in which we analysed PeptideAtlas peptides in search of coding genes novel to the Ensembl/GENCODE reference set,
The peptides suggested another 35 potential new coding genes, but the devil is in the detail. Thread shortly:
bmcgenomics.biomedcentral.com/articles/10....
The peptides suggested another 35 potential new coding genes, but the devil is in the detail. Thread shortly:
bmcgenomics.biomedcentral.com/articles/10....
An audit of the PeptideAtlas database uncovers evidence for repurposed pseudogenes and co-opted retroviral ORFs - BMC Genomics
Background The human genome has been the subject of scrutiny for more than two decades, yet new protein coding genes are still being uncovered and recently ribosome profiling experiments have provided...
bmcgenomics.biomedcentral.com
November 24, 2025 at 10:16 AM
A new paper out this weekend in which we analysed PeptideAtlas peptides in search of coding genes novel to the Ensembl/GENCODE reference set,
The peptides suggested another 35 potential new coding genes, but the devil is in the detail. Thread shortly:
bmcgenomics.biomedcentral.com/articles/10....
The peptides suggested another 35 potential new coding genes, but the devil is in the detail. Thread shortly:
bmcgenomics.biomedcentral.com/articles/10....
Somebody not qualified to lead the NIH.
Pop Quiz:
What is the definition of an “economist?”
What is the definition of an “economist?”
November 25, 2025 at 2:50 AM
Somebody not qualified to lead the NIH.
Reposted by Roland Dunbrack 🏳️🌈
One of my favorite things is getting to tell friends who are new to NYC that the subway "stand clear of the closing doors please" voice is a trans woman named Bernie Wagenblast and she's amazing.
November 24, 2025 at 6:19 PM
One of my favorite things is getting to tell friends who are new to NYC that the subway "stand clear of the closing doors please" voice is a trans woman named Bernie Wagenblast and she's amazing.
Reposted by Roland Dunbrack 🏳️🌈
No surprise the Trump NIH director doesn’t understand how science works—doesn’t get NIH has been *the* world-historic leader in innovation.
After all, he’s never actually done any science.
Even before his rightwing pundit career 2020-25, he spent his time with economists, not scientists.
After all, he’s never actually done any science.
Even before his rightwing pundit career 2020-25, he spent his time with economists, not scientists.
The NIH director told attendees the NIH doesn't do enough innovative research.
“What puts lives at risk is doing research that’s incremental,” Bhattacharya said. “All it does is advance the careers of the researchers that do it. It results in publications that don’t get used and aren’t replicable.”
“What puts lives at risk is doing research that’s incremental,” Bhattacharya said. “All it does is advance the careers of the researchers that do it. It results in publications that don’t get used and aren’t replicable.”
November 23, 2025 at 10:28 PM
No surprise the Trump NIH director doesn’t understand how science works—doesn’t get NIH has been *the* world-historic leader in innovation.
After all, he’s never actually done any science.
Even before his rightwing pundit career 2020-25, he spent his time with economists, not scientists.
After all, he’s never actually done any science.
Even before his rightwing pundit career 2020-25, he spent his time with economists, not scientists.
Reposted by Roland Dunbrack 🏳️🌈
About that exclusive, "closed-to-press" MAHA summit last week with RFK and JD Vance: I got in.
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
November 21, 2025 at 5:01 PM
About that exclusive, "closed-to-press" MAHA summit last week with RFK and JD Vance: I got in.
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
The @nytimes.com both-sidesing masked stormtroopers on American streets.
www.nytimes.com/2025/11/22/u...
www.nytimes.com/2025/11/22/u...
In North Carolina, the Border Patrol’s Presence Divides a Swing State
www.nytimes.com
November 22, 2025 at 10:01 PM
The @nytimes.com both-sidesing masked stormtroopers on American streets.
www.nytimes.com/2025/11/22/u...
www.nytimes.com/2025/11/22/u...
Jeff Bezos is in the files then. Only logical conclusion.
The Washington Post editorial board decided the Epstein files have “no public interest” before even seeing them. That’s a stunning position for any newsroom to take. Praising Clay Higgins as the lone ‘no’ vote, too? No wonder no one trusts legacy media. Absolutely disgusting.
November 22, 2025 at 8:06 PM
Jeff Bezos is in the files then. Only logical conclusion.
I’ve gotten all my NIH grants from NIGMS. They’ve never had a payline. Not sure if that’s good or bad but occasionally it gave me a bit of hope. But also their IC50 was usually around 20th percentile so at least there was hope.
November 22, 2025 at 8:01 PM
I’ve gotten all my NIH grants from NIGMS. They’ve never had a payline. Not sure if that’s good or bad but occasionally it gave me a bit of hope. But also their IC50 was usually around 20th percentile so at least there was hope.
Sometimes I go over to my X account to see just how bad things are over there. Besides getting called foul names when I defend trans people's existence, occasionally something really funny comes across. This is a grift beyond grifts. He learned redox in high school & it's been all redox ever since.
November 21, 2025 at 10:09 PM
Sometimes I go over to my X account to see just how bad things are over there. Besides getting called foul names when I defend trans people's existence, occasionally something really funny comes across. This is a grift beyond grifts. He learned redox in high school & it's been all redox ever since.
Reposted by Roland Dunbrack 🏳️🌈
The President of the United States just called for Democratic members of Congress to be executed. "HANG THEM", he posted.
If you're a person of influence in this country and you haven't picked a side, maybe now would be the time to pick a fucking side.
If you're a person of influence in this country and you haven't picked a side, maybe now would be the time to pick a fucking side.
November 20, 2025 at 4:15 PM
The President of the United States just called for Democratic members of Congress to be executed. "HANG THEM", he posted.
If you're a person of influence in this country and you haven't picked a side, maybe now would be the time to pick a fucking side.
If you're a person of influence in this country and you haven't picked a side, maybe now would be the time to pick a fucking side.
I’m glad I got my PhD from Neil
Rudenstine and not f*cking Larry Summers.
Rudenstine and not f*cking Larry Summers.
#BREAKING: Former Harvard President Lawrence H. Summers will immediately leave his role as an instructor at Harvard while the University investigates his ties to child sex trafficker Jeffrey Epstein.
Dhruv T. Patel and Cam N. Srivastava report.
Dhruv T. Patel and Cam N. Srivastava report.
Summers Will Not Finish Semester of Teaching as Harvard Investigates Epstein Ties | News | The Harvard Crimson
Former Harvard President Lawrence H. Summers will immediately leave his role as an instructor at Harvard while the University investigates his ties to child sex trafficker Jeffrey E. Epstein.
www.thecrimson.com
November 20, 2025 at 1:00 AM
I’m glad I got my PhD from Neil
Rudenstine and not f*cking Larry Summers.
Rudenstine and not f*cking Larry Summers.
Reposted by Roland Dunbrack 🏳️🌈
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Roland Dunbrack 🏳️🌈
The Salvation Army are a hate group. Do not forget that this winter.
November 17, 2025 at 5:04 PM
The Salvation Army are a hate group. Do not forget that this winter.
Reposted by Roland Dunbrack 🏳️🌈
Sexual harassment is a productivity tax on women in STEM
Imagine the things we could do with our time if we didn’t have to do this bsky.app/profile/chan...
I did my job. And then I did a job that never should have been my responsibility afterwards, sending emails and having meetings about how this was allowed to happen in the first place. Other women scholars had to spend their time explaining to Aspen leadership why this was not ok.
November 16, 2025 at 7:35 PM
Sexual harassment is a productivity tax on women in STEM
Reposted by Roland Dunbrack 🏳️🌈
CNN reports that only 2% of the 600+ people arrested without probable cause or warrants in the Chicagoland area in violation of a standing court order had any criminal records at all.
The idea that these are the worst people on the planet only makes sense if you see them as Nazis saw Jews in 1940.
The idea that these are the worst people on the planet only makes sense if you see them as Nazis saw Jews in 1940.
November 15, 2025 at 11:30 PM
CNN reports that only 2% of the 600+ people arrested without probable cause or warrants in the Chicagoland area in violation of a standing court order had any criminal records at all.
The idea that these are the worst people on the planet only makes sense if you see them as Nazis saw Jews in 1940.
The idea that these are the worst people on the planet only makes sense if you see them as Nazis saw Jews in 1940.
This is why Trump is sending Bondi after Democrats associated with Epstein. It's to shut down release of all the files.
November 15, 2025 at 2:34 AM
This is why Trump is sending Bondi after Democrats associated with Epstein. It's to shut down release of all the files.
Reposted by Roland Dunbrack 🏳️🌈
A new approach to pandemic preparedness:
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org
November 14, 2025 at 3:21 PM
A new approach to pandemic preparedness:
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym
Simple - 🤷♂️.
www.city-journal.org/article/nih-...
Reposted by Roland Dunbrack 🏳️🌈
Bhattacharya never attended residency and has never held a medical license. He has zero understanding of what it means to care for patients. He’s the dictionary definition of a hack.
November 14, 2025 at 4:26 PM
Bhattacharya never attended residency and has never held a medical license. He has zero understanding of what it means to care for patients. He’s the dictionary definition of a hack.
Reposted by Roland Dunbrack 🏳️🌈
Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers.
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
November 14, 2025 at 4:17 PM
Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers.
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research.
As @jenna-m-norton.bsky.social put well: 1/
This single sentence describes where we are now.
The attorney general and the FBI director, a manosphere podcaster bro, pulled into the situation room a member of Congress best known for getting kicked out of a Beetlejuice musical for drunkenly giving her date a handy, in order to pressure her about the president's child sex trafficking scandal.
November 13, 2025 at 4:43 AM
This single sentence describes where we are now.
Reposted by Roland Dunbrack 🏳️🌈
The attorney general and the FBI director, a manosphere podcaster bro, pulled into the situation room a member of Congress best known for getting kicked out of a Beetlejuice musical for drunkenly giving her date a handy, in order to pressure her about the president's child sex trafficking scandal.
November 12, 2025 at 11:23 PM
The attorney general and the FBI director, a manosphere podcaster bro, pulled into the situation room a member of Congress best known for getting kicked out of a Beetlejuice musical for drunkenly giving her date a handy, in order to pressure her about the president's child sex trafficking scandal.
Reposted by Roland Dunbrack 🏳️🌈
One of my earliest moments of radicalization was in 2005 when Larry Summers said that women biologically have less aptitude for science than men. Following that, scores of equally unimpressive people wrote pieces trying to explain or justify his remarks, when they should have called for his removal.
November 12, 2025 at 5:13 PM
One of my earliest moments of radicalization was in 2005 when Larry Summers said that women biologically have less aptitude for science than men. Following that, scores of equally unimpressive people wrote pieces trying to explain or justify his remarks, when they should have called for his removal.
@fetterman.senate.gov I hope Conor Lamb decimates you in your 2028 primary election. A lot of pain was caused by the shutdown and Democrats got nothing for working people bc of you and 7 other weasels.
Signed: Pennsylvania voter.
Signed: Pennsylvania voter.
November 10, 2025 at 6:51 PM
@fetterman.senate.gov I hope Conor Lamb decimates you in your 2028 primary election. A lot of pain was caused by the shutdown and Democrats got nothing for working people bc of you and 7 other weasels.
Signed: Pennsylvania voter.
Signed: Pennsylvania voter.
I bet Fetterman caved.
November 10, 2025 at 3:22 AM
I bet Fetterman caved.
Reposted by Roland Dunbrack 🏳️🌈
I’m stuck in bed between chemo treatments for metastatic coloncancer, wearing a take-home chemo pump attached to my chest.
I wanted to share my advice that you can benefit from ‘Letting Your Colleagues In’ don’t need to struggle alone
@insidehighered.com
www.insidehighered.com/opinion/care...
I wanted to share my advice that you can benefit from ‘Letting Your Colleagues In’ don’t need to struggle alone
@insidehighered.com
www.insidehighered.com/opinion/care...
Consider Sharing Health Challenges With Colleagues (opinion)
Being open with my colleagues about my cancer diagnosis has allowed me to access an enormous source of support and comfort.
www.insidehighered.com
November 6, 2025 at 3:15 PM
I’m stuck in bed between chemo treatments for metastatic coloncancer, wearing a take-home chemo pump attached to my chest.
I wanted to share my advice that you can benefit from ‘Letting Your Colleagues In’ don’t need to struggle alone
@insidehighered.com
www.insidehighered.com/opinion/care...
I wanted to share my advice that you can benefit from ‘Letting Your Colleagues In’ don’t need to struggle alone
@insidehighered.com
www.insidehighered.com/opinion/care...