Raquel Buj
@raquelbuj.bsky.social
Research Assistant Professor at The Wistar Institute, investigating the metabolic crosstalk between cancer and immune cells | Book & comic lover | Born and raised in Castelló 🍊
Reposted by Raquel Buj
September 7, 2025 at 9:32 PM
Olé tú @carlosalcaraz.bsky.social OLÉ TÚ!!!
September 7, 2025 at 9:38 PM
Olé tú @carlosalcaraz.bsky.social OLÉ TÚ!!!
Vamos Carlitos!!!
Os digo que me va a dar un parraque esta tarde.
Os digo que me va a dar un parraque esta tarde.
September 7, 2025 at 9:21 PM
Vamos Carlitos!!!
Os digo que me va a dar un parraque esta tarde.
Os digo que me va a dar un parraque esta tarde.
Reposted by Raquel Buj
September 5, 2025 at 9:42 PM
Reposted by Raquel Buj
Big day for multiple lab members who celebrated a promotion! Congrats to Apoorva Uboveja for promotion to Staff Scientist and Aidan Cole for starting as a postdoc! I am now a full professor too 🤓 Want to learn more about our science or join the lab? Visit Airdlab.com
Aird Lab
Airdlab.com
September 3, 2025 at 10:00 AM
Big day for multiple lab members who celebrated a promotion! Congrats to Apoorva Uboveja for promotion to Staff Scientist and Aidan Cole for starting as a postdoc! I am now a full professor too 🤓 Want to learn more about our science or join the lab? Visit Airdlab.com
Reposted by Raquel Buj
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...
doi.org
August 24, 2025 at 11:29 AM
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
I've been playing this gsme after work all week, and it's honestly really relaxing ❤️
TINY BOOKSHOP IS HERE!!!
You can finally open your cozy bookshop by the seaside on PC, Mac and Linux!
🔥 Head to Steam NOW to get #TinyBookshop with a 10% launch discount! 🔥
store.steampowered.c...
You can finally open your cozy bookshop by the seaside on PC, Mac and Linux!
🔥 Head to Steam NOW to get #TinyBookshop with a 10% launch discount! 🔥
store.steampowered.c...
August 16, 2025 at 11:24 PM
I've been playing this gsme after work all week, and it's honestly really relaxing ❤️
I found this in Lidl… there were only two boxes left, so I took both. You guys can't imagine how much I missed this! I know it's August (and these are Christmas cookies), but I’ll probably finish both boxes before Monday
August 14, 2025 at 5:26 PM
I found this in Lidl… there were only two boxes left, so I took both. You guys can't imagine how much I missed this! I know it's August (and these are Christmas cookies), but I’ll probably finish both boxes before Monday
Reposted by Raquel Buj
The summer has been busy! Along with the move and a PhD defense, we have updated two preprints:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming
Cellular senescence, characterized by a stable cell cycle arrest, is a well-documented consequence of several widely used chemotherapeutics that has context-dependent roles in cancer. Although senesce...
www.biorxiv.org
August 14, 2025 at 12:03 PM
The summer has been busy! Along with the move and a PhD defense, we have updated two preprints:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Raquel Buj
In the second, we discovered that cisplatin drives ovarian cancer metastasis through a metabolic cross-talk between senescent cancer cells with non-senescent cancer cells. We identified fructose as the upstream driver of this phenotype. First author Dr. Cole just defended!
August 14, 2025 at 12:03 PM
In the second, we discovered that cisplatin drives ovarian cancer metastasis through a metabolic cross-talk between senescent cancer cells with non-senescent cancer cells. We identified fructose as the upstream driver of this phenotype. First author Dr. Cole just defended!
Reposted by Raquel Buj
In the first, @raquelbuj.bsky.social discovered that tumors can respond to anti-PD1 without T cells! Mechanistically, this is through a zinc-dependent increase in macrophage phagocytosis, and this is driven through cancer cell CDKN2A-mediated zinc compartmentalization.
August 14, 2025 at 12:03 PM
In the first, @raquelbuj.bsky.social discovered that tumors can respond to anti-PD1 without T cells! Mechanistically, this is through a zinc-dependent increase in macrophage phagocytosis, and this is driven through cancer cell CDKN2A-mediated zinc compartmentalization.
Reposted by Raquel Buj
We asked metal band frontman Klaus about Tiny Bookshop’s release tomorrow: "Yo, I’m so excited for their big break! Can’t believe there’s only 1 day left… Oh, I’m starting to feel a little stage fright, now that I think about it...”
Meet Klaus at your Tiny Bookshop TOMORROW, 7 pm CEST, on Steam!!!
Meet Klaus at your Tiny Bookshop TOMORROW, 7 pm CEST, on Steam!!!
August 6, 2025 at 4:01 PM
We asked metal band frontman Klaus about Tiny Bookshop’s release tomorrow: "Yo, I’m so excited for their big break! Can’t believe there’s only 1 day left… Oh, I’m starting to feel a little stage fright, now that I think about it...”
Meet Klaus at your Tiny Bookshop TOMORROW, 7 pm CEST, on Steam!!!
Meet Klaus at your Tiny Bookshop TOMORROW, 7 pm CEST, on Steam!!!
Every-single-time
Website: Please log in with your username & password
Me: *tries*
Website: That's not your password
Me: *hits "forgot password" button*
Website: Sent the link to your email
Me: *clicks link, types in new password*
Website: You can't use that, it's your previous password
Me: SETS COMPUTER ON FIRE
Me: *tries*
Website: That's not your password
Me: *hits "forgot password" button*
Website: Sent the link to your email
Me: *clicks link, types in new password*
Website: You can't use that, it's your previous password
Me: SETS COMPUTER ON FIRE
August 5, 2025 at 4:29 PM
Every-single-time
Reposted by Raquel Buj
Beautiful and inspiring work from Gero Miesenböck and colleagues www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
www.nature.com
July 31, 2025 at 9:42 AM
Beautiful and inspiring work from Gero Miesenböck and colleagues www.nature.com/articles/s41...
Reposted by Raquel Buj
Myeloid-targeting immunotherapies, particularly anti-PD-L1, significantly enhance survival in mice with immune-evasive neuroblastoma by remodeling the tumor environment.
by Ménard M, Yoda H (...) Weiss WA et 17 al. in J Exp Med #MedSky
👉 get more here
📖 read the article:
by Ménard M, Yoda H (...) Weiss WA et 17 al. in J Exp Med #MedSky
👉 get more here
📖 read the article:
Myeloid-targeting immunotherapies overcome inhibitory barriers in immune-evasive neuroblastoma
This study describes a Mycn-nGEMM for neuroblastoma. Murine and human neuroblastomas showed profound immunosuppression mediated by PD-L1–expressing, TAMs.
rupress.org
July 23, 2025 at 8:45 AM
Reposted by Raquel Buj
Ozzy Osborne
1948 - 2025
1948 - 2025
July 22, 2025 at 7:53 PM
Ozzy Osborne
1948 - 2025
1948 - 2025
Reposted by Raquel Buj
Happy to see this fantastic paper by @mela-virus.bsky.social and her lab at @cimususc.bsky.social in which we have collaborated, finally published in Cell Death & Disease, “SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation”:
rdcu.be/evZx9
rdcu.be/evZx9
SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation
Cell Death & Disease - SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation
rdcu.be
July 13, 2025 at 10:51 AM
Happy to see this fantastic paper by @mela-virus.bsky.social and her lab at @cimususc.bsky.social in which we have collaborated, finally published in Cell Death & Disease, “SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation”:
rdcu.be/evZx9
rdcu.be/evZx9
Reposted by Raquel Buj
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...
www.science.org
July 11, 2025 at 7:52 AM
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...
Reposted by Raquel Buj
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
July 10, 2025 at 10:27 PM
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
Reposted by Raquel Buj
Extremely honored to receive this prize from @socdevbio.bsky.social, which recognizes not only my love for developmental biology, but the extremely online I am 🧪 (protect science, protect people, viva la dev bio!)
June 22, 2025 at 8:01 PM
Extremely honored to receive this prize from @socdevbio.bsky.social, which recognizes not only my love for developmental biology, but the extremely online I am 🧪 (protect science, protect people, viva la dev bio!)
Reposted by Raquel Buj
Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS
PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety
onto proteins related to immunity, transcription, and cell g...
www.pnas.org
June 12, 2025 at 5:54 AM
Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Raquel Buj
I pipetted today
To know if I still can
I focused on what’s in the tip
The only thing that’s real
To know if I still can
I focused on what’s in the tip
The only thing that’s real
June 10, 2025 at 4:48 PM
I pipetted today
To know if I still can
I focused on what’s in the tip
The only thing that’s real
To know if I still can
I focused on what’s in the tip
The only thing that’s real
Reposted by Raquel Buj
Here's a baby otter to start your week.
June 9, 2025 at 10:31 AM
Here's a baby otter to start your week.
Reposted by Raquel Buj
Spaniards have won 18 of the last 24 French Opens 🇪🇸
◽️ Rafael Nadal — 14
◽️ Carlos Alcaraz — 2
◽️ Juan Carlos Ferrero — 1
◽️ Alberto Costa — 1
www.nytimes.com/athletic/641...
◽️ Rafael Nadal — 14
◽️ Carlos Alcaraz — 2
◽️ Juan Carlos Ferrero — 1
◽️ Alberto Costa — 1
www.nytimes.com/athletic/641...
June 8, 2025 at 7:08 PM
Spaniards have won 18 of the last 24 French Opens 🇪🇸
◽️ Rafael Nadal — 14
◽️ Carlos Alcaraz — 2
◽️ Juan Carlos Ferrero — 1
◽️ Alberto Costa — 1
www.nytimes.com/athletic/641...
◽️ Rafael Nadal — 14
◽️ Carlos Alcaraz — 2
◽️ Juan Carlos Ferrero — 1
◽️ Alberto Costa — 1
www.nytimes.com/athletic/641...