Milo Imbeni
@pyramidalmilo.bsky.social
PhD in Maastricht, microglia and microscopes
Reposted by Milo Imbeni
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
November 27, 2025 at 4:40 AM
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
Reposted by Milo Imbeni
Great Review on the #evolution of #microglia
Microglia across evolution: from conserved origins to functional divergence | Cellular
www.nature.com/articles/s41...
Microglia across evolution: from conserved origins to functional divergence | Cellular
www.nature.com/articles/s41...
Microglia across evolution: from conserved origins to functional divergence - Cellular & Molecular Immunology
Cellular & Molecular Immunology - Microglia across evolution: from conserved origins to functional divergence
www.nature.com
November 22, 2025 at 7:20 AM
Great Review on the #evolution of #microglia
Microglia across evolution: from conserved origins to functional divergence | Cellular
www.nature.com/articles/s41...
Microglia across evolution: from conserved origins to functional divergence | Cellular
www.nature.com/articles/s41...
Reposted by Milo Imbeni
Constanze Depp is finding that microglia aren't any better at multitasking than we are—and that likely contributes to the development of Alzheimer's. That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪 🧠
November 10, 2025 at 7:50 PM
Constanze Depp is finding that microglia aren't any better at multitasking than we are—and that likely contributes to the development of Alzheimer's. That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪 🧠
Reposted by Milo Imbeni
PRESS RELEASE! Building on the pioneering work of Dr. Alison Goate, an int'l team, led by @mountsinainyc.bsky.social's Anne Schaefer, ID'd a distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers 👉 www.mountsinai.org/about/newsro...
November 12, 2025 at 2:10 PM
PRESS RELEASE! Building on the pioneering work of Dr. Alison Goate, an int'l team, led by @mountsinainyc.bsky.social's Anne Schaefer, ID'd a distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers 👉 www.mountsinai.org/about/newsro...
Reposted by Milo Imbeni
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
November 21, 2025 at 2:24 PM
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
Reposted by Milo Imbeni
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
BigVolumeBrowser: a new 3D multi volume/mesh/point clould (SMLM) data viewer
Hello everyone, I’d like to share with you another 3D viewer for FIJI, BigVolumeBrowser (full documentation link). It‘s a first initial public release, so there is still space for improvements. Le...
forum.image.sc
November 21, 2025 at 9:29 AM
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
Reposted by Milo Imbeni
Chatgpt uses em-dashes quite often & people started using the presence of em-dashes to raise concern that something (ex: homework) was written by ai. So the only reason anyone would instruct chatgpt to not use em-dashes is to hide the fact that the work was chatgpt generated. Groundbreaking ethics!
November 18, 2025 at 4:30 AM
Chatgpt uses em-dashes quite often & people started using the presence of em-dashes to raise concern that something (ex: homework) was written by ai. So the only reason anyone would instruct chatgpt to not use em-dashes is to hide the fact that the work was chatgpt generated. Groundbreaking ethics!
Reposted by Milo Imbeni
Last-minute advert for the Convpaint workshop at I2K by Roman Schwob! Interactive segmentation in @napari.org. Today 2:00 PM CET. Free registration:
www.i2kconference.org/workshops
www.i2kconference.org/workshops
November 18, 2025 at 12:13 PM
Last-minute advert for the Convpaint workshop at I2K by Roman Schwob! Interactive segmentation in @napari.org. Today 2:00 PM CET. Free registration:
www.i2kconference.org/workshops
www.i2kconference.org/workshops
Reposted by Milo Imbeni
I’m super excited to share that my PhD work is now out in npj Imaging (@natureportfolio.nature.com)! 🔬
You can read the paper here: rdcu.be/eOKdU
You can read the paper here: rdcu.be/eOKdU
November 17, 2025 at 9:35 AM
I’m super excited to share that my PhD work is now out in npj Imaging (@natureportfolio.nature.com)! 🔬
You can read the paper here: rdcu.be/eOKdU
You can read the paper here: rdcu.be/eOKdU
Reposted by Milo Imbeni
First ever public presentation of single cell evidence for non-spatial grid cells by Elena Gutierrez, Seb Veselic from Steve Kennerley lab. Steve an I have been dreaming of this moment for nearly 10 years. #sfn25
November 16, 2025 at 12:07 AM
First ever public presentation of single cell evidence for non-spatial grid cells by Elena Gutierrez, Seb Veselic from Steve Kennerley lab. Steve an I have been dreaming of this moment for nearly 10 years. #sfn25
Reposted by Milo Imbeni
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by Milo Imbeni
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
November 13, 2025 at 8:49 PM
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
Reposted by Milo Imbeni
Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)
November 13, 2025 at 2:32 PM
Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)
Reposted by Milo Imbeni
Mycophenolate mofetil reduces the branching of microglial processes https://www.biorxiv.org/content/10.1101/2025.11.12.687812v1
November 13, 2025 at 6:15 PM
Mycophenolate mofetil reduces the branching of microglial processes https://www.biorxiv.org/content/10.1101/2025.11.12.687812v1
Reposted by Milo Imbeni
Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @plosbiology.org 🧪 plos.io/49mmzcm
October 22, 2025 at 1:24 PM
Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @plosbiology.org 🧪 plos.io/49mmzcm
Reposted by Milo Imbeni
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
November 5, 2025 at 11:51 PM
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
Reposted by Milo Imbeni
Local #mRNAtranslation in polarized cells is well studied in neurons but what about #microglia? This study shows that #inflammation enhances microglial #RNA localization & translation via RNA-binding protein IMP1/ZBP1, regulating morphology, motility & phagocytosis @plosbiology.org 🧪 plos.io/486ZLMS
November 11, 2025 at 9:48 AM
Local #mRNAtranslation in polarized cells is well studied in neurons but what about #microglia? This study shows that #inflammation enhances microglial #RNA localization & translation via RNA-binding protein IMP1/ZBP1, regulating morphology, motility & phagocytosis @plosbiology.org 🧪 plos.io/486ZLMS
Reposted by Milo Imbeni
Diving into the literature… I think it's the first time I see correlative live-cell/EM data after photobleaching - it shows how intense light can actually destroy microtubules rather than just bleach fluorescent tubulin along a neurite (from onlinelibrary.wiley.com/doi/10.1002/...)
November 10, 2025 at 10:26 AM
Diving into the literature… I think it's the first time I see correlative live-cell/EM data after photobleaching - it shows how intense light can actually destroy microtubules rather than just bleach fluorescent tubulin along a neurite (from onlinelibrary.wiley.com/doi/10.1002/...)
Reposted by Milo Imbeni
Nightmare #423:
-- 1,140 sq ft spider web
-- populated by a metropolis of 111,000 spiders
-- in a cave
😱
www.nytimes.com/2025/11/08/s...
-- 1,140 sq ft spider web
-- populated by a metropolis of 111,000 spiders
-- in a cave
😱
www.nytimes.com/2025/11/08/s...
Stinking, Spongy, Dark, Huge: A Spider Web Unlike Any Seen Before
www.nytimes.com
November 8, 2025 at 7:44 PM
Nightmare #423:
-- 1,140 sq ft spider web
-- populated by a metropolis of 111,000 spiders
-- in a cave
😱
www.nytimes.com/2025/11/08/s...
-- 1,140 sq ft spider web
-- populated by a metropolis of 111,000 spiders
-- in a cave
😱
www.nytimes.com/2025/11/08/s...
Reposted by Milo Imbeni
Look out for this later #histSTM
(And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)
(And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)
November 8, 2025 at 6:53 AM
Look out for this later #histSTM
(And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)
(And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)
Reposted by Milo Imbeni
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
November 7, 2025 at 12:12 PM
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
Reposted by Milo Imbeni
Using #LLMs for science👨💻💬? We have a fun tool for you: introducing #folder2md4llms. It converts an entire folder of docs/code/pdfs/pptx into a single markdown file that you can upload to your chatbot of choice. We use it to talk with our publications database or code repos
github.com/HenriquesLab...
github.com/HenriquesLab...
October 28, 2025 at 5:22 PM
Using #LLMs for science👨💻💬? We have a fun tool for you: introducing #folder2md4llms. It converts an entire folder of docs/code/pdfs/pptx into a single markdown file that you can upload to your chatbot of choice. We use it to talk with our publications database or code repos
github.com/HenriquesLab...
github.com/HenriquesLab...
Reposted by Milo Imbeni
💥 DeepInverse is now part of the official PyTorch Landscape💥
We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc.
pytorch.org/blog/deepinv...
We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc.
pytorch.org/blog/deepinv...
DeepInverse Joins the PyTorch Ecosystem: the library for solving imaging inverse problems with deep learning – PyTorch
pytorch.org
November 5, 2025 at 5:31 PM
💥 DeepInverse is now part of the official PyTorch Landscape💥
We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc.
pytorch.org/blog/deepinv...
We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc.
pytorch.org/blog/deepinv...
Reposted by Milo Imbeni
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...