Aaron Kuan
@kuanawanda.bsky.social
Assistant prof @yaleneuro.bsky.social: multiscale connectomics with EM and Xray; decision-making; brain-wide cortical networks.
Reposted by Aaron Kuan
X-rays can resolve ultrastructure - milestone for ultrastructure imaging w/o cutting. Thanks to an amazing team -
@carlesbosch.bsky.social
@adrianawanner.bsky.social
Ana Diaz and collaborators
@crick.ac.uk
@psich.bsky.social and
@esrf.fr
and funders
@wellcometrust.bsky.social
@ukri.org
@carlesbosch.bsky.social
@adrianawanner.bsky.social
Ana Diaz and collaborators
@crick.ac.uk
@psich.bsky.social and
@esrf.fr
and funders
@wellcometrust.bsky.social
@ukri.org
#paper!
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods
Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...
www.nature.com
November 27, 2025 at 12:16 PM
X-rays can resolve ultrastructure - milestone for ultrastructure imaging w/o cutting. Thanks to an amazing team -
@carlesbosch.bsky.social
@adrianawanner.bsky.social
Ana Diaz and collaborators
@crick.ac.uk
@psich.bsky.social and
@esrf.fr
and funders
@wellcometrust.bsky.social
@ukri.org
@carlesbosch.bsky.social
@adrianawanner.bsky.social
Ana Diaz and collaborators
@crick.ac.uk
@psich.bsky.social and
@esrf.fr
and funders
@wellcometrust.bsky.social
@ukri.org
Reposted by Aaron Kuan
Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
November 27, 2025 at 10:21 AM
Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
Reposted by Aaron Kuan
#paper!
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods
Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...
www.nature.com
November 27, 2025 at 11:51 AM
#paper!
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
November 27, 2025 at 4:40 AM
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
Reposted by Aaron Kuan
#Nanoimaging symposium @crick.ac.uk!
At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science
🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25
At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science
🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25
Hard X-ray imaging of biological soft tissues symposium 2025
tinyurl.com
September 23, 2025 at 10:43 AM
#Nanoimaging symposium @crick.ac.uk!
At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science
🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25
At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science
🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25
Feeling grateful for support from @klingensteinorg.bsky.social for our research efforts, and excited to be part of this amazing cohort! 🥳🧠🔬
Congratulations Aaron T. Kuan, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Multiscale Functional Connectomics: A New Paradigm for Mapping the Brain." @kuanawanda.bsky.social
kuanlab.org
kuanlab.org
July 1, 2025 at 3:56 PM
Feeling grateful for support from @klingensteinorg.bsky.social for our research efforts, and excited to be part of this amazing cohort! 🥳🧠🔬
Latest exciting advances from @apacureanu.bsky.social: by applying self-supervised denoising, we now can resolve individual synapses with X-ray Nano-Holography (XNH), imaging through intact circuit volumes without the need for sectioning!
X-ray nanotomography can be your new friend for neuronal imaging. In our new #preprint (tinyurl.com/nanoXneuro) we present advances that push the spatial resolution limit for X-ray holographic nanotomography (XNH). We can now resolve synapses. 🧵
February 12, 2025 at 1:51 AM
Latest exciting advances from @apacureanu.bsky.social: by applying self-supervised denoising, we now can resolve individual synapses with X-ray Nano-Holography (XNH), imaging through intact circuit volumes without the need for sectioning!