Melike Eren
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neurowithmelike.bsky.social
Melike Eren
@neurowithmelike.bsky.social
960 followers 6.4K following 30 posts
MSc. Neuroscience &MSc.Physiotherapy| Just a researcher, microglia lover |I hope to become a PhD student in neuroscience | Neuroscience, Anatomy & Exercise Physiology
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neurowithmelike.bsky.social
Melike Eren @neurowithmelike.bsky.social · Sep 17
give.doctorswithoutborders.org/campaign/675...
Donate to Help save lives. Donate now.
Support our cause by donating to Doctors Without Borders. https://give.doctorswithoutborders.org/campaign/675296/donate
give.doctorswithoutborders.org
Reposted by Melike Eren
lpjlab.org
⚠️ Just out in @natmetabolism.nature.com ⚠️

Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠

Our Evridiki Asimakidou did a wonderful job leading this! 👏

www.nature.com/articles/s42...
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
www.nature.com
November 21, 2025 at 5:32 PM
Reposted by Melike Eren
benitezlab.bsky.social
The #Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in #microglia www.nature.com/articles/s41...
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia - Nature Neuroscience
Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...
www.nature.com
November 25, 2025 at 3:49 PM
Reposted by Melike Eren
clemmensenc.bsky.social
Our latest review, led by @anikavear.bsky.social with Michael Heneka, explores the emerging role of incretin-based therapies in neurodegenerative disease treatment www.nature.com/articles/s42...
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s dise...
www.nature.com
April 14, 2025 at 9:19 AM
Reposted by Melike Eren
lilykeane.bsky.social
🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...
www.cell.com
February 6, 2025 at 8:35 PM
Reposted by Melike Eren
zoltan-molnar.bsky.social
Neonatal hypoxic–ischaemic encephalopathy (HIE) is a leading cause of infant morbidity and mortality. Cortical subplate neurons transiently secrete a brain specific protein, neuroserpin.
We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cell...).
Neonatal hypoxic–ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity and mortality worldwide, with therapeutic hypothermia being the only clinically approved treatment. Cortical subplate neurons have transient secretory function during development and one of the protein they secrete in mouse and human is neuroserpin encoded by the serpini1 gene (https://doi.org/10.3389/fnins.2015.00100; https://doi.org/10.1111/joa.12931). We proposed that subplate might influence cortical circuit formation through a transient secretory function. We have previously demonstrated that exogeneous neuroserpin is protective agains ER stress and hypoxia/ischaemia in adult (DOI: 10.4103/NRR.NRR-D-24-00044). Recent work from Onoda et al. suggests that the brain specific neuroserpin is also a sensitive indicator for abnormal brain development in mild fetal growth restriction DOI: 10.1016/j.isci.2025.113237). In the recent Special Issue of Cells on Perinatal Brain Injury—from Pathophysiology to Therapy we show that endogenous neuroserpin alone is insufficient for neuroprotection against hypoxia ischaemia induced damage, but exogenous neuroserpin shows promise as a pharmacological intervention for mild neonatal HIE (https://doi.org/10.3390/cells14231840).
November 22, 2025 at 3:11 PM
Reposted by Melike Eren
taniawong.bsky.social
🚨 New review out from our lab! We’re pleased to share our latest article @cp-cellreports.bsky.social exploring the airway immunometabolic response to common bacterial and viral pathogens. Shout out to @ridhimaw.bsky.social, Eric Tang and Roy Wong.
👉 Read it here: www.cell.com/cell-reports...
Airway immunometabolic responses during pulmonary bacterial and viral infections
Wadhwa et al. examine how respiratory bacterial and viral pathogens exploit host metabolism to evade immune responses and influence disease outcomes. They underscore the need for deeper insight into i...
www.cell.com
November 23, 2025 at 2:59 AM
Reposted by Melike Eren
msf.org
Don’t forget to sign up for the upcoming MSF Paediatric Days, held 24-25 November.

On Day 1 we will focus on paediatric care in conflict settings, addressing physical trauma and mental health.

🔗 Register today to join the conversation:
MSF Paediatric Days 2025
msf.me
November 23, 2025 at 1:23 PM
Reposted by Melike Eren
profsimonfisher.bsky.social
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
What enables human language? A biocultural framework
Explaining the origins of language is a key challenge in understanding ourselves as a species. We present an empirical framework that draws on synergies across fields to facilitate robust studies of l...
www.science.org
November 23, 2025 at 11:54 AM
Reposted by Melike Eren
scienceofpd.bsky.social
Researchers analyzed structural & task-free functional MRI scans from patients across the #Alzheimers -frontotemporal dementia (FTD) spectrum to identify relationships between gray matter atrophy & functional connectivity
www.nature.com/articles/s41...
November 23, 2025 at 12:03 PM
Reposted by Melike Eren
labwaggoner.bsky.social
Review @natmetabolism.nature.com The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease
www.nature.com/articles/s42...
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
www.nature.com
November 21, 2025 at 6:58 PM
Reposted by Melike Eren
msf.ca
#Sudan: Families fleeing #ElFasher are arriving in #Tawila exhausted, with many children facing severe malnutrition and dehydration. Displacement is rising and medical needs are overwhelming.

Josephine Goodyer, MSF Pediatrician who worked in Tawila from July to August, updates:
November 21, 2025 at 5:08 PM
Reposted by Melike Eren
lukensjohnr.bsky.social
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
November 21, 2025 at 2:24 PM
Reposted by Melike Eren
sinaibrain.bsky.social
NEW STUDY! Glial spatial organization is critical for neural repair after #SpinalCordInjury. Here, Icahn Mount Sinai's #ZouLab & @labfriedel.bsky.social ID guidance receptor Plexin‑B1 as a regulator of membrane integrity, process plasticity & astrocyte alignment. ➡️ www.nature.com/articles/s41...
November 19, 2025 at 9:26 PM
Reposted by Melike Eren
haoyin.bsky.social
Inflammatory phenotype of Smooth Muscle Cell needed for Muscular Atherosclerotic Lesion Cap formation

Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC

#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
November 19, 2025 at 8:06 PM
Reposted by Melike Eren
ertrunnell.bsky.social
👩‍⚕️👨‍⚕️ @imrasurgical.bsky.social is driving the future of robotic surgery training.

Their high-fidelity simulation models mimic real tissue, including feel, bleeding, & instrument response, without the use of live animals.

www.youtube.com/watch?v=kjMf...

#MedSky #MedEd #SurgSky #SurgEd
The Future of Surgical Training is Animal-Free
YouTube video by PETA (People for the Ethical Treatment of Animals)
www.youtube.com
November 19, 2025 at 5:06 PM
Reposted by Melike Eren
chrjcar.bsky.social
Researchers transplanted microglia to discover their role in how mice brains respond to anxiety. Results suggest specific neuropsychiatric disorders may result from defects in the #brain #ImmuneSystem and open the door for new #anxiety disorder treatments.
healthcare.utah.edu/newsroom/new...
Research in Mice Reveals Brain Cells That Drive—And Prevent—Anxiety
Cells in the brain's immune system can act as "accelerators" and "brakes" for anxiety, opening the door to new treatments for anxiety disorders.
healthcare.utah.edu
November 19, 2025 at 2:36 AM
Reposted by Melike Eren
castltrastondrs.bsky.social
allowing bacterial endotoxins like LPS to enter systemic circulation, activating TLR4 on microglia & triggering NF-κB-mediated neuroinflammation that exacerbates dopaminergic neuron loss
@bmc.springernature.com

translationalneurodegeneration.biomedcentral.com/articles/10....
TLR2 and TLR4 in Parkinson’s disease pathogenesis: the environment takes a toll on the gut - Translational Neurodegeneration
Parkinson’s disease (PD) is an incurable, devastating disorder that is characterized by pathological protein aggregation and neurodegeneration in the substantia nigra. In recent years, growing evidenc...
translationalneurodegeneration.biomedcentral.com
November 19, 2025 at 5:40 AM
Reposted by Melike Eren
scienceofpd.bsky.social
Exploring the effects of p.A53T-αSyn astrocytes on dopamine neurons in neuron–astrocyte cocultures, researchers find cell-intrinsic pathologies in p.A53T-αSyn astrocytes (calcium dyshomeostasis & accumulation of protein aggregates)
www.pnas.org/doi/10.1073/...
Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson’s disease iPSC model | PNAS
Alpha-Synuclein (αSyn) plays a central role in Parkinson’s disease (PD), and the p.A53T mutation causes an early-onset familial form of PD with sev...
www.pnas.org
November 18, 2025 at 11:07 PM
Reposted by Melike Eren
womeninneurouk.bsky.social
Introducing the experts joining our webinar in partnership with the BPS

Prof. Kirsty Bannister – pain mechanisms
Prof. Katy Vincent – gender differences in pain
Dr. Letizia Pontoriero – clinical management and research
📅 Wednesday, 26 November | 6:30 PM
🔗 Register: us06web.zoom.us/webinar/regi...
November 12, 2025 at 9:31 PM
Reposted by Melike Eren
juliet-turner.bsky.social
POV: you are a young woman celebrating a recent academic success
November 17, 2025 at 7:20 PM
Reposted by Melike Eren
pessoabrain.bsky.social
𝗔𝗿𝗼𝘂𝘀𝗮𝗹 𝗮𝘀 𝗮 𝘂𝗻𝗶𝘃𝗲𝗿𝘀𝗮𝗹 𝗲𝗺𝗯𝗲𝗱𝗱𝗶𝗻𝗴 𝗳𝗼𝗿 𝘀𝗽𝗮𝘁𝗶𝗼𝘁𝗲𝗺𝗽𝗼𝗿𝗮𝗹 𝗯𝗿𝗮𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀
"...support hypothesis that spontaneous spatially structured fluctuations in brain-wide physiology on timescales of seconds ... are in large part expressions of lowdimensional, organism-wide dynamical system"
doi.org/10.1038/s415...
November 16, 2025 at 4:25 PM
Reposted by Melike Eren
ertrunnell.bsky.social
Deadline coming up! ⌛

The #NIH Common Fund is seeking applicants to carry out pilot studies that advance the Human Virome Program.

#virome #virology #funding #grant #NIHfunding
Dark red, pastel cyan, and vivid light red graphic with cartoons of viruses and cells and stacks of papers with bullseyes. The text reads: “National Institutes of Health Pilot Projects to Enhance the Human Virome Program. Submission deadline: November 24, Review period: March – May 2026, Earliest start date: July 2026. RFA-RM-25-006.”
November 17, 2025 at 3:59 AM
neurowithmelike.bsky.social
www.jneurosci.org/content/45/4...
Astrocytes as Therapeutic Targets in Neurodegenerative Disorders
Astrocytes play crucial roles in central nervous system homeostasis, regulating neuronal and synaptic activity, modulating immune responses, and preserving the integrity of the blood–brain barrier. Re...
www.jneurosci.org
November 16, 2025 at 9:11 PM
Reposted by Melike Eren
artologica.net
Here's the lineup of #sfn25 artist exhibitors all on one page
SfN 2025 Art of Neuroscience
Full list of Exhibitors
open.substack.com
November 10, 2025 at 10:25 PM
Reposted by Melike Eren
psalmotoxin.bsky.social
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch

Here's our accompanying review!
www.jneurosci.org/content/45/4...
Figure 1. Non-neuronal–neuron communication in the skin. (1) Non-neuronal cells and extracellular matrix in the skin. (2) When in ammatory events such as IL-6, ATP, and protease production from injury or infection are introduced, it causes an activation of cells, a disruption in extracellular matrix, and damage to sensory neurons. (3) During in ammatory cascades, injured or sensitized neurons potentiate pain and the development of a chronic pain state. Figure 2. Cell–cell interactions in joint pain. Numerous pathogenic changes occur within the OA joint and other musculoskeletal conditions that can contribute to pain, including cartilage degradation, synovitis, and bone remodeling (1). Within the joint evidence has established the role of some key non-neuronal cell types that contribute to pain (2) and some of the signaling nociceptor activation and sensitization mechanisms involved (3). There is also growing evidence for cell–cell interactions within the DRG that contribute to pain (4). See text for more details. Figure 3. Keratinocytes contribute to normal touch and chemotherapy-induced mechanical sensitivity through PIEZO1. Keratinocytes in the most super cial layer of the skin respond to mechanical forces via their expression of PIEZO1 channels and activated keratinocytes release ATP which signals to P2X4 channels on cutaneous sensory nerve endings. After a patient is treated with the chemotherapeutic paclitaxel, keratinocyte PIEZO1 is sensitized; the keratinocytes release more ATP and additional mediators, resulting in greater action potential signaling in sensory neurons that is sent to the spinal cord and brain through touch and pain pathways.
November 12, 2025 at 6:19 PM