Michael Love
@mikelove.bsky.social
Genetics, bioinformatics, comp bio, statistics, data science, open source, open science!
Reposted by Michael Love
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Michael Love
There are two complementary views of scientific advance: the "heroes" view, individual geniuses driving unique one-of-a-kind advances, and the "multiple discovery" or zeitgeist view, that the time is ripe for a discovery, and the details of who makes it first, where, and how are, well, details.(1/3)
November 8, 2025 at 9:23 AM
There are two complementary views of scientific advance: the "heroes" view, individual geniuses driving unique one-of-a-kind advances, and the "multiple discovery" or zeitgeist view, that the time is ripe for a discovery, and the details of who makes it first, where, and how are, well, details.(1/3)
Reposted by Michael Love
Are you using any of our factor models, such as MOFA? 🛵
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
November 7, 2025 at 10:29 AM
Are you using any of our factor models, such as MOFA? 🛵
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
Reposted by Michael Love
Now a nice series of papers using genetics to "uncouple" excess adiposity from its adverse metabolic effects. Here for metabolic traits www.nature.com/articles/s42..., here including non metabolic traits elifesciences.org/articles/72452 & here using partitioned PRS www.nature.com/articles/s41...
When more is not worse: Genetic subtypes of obesity challenge conventional risk paradigms
Emerging evidence challenges the view of obesity as a uniform metabolic risk. Spotlighting
the recent Nature Medicine study by Chami et al. this piece discusses how “uncoupling”
adiposity from its car...
www.cell.com
November 7, 2025 at 9:46 AM
Now a nice series of papers using genetics to "uncouple" excess adiposity from its adverse metabolic effects. Here for metabolic traits www.nature.com/articles/s42..., here including non metabolic traits elifesciences.org/articles/72452 & here using partitioned PRS www.nature.com/articles/s41...
Reposted by Michael Love
Ben Langmead @benlangmead.bsky.social delivers the official opening for this year's Genome Informatics Conference #GI2025 at Cold Spring Harbor Laboratory.
List of talks and posters: meetings.cshl.edu/abstracts.as...
List of talks and posters: meetings.cshl.edu/abstracts.as...
November 6, 2025 at 12:38 AM
Ben Langmead @benlangmead.bsky.social delivers the official opening for this year's Genome Informatics Conference #GI2025 at Cold Spring Harbor Laboratory.
List of talks and posters: meetings.cshl.edu/abstracts.as...
List of talks and posters: meetings.cshl.edu/abstracts.as...
Reposted by Michael Love
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...
doi.org
November 4, 2025 at 9:31 PM
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Reposted by Michael Love
As new human assemblies become available on beta.ensembl.org - which human reference genome will you choose? This article explores the question with insights from Ensembl’s own Fergal Martin - www.nature.com/articles/s41...
#HumanGenomics #Pangenomes #ReferenceGenomes
#HumanGenomics #Pangenomes #ReferenceGenomes
Choose your human genome reference wisely - Nature Methods
Scientists can choose between multiple human genome references, and a pangenome reference is coming. Deciding what to use when is not quite straightforward.
www.nature.com
November 4, 2025 at 12:28 PM
As new human assemblies become available on beta.ensembl.org - which human reference genome will you choose? This article explores the question with insights from Ensembl’s own Fergal Martin - www.nature.com/articles/s41...
#HumanGenomics #Pangenomes #ReferenceGenomes
#HumanGenomics #Pangenomes #ReferenceGenomes
Reposted by Michael Love
And it's a wrap! We just finished a fantastic #RNA #Theraputics meeting in Palermo 🇮🇹😀 And yes, the location was beautiful and the food was 😋 but l want to share a little from the cool things I learned about this week, as they may be interesting for you too...
November 1, 2025 at 11:58 PM
And it's a wrap! We just finished a fantastic #RNA #Theraputics meeting in Palermo 🇮🇹😀 And yes, the location was beautiful and the food was 😋 but l want to share a little from the cool things I learned about this week, as they may be interesting for you too...
Reposted by Michael Love
UniProt is changing its reference proteomes resource.
Reference proteomes will remain in UniProtKB, while others will move to UniParc.
Read more about these changes:
www.ebi.ac.uk/about/news/u...
🧬 🖥️
Uniprot is a collaboration between EMBL-EBI, @sib.swiss & the Protein Information Resource.
Reference proteomes will remain in UniProtKB, while others will move to UniParc.
Read more about these changes:
www.ebi.ac.uk/about/news/u...
🧬 🖥️
Uniprot is a collaboration between EMBL-EBI, @sib.swiss & the Protein Information Resource.
Changes to UniProt proteomes
UniProt, the data resource for protein sequence and function information, is making major changes to its proteomes resource and to the UniProt Knowledgebase. UniProt has developed a new workflow that ...
www.ebi.ac.uk
November 4, 2025 at 9:58 AM
UniProt is changing its reference proteomes resource.
Reference proteomes will remain in UniProtKB, while others will move to UniParc.
Read more about these changes:
www.ebi.ac.uk/about/news/u...
🧬 🖥️
Uniprot is a collaboration between EMBL-EBI, @sib.swiss & the Protein Information Resource.
Reference proteomes will remain in UniProtKB, while others will move to UniParc.
Read more about these changes:
www.ebi.ac.uk/about/news/u...
🧬 🖥️
Uniprot is a collaboration between EMBL-EBI, @sib.swiss & the Protein Information Resource.
Reposted by Michael Love
SIB is organizing the next edition of #eccb2026 (Geneva, 31.08.2026 - 04.09.2026), and we are now inviting the community to submit their tutorial and workshop proposals.
👉 A great opportunity to share tools, methods and expertise with 1,000+ international participants. Deadline: 5 January 2026.
👉 A great opportunity to share tools, methods and expertise with 1,000+ international participants. Deadline: 5 January 2026.
📣 The call for tutorials & workshops at #ECCB2026 is now open! Share your tools, methods or expertise with the community.
🗓️ Deadline: 5 January 2026
👉 Submit: tinyurl.com/tw-eccb26
💡 ECCB will take place on 31 Aug–4 Sept in Geneva, gathering 1,000+ scientists from academia, industry, & healthcare.
🗓️ Deadline: 5 January 2026
👉 Submit: tinyurl.com/tw-eccb26
💡 ECCB will take place on 31 Aug–4 Sept in Geneva, gathering 1,000+ scientists from academia, industry, & healthcare.
November 3, 2025 at 8:10 AM
SIB is organizing the next edition of #eccb2026 (Geneva, 31.08.2026 - 04.09.2026), and we are now inviting the community to submit their tutorial and workshop proposals.
👉 A great opportunity to share tools, methods and expertise with 1,000+ international participants. Deadline: 5 January 2026.
👉 A great opportunity to share tools, methods and expertise with 1,000+ international participants. Deadline: 5 January 2026.
Reposted by Michael Love
I’ve spent many years explaining/defending biorxiv’s “no reviews” policy.
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
Attention Authors: Updated Practice for Review Articles and Position Papers in arXiv CS Category – arXiv blog
blog.arxiv.org
November 2, 2025 at 5:33 PM
I’ve spent many years explaining/defending biorxiv’s “no reviews” policy.
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
Reposted by Michael Love
Cars are not sentient beings prowling streets. They're controlled by humans. The _only_ danger to kids is those drivers. (Poisoned candy is not a thing.)
Where's the one suggestion to drivers to go at a safe speed (which at night, w/ kids around, is 15mph) & put phones down & pay utmost attention?
Where's the one suggestion to drivers to go at a safe speed (which at night, w/ kids around, is 15mph) & put phones down & pay utmost attention?
October 31, 2025 at 1:02 PM
Cars are not sentient beings prowling streets. They're controlled by humans. The _only_ danger to kids is those drivers. (Poisoned candy is not a thing.)
Where's the one suggestion to drivers to go at a safe speed (which at night, w/ kids around, is 15mph) & put phones down & pay utmost attention?
Where's the one suggestion to drivers to go at a safe speed (which at night, w/ kids around, is 15mph) & put phones down & pay utmost attention?
Reposted by Michael Love
Thanks, everyone, for an incredible first day on the campaign trail!
I'm not new to fighting for Western North Carolina, but I *am* new to running for office -- and I can't tell you how much I appreciate your outpouring of support.
Onward! #NC11
I'm not new to fighting for Western North Carolina, but I *am* new to running for office -- and I can't tell you how much I appreciate your outpouring of support.
Onward! #NC11
October 24, 2025 at 11:04 PM
Thanks, everyone, for an incredible first day on the campaign trail!
I'm not new to fighting for Western North Carolina, but I *am* new to running for office -- and I can't tell you how much I appreciate your outpouring of support.
Onward! #NC11
I'm not new to fighting for Western North Carolina, but I *am* new to running for office -- and I can't tell you how much I appreciate your outpouring of support.
Onward! #NC11
Reposted by Michael Love
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 30, 2025 at 3:35 PM
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
Reposted by Michael Love
Hi-C informed kernel association test: integrating 3-dimensional genome structure into variant-set association for whole-genome sequencing data https://www.biorxiv.org/content/10.1101/2025.10.28.684891v1
October 30, 2025 at 11:47 AM
Hi-C informed kernel association test: integrating 3-dimensional genome structure into variant-set association for whole-genome sequencing data https://www.biorxiv.org/content/10.1101/2025.10.28.684891v1
Reposted by Michael Love
🧬 EuroBioC2026 is coming to Turku, Finland, from June 3–5, 2026!
Expect 3 exciting days with the Bioconductor community, showcasing the latest advances in Bioconductor software and emerging technologies shaping computational biology.
👉 More details soon at eurobioc2026.bioconductor.org
Expect 3 exciting days with the Bioconductor community, showcasing the latest advances in Bioconductor software and emerging technologies shaping computational biology.
👉 More details soon at eurobioc2026.bioconductor.org
October 29, 2025 at 9:02 AM
🧬 EuroBioC2026 is coming to Turku, Finland, from June 3–5, 2026!
Expect 3 exciting days with the Bioconductor community, showcasing the latest advances in Bioconductor software and emerging technologies shaping computational biology.
👉 More details soon at eurobioc2026.bioconductor.org
Expect 3 exciting days with the Bioconductor community, showcasing the latest advances in Bioconductor software and emerging technologies shaping computational biology.
👉 More details soon at eurobioc2026.bioconductor.org
Reposted by Michael Love
Come work with me! We're hiring a new *Director of Innovation* at the UVA School of Data Science jobs.virginia.edu/us/en/job/R0... 🧬🖥️🧪
October 30, 2025 at 9:07 AM
Come work with me! We're hiring a new *Director of Innovation* at the UVA School of Data Science jobs.virginia.edu/us/en/job/R0... 🧬🖥️🧪
Reposted by Michael Love
About half the GigaScience editorial board (incl me) just resigned (academic.oup.com/gigascience/... is not yet updated). I resigned because it is very unclear what is happening and why - see @scedmunds.bsky.social blog post gigasciencejournal.com/blog/and-its..., for eg
Editorial_Board
Editorial Team
Editor-in-Chief
Xun Xu, PhD; BGI Research, Shenzhen, China
Executive Editor
Hongling Zhou; GigaScience Press, BGI Shenzhen, China
Edito
academic.oup.com
October 29, 2025 at 4:03 PM
About half the GigaScience editorial board (incl me) just resigned (academic.oup.com/gigascience/... is not yet updated). I resigned because it is very unclear what is happening and why - see @scedmunds.bsky.social blog post gigasciencejournal.com/blog/and-its..., for eg
Reposted by Michael Love
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
October 28, 2025 at 9:31 PM
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
Reposted by Michael Love
Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !
October 27, 2025 at 6:20 PM
Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !
Reposted by Michael Love
The UNC Department of Biology is seeking a Director of Biology Teaching Labs, a key leadership role overseeing our undergraduate laboratory program. 1/n
Learn more and apply here: unc.peopleadmin.com/postings/308...
Learn more and apply here: unc.peopleadmin.com/postings/308...
Director of Biology Teaching Labs
The Director of Biology Teaching Labs provides leadership and direction in the management of the Biology Department's undergraduate laboratories and will be responsible for the undergraduate laborator...
unc.peopleadmin.com
October 27, 2025 at 2:12 PM
The UNC Department of Biology is seeking a Director of Biology Teaching Labs, a key leadership role overseeing our undergraduate laboratory program. 1/n
Learn more and apply here: unc.peopleadmin.com/postings/308...
Learn more and apply here: unc.peopleadmin.com/postings/308...
Reposted by Michael Love
'We hypothesize that CGIs, particularly those associated with housekeeping or developmentally important genes and which are evolutionarily older than tissue-specific genes (32, 34), have been maintained during evolution by escaping TE invasion.'
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements | PNAS
The origins of CpG islands (CGIs) are not known. They are relatively short GC-rich
regions of DNA with a higher-than-expected occurrence of CpG din...
www.pnas.org
October 26, 2025 at 5:51 PM
'We hypothesize that CGIs, particularly those associated with housekeeping or developmentally important genes and which are evolutionarily older than tissue-specific genes (32, 34), have been maintained during evolution by escaping TE invasion.'
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Michael Love
I've been around long enough & seen enough attempts to form the opinion that all metrics that attempt to summarize scientific productivity as a number are bad. Not just in practice, but conceptually fawed. They incentivize faculty to take shortcuts where they shouldn't, in peer evaluation.
Hilariously bad idea. In my subfield author lists are almost always alphabetical!
🧪For those of us who do complex collaborations with multiple corresponding authors this is terrible . I suspect it will also hit female authors disproportionately as they tend to have more collaborations across fields…https://www.nature.com/articles/d41586-025-03281-4
October 26, 2025 at 1:27 PM
I've been around long enough & seen enough attempts to form the opinion that all metrics that attempt to summarize scientific productivity as a number are bad. Not just in practice, but conceptually fawed. They incentivize faculty to take shortcuts where they shouldn't, in peer evaluation.
Reposted by Michael Love
The NIH institute director firing last Friday is very bad.
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
October 23, 2025 at 4:02 AM
The NIH institute director firing last Friday is very bad.
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
Reposted by Michael Love
1/6 Movi 2 is here: faster and more space-efficient for pangenome queries. Its fastest mode uses half the memory of Movi 1 while running ~30% faster. github.com/mohsenzakeri...
GitHub - mohsenzakeri/Movi: Fast, Cache-Efficient, and Scalable Queries on Pangenomes
Fast, Cache-Efficient, and Scalable Queries on Pangenomes - mohsenzakeri/Movi
github.com
October 21, 2025 at 8:00 PM
1/6 Movi 2 is here: faster and more space-efficient for pangenome queries. Its fastest mode uses half the memory of Movi 1 while running ~30% faster. github.com/mohsenzakeri...