Michael Love
@mikelove.bsky.social
Genetics, bioinformatics, comp bio, statistics, data science, open source, open science!
it's in my slide deck when I give talks on this topic
October 28, 2025 at 9:51 AM
it's in my slide deck when I give talks on this topic
Compiling some answers to you... this is an older data point showing symmetry over all cis eQTL signals pubmed.ncbi.nlm.nih.gov/28257690/
September 18, 2025 at 6:28 PM
Compiling some answers to you... this is an older data point showing symmetry over all cis eQTL signals pubmed.ncbi.nlm.nih.gov/28257690/
Our first Fall #tidyomics meeting will be this Wed 10 September, early in US / noon in Europe / late in Australia. Feel free to join if you're interested in what we are doing to make omics data more amenable to tidy data analysis.
Organized with Stefano @stemang.bsky.social
Organized with Stefano @stemang.bsky.social
September 8, 2025 at 7:45 PM
Our first Fall #tidyomics meeting will be this Wed 10 September, early in US / noon in Europe / late in Australia. Feel free to join if you're interested in what we are doing to make omics data more amenable to tidy data analysis.
Organized with Stefano @stemang.bsky.social
Organized with Stefano @stemang.bsky.social
Also, it's worth playing around with AI, e.g. ChatGPT gave the right answer here, as it has been trained on ten years of support site posts.
August 24, 2025 at 4:25 PM
Also, it's worth playing around with AI, e.g. ChatGPT gave the right answer here, as it has been trained on ten years of support site posts.
Using these new, more well-powered eQTL data, we found the additional signals allow us to increase colocalizations with GWAS compared to the smaller studies.
Interestingly, these colocalizing signals are mostly uniform across the range of eQTL signal strength.
Interestingly, these colocalizing signals are mostly uniform across the range of eQTL signal strength.
August 18, 2025 at 12:18 PM
Using these new, more well-powered eQTL data, we found the additional signals allow us to increase colocalizations with GWAS compared to the smaller studies.
Interestingly, these colocalizing signals are mostly uniform across the range of eQTL signal strength.
Interestingly, these colocalizing signals are mostly uniform across the range of eQTL signal strength.
At n=2,000, we estimate one can theoretically detect 37% of all eQTL.
August 18, 2025 at 12:18 PM
At n=2,000, we estimate one can theoretically detect 37% of all eQTL.
From signal strength modeling, we found that with 500 samples, one can detect <0.1 to 60% of eQTL, across a range of possible signal strengths.
August 18, 2025 at 12:18 PM
From signal strength modeling, we found that with 500 samples, one can detect <0.1 to 60% of eQTL, across a range of possible signal strengths.
This sounds true to me
!["When you vibe code, you are incurring tech debt as fast as the LLM can spit it out.
Which is why vibe coding is perfect for prototypes and throwaway projects: It'
s only
legacy code if you have to maintain it! !...]
The worst possible situation is to have a non-programmer vibe code a large project that they intend to maintain. This would be the equivalent of giving a credit card to a child without first explaining the concept of debt. [...]"](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:gxxr4j7mf2sc3ebakcghqm6p/bafkreiehhrnrupyuwkvewpvj22ozapeqpwtyvs43plc4yseyvda4vt4qem@jpeg)
August 5, 2025 at 10:34 AM
This sounds true to me
I recently ran a session at CSAMA with Laurent Gatto and this is the way. "Good enough" with knowledge of the tools that can help you get there. Here's some of the recs from the paper.
July 13, 2025 at 5:13 AM
I recently ran a session at CSAMA with Laurent Gatto and this is the way. "Good enough" with knowledge of the tools that can help you get there. Here's some of the recs from the paper.
Congratulations to Yuriko Harigaya on a successful thesis defense in the Valdar and Love labs! Work on Bayesian model selection for QTL, in the space of GxE and GxT. Way to go Yuriko 🎉
June 30, 2025 at 5:10 PM
Congratulations to Yuriko Harigaya on a successful thesis defense in the Valdar and Love labs! Work on Bayesian model selection for QTL, in the space of GxE and GxT. Way to go Yuriko 🎉
Alex and Mike wrapping up a great joint Bioconductor & Galaxy summit at Cold Spring Harbor. There was a lot to learn from each other and shared educational goals. Great talks and keynotes from Jason Williams, Charlotte Soneson and Sergei Pond.
@mikeschatz.bsky.social
#GBCC2025
@mikeschatz.bsky.social
#GBCC2025
June 26, 2025 at 4:06 PM
Alex and Mike wrapping up a great joint Bioconductor & Galaxy summit at Cold Spring Harbor. There was a lot to learn from each other and shared educational goals. Great talks and keynotes from Jason Williams, Charlotte Soneson and Sergei Pond.
@mikeschatz.bsky.social
#GBCC2025
@mikeschatz.bsky.social
#GBCC2025
Tuomas Borman from @antagomir.bsky.social lab demonstrating why data containers are so useful (book >> loose pages)
Online book for microbiome analysis:
microbiome.github.io/OMA/docs/dev...
#GBCC2025
Online book for microbiome analysis:
microbiome.github.io/OMA/docs/dev...
#GBCC2025
June 26, 2025 at 2:47 PM
Tuomas Borman from @antagomir.bsky.social lab demonstrating why data containers are so useful (book >> loose pages)
Online book for microbiome analysis:
microbiome.github.io/OMA/docs/dev...
#GBCC2025
Online book for microbiome analysis:
microbiome.github.io/OMA/docs/dev...
#GBCC2025
June 25, 2025 at 2:46 PM
This is why bsky is the best
June 21, 2025 at 9:19 PM
This is why bsky is the best
Up until June 2 (Monday) you can apply for scholarship to attend GBCC2025 at Cold Spring Harbor Laboratory. This is the Bioconductor / Galaxy joint conference at the end of June. You should submit a poster abstract to apply for scholarship. Scholarship details below.
May 29, 2025 at 4:20 PM
Up until June 2 (Monday) you can apply for scholarship to attend GBCC2025 at Cold Spring Harbor Laboratory. This is the Bioconductor / Galaxy joint conference at the end of June. You should submit a poster abstract to apply for scholarship. Scholarship details below.
Oops I found Table S7 now. So it looks like it's sometimes even more with absolute number. Does that sound right?
May 21, 2025 at 6:07 PM
Oops I found Table S7 now. So it looks like it's sometimes even more with absolute number. Does that sound right?
Now is the time to speak out in support of free speech and academic independence of US universities
![PRELIMINARY STATEMENT
This case involves an unprecedented threat from the Trump administration to withhold nearly nine billion dollars in federal funding to one of our nation's leading universities unless it accedes to changes that fundamentally compromise the university's independence and the free speech rights of its faculty and students. On March 31, 2025, Defendants' announced an investigation into federal grants that support critical research projects at Harvard University. On April 3, as a result of that investigation, Defendants made clear that funding would be terminated if Harvard did not "immediate[ly]" implement a litany of sweeping but vaguely-worded demands for changes to university operations, governance, hiring, admissions, curriculum, and student discipline. There is no doubt that, absent Harvard's capitulation to these demands, the cancellation of federal funding is imminent: Defendants have already cancelled or frozen hundreds of millions of dollars in funding for other universities that have been similarly targeted, with further cuts still
threatened.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:gxxr4j7mf2sc3ebakcghqm6p/bafkreifwaxqfcdgyrxwacdscjiplgea5keohfr4lotsv3x7ngfmlbravsi@jpeg)
April 12, 2025 at 2:35 PM
Now is the time to speak out in support of free speech and academic independence of US universities
My brother planted these secretly when he stayed with us in October last year 🥹
March 27, 2025 at 2:18 PM
My brother planted these secretly when he stayed with us in October last year 🥹
Fantastic defense this morning and body of work from Noor Pratap Singh! @noorpratap.bsky.social
Congrats Dr. Singh, it's been a pleasure collaborating with you and @robp.bsky.social. Looking forward to what comes next in your scientific career 🎉
Congrats Dr. Singh, it's been a pleasure collaborating with you and @robp.bsky.social. Looking forward to what comes next in your scientific career 🎉
March 13, 2025 at 2:13 PM
Fantastic defense this morning and body of work from Noor Pratap Singh! @noorpratap.bsky.social
Congrats Dr. Singh, it's been a pleasure collaborating with you and @robp.bsky.social. Looking forward to what comes next in your scientific career 🎉
Congrats Dr. Singh, it's been a pleasure collaborating with you and @robp.bsky.social. Looking forward to what comes next in your scientific career 🎉
I usually put in this quote in classes when I introduce tidyverse and piping operations
November 26, 2024 at 2:27 PM
I usually put in this quote in classes when I introduce tidyverse and piping operations
July 24, 2024 at 3:19 PM