Matthias Krause
@matthias-krause.bsky.social
Pinned
Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. We resolve a longstanding controversy by showing that Wnt3a triggers rapid Clathrin-Mediated and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
Reposted by Matthias Krause
Super proud to be part of SFB1348 — and excited to share that I now officially have my own lab in Münster! 🎉🪰
We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.
I’ll soon hire my first #PhD student — feel free to reach out!
#juniorPI #Science #devbio
We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.
I’ll soon hire my first #PhD student — feel free to reach out!
#juniorPI #Science #devbio
November 25, 2025 at 3:57 PM
Super proud to be part of SFB1348 — and excited to share that I now officially have my own lab in Münster! 🎉🪰
We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.
I’ll soon hire my first #PhD student — feel free to reach out!
#juniorPI #Science #devbio
We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.
I’ll soon hire my first #PhD student — feel free to reach out!
#juniorPI #Science #devbio
Reposted by Matthias Krause
Exciting new findings on mechanisms of Wnt signalosomes --from Sheng-yuan Wu's PhD project in @matthias-krause.bsky.social lab! Great collaborators, great story. #xenopus 🐸
Sequestration of Ena/VASP proteins impedes in vivo Wnt activation driving Xenopus embryonic development. Our results suggest Mena as a crucial mediator of Wnt signalosome endocytosis thus promoting canonical Wnt signalling.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling.
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
www.biorxiv.org
November 25, 2025 at 1:15 PM
Exciting new findings on mechanisms of Wnt signalosomes --from Sheng-yuan Wu's PhD project in @matthias-krause.bsky.social lab! Great collaborators, great story. #xenopus 🐸
Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. We resolve a longstanding controversy by showing that Wnt3a triggers rapid Clathrin-Mediated and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
November 25, 2025 at 10:58 AM
Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. We resolve a longstanding controversy by showing that Wnt3a triggers rapid Clathrin-Mediated and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
Reposted by Matthias Krause
The Lab of Stephan Grill at MPI-CBG has finally made it to Bluesky and we also have a brand new homepage: grill-lab.org
Check it out.
Check it out.
November 6, 2025 at 1:09 PM
The Lab of Stephan Grill at MPI-CBG has finally made it to Bluesky and we also have a brand new homepage: grill-lab.org
Check it out.
Check it out.
Reposted by Matthias Krause
📣 Fully funded PhD position available in collaboration with @jasonkinglab.bsky.social in @mcb-sheffield.bsky.social
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways?
📅 Deadline: 7th January 2026
More info 👇
www.findaphd.com/phds/project...
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways?
📅 Deadline: 7th January 2026
More info 👇
www.findaphd.com/phds/project...
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? at University of Sheffield on FindAPhD.com
PhD Project - BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
November 5, 2025 at 8:17 AM
📣 Fully funded PhD position available in collaboration with @jasonkinglab.bsky.social in @mcb-sheffield.bsky.social
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways?
📅 Deadline: 7th January 2026
More info 👇
www.findaphd.com/phds/project...
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways?
📅 Deadline: 7th January 2026
More info 👇
www.findaphd.com/phds/project...
Reposted by Matthias Krause
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
October 23, 2025 at 5:25 PM
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
The cell dynamics conference in 2026 not to be missed: Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology.
Register now:
bit.ly/Dynamic-Cell-VI
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology.
Register now:
bit.ly/Dynamic-Cell-VI
October 22, 2025 at 11:36 AM
The cell dynamics conference in 2026 not to be missed: Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology.
Register now:
bit.ly/Dynamic-Cell-VI
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology.
Register now:
bit.ly/Dynamic-Cell-VI
Reposted by Matthias Krause
Dear funding agencies,
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
October 14, 2025 at 7:24 PM
Dear funding agencies,
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
Reposted by Matthias Krause
Registration is OPEN for our Spring Meeting: Dynamic Cell VI
co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
bit.ly/Dynamic-Cell-VI
October 13, 2025 at 3:31 PM
Registration is OPEN for our Spring Meeting: Dynamic Cell VI
co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Reposted by Matthias Krause
Optogenetic control of PLC-γ1 activity polarizes cell motility https://www.biorxiv.org/content/10.1101/2025.10.09.681531v1
October 12, 2025 at 3:30 AM
Optogenetic control of PLC-γ1 activity polarizes cell motility https://www.biorxiv.org/content/10.1101/2025.10.09.681531v1
In our revised NHSL1/2-FEME manuscript led by @jonny-cope.bsky.social we provide the additional functional insights that NHSL1 is not required for Dynamin recruitment but promotes carrier formation in Fast Endophilin Mediated Endocytosis (FEME) by increasing actin polymerisation at sites of FEME.
Nance-Horan Syndrome-like 1 interacts with endophilin A2 and Ena/VASP proteins to promote fast endophilin-mediated endocytosis.
Endocytosis, crucial for various physiological processes, facilitates receptor and extracellular material uptake. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A2 (EndoA2), enables...
www.biorxiv.org
October 10, 2025 at 2:37 PM
In our revised NHSL1/2-FEME manuscript led by @jonny-cope.bsky.social we provide the additional functional insights that NHSL1 is not required for Dynamin recruitment but promotes carrier formation in Fast Endophilin Mediated Endocytosis (FEME) by increasing actin polymerisation at sites of FEME.
Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
bit.ly/Dynamic-Cell-VI
October 10, 2025 at 2:24 PM
Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
bit.ly/Dynamic-Cell-VI
Reposted by Matthias Krause
If anyone ever wants to brush up on a lot of cell migration concepts don't forget we have several wonderful scientists who have given talks previously in cell migration seminars. I find it so comforting to go look at old videos, maybe someone else who will do as well!!
youtube.com/@cellmigrati...
youtube.com/@cellmigrati...
Cell Migration Seminars
Cell Migration Seminars every Tuesday at 16:00 BST.
youtube.com
September 29, 2025 at 1:48 AM
If anyone ever wants to brush up on a lot of cell migration concepts don't forget we have several wonderful scientists who have given talks previously in cell migration seminars. I find it so comforting to go look at old videos, maybe someone else who will do as well!!
youtube.com/@cellmigrati...
youtube.com/@cellmigrati...
Reposted by Matthias Krause
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
Bioimage Analysis Specialist | King's College London
www.kcl.ac.uk
September 29, 2025 at 9:48 AM
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
Reposted by Matthias Krause
Next, at #EYSF2025 @reviewcommons.org is presented by @saramonaco-rc.bsky.social. It’s journal-agnostic, concentrates on science only and can save time as the peer-reviewed preprints can easily be resubmitted. How great would it be if we could ditch publishing and switch to reviewed preprints?
September 24, 2025 at 12:27 PM
Next, at #EYSF2025 @reviewcommons.org is presented by @saramonaco-rc.bsky.social. It’s journal-agnostic, concentrates on science only and can save time as the peer-reviewed preprints can easily be resubmitted. How great would it be if we could ditch publishing and switch to reviewed preprints?
Reposted by Matthias Krause
I’m not sure as a community we **truely** acknowledged how powerful the #CellMigrationSeminarSeries series was at keeping us connected at such an uncertain time. Thank-you @ankita13jha.bsky.social @adamshellard.bsky.social @drjenmitchell.bsky.social & @simplythebex.bsky.social
September 29, 2025 at 2:07 AM
I’m not sure as a community we **truely** acknowledged how powerful the #CellMigrationSeminarSeries series was at keeping us connected at such an uncertain time. Thank-you @ankita13jha.bsky.social @adamshellard.bsky.social @drjenmitchell.bsky.social & @simplythebex.bsky.social
Reposted by Matthias Krause
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
September 17, 2025 at 5:20 PM
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
Reposted by Matthias Krause
Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social
thenode.biologists.com/jobs/postdoc...
thenode.biologists.com/jobs/postdoc...
Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node
The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...
thenode.biologists.com
August 5, 2025 at 10:15 AM
Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social
thenode.biologists.com/jobs/postdoc...
thenode.biologists.com/jobs/postdoc...
Reposted by Matthias Krause
🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay!
🔬 Study cytoskeletal signaling in collective cell migration
🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France
🗓️ Apply by Aug 22 via the following link:
emploi.cnrs.fr/Offres/Docto...
🔬 Study cytoskeletal signaling in collective cell migration
🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France
🗓️ Apply by Aug 22 via the following link:
emploi.cnrs.fr/Offres/Docto...
August 6, 2025 at 7:10 PM
🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay!
🔬 Study cytoskeletal signaling in collective cell migration
🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France
🗓️ Apply by Aug 22 via the following link:
emploi.cnrs.fr/Offres/Docto...
🔬 Study cytoskeletal signaling in collective cell migration
🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France
🗓️ Apply by Aug 22 via the following link:
emploi.cnrs.fr/Offres/Docto...
Reposted by Matthias Krause
Drosophila as a model system to understand #collagen IV-related genetic disease. Learn how fly genetics and exploding brain tissue can inform on #ECM defects and pathological mechanisms. Team effort led by a very talented recent PhD graduate, Angus Nichols. doi.org/10.1016/j.ma...
July 28, 2025 at 9:30 AM
Drosophila as a model system to understand #collagen IV-related genetic disease. Learn how fly genetics and exploding brain tissue can inform on #ECM defects and pathological mechanisms. Team effort led by a very talented recent PhD graduate, Angus Nichols. doi.org/10.1016/j.ma...
Reposted by Matthias Krause
In new @jcb.org study from Muziyue Wu et al. @oweinerlab.bsky.social, in vivo biochemistry sheds new light on how the WAVE complex templates the characteristic shape of lamellipodial protrusions. rupress.org/jcb/article/...
#Cytoskeleton #Actin #Migration #Motility #Biophysics
#Cytoskeleton #Actin #Migration #Motility #Biophysics
July 16, 2025 at 6:45 PM
In new @jcb.org study from Muziyue Wu et al. @oweinerlab.bsky.social, in vivo biochemistry sheds new light on how the WAVE complex templates the characteristic shape of lamellipodial protrusions. rupress.org/jcb/article/...
#Cytoskeleton #Actin #Migration #Motility #Biophysics
#Cytoskeleton #Actin #Migration #Motility #Biophysics
Reposted by Matthias Krause
I am so proud of @jezcarlton.bsky.social . What a magnificent inaugural lecture, many congratulations Professor Carlton!
July 16, 2025 at 10:14 PM
I am so proud of @jezcarlton.bsky.social . What a magnificent inaugural lecture, many congratulations Professor Carlton!
Reposted by Matthias Krause
OMG, this is such a cool paper from Patrick Caswell's lab. They express Rab25-mCherry-GFP-nanobody in cells, microinject GFP-magnetic particles, then use a magnet to pull Rab25 to the plasma membrane to show that it can trigger actin protrusions! I want this system.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration
Repositioning of Rab25 vesicles containing formin and integrin cargos to the cell periphery promotes protrusion formation.
www.science.org
July 8, 2025 at 9:21 PM
OMG, this is such a cool paper from Patrick Caswell's lab. They express Rab25-mCherry-GFP-nanobody in cells, microinject GFP-magnetic particles, then use a magnet to pull Rab25 to the plasma membrane to show that it can trigger actin protrusions! I want this system.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Manuscript from our lab on BioRxiv: We provide mechanistic insights that NHSL1 promotes Fast endophilin mediated carrier formation via both endophilin and Ena/VASP proteins thereby may facilitate membrane bending and Ena/VASP mediated actin polymerisation. www.biorxiv.org/content/10.1...
Nance-Horan Syndrome-like 1 interacts with endophilin and Ena/VASP proteins to promote fast endophilin-mediated endocytosis
Endocytosis is crucial for various physiological processes, facilitating the uptake of membrane proteins and extracellular material. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A (EndoA), enables clathrin-independent, ligand-induced receptor uptake at the leading edge of cells. Whilst F-actin polymerisation is essential for FEME, how actin dynamics are regulated at sites of FEME is unknown. NHSL1, a member of the Nance-Horan Syndrome protein family, localises to the leading edge of cells, where it regulates migration, and to vesicular puncta, where its function is undetermined. Here, we show that NHSL1 and its uncharacterised family member NHSL2 co-localise and engage in direct, multivalent interactions with EndoA. NHSL1 also binds Ena/VASP proteins, a family of actin elongators. NHSL1 promotes FEME in cells and its interactions with EndoA and Ena/VASP proteins are required for this function. Thus, NHSL1 may cooperate with EndoA and Ena/VASP proteins to control membrane invagination and actin polymerisation, thereby mediating FEME. ### Competing Interest Statement The authors have declared no competing interest.
www.biorxiv.org
July 8, 2025 at 10:19 AM
Manuscript from our lab on BioRxiv: We provide mechanistic insights that NHSL1 promotes Fast endophilin mediated carrier formation via both endophilin and Ena/VASP proteins thereby may facilitate membrane bending and Ena/VASP mediated actin polymerisation. www.biorxiv.org/content/10.1...
Reposted by Matthias Krause
Interested in applying for a Marie Skłodowska-Curie Postdoc Fellowship? Contact me for exciting postdoc projects in neural crest or cancer cell migration, endocytosis, advanced imaging at King’s College London. [email protected]
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...
Postdoctoral Fellowships
The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.
marie-sklodowska-curie-actions.ec.europa.eu
July 4, 2025 at 9:16 AM
Interested in applying for a Marie Skłodowska-Curie Postdoc Fellowship? Contact me for exciting postdoc projects in neural crest or cancer cell migration, endocytosis, advanced imaging at King’s College London. [email protected]
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...