Matthias Krause
@matthias-krause.bsky.social
Sequestration of Ena/VASP proteins impedes in vivo Wnt activation driving Xenopus embryonic development. Our results suggest Mena as a crucial mediator of Wnt signalosome endocytosis thus promoting canonical Wnt signalling.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling.
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
www.biorxiv.org
November 25, 2025 at 10:58 AM
Sequestration of Ena/VASP proteins impedes in vivo Wnt activation driving Xenopus embryonic development. Our results suggest Mena as a crucial mediator of Wnt signalosome endocytosis thus promoting canonical Wnt signalling.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This requires Ena/VASP proteins and is specifically promoted by Mena. Upon Wnt stimulation, Mena redistributes from focal adhesions to signalosomes, Wnt-receptor clusters. Mena directly binds Wnt-coreceptors LRP5/6 in a phosphorylation-dependent manner increasing Wnt signal transduction.
November 25, 2025 at 10:58 AM
This requires Ena/VASP proteins and is specifically promoted by Mena. Upon Wnt stimulation, Mena redistributes from focal adhesions to signalosomes, Wnt-receptor clusters. Mena directly binds Wnt-coreceptors LRP5/6 in a phosphorylation-dependent manner increasing Wnt signal transduction.
NHSL1 promotes FEME and its interactions with EndoA2 and Ena/VASP proteins are required for this function. Thus, it may cooperate with EndoA2 and Ena/VASP proteins to control membrane invagination and actin polymerisation, thereby mediating FEME.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Nance-Horan Syndrome-like 1 interacts with endophilin A2 and Ena/VASP proteins to promote fast endophilin-mediated endocytosis.
Endocytosis, crucial for various physiological processes, facilitates receptor and extracellular material uptake. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A2 (EndoA2), enables...
www.biorxiv.org
October 10, 2025 at 2:37 PM
NHSL1 promotes FEME and its interactions with EndoA2 and Ena/VASP proteins are required for this function. Thus, it may cooperate with EndoA2 and Ena/VASP proteins to control membrane invagination and actin polymerisation, thereby mediating FEME.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Congratulations, Jez!!
July 17, 2025 at 6:16 AM
Congratulations, Jez!!