Kyle Dyson
@kyledyson.bsky.social
Husband & Father | Stanford Pathology AP/NP PGY-2 | MD-PhD @UFBTIP | Passionate about the CNS and immunotherapy
Reposted by Kyle Dyson
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
www.nature.com
December 10, 2024 at 3:03 AM
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
Reposted by Kyle Dyson
Guardians of the Brain.
A brief review of 6 recent, important reports that help us understand the brain-immune system axis
erictopol.substack.com/p/guardians-...
in the new Ground Truths, open-access (free)
relevance: #LongCovid, brain tumors, multiple sclerosis, ME/CFS, autoimmunity
A brief review of 6 recent, important reports that help us understand the brain-immune system axis
erictopol.substack.com/p/guardians-...
in the new Ground Truths, open-access (free)
relevance: #LongCovid, brain tumors, multiple sclerosis, ME/CFS, autoimmunity
December 8, 2024 at 8:54 PM
Guardians of the Brain.
A brief review of 6 recent, important reports that help us understand the brain-immune system axis
erictopol.substack.com/p/guardians-...
in the new Ground Truths, open-access (free)
relevance: #LongCovid, brain tumors, multiple sclerosis, ME/CFS, autoimmunity
A brief review of 6 recent, important reports that help us understand the brain-immune system axis
erictopol.substack.com/p/guardians-...
in the new Ground Truths, open-access (free)
relevance: #LongCovid, brain tumors, multiple sclerosis, ME/CFS, autoimmunity
Reposted by Kyle Dyson
Reposted by Kyle Dyson
1) GREAT DEBATE: Pre-treatment #predictive #biomarkers: INF-y vs. #Immunoscore vs. #multiplexIF /next-generation #spatialbiology. A 3-way debate..
Drs. Christian Blank vs Jerome Galon vs Janis M. Taube. Dr Blank starts. IFNg sig improves 2 ID pts who need more Tx #Bridge2024 @sitcancer.bsky.social
Drs. Christian Blank vs Jerome Galon vs Janis M. Taube. Dr Blank starts. IFNg sig improves 2 ID pts who need more Tx #Bridge2024 @sitcancer.bsky.social
December 5, 2024 at 1:28 PM
1) GREAT DEBATE: Pre-treatment #predictive #biomarkers: INF-y vs. #Immunoscore vs. #multiplexIF /next-generation #spatialbiology. A 3-way debate..
Drs. Christian Blank vs Jerome Galon vs Janis M. Taube. Dr Blank starts. IFNg sig improves 2 ID pts who need more Tx #Bridge2024 @sitcancer.bsky.social
Drs. Christian Blank vs Jerome Galon vs Janis M. Taube. Dr Blank starts. IFNg sig improves 2 ID pts who need more Tx #Bridge2024 @sitcancer.bsky.social
Reposted by Kyle Dyson
A neuro-lymphatic communication guides lymphatic development by CXCL12 and CXCR4 signaling
Read this Research Article by Long Nguyen Hoang Do, Xiaolei Liu @templemedschool.bsky.social and colleagues:
https://buff.ly/49lSHLb
Read this Research Article by Long Nguyen Hoang Do, Xiaolei Liu @templemedschool.bsky.social and colleagues:
https://buff.ly/49lSHLb
December 4, 2024 at 9:51 AM
A neuro-lymphatic communication guides lymphatic development by CXCL12 and CXCR4 signaling
Read this Research Article by Long Nguyen Hoang Do, Xiaolei Liu @templemedschool.bsky.social and colleagues:
https://buff.ly/49lSHLb
Read this Research Article by Long Nguyen Hoang Do, Xiaolei Liu @templemedschool.bsky.social and colleagues:
https://buff.ly/49lSHLb
Reposted by Kyle Dyson
NKG2A-mediated immune modulation of NK cells by Staphylococcus aureus
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 5, 2024 at 12:54 AM
NKG2A-mediated immune modulation of NK cells by Staphylococcus aureus
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kyle Dyson
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
Reposted by Kyle Dyson
Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. https://www.biorxiv.org/content/10.1101/2024.12.03.626669v1
Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. https://www.biorxiv.org/content/10.1101/2024.12.03.626669v1
Immune checkpoint inhibitors such as anti-PD-1 antibodies (aPD1) can be effective in treating advanc
www.biorxiv.org
December 4, 2024 at 10:47 PM
Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. https://www.biorxiv.org/content/10.1101/2024.12.03.626669v1
Reposted by Kyle Dyson
T cell receptor–centric perspective improves single-cell analysis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
T cell receptor–centric perspective to multimodal single-cell data analysis
T cell receptor–centric perspective improves single-cell analysis.
www.science.org
December 2, 2024 at 10:14 PM
T cell receptor–centric perspective improves single-cell analysis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Kyle Dyson
Our massive effort to recontextualize #single #T-cell data is now out in Science Advances! We developed a new system, STEGO, to do a TCR-first analysis, and reanalyzed 12 studies and more than 500 000 individual T-cells.
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...
T cell receptor–centric perspective to multimodal single-cell data analysis
T cell receptor–centric perspective improves single-cell analysis.
doi.org
December 2, 2024 at 8:30 AM
Our massive effort to recontextualize #single #T-cell data is now out in Science Advances! We developed a new system, STEGO, to do a TCR-first analysis, and reanalyzed 12 studies and more than 500 000 individual T-cells.
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...
Reposted by Kyle Dyson
Reposted by Kyle Dyson
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature
Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
www.nature.com
December 1, 2024 at 1:46 AM
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kyle Dyson
Integrative mapping of human CD8+ T cells in inflammation and cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Integrative mapping of human CD8+ T cells in inflammation and cancer - Nature Methods
scAtlasVAE is a deep learning-based model for cross-atlas integration. Here it enables the development of a large-scale human CD8+ T cell atlas with integrated T cell receptor data.
www.nature.com
November 29, 2024 at 8:03 PM
Integrative mapping of human CD8+ T cells in inflammation and cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kyle Dyson
KEAP1-mediated suppression of NRF2 required for optimal expansion of CD8+ T cells during chronic antigen exposure:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation
KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.
www.science.org
November 29, 2024 at 9:32 PM
KEAP1-mediated suppression of NRF2 required for optimal expansion of CD8+ T cells during chronic antigen exposure:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Kyle Dyson
"Here, we identify an alternative splicing isoform of human PD-1, which carries a 28-base pairs extension retained from 5′ region of intron 2 (PD-1^28), is expressed in peripheral T cells and tumor infiltrating lymphocytes."
#Immunology #Immunotherapy
www.nature.com/articles/s41...
#Immunology #Immunotherapy
www.nature.com/articles/s41...
A splicing isoform of PD-1 promotes tumor progression as a potential immune checkpoint - Nature Communications
Whether PD-1 splicing isoforms impact T cell anti-tumor capacity has not been fully illustrated. Here the authors identify a human PD-1 isoform, PD-1^28, which functions to suppress anti-cancer immuni...
www.nature.com
November 29, 2024 at 9:32 PM
"Here, we identify an alternative splicing isoform of human PD-1, which carries a 28-base pairs extension retained from 5′ region of intron 2 (PD-1^28), is expressed in peripheral T cells and tumor infiltrating lymphocytes."
#Immunology #Immunotherapy
www.nature.com/articles/s41...
#Immunology #Immunotherapy
www.nature.com/articles/s41...
Reposted by Kyle Dyson
✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR
November 28, 2024 at 7:33 PM
✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR
Reposted by Kyle Dyson
new out in Nature www.nature.com/articles/s41...
Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers - Nature
We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion, intratumoural su...
www.nature.com
November 28, 2024 at 9:01 AM
new out in Nature www.nature.com/articles/s41...
Reposted by Kyle Dyson
This paper is now online: www.nature.com/articles/s41... and it is fascinating!!
November 27, 2024 at 5:38 PM
This paper is now online: www.nature.com/articles/s41... and it is fascinating!!
Reposted by Kyle Dyson
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer | NEJM
Patients with microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted therapi...
www.nejm.org
November 28, 2024 at 4:01 AM
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Kyle Dyson
Sometimes I read a pre-print that moves the needle, typically on bioRxiv where all the good new stuff first appears. Two first class tech-dev pioneers and their fearless postdocs collaborate creating tour de-force methods -->
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...
www.biorxiv.org
November 28, 2024 at 3:05 AM
Sometimes I read a pre-print that moves the needle, typically on bioRxiv where all the good new stuff first appears. Two first class tech-dev pioneers and their fearless postdocs collaborate creating tour de-force methods -->
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kyle Dyson
Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
November 27, 2024 at 3:58 PM
Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Kyle Dyson
Neural Guidance of Lymphatics
#SchwannCell CXCL12⏫ Sprouting/Patterning of CXCR4+ #LymphaticEndothelialCell
Prox1-CreERT2:Cxcr4f/f🐭
⬇️ Lymphatic Valve formation
⬇️ VEGF-C-induced #Lymphangiogenesis
Xiaolei Liu lab Development 2024 @biologists.bsky.social
journals.biologists.com/dev/article-...
#SchwannCell CXCL12⏫ Sprouting/Patterning of CXCR4+ #LymphaticEndothelialCell
Prox1-CreERT2:Cxcr4f/f🐭
⬇️ Lymphatic Valve formation
⬇️ VEGF-C-induced #Lymphangiogenesis
Xiaolei Liu lab Development 2024 @biologists.bsky.social
journals.biologists.com/dev/article-...
November 24, 2024 at 8:31 PM
Neural Guidance of Lymphatics
#SchwannCell CXCL12⏫ Sprouting/Patterning of CXCR4+ #LymphaticEndothelialCell
Prox1-CreERT2:Cxcr4f/f🐭
⬇️ Lymphatic Valve formation
⬇️ VEGF-C-induced #Lymphangiogenesis
Xiaolei Liu lab Development 2024 @biologists.bsky.social
journals.biologists.com/dev/article-...
#SchwannCell CXCL12⏫ Sprouting/Patterning of CXCR4+ #LymphaticEndothelialCell
Prox1-CreERT2:Cxcr4f/f🐭
⬇️ Lymphatic Valve formation
⬇️ VEGF-C-induced #Lymphangiogenesis
Xiaolei Liu lab Development 2024 @biologists.bsky.social
journals.biologists.com/dev/article-...
Reposted by Kyle Dyson
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology
Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...
www.nature.com
November 25, 2024 at 8:10 PM
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kyle Dyson
www.nature.com/articles/s41...
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Next-generation combination approaches for immune checkpoint therapy - Nature Immunology
In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.
www.nature.com
November 25, 2024 at 8:43 PM
www.nature.com/articles/s41...
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Reposted by Kyle Dyson
The hallmarks of cancer immune evasion
The hallmarks of cancer immune evasion
Cancer cells often evade the host immune system, challenging the effectiveness of
immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms
of immune evasion within the “thr...
www.cell.com
November 25, 2024 at 3:45 AM
The hallmarks of cancer immune evasion