Dr. Josephine Chandler
@jrchandler.bsky.social
Mom, microbiologist, Associate Professor at the University of Kansas, occasional sewer
Reposted by Dr. Josephine Chandler
Research universities are often the largest employers in their region. They are often the primary health care providers to communities. This funding shift will not only reduce US research leadership, it will put working people out of work and reduce healthcare access.
Excellent 🧵 on this evening's NIH announcement of a dramatic reduction in indirect rates for research institutions, which amounts to a generational restructuring of the US research and development ecosystem. These cuts are effective immediately, not just for new grants but for existing ones.
6. The policy does not just affect funding going forward. All existing NIH grants will have their indirect rates cut to 15% as of today, the date of issuance.
For a large university, this creates a sudden and catastrophic shortfall of hundreds of millions of dollars against already budgeted funds.
For a large university, this creates a sudden and catastrophic shortfall of hundreds of millions of dollars against already budgeted funds.
February 8, 2025 at 1:40 AM
Research universities are often the largest employers in their region. They are often the primary health care providers to communities. This funding shift will not only reduce US research leadership, it will put working people out of work and reduce healthcare access.
Reposted by Dr. Josephine Chandler
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Science Homecoming
sciencehomecoming.com
February 18, 2025 at 5:12 PM
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Reposted by Dr. Josephine Chandler
Interactions between the nitrogen phosphotransferase system of Pseudomonas aeruginosa and its quorum sensing circuits.
A new preprint from @jrchandler.bsky.social's group
www.biorxiv.org/content/10.1...
A new preprint from @jrchandler.bsky.social's group
www.biorxiv.org/content/10.1...
Quorum sensing regulation by the nitrogen phosphotransferase system in Pseudomonas aeruginosa
In the opportunistic pathogen Pseudomonas aeruginosa , the nitrogen-related phosphotransferase system (PTSNtr) influences multiple virulence behaviors. The PTSNtr is comprised of three enzymes: first ...
www.biorxiv.org
February 5, 2025 at 6:32 PM
Interactions between the nitrogen phosphotransferase system of Pseudomonas aeruginosa and its quorum sensing circuits.
A new preprint from @jrchandler.bsky.social's group
www.biorxiv.org/content/10.1...
A new preprint from @jrchandler.bsky.social's group
www.biorxiv.org/content/10.1...
Reposted by Dr. Josephine Chandler
Scientists and journalists need to figure out right quick how to explain to the average person how a massive change in research indirects will impact the medical care they and their children get (eg at the local children’s hospital), the education their children will get, the price of tuition, etc.
February 8, 2025 at 1:35 AM
Scientists and journalists need to figure out right quick how to explain to the average person how a massive change in research indirects will impact the medical care they and their children get (eg at the local children’s hospital), the education their children will get, the price of tuition, etc.
Reposted by Dr. Josephine Chandler
I am confident that scientific societies will play an unusually important role in the coming years. If you are a microbiologist of any kind, please consider joining @asm.org if you haven't already. There are many ways to get involved, including advocacy.
To learn more:
asm.org/About-ASM/Vo...
To learn more:
asm.org/About-ASM/Vo...
Volunteer With ASM | Overview
ASM volunteer opportunities range from speaking with legislators about funding research during ASM's annual Hill Day, to writing articles for asm.org, to serving on committees and the Board of Directo...
asm.org
January 23, 2025 at 9:21 PM
I am confident that scientific societies will play an unusually important role in the coming years. If you are a microbiologist of any kind, please consider joining @asm.org if you haven't already. There are many ways to get involved, including advocacy.
To learn more:
asm.org/About-ASM/Vo...
To learn more:
asm.org/About-ASM/Vo...
Reposted by Dr. Josephine Chandler
My NIH study section that was to meet tomorrow was one of those canceled. This represents many months of work by the applicants and by the NIH staff and reviewers. Devastating is the correct word.
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 11:52 PM
My NIH study section that was to meet tomorrow was one of those canceled. This represents many months of work by the applicants and by the NIH staff and reviewers. Devastating is the correct word.
Reposted by Dr. Josephine Chandler
The Undergraduate Biology Program is rolling out a bunch of scholarships & awards for Spring 2025! 🌟 Whether you're all about academics, digging deep into research, or ready to travel and expand your horizons, we've got opportunities for you. biology.ku.edu/scholarships
January 22, 2025 at 6:35 PM
The Undergraduate Biology Program is rolling out a bunch of scholarships & awards for Spring 2025! 🌟 Whether you're all about academics, digging deep into research, or ready to travel and expand your horizons, we've got opportunities for you. biology.ku.edu/scholarships
Reposted by Dr. Josephine Chandler
The story behind the paper: conceptually, this material was the 2nd part of Dr Renae Cruz’s thesis. But the Covid-19 pandemic intervened, and she graduated in May 2020. Because of the pandemic, the project did not move forward for two years. /1
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
RhlR-mediated cooperation in cystic fibrosis-adapted isolates of Pseudomonas aeruginosa | Journal of Bacteriology
Quorum sensing (QS) mutants arise in a variety of populations of bacteria, but mutants
of the gene encoding the transcription factor RhlR in Pseudomonas aeruginosa appear to be infrequent. Our work pr...
journals.asm.org
December 13, 2024 at 4:23 PM
The story behind the paper: conceptually, this material was the 2nd part of Dr Renae Cruz’s thesis. But the Covid-19 pandemic intervened, and she graduated in May 2020. Because of the pandemic, the project did not move forward for two years. /1
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Dr. Josephine Chandler
Impostor syndrome: “I don't know what I'm doing. It's only a matter of time until everyone finds out."
Growth mindset: "I don't know what I'm doing yet. It's only a matter of time until I figure it out."
The highest form of self-confidence is believing in your ability to learn.
Growth mindset: "I don't know what I'm doing yet. It's only a matter of time until I figure it out."
The highest form of self-confidence is believing in your ability to learn.
December 5, 2024 at 1:44 PM
Impostor syndrome: “I don't know what I'm doing. It's only a matter of time until everyone finds out."
Growth mindset: "I don't know what I'm doing yet. It's only a matter of time until I figure it out."
The highest form of self-confidence is believing in your ability to learn.
Growth mindset: "I don't know what I'm doing yet. It's only a matter of time until I figure it out."
The highest form of self-confidence is believing in your ability to learn.
Reposted by Dr. Josephine Chandler
I had an excellent visit to KU today, hosted by @jrchandler.bsky.social! Great people and science here.
When I was a PhD student I would not have imagined that I would be advertised on a flyer next to my mentor Stanley Perlman — although, notably, he is a “distinguished speaker” and I am not.
When I was a PhD student I would not have imagined that I would be advertised on a flyer next to my mentor Stanley Perlman — although, notably, he is a “distinguished speaker” and I am not.
March 5, 2024 at 3:08 AM
I had an excellent visit to KU today, hosted by @jrchandler.bsky.social! Great people and science here.
When I was a PhD student I would not have imagined that I would be advertised on a flyer next to my mentor Stanley Perlman — although, notably, he is a “distinguished speaker” and I am not.
When I was a PhD student I would not have imagined that I would be advertised on a flyer next to my mentor Stanley Perlman — although, notably, he is a “distinguished speaker” and I am not.
Reposted by Dr. Josephine Chandler
🚨Travel awards for Early Career Researchers to attend ASM Microbe🧫
1. Awarded through ASM Branches
2. $1650 per award, 3 per branch
3. Apps open now!
4. Named for Peggy Cotter, ASM past president & advocate
5. A proud accomplishment when I was COMS Chair
6. Apply / share!
asm.org/Travel-Award...
1. Awarded through ASM Branches
2. $1650 per award, 3 per branch
3. Apps open now!
4. Named for Peggy Cotter, ASM past president & advocate
5. A proud accomplishment when I was COMS Chair
6. Apply / share!
asm.org/Travel-Award...
Peggy Cotter Travel Award
ASM is a nonprofit professional society that publishes scientific journals and advances microbiology through advocacy, global health and diversity in STEM programs.
asm.org
November 19, 2024 at 6:01 PM
🚨Travel awards for Early Career Researchers to attend ASM Microbe🧫
1. Awarded through ASM Branches
2. $1650 per award, 3 per branch
3. Apps open now!
4. Named for Peggy Cotter, ASM past president & advocate
5. A proud accomplishment when I was COMS Chair
6. Apply / share!
asm.org/Travel-Award...
1. Awarded through ASM Branches
2. $1650 per award, 3 per branch
3. Apps open now!
4. Named for Peggy Cotter, ASM past president & advocate
5. A proud accomplishment when I was COMS Chair
6. Apply / share!
asm.org/Travel-Award...
Reposted by Dr. Josephine Chandler
A thread on NIH Reorganization and the Scientific Management Review Board (SMRB)
Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through.
1/n
Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through.
1/n
November 20, 2024 at 12:39 PM
A thread on NIH Reorganization and the Scientific Management Review Board (SMRB)
Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through.
1/n
Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through.
1/n
Reposted by Dr. Josephine Chandler
Cuboidal cell packing is a common yet understudied route to multicellularity. In work led by @rpineau.bsky.social and Ozan Bozdag we explore its origin as a multicellular geometry capable of supporting a transition in individuality using fission yeast. 1/14 www.biorxiv.org/content/14.1...
November 6, 2023 at 6:34 PM
Cuboidal cell packing is a common yet understudied route to multicellularity. In work led by @rpineau.bsky.social and Ozan Bozdag we explore its origin as a multicellular geometry capable of supporting a transition in individuality using fission yeast. 1/14 www.biorxiv.org/content/14.1...
Reposted by Dr. Josephine Chandler
Rapid bacteria-phage coevolution drives the emergence of multiscale networks www.science.org/doi/abs/10.1... #jcampubs
Science | AAAS
www.science.org
November 10, 2023 at 2:21 PM
Rapid bacteria-phage coevolution drives the emergence of multiscale networks www.science.org/doi/abs/10.1... #jcampubs
Reposted by Dr. Josephine Chandler
Got my shot--go get yours--its fast and easy
November 18, 2023 at 1:19 AM
Got my shot--go get yours--its fast and easy
Reposted by Dr. Josephine Chandler
Now this looks interesting!
"Promoter capture drives the emergence of proto-genes in Escherichia coli"
uz-Zaman MH , D'Alton S , Barrick JE , Ochman H
www.biorxiv.org/content/10.1...
#evolution #innovation #LTEE #bacteria #genetics #genomics #science
"Promoter capture drives the emergence of proto-genes in Escherichia coli"
uz-Zaman MH , D'Alton S , Barrick JE , Ochman H
www.biorxiv.org/content/10.1...
#evolution #innovation #LTEE #bacteria #genetics #genomics #science
November 22, 2023 at 3:33 PM
Now this looks interesting!
"Promoter capture drives the emergence of proto-genes in Escherichia coli"
uz-Zaman MH , D'Alton S , Barrick JE , Ochman H
www.biorxiv.org/content/10.1...
#evolution #innovation #LTEE #bacteria #genetics #genomics #science
"Promoter capture drives the emergence of proto-genes in Escherichia coli"
uz-Zaman MH , D'Alton S , Barrick JE , Ochman H
www.biorxiv.org/content/10.1...
#evolution #innovation #LTEE #bacteria #genetics #genomics #science
Reposted by Dr. Josephine Chandler
A lovely article from the Cystic Fibrosis Trust, about a visit made by someone with CF to a microbiology lab leading work on antimicrobial drug discovery #MicroSky www.cysticfibrosis.org.uk/news/the-oth...
November 22, 2023 at 6:41 PM
A lovely article from the Cystic Fibrosis Trust, about a visit made by someone with CF to a microbiology lab leading work on antimicrobial drug discovery #MicroSky www.cysticfibrosis.org.uk/news/the-oth...
Reposted by Dr. Josephine Chandler
Reposted by Dr. Josephine Chandler
I have too much on my plate.
Me at work 🤝 Me at Thanksgiving dinner
Me at work 🤝 Me at Thanksgiving dinner
November 21, 2023 at 3:24 PM
I have too much on my plate.
Me at work 🤝 Me at Thanksgiving dinner
Me at work 🤝 Me at Thanksgiving dinner
Reposted by Dr. Josephine Chandler
Receptor-independent response to an AHL signal in surface-grown Pseudomonas aeruginosa -- from the Déziel group
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Surface growth of Pseudomonas aeruginosa reveals a regulatory effect of 3-oxo-C12-homoserine lactone...
The bacterium Pseudomonas aeruginosa colonizes and thrives in many environments, in which it is typically found in surface-associated
polymicrobial communities known as biofilms. Adaptation to this so...
journals.asm.org
September 21, 2023 at 3:43 PM
Receptor-independent response to an AHL signal in surface-grown Pseudomonas aeruginosa -- from the Déziel group
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Dr. Josephine Chandler
My lab's first big research paper is now out in mBio! 🎉
We ask: how can Legionella antagonize other microbes with reactive oxygen species without hurting themselves? Answer: several dynamics seem to generate a 'toxic moat' of ROS around producers
pubmed.ncbi.nlm.nih.gov/37728338/
We ask: how can Legionella antagonize other microbes with reactive oxygen species without hurting themselves? Answer: several dynamics seem to generate a 'toxic moat' of ROS around producers
pubmed.ncbi.nlm.nih.gov/37728338/
September 25, 2023 at 9:26 PM
My lab's first big research paper is now out in mBio! 🎉
We ask: how can Legionella antagonize other microbes with reactive oxygen species without hurting themselves? Answer: several dynamics seem to generate a 'toxic moat' of ROS around producers
pubmed.ncbi.nlm.nih.gov/37728338/
We ask: how can Legionella antagonize other microbes with reactive oxygen species without hurting themselves? Answer: several dynamics seem to generate a 'toxic moat' of ROS around producers
pubmed.ncbi.nlm.nih.gov/37728338/
This is totally beautiful
September 9, 2023 at 3:30 AM
This is totally beautiful
Reposted by Dr. Josephine Chandler
Text from a friend. Paging @ass_deans.
September 7, 2023 at 3:27 AM
Text from a friend. Paging @ass_deans.
Our kids started school in august and within two weeks we had covid. What is the point of rolling out the vaccine in late September?
@mikethemadbiol.bsky.social
Can I ask a question?
The new vaccine isn't until the end of September....
My kid join the pool of Petri dishes today, September 5th...
Does the FDA and CDC just not know how to use Google calendar?
Can I ask a question?
The new vaccine isn't until the end of September....
My kid join the pool of Petri dishes today, September 5th...
Does the FDA and CDC just not know how to use Google calendar?
September 7, 2023 at 4:25 AM
Our kids started school in august and within two weeks we had covid. What is the point of rolling out the vaccine in late September?