@insulinaddict.bsky.social
Reposted
Reposted
Proud present our latest work led by Blessy Paul, now in Developmental Cell @cellpress.bsky.social.
Here, we characterize an ER-localized antioxidant enzyme in humans and Drosophila that acts as a lipid quality control factor to suppress ER lipid oxidation.
www.cell.com/developmenta...
Here, we characterize an ER-localized antioxidant enzyme in humans and Drosophila that acts as a lipid quality control factor to suppress ER lipid oxidation.
www.cell.com/developmenta...
Paraoxonase-like APMAP maintains endoplasmic-reticulum-associated lipid and lipoprotein homeostasis
Here, Paul et al. show that APMAP is an ER-localized paraoxonase-like enzyme that
suppresses lipid oxidation and redox stress at the ER network. APMAP loss leads to
ER stress, redox disruption, phosph...
www.cell.com
May 5, 2025 at 1:10 PM
Proud present our latest work led by Blessy Paul, now in Developmental Cell @cellpress.bsky.social.
Here, we characterize an ER-localized antioxidant enzyme in humans and Drosophila that acts as a lipid quality control factor to suppress ER lipid oxidation.
www.cell.com/developmenta...
Here, we characterize an ER-localized antioxidant enzyme in humans and Drosophila that acts as a lipid quality control factor to suppress ER lipid oxidation.
www.cell.com/developmenta...
Reposted
Out today, we report how small chemical modifications in the metabolism of ergosterol are needed for yeast membranes to phase seperate into ordered yet fluid domains www.science.org/doi/10.1126/... (1/n)
Structural dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation
The metabolism of ergosterol shapes this lipid to allow the formation of fluid membrane domains in yeast cells.
www.science.org
April 24, 2025 at 3:04 PM
Out today, we report how small chemical modifications in the metabolism of ergosterol are needed for yeast membranes to phase seperate into ordered yet fluid domains www.science.org/doi/10.1126/... (1/n)
Reposted
Here’s the show. Please watch!
It’s all about HHS and the first segment is about NIH.
www.youtube.com/watch?v=8H34...
It’s all about HHS and the first segment is about NIH.
www.youtube.com/watch?v=8H34...
RFK Jr. & HHS: Last Week Tonight with John Oliver (HBO)
YouTube video by LastWeekTonight
www.youtube.com
April 28, 2025 at 12:05 PM
Here’s the show. Please watch!
It’s all about HHS and the first segment is about NIH.
www.youtube.com/watch?v=8H34...
It’s all about HHS and the first segment is about NIH.
www.youtube.com/watch?v=8H34...
Reposted
Structural basis of lipid transfer by a bridge-like lipid-transfer protein
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature
The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...
www.nature.com
April 23, 2025 at 7:24 PM
Structural basis of lipid transfer by a bridge-like lipid-transfer protein
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
The Drosophila G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitation https://www.biorxiv.org/content/10.1101/2025.04.19.649675v1
April 23, 2025 at 11:32 PM
The Drosophila G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitation https://www.biorxiv.org/content/10.1101/2025.04.19.649675v1
Reposted
Comprehensive Identification of Lipid–Membrane Protein Interactions via Advanced Proteomics and Extended Lipid-Immobilized Bead Technology #AC pubs.acs.org/doi/10.1021/...
Comprehensive Identification of Lipid–Membrane Protein Interactions via Advanced Proteomics and Extended Lipid-Immobilized Bead Technology
In biological membranes, lipids interact with membrane proteins (MPs) and play important roles in allosterically regulating their structure and function. Analyzing lipid–MP interactions is necessary f...
pubs.acs.org
April 15, 2025 at 6:23 PM
Comprehensive Identification of Lipid–Membrane Protein Interactions via Advanced Proteomics and Extended Lipid-Immobilized Bead Technology #AC pubs.acs.org/doi/10.1021/...
www.biorxiv.org/content/10.1... #lipidtime our preprint is out! Building lipids in glia by eating neuronal membrains, with a key role for lysosomal GBA in anabolism!
Glia phagocytose neuronal sphingolipids to infiltrate developing synapses
The complex morphologies of mature neurons and glia emerge through profound rearrangements of cell membranes during development. Despite being integral components of these membranes, it is unclear whe...
www.biorxiv.org
April 16, 2025 at 4:23 PM
www.biorxiv.org/content/10.1... #lipidtime our preprint is out! Building lipids in glia by eating neuronal membrains, with a key role for lysosomal GBA in anabolism!
Reposted
If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social
April 10, 2025 at 6:06 AM
If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social
Reposted
Happy to share our latest paper on the role of PIP2 in Drosophila PGC formation - congratulations to Marcus and colleagues!
www.cell.com/current-biol...
www.cell.com/current-biol...
Formation of Drosophila germ cells requires spatial patterning of phospholipids
With mathematical modeling and experiments, Kilwein et al. show that Drosophila primordial
germ cells bud from the embryo by outward membrane buckling driven by actin polymerization.
Germ granules loc...
www.cell.com
April 8, 2025 at 6:34 PM
Happy to share our latest paper on the role of PIP2 in Drosophila PGC formation - congratulations to Marcus and colleagues!
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
The Coming Out of a Transgender Scientist
"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."
thereader.mitpress.mit.edu
April 8, 2025 at 8:24 PM
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
Reposted
My first-author #lipidtime paper is out
@NatureComms
! We studied how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in mouse developing myelin and explored nonvesicular lipid transport involved doi.org/10.1038/s414... (1/n)
@NatureComms
! We studied how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in mouse developing myelin and explored nonvesicular lipid transport involved doi.org/10.1038/s414... (1/n)
November 12, 2024 at 12:50 PM
My first-author #lipidtime paper is out
@NatureComms
! We studied how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in mouse developing myelin and explored nonvesicular lipid transport involved doi.org/10.1038/s414... (1/n)
@NatureComms
! We studied how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in mouse developing myelin and explored nonvesicular lipid transport involved doi.org/10.1038/s414... (1/n)
Reposted
Reposted
CORRESPONDENCE | Y El Abiead, @pieterdorrestein.bsky.social et al. ( @ucsandiego.bsky.social ):
Discovery of metabolites prevails amid in-source fragmentation
#massspec
https://bit.ly/4jjNVl9
Discovery of metabolites prevails amid in-source fragmentation
#massspec
https://bit.ly/4jjNVl9
April 5, 2025 at 6:18 PM
CORRESPONDENCE | Y El Abiead, @pieterdorrestein.bsky.social et al. ( @ucsandiego.bsky.social ):
Discovery of metabolites prevails amid in-source fragmentation
#massspec
https://bit.ly/4jjNVl9
Discovery of metabolites prevails amid in-source fragmentation
#massspec
https://bit.ly/4jjNVl9
Reposted
YES
ALWAYS TELL THE NAZIS TO GO EAT SHIT
ALWAYS TELL THE NAZIS TO GO EAT SHIT
“Facing pressure to scrub its website of diversity and inclusion references, a Japanese American National Museum leader says the museum will ‘scrub nothing.’” 🔥
Japanese American National Museum takes a stand against DOGE cuts to NEH
The National Endowment for the Humanities warned museums across the country that it was slashing funding, including money previously pledged to places such as LACMA and the Japanese American National ...
www.latimes.com
April 6, 2025 at 4:20 AM
YES
ALWAYS TELL THE NAZIS TO GO EAT SHIT
ALWAYS TELL THE NAZIS TO GO EAT SHIT
Reposted
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers
can have drastically different phospholipid abundances between their two leaflets.
This lipid abundance asymmetry...
www.cell.com
April 3, 2025 at 3:07 PM
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Reposted
1) Fox News is for real not showing stock-market ticker during this week's collapse.
2) Its economic news is "strong jobs report."
3) Every time I've checked in today, the coverage has been "illegal immigrants committing new crimes."
This is state propaganda, on a par with North Korea or PRC.
2) Its economic news is "strong jobs report."
3) Every time I've checked in today, the coverage has been "illegal immigrants committing new crimes."
This is state propaganda, on a par with North Korea or PRC.
April 4, 2025 at 8:16 PM
1) Fox News is for real not showing stock-market ticker during this week's collapse.
2) Its economic news is "strong jobs report."
3) Every time I've checked in today, the coverage has been "illegal immigrants committing new crimes."
This is state propaganda, on a par with North Korea or PRC.
2) Its economic news is "strong jobs report."
3) Every time I've checked in today, the coverage has been "illegal immigrants committing new crimes."
This is state propaganda, on a par with North Korea or PRC.
Reposted
I've already had two federal grants terminated and face a 33% pay cut due to future terminations. It's painful, but not as painful as the conversations I'm having every day with brilliant trainees in graduate school and postdoctoral positions who see little future for themselves in US science.
www.nytimes.com/2025/04/03/o...
Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security
Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security
Opinion | The Uncertain Fate of the Young American Scientist (Gift Article)
Young researchers are choosing between staying in science and staying in the United States.
www.nytimes.com
April 5, 2025 at 1:09 AM
I've already had two federal grants terminated and face a 33% pay cut due to future terminations. It's painful, but not as painful as the conversations I'm having every day with brilliant trainees in graduate school and postdoctoral positions who see little future for themselves in US science.
Reposted
And yet Joe Rogan puts guests on who say "Vaccines aren't actually responsible for the reduction in infectious diseases.”
March 30, 2025 at 5:30 PM
And yet Joe Rogan puts guests on who say "Vaccines aren't actually responsible for the reduction in infectious diseases.”
Reposted
thank you Senator Young for speaking up from the Republican side of the aisle in support of funding scientific and medical research
“𝘗𝘰𝘭𝘪𝘤𝘺𝘮𝘢𝘬𝘦𝘳𝘴 𝘮𝘶𝘴𝘵 𝘴𝘶𝘧𝘧𝘪𝘤𝘪𝘦𝘯𝘵𝘭𝘺 𝘧𝘶𝘯𝘥 𝘧𝘦𝘥𝘦𝘳𝘢𝘭 𝘪𝘯𝘷𝘦𝘴𝘵𝘮𝘦𝘯𝘵 𝘪𝘯 𝘣𝘢𝘴𝘪𝘤 𝘢𝘯𝘥 𝘢𝘱𝘱𝘭𝘪𝘦𝘥 𝘴𝘤𝘪𝘦𝘯𝘤𝘦 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩 𝘢𝘴 𝘱𝘢𝘳𝘵 𝘰𝘧 𝘵𝘩𝘦 𝘢𝘯𝘯𝘶𝘢𝘭 𝘤𝘰𝘯𝘨𝘳𝘦𝘴𝘴𝘪𝘰𝘯𝘢𝘭 𝘢𝘱𝘱𝘳𝘰𝘱𝘳𝘪𝘢𝘵𝘪𝘰𝘯𝘴 𝘱𝘳𝘰𝘤𝘦𝘴𝘴”
“𝘗𝘰𝘭𝘪𝘤𝘺𝘮𝘢𝘬𝘦𝘳𝘴 𝘮𝘶𝘴𝘵 𝘴𝘶𝘧𝘧𝘪𝘤𝘪𝘦𝘯𝘵𝘭𝘺 𝘧𝘶𝘯𝘥 𝘧𝘦𝘥𝘦𝘳𝘢𝘭 𝘪𝘯𝘷𝘦𝘴𝘵𝘮𝘦𝘯𝘵 𝘪𝘯 𝘣𝘢𝘴𝘪𝘤 𝘢𝘯𝘥 𝘢𝘱𝘱𝘭𝘪𝘦𝘥 𝘴𝘤𝘪𝘦𝘯𝘤𝘦 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩 𝘢𝘴 𝘱𝘢𝘳𝘵 𝘰𝘧 𝘵𝘩𝘦 𝘢𝘯𝘯𝘶𝘢𝘭 𝘤𝘰𝘯𝘨𝘳𝘦𝘴𝘴𝘪𝘰𝘯𝘢𝘭 𝘢𝘱𝘱𝘳𝘰𝘱𝘳𝘪𝘢𝘵𝘪𝘰𝘯𝘴 𝘱𝘳𝘰𝘤𝘦𝘴𝘴”
Opinion | Funding for R&D isn’t a gift to academia
Investing in scientific research and development is vital to U.S. security.
www.washingtonpost.com
March 31, 2025 at 3:45 AM
thank you Senator Young for speaking up from the Republican side of the aisle in support of funding scientific and medical research
“𝘗𝘰𝘭𝘪𝘤𝘺𝘮𝘢𝘬𝘦𝘳𝘴 𝘮𝘶𝘴𝘵 𝘴𝘶𝘧𝘧𝘪𝘤𝘪𝘦𝘯𝘵𝘭𝘺 𝘧𝘶𝘯𝘥 𝘧𝘦𝘥𝘦𝘳𝘢𝘭 𝘪𝘯𝘷𝘦𝘴𝘵𝘮𝘦𝘯𝘵 𝘪𝘯 𝘣𝘢𝘴𝘪𝘤 𝘢𝘯𝘥 𝘢𝘱𝘱𝘭𝘪𝘦𝘥 𝘴𝘤𝘪𝘦𝘯𝘤𝘦 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩 𝘢𝘴 𝘱𝘢𝘳𝘵 𝘰𝘧 𝘵𝘩𝘦 𝘢𝘯𝘯𝘶𝘢𝘭 𝘤𝘰𝘯𝘨𝘳𝘦𝘴𝘴𝘪𝘰𝘯𝘢𝘭 𝘢𝘱𝘱𝘳𝘰𝘱𝘳𝘪𝘢𝘵𝘪𝘰𝘯𝘴 𝘱𝘳𝘰𝘤𝘦𝘴𝘴”
“𝘗𝘰𝘭𝘪𝘤𝘺𝘮𝘢𝘬𝘦𝘳𝘴 𝘮𝘶𝘴𝘵 𝘴𝘶𝘧𝘧𝘪𝘤𝘪𝘦𝘯𝘵𝘭𝘺 𝘧𝘶𝘯𝘥 𝘧𝘦𝘥𝘦𝘳𝘢𝘭 𝘪𝘯𝘷𝘦𝘴𝘵𝘮𝘦𝘯𝘵 𝘪𝘯 𝘣𝘢𝘴𝘪𝘤 𝘢𝘯𝘥 𝘢𝘱𝘱𝘭𝘪𝘦𝘥 𝘴𝘤𝘪𝘦𝘯𝘤𝘦 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩 𝘢𝘴 𝘱𝘢𝘳𝘵 𝘰𝘧 𝘵𝘩𝘦 𝘢𝘯𝘯𝘶𝘢𝘭 𝘤𝘰𝘯𝘨𝘳𝘦𝘴𝘴𝘪𝘰𝘯𝘢𝘭 𝘢𝘱𝘱𝘳𝘰𝘱𝘳𝘪𝘢𝘵𝘪𝘰𝘯𝘴 𝘱𝘳𝘰𝘤𝘦𝘴𝘴”
Reposted
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins | Science www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 27, 2025 at 10:40 PM
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins | Science www.science.org/doi/10.1126/...
Reposted
Incredible 4Pi and pan-expansion imaging of the Golgi 👇
March 29, 2025 at 4:03 PM
Incredible 4Pi and pan-expansion imaging of the Golgi 👇
Reposted
Thank you for sharing news of our initiative... we are an interdisciplinary team of researchers from U of Maryland, UPenn, and Georgia Tech + more whose aim is to communicate the impacts of federal cuts on science and health research nationwide. Full explainer thread here:
bsky.app/profile/josh...
bsky.app/profile/josh...
March 29, 2025 at 10:10 PM
Thank you for sharing news of our initiative... we are an interdisciplinary team of researchers from U of Maryland, UPenn, and Georgia Tech + more whose aim is to communicate the impacts of federal cuts on science and health research nationwide. Full explainer thread here:
bsky.app/profile/josh...
bsky.app/profile/josh...
Reposted
Pemberton, Burke, Balla et al. report the generation & characterization of an engineered active fragment of PIKfyve and its use to generate extra PI(3,5)P2 in endomembrane compartments & test the function of PI(3,5)P2 #biosensors rupress.org/jcb/article/...
#lipids #CellSignaling
#lipids #CellSignaling
March 26, 2025 at 7:17 PM
Pemberton, Burke, Balla et al. report the generation & characterization of an engineered active fragment of PIKfyve and its use to generate extra PI(3,5)P2 in endomembrane compartments & test the function of PI(3,5)P2 #biosensors rupress.org/jcb/article/...
#lipids #CellSignaling
#lipids #CellSignaling
Reposted
Hey fellow Drosophila researchers - if you haven't heard, the UMGC is offering ultra low-cost genome sequencing! See here to learn more: z.umn.edu/UMGC-MOSS #Dros25
March 22, 2025 at 11:39 PM
Hey fellow Drosophila researchers - if you haven't heard, the UMGC is offering ultra low-cost genome sequencing! See here to learn more: z.umn.edu/UMGC-MOSS #Dros25