Ian Sudbery
@iansudbery.bsky.social
Senior Lecturer in Bioinformatics at the University of Sheffield. Likes gene regulation, 3' UTRs, non-coding RNA and dancing. He/Him/His
Also at [email protected]
Also at [email protected]
Reposted by Ian Sudbery
🧵 1/ In bioinformatics, cutoffs rule everything.
What’s “significant”? What’s not?
Let’s talk thresholds—and how they shape your science.
What’s “significant”? What’s not?
Let’s talk thresholds—and how they shape your science.
November 22, 2025 at 2:15 PM
🧵 1/ In bioinformatics, cutoffs rule everything.
What’s “significant”? What’s not?
Let’s talk thresholds—and how they shape your science.
What’s “significant”? What’s not?
Let’s talk thresholds—and how they shape your science.
Reposted by Ian Sudbery
My alma mater, Leicester University, is dissolving its Geology Department leading to the loss of 14 staff. Palaeo is being completely axed, despite Leicester's long and storied history in this area (and its current strengths). Please sign this petition!!: www.change.org/p/save-geolo...
Sign the Petition
Save Geology at the University of Leicester
www.change.org
November 19, 2025 at 9:10 AM
My alma mater, Leicester University, is dissolving its Geology Department leading to the loss of 14 staff. Palaeo is being completely axed, despite Leicester's long and storied history in this area (and its current strengths). Please sign this petition!!: www.change.org/p/save-geolo...
Reposted by Ian Sudbery
people are actually very susceptible to just-so stories about human origins because listening to bullshit helped us survive on the savanna
fake evo-psych has cooked a lot of people's brains
November 18, 2025 at 1:48 AM
people are actually very susceptible to just-so stories about human origins because listening to bullshit helped us survive on the savanna
Reposted by Ian Sudbery
I am on strike this week, in support of colleagues placed at risk of compulsory redundancy.
www.ucu.org.uk/article/1423...
If you a student and want to know more/how to support the strike, see here: ucu.group.shef.ac.uk/industrial-a...
@sheffielducu.bsky.social
www.ucu.org.uk/article/1423...
If you a student and want to know more/how to support the strike, see here: ucu.group.shef.ac.uk/industrial-a...
@sheffielducu.bsky.social
November 17, 2025 at 9:21 AM
I am on strike this week, in support of colleagues placed at risk of compulsory redundancy.
www.ucu.org.uk/article/1423...
If you a student and want to know more/how to support the strike, see here: ucu.group.shef.ac.uk/industrial-a...
@sheffielducu.bsky.social
www.ucu.org.uk/article/1423...
If you a student and want to know more/how to support the strike, see here: ucu.group.shef.ac.uk/industrial-a...
@sheffielducu.bsky.social
Reposted by Ian Sudbery
Saw the sun rise across the Pennines this morning as I was on my way to Sheffield, sadly I’m here because we’re on strike to stand against compulsory redundancies at Sheffield, the continued erosion of our working conditions & students’ learning conditions
@sheffielducu.bsky.social
@sheffielducu.bsky.social
November 17, 2025 at 12:05 PM
Saw the sun rise across the Pennines this morning as I was on my way to Sheffield, sadly I’m here because we’re on strike to stand against compulsory redundancies at Sheffield, the continued erosion of our working conditions & students’ learning conditions
@sheffielducu.bsky.social
@sheffielducu.bsky.social
Reposted by Ian Sudbery
On strike again to fight back against the relentless pursuit of damaging cuts and restructures by the appalling management at @sheffielduni.bsky.social We won't stand idly by while they continue to drive this institution into the ground! @sheffielducu.bsky.social
November 17, 2025 at 2:52 PM
On strike again to fight back against the relentless pursuit of damaging cuts and restructures by the appalling management at @sheffielduni.bsky.social We won't stand idly by while they continue to drive this institution into the ground! @sheffielducu.bsky.social
Reposted by Ian Sudbery
First day of #UCU @sheffielducu.bsky.social strike action today - trying to prevent further compulsory redundancies.
And a well attended rally afterwards with our comrades from @ucuhallam.bsky.social
And a well attended rally afterwards with our comrades from @ucuhallam.bsky.social
November 17, 2025 at 2:38 PM
First day of #UCU @sheffielducu.bsky.social strike action today - trying to prevent further compulsory redundancies.
And a well attended rally afterwards with our comrades from @ucuhallam.bsky.social
And a well attended rally afterwards with our comrades from @ucuhallam.bsky.social
Reposted by Ian Sudbery
This morning picket @sheffielducu.bsky.social 💪
November 17, 2025 at 1:09 PM
This morning picket @sheffielducu.bsky.social 💪
Reposted by Ian Sudbery
Back at the picket line again today. Here’s why: www.ucu.org.uk/article/1423... @sheffielducu.bsky.social @ucu.org.uk #SheffieldUCU #strike
November 17, 2025 at 12:33 PM
Back at the picket line again today. Here’s why: www.ucu.org.uk/article/1423... @sheffielducu.bsky.social @ucu.org.uk #SheffieldUCU #strike
Reposted by Ian Sudbery
Solidarity with @sheffielducu.bsky.social with their strike action beginning today. We need to defend HE against the onslaught of cuts and redundancies that threaten the ability to do creative, radical and important research!
November 17, 2025 at 10:03 AM
Solidarity with @sheffielducu.bsky.social with their strike action beginning today. We need to defend HE against the onslaught of cuts and redundancies that threaten the ability to do creative, radical and important research!
Reposted by Ian Sudbery
Someone told me a real story: an AI team worked hard on a model to decipher the immune cell function.
Someone with biology background: what data did you use for the training?
Someone with biology background: what data did you use for the training?
November 17, 2025 at 12:22 AM
Someone told me a real story: an AI team worked hard on a model to decipher the immune cell function.
Someone with biology background: what data did you use for the training?
Someone with biology background: what data did you use for the training?
You can now using markdown in Google Docs!
November 14, 2025 at 1:56 PM
You can now using markdown in Google Docs!
Lies I tell you, Lies!
The difference in time between now and I can has cheezburger
Is the same between I can has Cheezburger and the Berlin Wall falling
Is the same between I can has Cheezburger and the Berlin Wall falling
November 14, 2025 at 1:02 PM
Lies I tell you, Lies!
Reposted by Ian Sudbery
![[Scene is a kitchen - a middle aged woman called JANET is boiling peas at the stove. A younger more colourfully dressed woman named LIZ approached her.]
JANET:
Ugh...
LIZ:
What's up?
JANET:
I am so bored of cooking peas!
LIZ:
Have you tried...
AI peas?
JANET:
AI peas?
LIZ:
They're peas with AI!
[Liz holds up to us a packet of peas labelled: Pea-i AI - Peas with AI].
LIZ:
Al-powered peas harness the potential of your peas
JANET:
What
LIZ [Now a voiceover as we cut to a whizzy technology diagram of peas all connected by meaningless dotted lines]
Why not take your peas to the next level with Al Peas' new Al tools to power your peas?
[Show a techno diagram of a pea with a label reading 'AI' pointing to a random zone in it]
LIZ:
Each pea has Al in a way we haven't quite worked out yet but it's fine
[Show Janet and Liz now in a Matrix-style world of peas]
LIZ:
With Al peas you can supercharge productivity and make AI work for your peas!
JANET:
What
LIZ:
Shut up
LIZ:
Our game-changing Pea-Al gives you the freedom to unlock the potential of the power of the future of your peas workflow
From opening the bag of peas
to boiling the peas
to eating the peas
To spending millions on adding Al to the peas and then having to work out what that even means.
JANET:
Is it really necessary to-
LIZ [Grabbing Janet by the collar]:
THE PEAS HAVE GOT AI, JANET
[Cut to an advert ending screen, with the bag of peas and the slogan:
AI PEAS: Just 'Peas' for god's sake buy the AI peas.
[Ends]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:4m3we4apbjayclzcnhwe3pfp/bafkreiayqa37f7kik7l7s7fbtfp2sir5ckb662ry2lylinyjrfa2rkvvka@jpeg)
Reposted by Ian Sudbery
Powerful read processing with matchbox https://www.biorxiv.org/content/10.1101/2025.11.09.685711v1
November 11, 2025 at 9:47 PM
Powerful read processing with matchbox https://www.biorxiv.org/content/10.1101/2025.11.09.685711v1
Tip for authors: If you keep telling me how insightful/perceptive/interesting/relevant my comments are in your response to reviewers, I'm not going to think you respect me, I'm going to think you used genAI to write the response.
November 11, 2025 at 11:53 AM
Tip for authors: If you keep telling me how insightful/perceptive/interesting/relevant my comments are in your response to reviewers, I'm not going to think you respect me, I'm going to think you used genAI to write the response.
Reposted by Ian Sudbery
yes. being a leftwing ex-Orthodox Jew, I maybe straddle a wider range of views among my friends and family than some (than many?)
it may be shocking to learn that: every bias I have ever seen the BBC accused of, I have also heard someone else say they have the precise opposite one
it may be shocking to learn that: every bias I have ever seen the BBC accused of, I have also heard someone else say they have the precise opposite one
In response to some of the comments:
If you agree with *all* the reporting of a news organisation that is both independent *and* non-partisan, then it's very unlikely to be independent and non-partisan.
This is true regardless of your politics.
Agreeing with all its reporting is the wrong test
If you agree with *all* the reporting of a news organisation that is both independent *and* non-partisan, then it's very unlikely to be independent and non-partisan.
This is true regardless of your politics.
Agreeing with all its reporting is the wrong test
Information underpins democracy and the BBC is a key part of that.
We need to protect our institutions
open.substack.com/pub/christin...
We need to protect our institutions
open.substack.com/pub/christin...
November 11, 2025 at 10:47 AM
yes. being a leftwing ex-Orthodox Jew, I maybe straddle a wider range of views among my friends and family than some (than many?)
it may be shocking to learn that: every bias I have ever seen the BBC accused of, I have also heard someone else say they have the precise opposite one
it may be shocking to learn that: every bias I have ever seen the BBC accused of, I have also heard someone else say they have the precise opposite one
Reposted by Ian Sudbery
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Human DICER1 hotspot mutation induces both loss and gain of miRNA function
Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...
rdcu.be
November 10, 2025 at 4:43 PM
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Reposted by Ian Sudbery
Picket demonstrating feeling about announcements of cuts to courses at University of Nottingham @uonucu.bsky.social @ucu.org.uk
November 10, 2025 at 9:32 AM
Picket demonstrating feeling about announcements of cuts to courses at University of Nottingham @uonucu.bsky.social @ucu.org.uk
Reposted by Ian Sudbery
This seems likely true from some research we have ongoing as well. One persistent problem the NHS has is it's held to a punishing standard of "efficiency" where it's always running at close to capacity, but any operations researcher will tell you run at 80% or so.
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Will a new mutated flu strain cause a rough winter?
Leading flu experts say they will not be surprised if this year's is the worst flu season for a decade.
www.bbc.co.uk
November 9, 2025 at 7:29 AM
This seems likely true from some research we have ongoing as well. One persistent problem the NHS has is it's held to a punishing standard of "efficiency" where it's always running at close to capacity, but any operations researcher will tell you run at 80% or so.
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Reposted by Ian Sudbery
Are you using any of our factor models, such as MOFA? 🛵
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
November 7, 2025 at 10:29 AM
Are you using any of our factor models, such as MOFA? 🛵
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
Reposted by Ian Sudbery
Staff at Dundee University are taking action again next week to defend jobs and resist compulsory redundancies.
A year after the university’s financial crisis, uncertainty still hangs over hundreds of staff.
Solidarity with Dundee UCU members fighting for fairness and job security. ✊
A year after the university’s financial crisis, uncertainty still hangs over hundreds of staff.
Solidarity with Dundee UCU members fighting for fairness and job security. ✊
News that further job cuts are coming is just another shocking revelation in a year when staff have been told one thing only to be told something different over the number of jobs to be cut and the need for compulsory redundancies.
DUCU co-president, Melissa D’Ascenzio
news.stv.tv/north/dundee...
DUCU co-president, Melissa D’Ascenzio
news.stv.tv/north/dundee...
University staff strikes set to continue amid job cut threats
Further strike action is expected from UCU members from November 10 next week amid a long running dispute with university bosses.
news.stv.tv
November 5, 2025 at 11:10 AM
Staff at Dundee University are taking action again next week to defend jobs and resist compulsory redundancies.
A year after the university’s financial crisis, uncertainty still hangs over hundreds of staff.
Solidarity with Dundee UCU members fighting for fairness and job security. ✊
A year after the university’s financial crisis, uncertainty still hangs over hundreds of staff.
Solidarity with Dundee UCU members fighting for fairness and job security. ✊
Reposted by Ian Sudbery
Chris' lab does very cool work, can recommend highly.
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:27 AM
Chris' lab does very cool work, can recommend highly.
Important to note that this is 3'-end sequencing, not full transcript sequening, so no use to anyone interested in transcript-structure, splicing, unannotated genes, or non-polyA transcripts.
But still, whole genome gene-expression, from cell pellet samples in 3 days for $50 is pretty amazing.
But still, whole genome gene-expression, from cell pellet samples in 3 days for $50 is pretty amazing.
🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
Plasmidsaurus now offers RNA sequencing for gene expression analysis:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results
Explore Plasmidsaurus RNA-Seq today.
November 3, 2025 at 1:32 PM
Important to note that this is 3'-end sequencing, not full transcript sequening, so no use to anyone interested in transcript-structure, splicing, unannotated genes, or non-polyA transcripts.
But still, whole genome gene-expression, from cell pellet samples in 3 days for $50 is pretty amazing.
But still, whole genome gene-expression, from cell pellet samples in 3 days for $50 is pretty amazing.
Reposted by Ian Sudbery
Next week LinkedIn will use your personal data for AI training by automatically enabling permissions.
To manually turn off go to:
Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off
To manually turn off go to:
Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off
November 2, 2025 at 5:07 AM
Next week LinkedIn will use your personal data for AI training by automatically enabling permissions.
To manually turn off go to:
Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off
To manually turn off go to:
Settings ➡️ Data Privacy ➡️ under
“How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off