Sandra Hake
@hake-chromatin.bsky.social
Professor for Genetics interested in chromatin structure, histone variants and histone modifications and their roles in gene regulation and disease development.
Reposted by Sandra Hake
Reposted by Sandra Hake
Extremely proud of my PhD student Lena Paasche, who won the prize for the best short-talk at the @gfgenetik.bsky.social symposium on "Epigenetics & Chromatin"! She is amazing: as scientist and as a wonderful and empathic person!
October 7, 2025 at 8:34 AM
Extremely proud of my PhD student Lena Paasche, who won the prize for the best short-talk at the @gfgenetik.bsky.social symposium on "Epigenetics & Chromatin"! She is amazing: as scientist and as a wonderful and empathic person!
Reposted by Sandra Hake
It has been a lot of fun to present our research focus and get to know the @gfgenetik.bsky.social! Thank you so much for having me and organising this great symposium! Looking forward to the next one!
Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.
September 28, 2025 at 2:38 PM
It has been a lot of fun to present our research focus and get to know the @gfgenetik.bsky.social! Thank you so much for having me and organising this great symposium! Looking forward to the next one!
Reposted by Sandra Hake
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin
Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...
www.biorxiv.org
September 27, 2025 at 6:55 AM
This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
Reposted by Sandra Hake
Pioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics.
#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
September 26, 2025 at 4:17 PM
Pioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics.
#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
Reposted by Sandra Hake
It was an awesome meeting! Fruitful discussion and lots of networking. Thanks to all attendees! More fotos will follow soon.
September 26, 2025 at 5:37 PM
It was an awesome meeting! Fruitful discussion and lots of networking. Thanks to all attendees! More fotos will follow soon.
Reposted by Sandra Hake
Just half a day in and it’s been a blast, with really incredible talks here on Giessen!
What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
Looking forward to exciting talks at the GfG Symposium in Gießen.
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
September 25, 2025 at 6:37 AM
Just half a day in and it’s been a blast, with really incredible talks here on Giessen!
Reposted by Sandra Hake
Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.
September 25, 2025 at 9:56 PM
Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.
Reposted by Sandra Hake
What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
Looking forward to exciting talks at the GfG Symposium in Gießen.
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
September 24, 2025 at 7:23 PM
What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
Reposted by Sandra Hake
Looking forward to exciting talks at the GfG Symposium in Gießen.
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
September 24, 2025 at 12:38 PM
Looking forward to exciting talks at the GfG Symposium in Gießen.
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud
#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social
Reposted by Sandra Hake
Please re-post:
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
EvoChromo: Evolutionary approaches to research in chromatin
Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…
meetings.embo.org
September 8, 2025 at 11:14 AM
Please re-post:
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Reposted by Sandra Hake
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Reposted by Sandra Hake
Useful data set:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Morphological map of under- and overexpression of genes in human cells - Nature Methods
This Resource presents the genetic subset of the 136,000 chemical and genetic perturbations tested by the Joint Undertaking for Morphological Profiling (JUMP) Cell Painting Consortium and associated a...
www.nature.com
September 4, 2025 at 12:28 PM
Useful data set:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sandra Hake
What makes genes burst www.cell.com/trends/cell-...
What makes genes burst
Genes burst. Instead of being monotonously transcribed by a steady stream of RNA polymerases,
active genes undergo transient and random pulses of transcription that are referred
to as gene bursting. T...
www.cell.com
September 3, 2025 at 8:45 PM
What makes genes burst www.cell.com/trends/cell-...
Reposted by Sandra Hake
out today: my labmate Shubham developed a super clever new technique to profile TF-DNA interactions with unprecedented resolution of low-affinity binding sites, revealing patterns in how these sites are organized in the genome to modulate TF occupancy:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multiple overlapping binding sites determine transcription factor occupancy - Nature
A new method enables comprehensive screening and identification of low-affinity DNA binding sites for transcription factors, and reveals that nucleotides flanking high-affinity binding sites create ov...
www.nature.com
September 3, 2025 at 3:33 PM
out today: my labmate Shubham developed a super clever new technique to profile TF-DNA interactions with unprecedented resolution of low-affinity binding sites, revealing patterns in how these sites are organized in the genome to modulate TF occupancy:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sandra Hake
Reposted by Sandra Hake
In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...
Preventing CpG hypermethylation in oocytes safeguards mouse development
Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases
restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b
knockout embryos die dur...
www.cell.com
September 2, 2025 at 3:54 PM
In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...
Reposted by Sandra Hake
Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders - GW4 BioMed MRC DTP
Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Sum...
gw4biomed.ac.uk
September 2, 2025 at 12:22 PM
Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
Reposted by Sandra Hake
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Reposted by Sandra Hake
Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...
Supervisors and Projects
www.bioch.ox.ac.uk
September 1, 2025 at 9:27 AM
Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...
Reposted by Sandra Hake
Two new druggable targets in ERG-driven prostate cancer - KMT2A and DOT1L www.nature.com/articles/s41...
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L - Nature Genetics
Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an enrichment for STAT3 ch...
www.nature.com
September 1, 2025 at 11:43 AM
Two new druggable targets in ERG-driven prostate cancer - KMT2A and DOT1L www.nature.com/articles/s41...
Reposted by Sandra Hake
Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins - Nature Communications
Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...
www.nature.com
August 29, 2025 at 7:27 PM
Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
Reposted by Sandra Hake
One more movie!
Using the RL algorithm (from pnas.org/doi/10.1073/...),
@masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility.
Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)
Using the RL algorithm (from pnas.org/doi/10.1073/...),
@masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility.
Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)
August 29, 2025 at 12:36 AM
One more movie!
Using the RL algorithm (from pnas.org/doi/10.1073/...),
@masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility.
Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)
Using the RL algorithm (from pnas.org/doi/10.1073/...),
@masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility.
Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)
Reposted by Sandra Hake
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
August 28, 2025 at 12:48 PM
If you like transcription regulation and its mechanisms, this WIP list is for you.
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB
I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.
go.bsky.app/8vTgeXB