Guillaume Méric
@gmeric.bsky.social
🇪🇺 🇫🇷 🇦🇺 in 🇬🇧 (he/him) | www.mericlab.com
Human microbiome(s), pathogen ecology & host-microbe genomics
Associate Professor @uniofbath.bsky.social
Clinical Affiliate @bakerresearchau.bsky.social @cambridgebaker.bsky.social
📍Bath, UK
Human microbiome(s), pathogen ecology & host-microbe genomics
Associate Professor @uniofbath.bsky.social
Clinical Affiliate @bakerresearchau.bsky.social @cambridgebaker.bsky.social
📍Bath, UK
Pinned
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
www.findaphd.com
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
Reposted by Guillaume Méric
Previous multiple sclerosis, now the potential role of Epstein Barr virus for driving lupus (SLE)
science.org/doi/10.1126/...
science.org/doi/10.1126/...
November 12, 2025 at 7:56 PM
Previous multiple sclerosis, now the potential role of Epstein Barr virus for driving lupus (SLE)
science.org/doi/10.1126/...
science.org/doi/10.1126/...
Reposted by Guillaume Méric
Guillaume has just moved on from the lab to a super exciting Assoc Prof in Microbiome at the University of Bath... he's amazing and if you're keen on a PhD check this out!
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
www.findaphd.com
November 12, 2025 at 1:49 PM
Guillaume has just moved on from the lab to a super exciting Assoc Prof in Microbiome at the University of Bath... he's amazing and if you're keen on a PhD check this out!
Thank you for the invitation! It was very nice to visit Norwich again. Great discussions on the day.
Celebrating our Annual Science Meeting organised by the Quadram Science Voice🧪
Staff came together to discuss recent advances, what’s next and reflect on their career paths 👣
Plus, @gmeric.bsky.social spoke about his research using large datasets to decipher links between gut microbes and health.
Staff came together to discuss recent advances, what’s next and reflect on their career paths 👣
Plus, @gmeric.bsky.social spoke about his research using large datasets to decipher links between gut microbes and health.
November 12, 2025 at 1:21 PM
Thank you for the invitation! It was very nice to visit Norwich again. Great discussions on the day.
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
www.findaphd.com
November 12, 2025 at 1:20 PM
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
Reposted by Guillaume Méric
QUESTION: anyone knows of a published example of a gene/operon which is toxic in Pseudomonas aeruginosa if in high copy plasmids, but ok in low copy? Got plenty of examples of my own for E. coli (esp of membrane protein genes), but struggling to find for Pae… Cheers!
#microsky #synbio
#microsky #synbio
October 13, 2025 at 12:48 PM
Reposted by Guillaume Méric
Does anyone know good intro videos describing "big picture" what sequence-analysis (ie mapping, assembly) is all about? I'm going to dig through @benlangmead.bsky.social 's amazing trove of videos, but I think they may be too compsci oriented for the biology student who's asking me about it
October 9, 2025 at 7:55 AM
Does anyone know good intro videos describing "big picture" what sequence-analysis (ie mapping, assembly) is all about? I'm going to dig through @benlangmead.bsky.social 's amazing trove of videos, but I think they may be too compsci oriented for the biology student who's asking me about it
Reposted by Guillaume Méric
Manually curated and harmonized metadata for over 110k metagenomic samples! (58k samples from the human gut alone!)🦠
Proud to have contributed to Metalog, the latest @borklab.bsky.social resource:
www.biorxiv.org/content/10.1...
#microsky #microbiome
Proud to have contributed to Metalog, the latest @borklab.bsky.social resource:
www.biorxiv.org/content/10.1...
#microsky #microbiome
August 15, 2025 at 1:54 PM
Manually curated and harmonized metadata for over 110k metagenomic samples! (58k samples from the human gut alone!)🦠
Proud to have contributed to Metalog, the latest @borklab.bsky.social resource:
www.biorxiv.org/content/10.1...
#microsky #microbiome
Proud to have contributed to Metalog, the latest @borklab.bsky.social resource:
www.biorxiv.org/content/10.1...
#microsky #microbiome
Reposted by Guillaume Méric
Our capability to prevent diseases from occurring is gaining momentum. Using A.I. to predict >1,200 diseases 20 years ahead adds to the ways we'll be able to achieve primary prevention.
nature.com/articles/d41...
erictopol.substack.com/p/dawn-of-a-...
nature.com/articles/d41...
erictopol.substack.com/p/dawn-of-a-...
October 1, 2025 at 4:30 PM
Our capability to prevent diseases from occurring is gaining momentum. Using A.I. to predict >1,200 diseases 20 years ahead adds to the ways we'll be able to achieve primary prevention.
nature.com/articles/d41...
erictopol.substack.com/p/dawn-of-a-...
nature.com/articles/d41...
erictopol.substack.com/p/dawn-of-a-...
Reposted by Guillaume Méric
Children and teens who had a Covid reinfection had a doubling of #LongCovid risk (PASC) and a significant increase in many other adverse outcomes (Figure) www.thelancet.com/journals/lan...
September 30, 2025 at 10:35 PM
Children and teens who had a Covid reinfection had a doubling of #LongCovid risk (PASC) and a significant increase in many other adverse outcomes (Figure) www.thelancet.com/journals/lan...
Reposted by Guillaume Méric
Staggering analysis here linking ciprofloxacin resistance to specific mutations in #Klebsiella.
In short, using ONLY genotype, one can reasonably predict phenotypic CIP MICs! See Fig 3 (below).
Loving the splitting of MIC and disk diffusion data as well.
#AMR #MicroSky #IDSky
In short, using ONLY genotype, one can reasonably predict phenotypic CIP MICs! See Fig 3 (below).
Loving the splitting of MIC and disk diffusion data as well.
#AMR #MicroSky #IDSky
September 27, 2025 at 6:07 AM
Staggering analysis here linking ciprofloxacin resistance to specific mutations in #Klebsiella.
In short, using ONLY genotype, one can reasonably predict phenotypic CIP MICs! See Fig 3 (below).
Loving the splitting of MIC and disk diffusion data as well.
#AMR #MicroSky #IDSky
In short, using ONLY genotype, one can reasonably predict phenotypic CIP MICs! See Fig 3 (below).
Loving the splitting of MIC and disk diffusion data as well.
#AMR #MicroSky #IDSky
Reposted by Guillaume Méric
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
September 25, 2025 at 9:29 PM
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
Reposted by Guillaume Méric
A new study, based on a survey of 1,150 workers suggests that the injection of AI tools into the workplace has not resulted in a magic productivity boom and instead increased the amount of time that workers say they spend fixing low-quality AI-generated “work.”
🔗 www.404media.co/ai-workslop-...
🔗 www.404media.co/ai-workslop-...
AI ‘Workslop’ Is Killing Productivity and Making Workers Miserable
AI slop is taking over workplaces. Workers said that they thought of their colleagues who filed low-quality AI work as "less creative, capable, and reliable than they did before receiving the output."
www.404media.co
September 23, 2025 at 3:53 PM
A new study, based on a survey of 1,150 workers suggests that the injection of AI tools into the workplace has not resulted in a magic productivity boom and instead increased the amount of time that workers say they spend fixing low-quality AI-generated “work.”
🔗 www.404media.co/ai-workslop-...
🔗 www.404media.co/ai-workslop-...
Reposted by Guillaume Méric
Great to see this out there! We infer the evolutionary pathways behind patterns of AMR in Klebsiella across 102 states, finding globally consistent principles, state-specific deviations (and covariates), and validating evol predictions with new genomes. biorxiv.org/content/10.1... 1/
September 22, 2025 at 7:56 AM
Great to see this out there! We infer the evolutionary pathways behind patterns of AMR in Klebsiella across 102 states, finding globally consistent principles, state-specific deviations (and covariates), and validating evol predictions with new genomes. biorxiv.org/content/10.1... 1/
Reposted by Guillaume Méric
If you are UK-based and working on any aspect of microbiomes (human, plant, insect, soil, animal, ...), please do sign up to Microbiome-Net for details of networking, funding and training opportunities.
forms.office.com/pages/respon...
forms.office.com/pages/respon...
September 13, 2025 at 6:31 AM
If you are UK-based and working on any aspect of microbiomes (human, plant, insect, soil, animal, ...), please do sign up to Microbiome-Net for details of networking, funding and training opportunities.
forms.office.com/pages/respon...
forms.office.com/pages/respon...
Reposted by Guillaume Méric
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
September 2, 2025 at 11:08 PM
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Reposted by Guillaume Méric
Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia:
doi.org/10.5281/zeno...
We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical
thinking, expertise, academic freedom, & scientific integrity.
1/n
doi.org/10.5281/zeno...
We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical
thinking, expertise, academic freedom, & scientific integrity.
1/n
September 6, 2025 at 8:13 AM
Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia:
doi.org/10.5281/zeno...
We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical
thinking, expertise, academic freedom, & scientific integrity.
1/n
doi.org/10.5281/zeno...
We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical
thinking, expertise, academic freedom, & scientific integrity.
1/n
Reposted by Guillaume Méric
A plasmid golden ratio? 🧬
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky
September 9, 2025 at 3:54 AM
A plasmid golden ratio? 🧬
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky
Reposted by Guillaume Méric
New blog post!
I added a new feature to @gbouras13.bsky.social's Pypolca: homopolymer-only polishing. Potentially useful for cross-sample polishing - early test on Cryptosporidium looks promising.
Check it out here:
rrwick.github.io/2025/09/04/h...
I added a new feature to @gbouras13.bsky.social's Pypolca: homopolymer-only polishing. Potentially useful for cross-sample polishing - early test on Cryptosporidium looks promising.
Check it out here:
rrwick.github.io/2025/09/04/h...
Cross-sample homopolymer polishing with Pypolca
a blog for miscellaneous bioinformatics stuff
rrwick.github.io
September 4, 2025 at 6:37 AM
New blog post!
I added a new feature to @gbouras13.bsky.social's Pypolca: homopolymer-only polishing. Potentially useful for cross-sample polishing - early test on Cryptosporidium looks promising.
Check it out here:
rrwick.github.io/2025/09/04/h...
I added a new feature to @gbouras13.bsky.social's Pypolca: homopolymer-only polishing. Potentially useful for cross-sample polishing - early test on Cryptosporidium looks promising.
Check it out here:
rrwick.github.io/2025/09/04/h...
Reposted by Guillaume Méric
Very happy to have been awarded Best Medium Talk at #MicroSeq2025! 🌟
Wonderful to see archaea receiving more attention in human microbiome research :)
Wonderful to see archaea receiving more attention in human microbiome research :)
First up, our Australian Society for Microbiology Awards! Best Lightning Talk goes to Penelope Galbraith, and Best Medium Talk to @gazollavolpiano.bsky.social! Thanks to @aussocmic.bsky.social for sponsoring these prizes, and congratulations to Penelope and Camila! Very well-deserved. #MicroSeq2025
September 4, 2025 at 6:30 AM
Very happy to have been awarded Best Medium Talk at #MicroSeq2025! 🌟
Wonderful to see archaea receiving more attention in human microbiome research :)
Wonderful to see archaea receiving more attention in human microbiome research :)
Reposted by Guillaume Méric
Pressures on science funding increasing, part 267
In 2025, the ERC received 3,329 proposals for Advanced Grant funding — 31% more than last year!
The selected projects will likely be announced in the spring of 2026.
More facts and figures on #ERCAdG applications 👇 europa.eu/!bm9gPT
#FrontierResearch
The selected projects will likely be announced in the spring of 2026.
More facts and figures on #ERCAdG applications 👇 europa.eu/!bm9gPT
#FrontierResearch
Applications for ERC Advanced Grants 2025: Facts and figures
The ERC Advanced Grants 2025 call closed for applications on 28 August 2025. These are the preliminary data on the submitted proposals:
europa.eu
September 2, 2025 at 11:54 AM
Pressures on science funding increasing, part 267
Reposted by Guillaume Méric
Only ONE more week to #MicroSeq2025! 🤩
The conference booklet (incl. schedule) will be released on Monday, September 1st. Registration is open until 11:59pm September 2nd, so there's still plenty of time to join the fun! Don't miss out!
Register below 👇
trybooking.com/events/landing/1424679
The conference booklet (incl. schedule) will be released on Monday, September 1st. Registration is open until 11:59pm September 2nd, so there's still plenty of time to join the fun! Don't miss out!
Register below 👇
trybooking.com/events/landing/1424679
August 27, 2025 at 2:25 AM
Only ONE more week to #MicroSeq2025! 🤩
The conference booklet (incl. schedule) will be released on Monday, September 1st. Registration is open until 11:59pm September 2nd, so there's still plenty of time to join the fun! Don't miss out!
Register below 👇
trybooking.com/events/landing/1424679
The conference booklet (incl. schedule) will be released on Monday, September 1st. Registration is open until 11:59pm September 2nd, so there's still plenty of time to join the fun! Don't miss out!
Register below 👇
trybooking.com/events/landing/1424679
Reposted by Guillaume Méric
Covid accelerates vascular aging
An 18-country, 38-center study of ~2,000 participants
—Effect predominantly in women, adding 5 years of aging
—Seen with non-hospitalized and mild-moderate Covid
—Reversible in some at 1-year; vaccination link to protection
apps.crossref.org/pendingpub/p...
An 18-country, 38-center study of ~2,000 participants
—Effect predominantly in women, adding 5 years of aging
—Seen with non-hospitalized and mild-moderate Covid
—Reversible in some at 1-year; vaccination link to protection
apps.crossref.org/pendingpub/p...
August 17, 2025 at 11:09 PM
Covid accelerates vascular aging
An 18-country, 38-center study of ~2,000 participants
—Effect predominantly in women, adding 5 years of aging
—Seen with non-hospitalized and mild-moderate Covid
—Reversible in some at 1-year; vaccination link to protection
apps.crossref.org/pendingpub/p...
An 18-country, 38-center study of ~2,000 participants
—Effect predominantly in women, adding 5 years of aging
—Seen with non-hospitalized and mild-moderate Covid
—Reversible in some at 1-year; vaccination link to protection
apps.crossref.org/pendingpub/p...
Reposted by Guillaume Méric
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Reposted by Guillaume Méric
Was great to put the dream team back together for a commentary on this with @alisonmather.bsky.social very cool study on AMR flow through food production chains in Europe www.nature.com/articles/s41...
July 31, 2025 at 10:26 AM
Was great to put the dream team back together for a commentary on this with @alisonmather.bsky.social very cool study on AMR flow through food production chains in Europe www.nature.com/articles/s41...
Reposted by Guillaume Méric
#Review
A discussion on the processes driving bacterial evolution and emergence of pathogenesis within hosts, the importance of understanding within-host genetic diversity, and the implications for transmission analysis and infectious disease control.
#MicroSky 🦠
www.nature.com/articles/s41...
A discussion on the processes driving bacterial evolution and emergence of pathogenesis within hosts, the importance of understanding within-host genetic diversity, and the implications for transmission analysis and infectious disease control.
#MicroSky 🦠
www.nature.com/articles/s41...
Within-host bacterial evolution and the emergence of pathogenicity - Nature Microbiology
In this Review, Tonkin-Hill et al. discuss the processes driving bacterial evolution and emergence of pathogenesis within hosts, the importance of understanding within-host genetic diversity, and the ...
www.nature.com
July 30, 2025 at 3:40 PM
#Review
A discussion on the processes driving bacterial evolution and emergence of pathogenesis within hosts, the importance of understanding within-host genetic diversity, and the implications for transmission analysis and infectious disease control.
#MicroSky 🦠
www.nature.com/articles/s41...
A discussion on the processes driving bacterial evolution and emergence of pathogenesis within hosts, the importance of understanding within-host genetic diversity, and the implications for transmission analysis and infectious disease control.
#MicroSky 🦠
www.nature.com/articles/s41...