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Reposted by Arun Durvasula

Rick Steves @ricksteves.bsky.social · 3d

Thread:

A year ago yesterday was a very happy day for me. I had lost my prostate. It was good riddance, as it was riddled with cancer. I’m now cancer-free — and thankful for the tax-funded technology that saved my life.

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Reposted by Arun Durvasula

Molecular Biology and Evolution @molbioevol.bsky.social · 3d

The MBE Best Student Paper award of 2024 goes to Julien Joseph (winner) and William S. Henriques (runner-up).

👏 Congratulations Julien and William for this recognition of your amazing work!

Check below for details on their research ⬇️

MBE Best Student Paper of 2024 award | Julien Joseph (Winner), William S. Henriques (Honorable mention)

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Reposted by Arun Durvasula

Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 3d

PEQG website live! genetics-gsa.org/peqg-2026/

Homepage - 2026 Population, Evolutionary, and Quantitative Genetics Conference

Visit our website to learn more.

genetics-gsa.org

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Reposted by Arun Durvasula

Genetics Society of America @genetics-gsa.bsky.social · 4d

Science is intertwined with eugenics, and eugenic ideologies continue to negatively impact #Indigenous communities and science today.

Read a timely and important perspective piece in #GENETICS from @jazlynmooney.bsky.social and colleagues: buff.ly/T7rbV3k

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Reposted by Arun Durvasula

Ben Strober @bennystrobes.bsky.social · 5d

Exciting updates!!
(1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated)
(2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week!
(3) Learn more at stroberlab.com

Strober Lab

The Strober lab is a computational group at Boston Children's Hospital (a Harvard Medical School affiliated hospital) focused on developing statistical and machine learning tools applied to human gene...

stroberlab.com

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Reposted by Arun Durvasula

Stanford University Press @stanfordpress.bsky.social · 12d

Population Biology Modeling & Theory (PBMT) is a peer-reviewed journal reporting advances in modeling and theory within population biology. Its scope spans demography, ecology, epidemiology, evolutionary biology, population genetics, and phylogenetics. PBMT will be online soon.

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Reposted by Arun Durvasula

Ana Ignatieva @anaignatieva.bsky.social · 9d

Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)

The Length of Haplotype Blocks and Signals of Structural Variation in Reconstructed Genealogies

Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correla

academic.oup.com

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Reposted by Arun Durvasula

Julia Kreiner @jmkreiner.bsky.social · 23d

Would be excited to chat with folks looking for a postdoc in AI to develop models for genomic prediction...

A great opportunity for funding coming up soon is the Schmidt AI in Science fellowship, due October 13th! apply.interfolio.com/173322

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Reposted by Arun Durvasula

Kirk Lohmueller @klohmueller.bsky.social · 26d

In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!

Home

The SCalE Meeting is a free, one day regional academic meeting focused on evolutionary genetics and genomics. This year's SCalE Meeting is hosted by UCLA, sponsored by the Institute for Quantitative ...

www.scalemeeting.org

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Reposted by Arun Durvasula

Human Genetics and Genomics Advances @hggadvances.bsky.social · Sep 12

📣Online now from @arundurvasula.bsky.social & co!
📄Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers
👉https://bit.ly/47HmkYW

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Reposted by Arun Durvasula

Arun Durvasula @arundurvasula.bsky.social · Sep 12

Our work on leveraging pathway-specific polygenic scores to discover gene-environment interactions is now online at HGG Advances (@hggadvances.bsky.social). 10/10 great review process!

www.cell.com/hgg-advances...
cc @kewesterman.bsky.social

Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers

The authors describe a strategy for using pathway-specific polygenic scores to increase the detection and interpretability of gene-environment interactions, with an applied analysis uncovering genetic...

www.cell.com

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Reposted by Arun Durvasula

Arun Durvasula @arundurvasula.bsky.social · Sep 2

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

www.medrxiv.org

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Reposted by Arun Durvasula

The American Bystander @americanbystander.bsky.social · Sep 12

We regret to inform you we have returned to social media. Sorry.

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Arun Durvasula @arundurvasula.bsky.social · Sep 12

Our work on leveraging pathway-specific polygenic scores to discover gene-environment interactions is now online at HGG Advances (@hggadvances.bsky.social). 10/10 great review process!

www.cell.com/hgg-advances...
cc @kewesterman.bsky.social

Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers

The authors describe a strategy for using pathway-specific polygenic scores to increase the detection and interpretability of gene-environment interactions, with an applied analysis uncovering genetic...

www.cell.com

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Arun Durvasula @arundurvasula.bsky.social · Sep 9

First author @xilinjiang.bsky.social is now on Bluesky!

Arun Durvasula @arundurvasula.bsky.social · Sep 2

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

www.medrxiv.org

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Reposted by Arun Durvasula

Jeffrey Ross-Ibarra @jrossibarra.bsky.social · Sep 3

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

Homepage - Population, Evolutionary, and Quantitative Genetics Conference

Visit our website to learn more.

genetics-gsa.org

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Reposted by Arun Durvasula

Mike Inouye @mikeinouye.bsky.social · Sep 3

📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1...

Very cool results: Accumulating E with age reduces heritability & PGS effects

Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social

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Arun Durvasula @arundurvasula.bsky.social · Sep 2

There's a lot more that would take quite a bit more space to explain, so please check out the manuscript: www.medrxiv.org/content/10.1...

The Supplementary Note also has some good stuff! Thanks to our coauthors as well: Alkes Price, John Danesh, Gil McVean, @mikeinouye.bsky.social, and Sarah Urbut!

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

www.medrxiv.org

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Arun Durvasula @arundurvasula.bsky.social · Sep 2

This model is able to explain 85% of the variation in PRS across age (of which there is a lot! See Figure 5).

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Arun Durvasula @arundurvasula.bsky.social · Sep 2

In our new manuscript, we show that age-dependent architectures for complex traits and predicted disease liability are driven by the accumulation of variance from environmental exposures and an age-dependent liability threshold model (liability-threshold+EA model).

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Arun Durvasula @arundurvasula.bsky.social · Sep 2

Xilin observed decreasing PRS accuracy with age across many diseases (see figure) and we wondered if GxE played a role.

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Arun Durvasula @arundurvasula.bsky.social · Sep 2

This project started as a follow-up to my paper earlier this year on GxE[1] and on a previous paper led by Xilin that looked at age-dependency of genetic variants on complex disease risk [2]

1. www.cell.com/ajhg/abstrac...
2. journals.plos.org/plosgenetics...

Distinct explanations underlie gene-environment interactions in the UK Biobank

The role of gene-environment (GxE) interaction in disease and complex trait architectures is widely hypothesized but currently unknown. Here, we apply three statistical approaches to quantify and dist...

www.cell.com

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Arun Durvasula @arundurvasula.bsky.social · Sep 2

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

www.medrxiv.org

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Reposted by Arun Durvasula

Alondra Nelson @alondra.bsky.social · Aug 20

Call for Papers! 🧵

The Public's Science–A New Social Contract for American Research Policy a Special Issue of The ANNALS of the American Academy of Political and Social Science

Editors: Alondra Nelson (IAS) and Jenny Reardon (UC, Santa Cruz)

Abstract Deadline: Sept 19

www.ias.edu/stsv-lab/pub...

Public Science

Call for Papers Special Issue of The ANNALS of the American Academy of Political and Social ScienceThe Public's Science–A New Social Contract for American Research Policy

www.ias.edu

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Reposted by Arun Durvasula

Richard Lenski @relenski.bsky.social · Aug 12

Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime.

telliamedrevisited.wordpress.com/2025/08/12/s...

STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.

STEPS To It

Announcing a new program, called STEPS, to simulate the dynamics of evolving microbial populations.

telliamedrevisited.wordpress.com

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