François Leulier
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francoisleulier.bsky.social
François Leulier
@francoisleulier.bsky.social
1.4K followers 550 following 190 posts
Scientist, Biologist @CNRS
Director and Group leader @IGFLyon @ENSLyon
We study how the #Microbiome together with #Nutrition influence #Juvenile #Physiology using #InMice and #Drosophila as models.
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francoisleulier.bsky.social
François Leulier @francoisleulier.bsky.social · Nov 23
After 11months on this platform, so happy to see the momentum finally happening!
Let’s repeat a proper introduction:
My lab studies how the #Microbiome together with #Nutrition influence #Development and Juvenile #Physiology using #Mice and #Drosophila as models… we also do lot’s of #Microbiology
Reposted by François Leulier
plosbiology.org
Decoding the body’s internal signals could revolutionize Whole Person Health. This Perspective suggests a research framework linking brain, body and behavior to foster resilience, self-regulation and holistic well-being #neurosky #interoception 🧪
Interoception as a central mechanism in Whole Person Health
Decoding the body’s internal signals could revolutionize Whole Person Health. This Perspective suggests a research framework linking brain, body and behavior to foster resilience, self-regulation and…
plos.io
November 15, 2025 at 5:07 PM
Reposted by François Leulier
plosbiology.org
Interoceptive signals from organs such as heart, lungs and gut influence many aspects of organismal physiology and behavior. This Perspective argues that liver signaling via the vagal nerve is another avenue of body-brain communication that shapes metabolism and mood #neurosky 🧪
Does the liver talk to the brain? If so, how and why?
Interoceptive signals from visceral organs, such as heart, lungs and gut, are known to influence many aspects of organismal physiology and behavior. This Perspective argues that liver signaling via…
plos.io
November 15, 2025 at 5:10 PM
francoisleulier.bsky.social
Well @microbiome.bsky.social it has been done in flies with effect 😉

www.cell.com/cell-host-mi...
November 14, 2025 at 6:27 PM
Reposted by François Leulier
josetelesreis.bsky.social
Excited to share our new paper out in Cell Reports Methods! @cp-cellrepmethods.bsky.social
🎉🎉🎉
We present EyaHOST, a modular Drosophila genetic system that enables precise and independent manipulation of tumours and host tissues to dissect tumour-host interactions.
www.cell.com/cell-reports...
EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster
Teles-Reis et al. present EyaHOST, a modular Drosophila system that enables clone generation in the eye disc with independent genetic manipulation of other tissues. EyaHOST uses an Eya-KD “kick-out” s...
www.cell.com
November 5, 2025 at 11:07 PM
Reposted by François Leulier
hansonmark.bsky.social
We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing:

a 🧵 1/n

Drain: arxiv.org/abs/2511.04820
Strain: direct.mit.edu/qss/article/...
Oligopoly: direct.mit.edu/qss/article/...
A table showing profit margins of major publishers. A snippet of text related to this table is below. 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year. A figure detailing the drain on researcher time. 1. The four-fold drain 1.2 Time The number of papers published each year is growing faster than the scientific workforce, with the number of papers per researcher almost doubling between 1996 and 2022 (Figure 1A). This reflects the fact that publishers’ commercial desire to publish (sell) more material has aligned well with the competitive prestige culture in which publications help secure jobs, grants, promotions, and awards. To the extent that this growth is driven by a pressure for profit, rather than scholarly imperatives, it distorts the way researchers spend their time. The publishing system depends on unpaid reviewer labour, estimated to be over 130 million unpaid hours annually in 2020 alone (9). Researchers have complained about the demands of peer-review for decades, but the scale of the problem is now worse, with editors reporting widespread difficulties recruiting reviewers. The growth in publications involves not only the authors’ time, but that of academic editors and reviewers who are dealing with so many review demands. Even more seriously, the imperative to produce ever more articles reshapes the nature of scientific inquiry. Evidence across multiple fields shows that more papers result in ‘ossification’, not new ideas (10). It may seem paradoxical that more papers can slow progress until one considers how it affects researchers’ time. While rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work. The result is a treadmill of constant activity with limited progress whereas core scholarly practices – such as reading, reflecting and engaging with others’ contributions – is de-prioritized. What looks like productivity often masks intellectual exhaustion built on a demoralizing, narrowing scientific vision. A table of profit margins across industries. The section of text related to this table is below: 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year. The costs of inaction are plain: wasted public funds, lost researcher time, compromised scientific integrity and eroded public trust. Today, the system rewards commercial publishers first, and science second. Without bold action from the funders we risk continuing to pour resources into a system that prioritizes profit over the advancement of scientific knowledge.
November 11, 2025 at 11:52 AM
Reposted by François Leulier
fly-eds.bsky.social
The European Drosophila Society #flyEDS extends the condolences on the passing of Antonio García-Bellido, considered the founder of the Spanish school of #Drosophila genetics and an influential figure in developmental biology research worldwide. May he rest in peace.
November 11, 2025 at 2:15 PM
Reposted by François Leulier
msumgi.bsky.social
The Long-Term Evolution Experiment has returned home. Led by Professors Richard Lenski (@relenski.bsky.social) and Jeffrey Barrick, this groundbreaking work continues to reveal how bacteria evolve in real time. 12 flasks. 1 legacy.

🔗https://tinyurl.com/f6vjyjvr
Rich Lenski adds information to the Long-Term Evolution Experiment lab notebook after restarting the experiment at MSU. Jeff Barrick and Devin Lake stand behind him.
November 10, 2025 at 3:25 PM
Reposted by François Leulier
maitrejl.bsky.social
Want to join a happy bunch 🥳 to organise meetings, outreach activities and other initiatives about developmental biology in France? Apply and/or vote 🗳️!
sfbd.bsky.social SFBD_BioDev @sfbd.bsky.social · 6d
🚨🚨🚨
The SFBD board needs to be renewed with 5 members
We wish to strengthen our board with young scientists

To apply: send a brief text introducing your research interests and motivations to [email protected] by December 4th
Elections will be held online from December 10th to 17th
Please share the info
November 10, 2025 at 12:00 PM
Reposted by François Leulier
fly-broadcast.bsky.social
A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation
#Drosophila
A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation #Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 9, 2025 at 3:23 AM
francoisleulier.bsky.social
Latest from the lab by @longweibai.bsky.social
www.biorxiv.org/content/10.1...
1/6
A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signalling
Animal survival in fluctuating environments depend on the ability to modulate their developmental pace in response to nutrient availability, a phenomenon known as developmental plasticity. In Drosophi...
www.biorxiv.org
November 8, 2025 at 2:44 PM
francoisleulier.bsky.social
The 2nd edition of Comprehensive Molecular #Insect Science is out. As section editor for #Immunity and #Symbiosis, I had the privilege to work with outstanding contributors.
Other sections cover #genomics, #physiology, #neurobiology, and #ecology
🔗 www.sciencedirect.com/referencewor...
#SymbioSky
Comprehensive Molecular Insect Science
Comprehensive Molecular Insect Science, Second Edition is a unique resource that provides extensive review articles on contemporary topics in insect s...
www.sciencedirect.com
November 7, 2025 at 6:16 AM
Reposted by François Leulier
fly-broadcast.bsky.social
Layers of immunity: Deconstructing the Drosophila effector response
#Drosophila
Layers of immunity: Deconstructing the Drosophila effector response #Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 5, 2025 at 6:23 PM
Reposted by François Leulier
fly-broadcast.bsky.social
Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila
#Drosophila
Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes in Drosophila #Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 5, 2025 at 6:23 PM
Reposted by François Leulier
agros.bsky.social
[Podcast] Avec Sciences | "La double vie d'une enzyme du métabolisme des graisses" par @alexandradelbot.bsky.social
La double vie d’une enzyme du métabolisme des graisses
Une nouvelle étude montre que l’enzyme HSL, connue pour libérer les graisses, agit aussi le stockage des lipides. Selon sa localisation, elle jouerait des rôles différents. Une découverte qui permet u...
www.radiofrance.fr
November 5, 2025 at 6:48 AM
Reposted by François Leulier
embo.org
The Initiative for Science in Europe, of which EMBO is a member, has just released its statement on the European Commission’s proposal for the next Multiannual Financial Framework (MFF 2028–34), including Framework Programme 10 (FP10).

Read the full statement here:
initiative-se.eu/wp-content/u...
November 4, 2025 at 4:51 PM
Reposted by François Leulier
cyrilpedia.bsky.social
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Origins of the Lab Mouse
How the mouse found its way from Victorian novelty to a biomedical mainstay.
www.asimov.press
November 3, 2025 at 6:25 PM
Reposted by François Leulier
devmetphys.bsky.social
We’re excited for our very first “Metabolism in Development & Physiology” seminar next week!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
November 3, 2025 at 2:09 PM
francoisleulier.bsky.social
Congrats Meiling, team and collaborators. Nice to see you are pushing the search for the mechanistic underpinnings of L.plantarum’s influence on mammalian developmental growth.
November 1, 2025 at 6:12 PM
Reposted by François Leulier
gonzalezlabbcn.bsky.social
Join us in Montpellier if you are interested in #evolution #genomics #adaptation #invasive species or if you want to get to know a collegial group of #Drosophila enthusiasts
droseu.bsky.social DrosEU @droseu.bsky.social · 16d
🪰 🧬16th #DrosEU2026 Workshop & Satellite #DrosophilaSuzukii Meeting Conference will take place 13–17 April 2026 in #Montpellier, France 🇫🇷.

We look forward to connecting with colleagues across Europe to discuss new research in #Drosophila #genomics #evolution & #CitizenScience +info 👉 droseu.net
October 31, 2025 at 5:59 PM
Reposted by François Leulier
corderolab.bsky.social
So looking forward to this. Please sign up!!
bardinlab.bsky.social Bardin Lab @bardinlab.bsky.social · 24d
I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.
October 30, 2025 at 5:19 AM
Reposted by François Leulier
lucksmith.bsky.social
🪰 folks! Despite Harvard lawsuit outcome, FlyBase NIH grant was not released. FlyBase now runs on the public, like NPR, PBS etc. If we don't step up, it can go away! Donations site on flybase.org homepage. Note: it links to IU stock center, but its for FlyBase, see instructions. pls give+share! 2/2
FlyBase Homepage
FlyBase: a database for drosophila genetics and molecular biology
flybase.org
October 29, 2025 at 12:31 PM
Reposted by François Leulier
inrae-france.bsky.social
#RP_INRAE De nouvelles pistes de recherche dans la lutte contre les insectes ravageurs avec la découverte de structures membranaires en réseau construites par des bactéries symbiotiques du charançon pour mieux se nourrir.
Étude co-pilotée avec @insa-lyon.fr

➡️ url.inrae.fr/4qLzH1g
Découverte de bactéries architectes - image au microscope électronique
October 29, 2025 at 2:21 PM
Reposted by François Leulier
devmetphys.bsky.social
We are thrilled to announce the inaugural Metabolism in Development & Physiology virtual seminar, a new series connecting researchers across all stages & disciplines in metabolism!

🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)

See you there!
October 28, 2025 at 4:13 PM
Reposted by François Leulier
microbiome.bsky.social
We selected the laziest mouse at each round to inoculate the next batch of germfree mice: over rounds of selection and passaging, behavior shifted without changes to the mouse genome: rdcu.be/eM3rO
🦠🧫
Selection and transmission of the gut microbiome alone can shift mammalian behavior
Nature Communications - Here, the authors present evidence that the gut microbiome alone, without changes in the host genome, can shape how animals respond to selection, identifying a bacterium and...
rdcu.be
October 28, 2025 at 7:51 AM
Reposted by François Leulier
neuroendolille.bsky.social
"En France aussi, la liberté académique subit des attaques politiques depuis plusieurs années, notamment avec l’émergence de groupes d’intérêt (...)"

www.lemonde.fr/sciences/art...
Budget 2026 : « La taxation des expérimentations animales mettrait en péril la recherche en France »
TRIBUNE. Dans une tribune au « Monde », des représentants de sociétés savantes, de fondations, d’associations et de réseaux scientifiques mettent en garde contre le dépôt d’amendements au projet de lo...
www.lemonde.fr
October 28, 2025 at 5:30 PM