François Leulier
@francoisleulier.bsky.social
Scientist, Biologist @CNRS
Director and Group leader @IGFLyon @ENSLyon
We study how the #Microbiome together with #Nutrition influence #Juvenile #Physiology using #InMice and #Drosophila as models.
Director and Group leader @IGFLyon @ENSLyon
We study how the #Microbiome together with #Nutrition influence #Juvenile #Physiology using #InMice and #Drosophila as models.
Here is a follow up work by @memartino.bsky.social and @schwarzergnoto.bsky.social
Nice in host-evolution story!
bmcbiol.biomedcentral.com/articles/10....
Nice in host-evolution story!
bmcbiol.biomedcentral.com/articles/10....
Gut microbe Lactiplantibacillus plantarum undergoes different evolutionary trajectories between insects and mammals - BMC Biology
Background Animals form complex symbiotic associations with their gut microbes, whose evolution is determined by an intricate network of host and environmental factors. In many insects, such as Drosop...
bmcbiol.biomedcentral.com
November 15, 2025 at 7:32 PM
Here is a follow up work by @memartino.bsky.social and @schwarzergnoto.bsky.social
Nice in host-evolution story!
bmcbiol.biomedcentral.com/articles/10....
Nice in host-evolution story!
bmcbiol.biomedcentral.com/articles/10....
But one-sided 😉
Cool results from your lab! Congrats
Cool results from your lab! Congrats
November 14, 2025 at 6:41 PM
But one-sided 😉
Cool results from your lab! Congrats
Cool results from your lab! Congrats
Indeed monoassociation!
November 14, 2025 at 6:39 PM
Indeed monoassociation!
Our results in #Drosophila illustrate that enterokines can regulate IGF signalling, beyond insulin release per se. An evolutionarily conserved or convergent strategy in regulating developmental plasticity in animals?
6/6
6/6
November 8, 2025 at 2:44 PM
Our results in #Drosophila illustrate that enterokines can regulate IGF signalling, beyond insulin release per se. An evolutionarily conserved or convergent strategy in regulating developmental plasticity in animals?
6/6
6/6
This work expands the concept of decretins, first proposed by Seung K. Kim al. in the context of sugar metabolism regulation in adults, to include developmental pace control
www.cell.com/cell-metabol...
5/6
www.cell.com/cell-metabol...
5/6
Suppression of Insulin Production and Secretion by a Decretin Hormone
Classical studies in mammals suggest that fasting induces circulating hormones that
actively suppress insulin production and secretion. Alfa et al. identify a nutrient-responsive
“decretin” hormone pa...
www.cell.com
November 8, 2025 at 2:44 PM
This work expands the concept of decretins, first proposed by Seung K. Kim al. in the context of sugar metabolism regulation in adults, to include developmental pace control
www.cell.com/cell-metabol...
5/6
www.cell.com/cell-metabol...
5/6
We establish that Limostatin acts as a « decretin » (in opposition to the famous incretin, such as GLP-1), ie decreasing circulating levels of Insulin-like peptides, enabling juveniles to adapt developmental pace and preserve viability while nutrients are scarce
4/6
4/6
November 8, 2025 at 2:44 PM
We establish that Limostatin acts as a « decretin » (in opposition to the famous incretin, such as GLP-1), ie decreasing circulating levels of Insulin-like peptides, enabling juveniles to adapt developmental pace and preserve viability while nutrients are scarce
4/6
4/6
We found Limostatin induced in a handful of enteroendocrine cells ONLY when nutrient shortage is sensed
3/6
3/6
November 8, 2025 at 2:44 PM
We found Limostatin induced in a handful of enteroendocrine cells ONLY when nutrient shortage is sensed
3/6
3/6
Limostatin is a nutrient-sensitive enterokine coordinating developmental plasticity through inter-organ signalling
2/6
2/6
November 8, 2025 at 2:44 PM
Limostatin is a nutrient-sensitive enterokine coordinating developmental plasticity through inter-organ signalling
2/6
2/6