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iMeta Science @imetascience.bsky.social · 15h

Abnormal membrane potentials & ion channel signatures drive #tumor growth, metastasis & immune evasion
💊 Ion channel drugs, tumor-treating fields & nano-delivery offer new precision therapies
🧠 Electro-immunotherapy reshapes the TME
🔗 doi.org/10.1002/imm3...
#CancerResearch #Immunotherapy

Tumor Electrophysiology in Precision Tumor Therapy

This review highlights tumor electrophysiological hallmarks as therapeutic targets in precision oncology. We examine how membrane potential alterations and ion channel fingerprints drive malignancy, ...

doi.org

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iMeta Science @imetascience.bsky.social · 15h

🧬 Benchmarking 14 spatial clustering methods across ~600 #SpatialTranscriptomics datasets
🧫 10 technologies, 8 organs — consistent insights
⚙️ Clear guidance for method choice & preprocessing
🔗 doi.org/10.1002/imt2...
#Bioinformatics #SpatialOmics #scRNA

A comprehensive benchmarking for spatially resolved transcriptomics clustering methods across variable technologies, organs, and replicates

Spatial clustering is a critical step in spatially resolved transcriptomics. Here, we conducted a comprehensive benchmarking analysis of 14 spatial clustering methods using ~600 datasets, including b...

doi.org

1

iMeta Science @imetascience.bsky.social · 16h

🌏 #Soil pH shapes microbial #nitrogen cycling in Japanese forests 🌲
🧪 Acidic soils host stress-tolerant microbes retaining N
⚙️ Neutral soils favor energy-efficient taxa releasing #ammonium & driving #nitrification
🔗 doi.org/10.1002/imo2...

#SoilHealth #Microbiome #metabolism

Soil pH modulates microbial nitrogen allocation in soil via compositional and metabolic shifts across forests in Japan

This study reveals how soil pH regulates microbial N allocation in forest soils across Japan. We show that microbial abundance controls the overall rate of N cycling, while microbial composition and ...

doi.org

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iMeta Science @imetascience.bsky.social · 23d

🧩 New insights into the #gut–#brain axis:
🦠L-lysine boosts barrier function & eases anxiety via tryptophan metabolism
😟H. biformis strengthens the barrier but worsens #anxiety
💻Multi-omics reveal lysine degradation as a key mechanism
🔗 doi.org/10.1002/imo2...
#microbiome #Bioinformatics

A reciprocal interaction between L‐lysine and Holdemanella biformis modulates intestinal barrier function and anxiety in irritable bowel syndrome

This study uncovers a complex interaction between l-lysine and Holdemanella biformis (H. biformis) in irritable bowel syndrome (IBS). l-lysine enhances intestinal barrier function and alleviates anxi....

doi.org

iMeta Science @imetascience.bsky.social · 27d

🚀 317 R scripts for biomedical research, no coding barrier
⏱️ Standardized design saves time
✅ Verified, annotated, reproducible
🧬 Covers #scRNA-seq, spatial #transcriptomics, #ML & more
🔗 doi.org/10.1002/imm3...
#Bioinformatics

FigureYa: A Standardized Visualization Framework for Enhancing Biomedical Data Interpretation and Research Efficiency

FigureYa integrates 317 visualization tools across diverse biomedical domains, categorized by research type, analytical method, and output format. This resource streamlines data interpretation and en...

doi.org

iMeta Science @imetascience.bsky.social · Sep 20

🫀🦠 Gut–heart axis in #CAD: distinct microbial & metabolic shifts across normal, sCAD & ACS;
ACS signatures partly reversible.
Multi-omics #ML outperforms clinical risk factors in stratifying CAD subtypes.
🔗 onlinelibrary.wiley.com/doi/10.1002/... #microbiome