@fillouxlab.bsky.social
Pinned
Happy to be on bsky and to introduce my @SCELSE group in Singapore @NTU and working on #T6SS #Biofilm #c-di-GMP #Pseudomonas #antibiotics From left to right Sujatha, Casandra, Yu Fen, Kay, Qiu Ting and Peggy. They are brilliant so stay tune and follow.
Reposted
Type VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking.
A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli.
dx.plos.org/10.1371/jour...
A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli.
dx.plos.org/10.1371/jour...
Structural characterization of the YbbAP-TesA ABC transporter identifies it as a lipid hydrolase complex that extracts hydrophobic compounds from the bacterial inner membrane
In E.coli, three of the four Type VII ABC transporter systems have been structurally characterized. This study solves cryo-EM structures of the fourth Type VII ABC system, YbbAP-TesA, and suggests tha...
dx.plos.org
November 26, 2025 at 12:46 PM
Type VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking.
A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli.
dx.plos.org/10.1371/jour...
A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli.
dx.plos.org/10.1371/jour...
Reposted
Excited to share our latest research in @natmicrobiol.nature.com . We uncover hundreds of inhibitory interactions between common chemical pollutants and human gut bacteria. A thread🧵 (1/10) #microbiomesky #microsky @kiranrpatil.bsky.social lab @mrc-tu.bsky.social www.nature.com/articles/s41...
Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro - Nature Microbiology
Screening of 1,076 compounds reveals 168 chemical pollutants with inhibitory effects on gut bacteria and genetic screens indicate commonality between pollutant and antibiotic resistance.
www.nature.com
November 26, 2025 at 10:30 AM
Excited to share our latest research in @natmicrobiol.nature.com . We uncover hundreds of inhibitory interactions between common chemical pollutants and human gut bacteria. A thread🧵 (1/10) #microbiomesky #microsky @kiranrpatil.bsky.social lab @mrc-tu.bsky.social www.nature.com/articles/s41...
Reposted
Want to see something that will fry your brain? Disappearing reappearing plaques on P aeruginosa @dominickfaith.bsky.social
🧫🦠🧪
🧫🦠🧪
November 25, 2025 at 11:42 PM
Want to see something that will fry your brain? Disappearing reappearing plaques on P aeruginosa @dominickfaith.bsky.social
🧫🦠🧪
🧫🦠🧪
In Melbourne for a symposium organized by the ARC Biofilm Research and Innovation Centre. It was really nice to be welcomed by my colleague and friend @abdou-hachani.bsky.social
November 24, 2025 at 8:09 PM
In Melbourne for a symposium organized by the ARC Biofilm Research and Innovation Centre. It was really nice to be welcomed by my colleague and friend @abdou-hachani.bsky.social
Reposted
Fortuitous timing for my NTU-SBS seminar to land in World Antimicrobial Awareness Week #WAAW. I took the opportunity to showcase our research into alternate bacterial lifestyles and how we are leveraging this understanding to develop innovative approaches to combat AMR
🧫🧪
@scelse.bsky.social
🧫🧪
@scelse.bsky.social
November 22, 2025 at 2:26 AM
Fortuitous timing for my NTU-SBS seminar to land in World Antimicrobial Awareness Week #WAAW. I took the opportunity to showcase our research into alternate bacterial lifestyles and how we are leveraging this understanding to develop innovative approaches to combat AMR
🧫🧪
@scelse.bsky.social
🧫🧪
@scelse.bsky.social
Reposted
Read the latest Microbe Profile on Streptomyces formicae KY5: an ANT-ibiotic factory. Published Open Access and fee-free in Microbiology using a Publish and Read agreement: doi.org/10.1099/mic.... #MicrobioJ #PublishAndRead
November 22, 2025 at 2:32 AM
Read the latest Microbe Profile on Streptomyces formicae KY5: an ANT-ibiotic factory. Published Open Access and fee-free in Microbiology using a Publish and Read agreement: doi.org/10.1099/mic.... #MicrobioJ #PublishAndRead
Reposted
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
November 21, 2025 at 7:05 PM
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
Reposted
Two intense days underscored SCELSE’s strength in true multi-disciplinarity — broad enough to collaborate, deep enough to push boundaries. A retreat filled with ideas across health, climate, and food. Kudos to Prof Whitchurch @cwhitch.bsky.social for organising a strong event.
November 20, 2025 at 7:46 AM
Two intense days underscored SCELSE’s strength in true multi-disciplinarity — broad enough to collaborate, deep enough to push boundaries. A retreat filled with ideas across health, climate, and food. Kudos to Prof Whitchurch @cwhitch.bsky.social for organising a strong event.
Reposted
The Microbiology Society is pleased to announce the winners of our 2026 Prizes! The winners will be awarded and deliver Prize Lectures at Annual Conference 2026 in Belfast from 13–16 April. Find out more about it: microb.io/PrizeWinners.... Meet the winners below. #Microbio26
November 19, 2025 at 2:58 PM
The Microbiology Society is pleased to announce the winners of our 2026 Prizes! The winners will be awarded and deliver Prize Lectures at Annual Conference 2026 in Belfast from 13–16 April. Find out more about it: microb.io/PrizeWinners.... Meet the winners below. #Microbio26
Reposted
Here’s @tosinorababa.bsky.social & @nreddy.bsky.social showing the ways we grow bacteria in the lab to simulate conditions in an infected patient - we have models of #CysticFibrosis lung, endotracheal tube & chronic wound, all compliant with efforts to reduce & replace animals in research.
November 19, 2025 at 7:39 PM
Here’s @tosinorababa.bsky.social & @nreddy.bsky.social showing the ways we grow bacteria in the lab to simulate conditions in an infected patient - we have models of #CysticFibrosis lung, endotracheal tube & chronic wound, all compliant with efforts to reduce & replace animals in research.
Reposted
SCELSE’s annual Scientific Retreat begins tomorrow. Two days of presentations, posters, and breakout discussions will sharpen the next phase of our biofilm and microbiome research aligned with the UN Sustainable Development Goals. @cwhitch.bsky.social @fillouxlab.bsky.social
November 17, 2025 at 11:59 AM
SCELSE’s annual Scientific Retreat begins tomorrow. Two days of presentations, posters, and breakout discussions will sharpen the next phase of our biofilm and microbiome research aligned with the UN Sustainable Development Goals. @cwhitch.bsky.social @fillouxlab.bsky.social
Reposted
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae
Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...
www.nature.com
November 15, 2025 at 3:55 PM
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Reposted
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 13, 2025 at 8:14 PM
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Reposted
Very excited to share our latest work in Science on metagenomic editing (MetaEdit) of the gut microbiome in vivo & directly modifying unculturable immune-modulatory SFB bug in the small intestine. 🦠🧬🛠️
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 13, 2025 at 8:53 PM
Very excited to share our latest work in Science on metagenomic editing (MetaEdit) of the gut microbiome in vivo & directly modifying unculturable immune-modulatory SFB bug in the small intestine. 🦠🧬🛠️
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
‘The latest surveillance data found that the number of antibiotic-resistant infections in 2024 equated to an average of nearly 400 newly reported cases a week.’
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Deaths linked to antibiotic-resistant superbugs rose 17% in England in 2024
Data also shows an average of nearly 400 newly reported cases of antibiotic-resistant infections a week last year
www.theguardian.com
November 13, 2025 at 11:27 PM
‘The latest surveillance data found that the number of antibiotic-resistant infections in 2024 equated to an average of nearly 400 newly reported cases a week.’
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Reposted
A duet of T6SS effectors
Preview of new work reporting a BtapC-orchestrated co-secretion mechanism for T6SS effectors BtpeA and BtaeB in gut Bacteroidota, revealing a conserved strategy for interbacterial competition and gut microbiota modulation
www.cell.com/cell-host-mi...
Preview of new work reporting a BtapC-orchestrated co-secretion mechanism for T6SS effectors BtpeA and BtaeB in gut Bacteroidota, revealing a conserved strategy for interbacterial competition and gut microbiota modulation
www.cell.com/cell-host-mi...
A duet of T6SS effectors
How do gut bacteria outcompete rivals in dense microbial ecosystems? In this issue
of Cell Host & Microbe, Li et al. report a BtapC-orchestrated co-secretion mechanism
of T6SS effectors BtpeA and Btae...
www.cell.com
November 13, 2025 at 8:20 PM
A duet of T6SS effectors
Preview of new work reporting a BtapC-orchestrated co-secretion mechanism for T6SS effectors BtpeA and BtaeB in gut Bacteroidota, revealing a conserved strategy for interbacterial competition and gut microbiota modulation
www.cell.com/cell-host-mi...
Preview of new work reporting a BtapC-orchestrated co-secretion mechanism for T6SS effectors BtpeA and BtaeB in gut Bacteroidota, revealing a conserved strategy for interbacterial competition and gut microbiota modulation
www.cell.com/cell-host-mi...
Reposted
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
November 12, 2025 at 4:21 PM
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
Reposted
Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23 | Journal of Natural Products pubs.acs.org/doi/full/10....
Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23
Natural products derived from symbiotic microbes remain a rich source of structurally diverse and bioactive molecules. In this study, we report de novo genome sequencing of the termite-associated iso...
pubs.acs.org
November 11, 2025 at 7:24 PM
Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23 | Journal of Natural Products pubs.acs.org/doi/full/10....
Reposted
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system - Nature Communications
Bacteria use the type III secretion system (T3SS) to inject proteins into target cells. Here, Brianceau et al. show that a core structural component, SctD, exchanges between a T3SS-bound and a freely ...
www.nature.com
November 11, 2025 at 9:28 PM
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
#MicrobiologyMonday: Bacteria swarm, but DYK they also "swash"? This flagella-independent movement is tied to fermentation: as cells ferment sugars, they create local osmolarity gradients, which generate a wave of fluid driving expansion. #JBacteriology: asm.social/2Gh
November 10, 2025 at 5:03 PM
#MicrobiologyMonday: Bacteria swarm, but DYK they also "swash"? This flagella-independent movement is tied to fermentation: as cells ferment sugars, they create local osmolarity gradients, which generate a wave of fluid driving expansion. #JBacteriology: asm.social/2Gh
Reposted
The pathogenic bacteria Shigella avoids detection inside host cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
Read more in the eLife Insight Article: buff.ly/1mIc6m0
Read more in the eLife Insight Article: buff.ly/1mIc6m0
November 10, 2025 at 11:28 PM
The pathogenic bacteria Shigella avoids detection inside host cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
Read more in the eLife Insight Article: buff.ly/1mIc6m0
Read more in the eLife Insight Article: buff.ly/1mIc6m0
With Kevin Pethe for a night celebration of the LKCMedicine @NTU 15th anniversary celebration.
November 10, 2025 at 1:02 AM
With Kevin Pethe for a night celebration of the LKCMedicine @NTU 15th anniversary celebration.
Reposted
By studying the process through which a soil bacterium naturally produces a well-known drug, scientists have discovered a powerful antibiotic that could help to fight drug-resistant infections
go.nature.com/4oyN3wc
go.nature.com/4oyN3wc
Powerful new antibiotic that can kill superbugs discovered in soil bacteria
Nature - Surprise discovery could pave the way for new treatments against drug-resistant infections.
go.nature.com
November 9, 2025 at 3:09 PM
By studying the process through which a soil bacterium naturally produces a well-known drug, scientists have discovered a powerful antibiotic that could help to fight drug-resistant infections
go.nature.com/4oyN3wc
go.nature.com/4oyN3wc
Reposted
The hitchhiker’s guide to cross-species DNA delivery
@cp-trendsmicrobiol.bsky.social Spotlight by Kotaro Kiga and Rodrigo Ibarra-Chávez
www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social Spotlight by Kotaro Kiga and Rodrigo Ibarra-Chávez
www.cell.com/trends/micro...
The hitchhiker’s guide to cross-species DNA delivery
Microbial hitchhikers are rewriting the rules of horizontal gene transfer. He, Patkowski,
et al. reveal how phage satellites assemble chimeric infective particles that deliver
DNA across species bound...
www.cell.com
November 9, 2025 at 9:39 AM
The hitchhiker’s guide to cross-species DNA delivery
@cp-trendsmicrobiol.bsky.social Spotlight by Kotaro Kiga and Rodrigo Ibarra-Chávez
www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social Spotlight by Kotaro Kiga and Rodrigo Ibarra-Chávez
www.cell.com/trends/micro...