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Reposted by dave dougan

David Pocock

@davidpocock.bsky.social

Save the CSIRO

Our national science & research agency is now facing more job cuts than under Tony Abbott

Call on the Albanese Govt to fund the scientists & research we need to tackle big issues we face from climate to food security and everything in between

www.davidpocock.com.au/save_our_csiro

November 19, 2025 at 9:49 AM

Reposted by dave dougan

Nick Feik

@nickfeik.bsky.social

Add this to the CSIRO cuts and uni cuts generally and the picture is unmistakable

Dr Shane Huntington OAM @drshanerrr.bsky.social · 1d

The success rate for NHMRC Ideas Grants announced yesterday was just over 8%. That means 11 of every 12 people who applied got rejected. This is a culture changing level of rejection and frankly a point of national shame. This is a crisis for research.
I will not rest until we see this resolved.

November 26, 2025 at 9:04 PM

Reposted by dave dougan

Waggoner Lab

@labwaggoner.bsky.social

We are all mosaics: vast genetic diversity found between cells in a single person @nature.com
www.nature.com/articles/d41...
@biorxivpreprint.bsky.social ⁦@mayoclinic.org @harvardmed.bsky.social @timcoorens.bsky.social @emblebi.bsky.social
www.biorxiv.org/content/10.1...

November 26, 2025 at 3:16 PM

Reposted by dave dougan

Waggoner Lab

@labwaggoner.bsky.social

A triple-action PROTAC for wild-type p53 cancer therapy @cp-cellrepmed.bsky.social @lorenwalensky.bsky.social @danafarber.bsky.social
www.cell.com/cell-reports...

November 26, 2025 at 8:28 PM

Reposted by dave dougan

Isa MG

@isamanrique.bsky.social

🏔️🌧️ 🧬 We wrote this Expert View on oxygen sensing, you can read it here! 👇🏼

N End Rules @n-end-rules.bsky.social · 5d

Recent advances in the mechanism, transduction and function of oxygen sensing in plants
#nendrule #hypoxia #plantscience
academic.oup.com/jxb/advance-...

Recent advances in the mechanism, transduction and function of oxygen sensing in plants

Abstract. Response to reduced ambient oxygen is a key component of plant adaptation in natural and farmed environments and is regulated by oxygen dependent

academic.oup.com

November 23, 2025 at 1:21 PM

Reposted by dave dougan

Beckmann Lab

@beckmannlab.bsky.social

How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI

November 23, 2025 at 3:47 PM

Reposted by dave dougan

Monte Rosa Therapeutics

@monterosatx.com

Through proteomic profiling of our proprietary compound library, our team identified a selective, fast, and potent molecular glue degrader that induces cereblon degradation via a novel mechanism.

Read the full paper in @natcomms.nature.com: rdcu.be/eQKQk

November 19, 2025 at 3:28 PM

Reposted by dave dougan

cryoEM papers

@cryoempapers.bsky.social

Structural basis for co-translational assembly of homo-oligomeric proteins www.biorxiv.org/content/10.1101/2025.11.12.687954v1 #cryoem

November 14, 2025 at 12:14 PM

Reposted by dave dougan

Trends in Biochemical Sciences

@cp-trendsbiochem.bsky.social

📝 Online now - the Spotlight "Unlocking the protein code: how our organs age across a lifetime" from Dongxue Wang and Jing Yang.

#Proteostasis #Aging #BiologicalClocks #Proteomics

Read it here: authors.elsevier.com/a/1m7Ts3S6Gf...

November 18, 2025 at 9:35 PM

dave dougan

@douganlab.bsky.social

Ribonuclease toxin RelE1 inhibits growth of Mycobacterium tuberculosis through specific cleavage of the ribosomal anti-Shine–Dalgarno region: academic.oup.com/nar/article/...

Validate User

academic.oup.com

November 18, 2025 at 11:36 PM

dave dougan

@douganlab.bsky.social

Development of a targeted BioPROTAC degrader selective for misfolded SOD1
www.nature.com/articles/s41...

Development of a targeted BioPROTAC degrader selective for misfolded SOD1 - Nature Communications

Conventional PROTACs have limited capacity for misfolded proteins. Here, authors develop a BioPROTAC containing an scFv specifically targeting misfolded SOD1, fused to an E3 ligase, and demonstrate a ...

www.nature.com

November 18, 2025 at 11:33 PM

Reposted by dave dougan

Science X / Phys.org

@sciencex.bsky.social

A fluorescent probe enables direct visualization and measurement of membrane tension in live bacteria, offering new insights into how bacteria interact with and respond to different surfaces. doi.org/hbbsxk

How bacteria 'feel' surfaces: Fluorescent probe visualizes and quantifies membrane tension

In natural environments, bacteria rarely live as free-swimming cells but are attached to surfaces as biofilms in medical devices, mobile phones or human tissue.

phys.org

November 18, 2025 at 8:02 PM

Reposted by dave dougan

Nature Structural & Molecular Biology

@natsmb.nature.com

ICYMI: New online: Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1

Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1

Nature Structural & Molecular Biology, Published online: 06 November 2025; doi:10.1038/s41594-025-01695-2The authors use time-resolved cryo-electron microscopy to reveal the interactions of the redox-active cofactor TXNL1 with the human 26S proteasome and detect ATPase motor states that indicate burst-like mechanisms for hand-over-hand substrate translocation.

go.nature.com

November 7, 2025 at 11:45 AM

Reposted by dave dougan

cryoEM papers

@cryoempapers.bsky.social

The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation www.biorxiv.org/content/10.1101/2025.11.08.687396v1 #cryoem

November 10, 2025 at 1:56 PM

dave dougan

@douganlab.bsky.social

How Pathogens Maintain Proteostasis During Infection
onlinelibrary.wiley.com/doi/10.1111/...

How Pathogens Maintain Proteostasis During Infection

Differential ribosome association of protein chaperones trigger factor and DnaK under sufficient and low cytoplasmic Mg2+ conditions. Trigger factor (TF) associates with ribosomes and cotranslational...

onlinelibrary.wiley.com

November 10, 2025 at 3:59 AM

dave dougan

@douganlab.bsky.social

In situ characterization of mitochondrial Hsp60-Hsp10 chaperone complex under folding stress | Science Advances www.science.org/doi/10.1126/...

In situ characterization of mitochondrial Hsp60-Hsp10 chaperone complex under folding stress

The mitochondrial Hsp60-Hsp10 complex clusters and shifts conformation in response to protein-folding stress.

www.science.org

October 27, 2025 at 12:17 AM

Reposted by dave dougan

Nature

@nature.com

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

go.nature.com/4hj9NNV

Economics Nobel prize won by researchers who showed how science boosts growth

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

go.nature.com

October 13, 2025 at 8:37 PM

dave dougan

@douganlab.bsky.social

Arctic seals face extinction and birds in decline globally, but there is some good news about green sea turtles www.cnn.com/2025/10/10/s...

Arctic seals face extinction and birds in decline globally, according to new Red List | CNN

More than a quarter of all animals, plants and fungi assessed are at risk of extinction, according to the latest IUCN Red List of Threatened Species.

www.cnn.com

October 13, 2025 at 11:31 PM

dave dougan

@douganlab.bsky.social

Well-exercised male mice appear to pass fitness to their male offspring | Science | AAAS www.science.org/content/arti...

Well-exercised male mice appear to pass fitness to their male offspring

Surprising epigenetic effect relies on snippets of RNA packaged within sperm

www.science.org

October 9, 2025 at 3:28 AM

Reposted by dave dougan

Cell Biology J-Club

@cellclub.bsky.social

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation | The EMBO Journal www.embopress.org/doi/full/10....

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation | The EMBO Journal

imageimageIn synucleinopathies such as Parkinson’s disease, the intrinsically disordered protein α-synuclein aggregates into amyloid fibrils. This study explores the effect of structural polymorphism ...

www.embopress.org

October 6, 2025 at 1:41 PM

Reposted by dave dougan

The Daum Lab

@daumlab.bsky.social

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

October 6, 2025 at 11:31 AM

Reposted by dave dougan

I Quit Smoking 🚭 📚 🐕

@iquitcigs.bsky.social

Dr Jane Goodall the name fits @2bdynamic.bsky.social @booksstlouis.bsky.social

KOJAMF🤘🖤🤘 @kojamf.bsky.social · Oct 5

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

October 6, 2025 at 6:24 PM

dave dougan

@douganlab.bsky.social

Single Particle Dynamics of Protein Aggregation and Disaggregation in the Presence of the sHsp Proteins IbpAB | Biochemistry pubs.acs.org/doi/10.1021/...