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clausenlab.bsky.social
Clausen Lab
@clausenlab.bsky.social
3.2K followers 1.9K following 67 posts
Molecular machines, Proteostasis, Ubiquitin Signaling, Cell Autonomous Defense, Protein Disorders and Team Nematode

@IMP Vienna
www.imp.ac.at/groups/tim-clausen/
Posts Replies Media Videos
Reposted by Clausen Lab
alexis-verger.cpesr.fr
The devil is in the details

Atomically accurate de novo design of antibodies with RFdiffusion

www.nature.com/articles/s41...

success rates against each target range from 0% to 2% 😆

for SARS-CoV2 RBD target, 9000 designs screened, 5 SPR confirmed binders.
November 13, 2025 at 8:11 AM
Reposted by Clausen Lab
maxperutzlabs.ac.at
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
November 12, 2025 at 10:32 AM
Reposted by Clausen Lab
womeninautophagy.bsky.social
Join us for Journal Club tomorrow, November 12th, as Dr. Elias Adriaenssens presents his recently published article in Nature Cell Biology, titled “Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.”

We look forward to seeing you there!
November 12, 2025 at 2:38 AM
Reposted by Clausen Lab
chembiobryan.bsky.social
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg

DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social

www.embl.org/about/info/c...
Chemical biology 2026
www.embl.org
November 11, 2025 at 5:46 PM
Reposted by Clausen Lab
crisprflydesign.bsky.social
🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social

www.nature.com/articles/s41...
Illustration of the molecular mechanism controlling mRNA export.
November 6, 2025 at 5:20 PM
Reposted by Clausen Lab
dimitristypas.bsky.social
Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.
High-throughput peptide-centric local stability assay extends protein–ligand identification to membrane proteins, tissues and bacteria - Nature Structural & Molecular Biology
Li et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends protein–ligand identification to membrane proteins, tissues and...
www.nature.com
November 6, 2025 at 8:40 AM
Reposted by Clausen Lab
kirsteinlab.bsky.social
Postdoc position available in my lab in Jena (Germany.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
Postdoc (m/f/x)
Our Research Group led by Janine Kirstein, Professorin at Friedrich-Schiller-University Jena, is looking for a highly motivated and talented Postdoctoral Researcher (m/f/x) to join a research project ...
jobs.leibniz-fli.de
November 4, 2025 at 7:39 AM
Reposted by Clausen Lab
maxperutzlabs.ac.at
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
Reposted by Clausen Lab
cyrilpedia.bsky.social
'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'
Tissue-specific consequences of tag fusions on protein expression in transgenic mice
Author summary To better understand the function of specific proteins, researchers need ways to quantify their abundance, to visualise their movements, to understand what other molecules they interact...
journals.plos.org
October 26, 2025 at 6:18 PM
Reposted by Clausen Lab
bioinfo.se
www.nature.com/articles/d41...
October 24, 2025 at 4:06 AM
Reposted by Clausen Lab
matthiasmuhar.bsky.social
On that note: hello world! My new lab on genetics of proteome remodeling is starting at the incredible MPI-CBG. We have big plans and open positions for PhD students and an RA. Apply now (!) at imprs.mpi-cbg.de and tinyurl.com/2vywj6f6 respectively.
October 21, 2025 at 9:53 PM
Reposted by Clausen Lab
johanneszuber.bsky.social
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Reposted by Clausen Lab
lindorfflarsen.bsky.social
The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert)

Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation

doi.org/10.1101/2025...
Fig. 1 – UBQLN2 is a conserved lysine-depleted protein. (A) Sequence comparison of UBQLN2 orthologs in the indicated species. Intrinsically disordered regions in human UBQLN2 based on MobiDB are shown as a blue bar. The domain organization based on the SMART database is marked. Lysine residues are marked as black squares. (B) ESM-2 predictions of all possible single amino acid substitutions of human UBQLN2 presented as a heat map. The wild-type residues are marked in blue. ESM-2 scores close to zero (light yellow colors) indicate that the amino acid substitution is compatible with the ESM-2 language model, whereas negative scores (dark orange colors) indicate that the variant is incompatible with the ESM-2 model. The domain organization (based on SMART) is aligned above the map. Note that substitutions to lysine or cysteine in general appear detrimental, in particular downstream of the UBL domain. (C) The AlphaFold2 predicted structured of human UBQLN2 (AF-Q9UHD9-F1) (left panel). The UBL domain is colored blue, and the UBA domain is colored orange and the STI1 regions green. Zoom in on the UBL domain (right panel) with the lysine residues highlighted as stick representations and colored based on the relative accessible surface area (rASA, dark red exposed; grey, buried).
October 7, 2025 at 9:20 PM
Reposted by Clausen Lab
mafdawson.bsky.social
Science has lost a GIANT and the world has lost one of the kindest most inspiring people I had the pleasure of knowing. Just an extraordinary man whose curiosity was infectious and whose dry wit will always be memorable- RIP John

www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 7:07 PM
Reposted by Clausen Lab
embojournal.org
Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides
Axel Mogk, Marta Carroni et al
www.embopress.org/doi/full/10....
September 29, 2025 at 11:56 AM
Reposted by Clausen Lab
sonjalorenzlab.bsky.social
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Reposted by Clausen Lab
nadlerlab.bsky.social
Spectacular work. Absolutely spectacular. Go check out the paper. It truly is #lipidtime now
September 15, 2025 at 6:07 PM
clausenlab.bsky.social
so well deserved
laskerfdn.bsky.social Albert and Mary Lasker Foundation @laskerfdn.bsky.social · Sep 11
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
September 12, 2025 at 8:29 AM
Reposted by Clausen Lab
agwrobel.bsky.social
Dear scientific community,

I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.

my.corehr.com/pls/uoxrecru...

my.corehr.com/pls/uoxrecru...
September 8, 2025 at 3:16 PM
Reposted by Clausen Lab
vbcscitraining.bsky.social
The Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Please share. Further details: www.vbcphd.at
September 5, 2025 at 12:18 PM
Reposted by Clausen Lab
gruberlab.bsky.social
Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...

With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:

Wadjet—Keeping a watchful eye on circular DNA.

www.cell.com/structure/fu...
September 5, 2025 at 6:29 AM
Reposted by Clausen Lab
inoagrafioti.bsky.social
WARM congratulations to: Tom DENDOOVEN, @martinpacesa.bsky.social, @mschuhmacher.bsky.social , @lfmilles.bsky.social, @preinerin.bsky.social,Markus Hopfler, @charleneboumendil.bsky.social, Gergo Gogl, @shifralansky.bsky.social, @alexanderbelyy.bsky.social,Erik Benson, @dbojar.bsky.social! 🤩 #ERCStG
erc.europa.eu European Research Council (ERC) @erc.europa.eu · Sep 4
📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 10:06 AM
Reposted by Clausen Lab
freddietheodoulou.bsky.social
Job opportunity: come join the excellent and friendly #ProteostasisUK community!
delladavid-lab.bsky.social delladavid-lab.bsky.social @delladavid-lab.bsky.social · Sep 2
Exciting news📣: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT
hireful.
tinyurl.com
September 3, 2025 at 11:56 AM
Reposted by Clausen Lab
jeremybaskin.bsky.social
I’ve already highlighted this landmark #lipidtime paper by @nadlerlab.bsky.social & colleagues, but ICYMI, do read André’s thread — this study is a huge leap forward in understanding the logic of intracellular lipid flux & is a phenomenal example of #chembio probes 🤝 quantitative imaging 🤝 modeling!
nadlerlab.bsky.social André Nadler @nadlerlab.bsky.social · Aug 21
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
August 31, 2025 at 5:35 PM
Reposted by Clausen Lab
dangrabarczyk.bsky.social
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles
Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...
www.cell.com
August 27, 2025 at 7:04 PM