Chung Hyun Cho
@chc-evobio.bsky.social
Postdoc in the Berger Group at the Gregor Mendel Institute - Vienna BioCenter @gmivienna.bsky.social @viennabiocenter.bsky.social | MSCA Fellow | Interest in evolutionary biology and currently studying chromatin
Reposted by Chung Hyun Cho
Active virus-host system in a Lokiarchaeon culture https://www.biorxiv.org/content/10.64898/2026.02.13.705702v1
February 14, 2026 at 12:15 PM
Active virus-host system in a Lokiarchaeon culture https://www.biorxiv.org/content/10.64898/2026.02.13.705702v1
Reposted by Chung Hyun Cho
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements https://www.biorxiv.org/content/10.64898/2026.02.07.704324v1
February 13, 2026 at 3:11 PM
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Reposted by Chung Hyun Cho
Structural ontogeny of protein-protein interactions
Structural ontogeny of protein-protein interactions
Science, Volume 391, Issue 6786 , February 2026.
www.science.org
February 12, 2026 at 9:14 PM
Structural ontogeny of protein-protein interactions
Reposted by Chung Hyun Cho
Registration is now open! The 4th edition of the Mendel Early Career Symposium will take place on 21-22 May at the GMI, part of the @viennabiocenter.bsky.social. This two-day event brings together researchers across career stages to discuss the latest research in all areas of plant science.
January 27, 2026 at 11:20 AM
Registration is now open! The 4th edition of the Mendel Early Career Symposium will take place on 21-22 May at the GMI, part of the @viennabiocenter.bsky.social. This two-day event brings together researchers across career stages to discuss the latest research in all areas of plant science.
Reposted by Chung Hyun Cho
Contractile Injection Systems - Hot Springs - cryoET: Read the final version of our paper here:
academic.oup.com/ismej/advanc...
#microsky #teamtomo
academic.oup.com/ismej/advanc...
#microsky #teamtomo
Thermophilic bacteria employ a contractile injection system in hot spring microbial mats
Abstract. Bacterial contractile injection systems (CISs) are multiprotein complexes that facilitate the bacterial response to environmental factors or inte
academic.oup.com
February 11, 2026 at 2:43 PM
Contractile Injection Systems - Hot Springs - cryoET: Read the final version of our paper here:
academic.oup.com/ismej/advanc...
#microsky #teamtomo
academic.oup.com/ismej/advanc...
#microsky #teamtomo
Reposted by Chung Hyun Cho
Check out our latest pre-print of our favourite pets - the breviates. This work was led by Zhezhen Yi in collaboration with @andrewjroger.bsky.social and many others! By studying diverse breviates we were able to see how different metabolic pathways can evolved in response to low-oxygen.
www.biorxiv.org
February 9, 2026 at 2:55 PM
Check out our latest pre-print of our favourite pets - the breviates. This work was led by Zhezhen Yi in collaboration with @andrewjroger.bsky.social and many others! By studying diverse breviates we were able to see how different metabolic pathways can evolved in response to low-oxygen.
Reposted by Chung Hyun Cho
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
February 9, 2026 at 3:04 PM
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
Reposted by Chung Hyun Cho
Spatial Proteomics Workshop for Protists
(see more in thread below)
Registration
Early Bird Monday 22nd June 2026.
Regular Monday 10th August 2026.
There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...
(see more in thread below)
Registration
Early Bird Monday 22nd June 2026.
Regular Monday 10th August 2026.
There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...
February 6, 2026 at 6:11 PM
Spatial Proteomics Workshop for Protists
(see more in thread below)
Registration
Early Bird Monday 22nd June 2026.
Regular Monday 10th August 2026.
There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...
(see more in thread below)
Registration
Early Bird Monday 22nd June 2026.
Regular Monday 10th August 2026.
There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...
Reposted by Chung Hyun Cho
🌊Paper announcement! 📣
Viral infections rewire the metabolic makeup of their host and thereby create distinct chemical signatures. Can we use metabolic biomarkers to diagnose infections of algal blooms in the ocean?
Well, take a look at our new article led by Conny Kuhlisch in @pnas.org
>>
Viral infections rewire the metabolic makeup of their host and thereby create distinct chemical signatures. Can we use metabolic biomarkers to diagnose infections of algal blooms in the ocean?
Well, take a look at our new article led by Conny Kuhlisch in @pnas.org
>>
Mapping of the viral shunt across widespread coccolithophore blooms using metabolic biomarkers | PNAS
The viral shunt is a fundamental ecosystem process which diverts the flux of organic
carbon fixed through photosynthesis during algal bloom events ...
doi.org
February 5, 2026 at 5:22 PM
🌊Paper announcement! 📣
Viral infections rewire the metabolic makeup of their host and thereby create distinct chemical signatures. Can we use metabolic biomarkers to diagnose infections of algal blooms in the ocean?
Well, take a look at our new article led by Conny Kuhlisch in @pnas.org
>>
Viral infections rewire the metabolic makeup of their host and thereby create distinct chemical signatures. Can we use metabolic biomarkers to diagnose infections of algal blooms in the ocean?
Well, take a look at our new article led by Conny Kuhlisch in @pnas.org
>>
Reposted by Chung Hyun Cho
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 10:37 AM
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Reposted by Chung Hyun Cho
DAY 243
SPECIES 243 - Ca. Lokiarchaeum ossiferum
STAGE: Archaea
MEDIUM: Arches Paper. Chromatek watercolor. Sakura pen
NOTES: Yesterday was 10% shading and 90% painting, Todays was 90% shading with a 10min paint job. Looked better before painting, but I'll spend some more time on later archaea.
SPECIES 243 - Ca. Lokiarchaeum ossiferum
STAGE: Archaea
MEDIUM: Arches Paper. Chromatek watercolor. Sakura pen
NOTES: Yesterday was 10% shading and 90% painting, Todays was 90% shading with a 10min paint job. Looked better before painting, but I'll spend some more time on later archaea.
February 3, 2026 at 7:24 AM
DAY 243
SPECIES 243 - Ca. Lokiarchaeum ossiferum
STAGE: Archaea
MEDIUM: Arches Paper. Chromatek watercolor. Sakura pen
NOTES: Yesterday was 10% shading and 90% painting, Todays was 90% shading with a 10min paint job. Looked better before painting, but I'll spend some more time on later archaea.
SPECIES 243 - Ca. Lokiarchaeum ossiferum
STAGE: Archaea
MEDIUM: Arches Paper. Chromatek watercolor. Sakura pen
NOTES: Yesterday was 10% shading and 90% painting, Todays was 90% shading with a 10min paint job. Looked better before painting, but I'll spend some more time on later archaea.
Reposted by Chung Hyun Cho
Comparative Genomics of Unicellular Eukaryotes (San Feliu, Spain):
Abstract submission is open, with a short deadline! comparativegenomics2026.com
Join us as we explore the most diverse, surprising, and still largely uncharted branches of the eukaryotic tree.
Abstract submission is open, with a short deadline! comparativegenomics2026.com
Join us as we explore the most diverse, surprising, and still largely uncharted branches of the eukaryotic tree.
February 2, 2026 at 6:49 PM
Comparative Genomics of Unicellular Eukaryotes (San Feliu, Spain):
Abstract submission is open, with a short deadline! comparativegenomics2026.com
Join us as we explore the most diverse, surprising, and still largely uncharted branches of the eukaryotic tree.
Abstract submission is open, with a short deadline! comparativegenomics2026.com
Join us as we explore the most diverse, surprising, and still largely uncharted branches of the eukaryotic tree.
Reposted by Chung Hyun Cho
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵
Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
January 30, 2026 at 3:21 PM
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵
Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
Reposted by Chung Hyun Cho
Please share!
PhD position (4 years) available in my group @zmbp-tuebingen.bsky.social. We look for candidates with solid aptitude in computer science to cross disciplines and use cutting edge imaging to understand host infection by destructive plant pathogens.
uni-tuebingen.de/universitaet...
PhD position (4 years) available in my group @zmbp-tuebingen.bsky.social. We look for candidates with solid aptitude in computer science to cross disciplines and use cutting edge imaging to understand host infection by destructive plant pathogens.
uni-tuebingen.de/universitaet...
January 30, 2026 at 3:04 PM
Please share!
PhD position (4 years) available in my group @zmbp-tuebingen.bsky.social. We look for candidates with solid aptitude in computer science to cross disciplines and use cutting edge imaging to understand host infection by destructive plant pathogens.
uni-tuebingen.de/universitaet...
PhD position (4 years) available in my group @zmbp-tuebingen.bsky.social. We look for candidates with solid aptitude in computer science to cross disciplines and use cutting edge imaging to understand host infection by destructive plant pathogens.
uni-tuebingen.de/universitaet...
Reposted by Chung Hyun Cho
The day is finally here!! On behalf of all the co-organizers the Comparative Genomics of Unicellular Eukaryotes website is open.
comparativegenomics2026.com
Invited speakers will be added to the website in the coming weeks. Watch this (well, that^) space!
comparativegenomics2026.com
Invited speakers will be added to the website in the coming weeks. Watch this (well, that^) space!
CGUE 2026 – Comparative Genomics of Unicellular Eukaryotes 2026. San Feliu, Spain. 5-10 October
comparativegenomics2026.com
January 30, 2026 at 4:20 PM
The day is finally here!! On behalf of all the co-organizers the Comparative Genomics of Unicellular Eukaryotes website is open.
comparativegenomics2026.com
Invited speakers will be added to the website in the coming weeks. Watch this (well, that^) space!
comparativegenomics2026.com
Invited speakers will be added to the website in the coming weeks. Watch this (well, that^) space!
Reposted by Chung Hyun Cho
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
www.science.org
January 30, 2026 at 6:11 AM
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
Reposted by Chung Hyun Cho
This is a very special paper for me. I had the idea of combining transcription factor binding with chromatin in 2016/8. It took some time, but thanks to Fred and Vikas, we can finally share the story in @plos.org Genetics looking at chromatin states in Arabidopsis and Marchantia. #PlantScience
Chromatin state architecture governs transcription factor accessibility across plant genomes
Author summary In eukaryotes, DNA is tightly associated with histone proteins. Histone covalent modifications and histones isoforms, also called histone variants provide most of the complexity of chro...
journals.plos.org
January 23, 2026 at 3:17 PM
This is a very special paper for me. I had the idea of combining transcription factor binding with chromatin in 2016/8. It took some time, but thanks to Fred and Vikas, we can finally share the story in @plos.org Genetics looking at chromatin states in Arabidopsis and Marchantia. #PlantScience
Reposted by Chung Hyun Cho
A reminder to sign up for the 2026 EMBO archaeal meeting im Cambridge: meetings.embo.org/event/26-arc.... Registration is open. We are looking forward to hosting you!
Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
meetings.embo.org
January 23, 2026 at 8:15 AM
A reminder to sign up for the 2026 EMBO archaeal meeting im Cambridge: meetings.embo.org/event/26-arc.... Registration is open. We are looking forward to hosting you!
Reposted by Chung Hyun Cho
FastSpeciesTree: Fast and Scalable Species tree Inference https://www.biorxiv.org/content/10.64898/2026.01.20.700630v1
January 22, 2026 at 3:32 AM
FastSpeciesTree: Fast and Scalable Species tree Inference https://www.biorxiv.org/content/10.64898/2026.01.20.700630v1
Reposted by Chung Hyun Cho
My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring!
mirdita.org
mirdita.org
Mirdita Lab - Laboratory for Computational Biology & Molecular Machine Learning
Mirdita Lab builds scalable bioinformatics methods.
mirdita.org
January 20, 2026 at 11:07 AM
My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring!
mirdita.org
mirdita.org
Reposted by Chung Hyun Cho
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
www.nature.com
January 19, 2026 at 4:39 PM
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Reposted by Chung Hyun Cho
The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles.
Learn more: https://scim.ag/49pv8mB
Learn more: https://scim.ag/49pv8mB
January 19, 2026 at 10:54 PM
The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles.
Learn more: https://scim.ag/49pv8mB
Learn more: https://scim.ag/49pv8mB
Reposted by Chung Hyun Cho
FYI were starting weird structure/evolution/biology stuff at Glasgow University!
If you're interested let me know! Tell your friends!
CRYO www.jobs.gla.ac.uk/job/research...
BIOINFO www.jobs.gla.ac.uk/job/research...
TECHNICIAN www.jobs.gla.ac.uk/job/technici...
#science #hiring #evolution
If you're interested let me know! Tell your friends!
CRYO www.jobs.gla.ac.uk/job/research...
BIOINFO www.jobs.gla.ac.uk/job/research...
TECHNICIAN www.jobs.gla.ac.uk/job/technici...
#science #hiring #evolution
January 18, 2026 at 2:42 PM
FYI were starting weird structure/evolution/biology stuff at Glasgow University!
If you're interested let me know! Tell your friends!
CRYO www.jobs.gla.ac.uk/job/research...
BIOINFO www.jobs.gla.ac.uk/job/research...
TECHNICIAN www.jobs.gla.ac.uk/job/technici...
#science #hiring #evolution
If you're interested let me know! Tell your friends!
CRYO www.jobs.gla.ac.uk/job/research...
BIOINFO www.jobs.gla.ac.uk/job/research...
TECHNICIAN www.jobs.gla.ac.uk/job/technici...
#science #hiring #evolution
Reposted by Chung Hyun Cho
Dominant contribution of Asgard archaea to eukaryogenesis.
tldr; Best guess, ~ 50% of conserved eukaryotic protein families are from from Asgard archaea!
#science #biology #evolution #nature #bioinformatics
www.nature.com/articles/s41...
tldr; Best guess, ~ 50% of conserved eukaryotic protein families are from from Asgard archaea!
#science #biology #evolution #nature #bioinformatics
www.nature.com/articles/s41...
Dominant contribution of Asgard archaea to eukaryogenesis - Nature
A survey of the reconstructed gene set of the last eukaryotic common ancestor shows a consistent link between Asgard archaea and the origin of numerous, functionally diverse eukaryotic genes, dem...
www.nature.com
January 18, 2026 at 2:24 PM
Dominant contribution of Asgard archaea to eukaryogenesis.
tldr; Best guess, ~ 50% of conserved eukaryotic protein families are from from Asgard archaea!
#science #biology #evolution #nature #bioinformatics
www.nature.com/articles/s41...
tldr; Best guess, ~ 50% of conserved eukaryotic protein families are from from Asgard archaea!
#science #biology #evolution #nature #bioinformatics
www.nature.com/articles/s41...
Reposted by Chung Hyun Cho
Is this a CT scan through an animal brain? Or optical sections of a very interesting alga?
With big thanks to @dudinlab.bsky.social for helpful tips and encouragement. Now to use these methods to answer some long-standing biological questions! #protistsonsky #Cymbomonas
With big thanks to @dudinlab.bsky.social for helpful tips and encouragement. Now to use these methods to answer some long-standing biological questions! #protistsonsky #Cymbomonas
January 19, 2026 at 7:45 PM
Is this a CT scan through an animal brain? Or optical sections of a very interesting alga?
With big thanks to @dudinlab.bsky.social for helpful tips and encouragement. Now to use these methods to answer some long-standing biological questions! #protistsonsky #Cymbomonas
With big thanks to @dudinlab.bsky.social for helpful tips and encouragement. Now to use these methods to answer some long-standing biological questions! #protistsonsky #Cymbomonas