Carlos Conde
@carlos-conde.bsky.social
Cell Biologist at i3S studying chromosome segregation.
Assistant Professor at ICBAS-University of Porto.
Assistant Professor at ICBAS-University of Porto.
Pinned
Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy
Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…
www.sciencedirect.com
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Carlos Conde
Alves Domingos, Green, Cheerambathur et al. reveal that the #kinetochore protein KNL-1 regulates the #actin #cytoskeleton to control dendrite branching. rupress.org/jcb/article/...
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
November 14, 2025 at 4:15 PM
Alves Domingos, Green, Cheerambathur et al. reveal that the #kinetochore protein KNL-1 regulates the #actin #cytoskeleton to control dendrite branching. rupress.org/jcb/article/...
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
Reposted by Carlos Conde
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
November 11, 2025 at 9:26 AM
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
Reposted by Carlos Conde
Cryptococcus neoformans employs both PP1 and PP2A phosphatases to silence the spindle checkpoint https://www.biorxiv.org/content/10.1101/2025.11.04.686612v1
November 6, 2025 at 6:30 PM
Cryptococcus neoformans employs both PP1 and PP2A phosphatases to silence the spindle checkpoint https://www.biorxiv.org/content/10.1101/2025.11.04.686612v1
Reposted by Carlos Conde
My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression.
info and application here
institut-curie.org/job/study-en....
info and application here
institut-curie.org/job/study-en....
Study Engineer (F/M) - Institut Curie
The Curie Institute Research CenterThe Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a str...
institut-curie.org
November 4, 2025 at 10:38 AM
My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression.
info and application here
institut-curie.org/job/study-en....
info and application here
institut-curie.org/job/study-en....
Reposted by Carlos Conde
📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
October 30, 2025 at 1:15 PM
📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
Reposted by Carlos Conde
1 week left to apply for PhD studentships with @cruk-cityoflondon.bsky.social. Great projects are on offer- including from our lab @qmbci.bsky.social developing new strategies to target the cell cycle as a cancer therapy
Project: www.colcc.ac.uk/2026-blic-ph...
Apply: www.colcc.ac.uk/black-leader...
Project: www.colcc.ac.uk/2026-blic-ph...
Apply: www.colcc.ac.uk/black-leader...
October 29, 2025 at 10:12 AM
1 week left to apply for PhD studentships with @cruk-cityoflondon.bsky.social. Great projects are on offer- including from our lab @qmbci.bsky.social developing new strategies to target the cell cycle as a cancer therapy
Project: www.colcc.ac.uk/2026-blic-ph...
Apply: www.colcc.ac.uk/black-leader...
Project: www.colcc.ac.uk/2026-blic-ph...
Apply: www.colcc.ac.uk/black-leader...
Reposted by Carlos Conde
Interactions with the nucleosome’s acidic patch and DNA entry/exit site give the chromosomal passenger complex CPC a non-catalytic role in stabilizing #centromeric chromatin
#cryoEM and biochemical, cellular data by AA Jeyaprakash and coworkers
www.embopress.org/doi/full/10....
#cryoEM and biochemical, cellular data by AA Jeyaprakash and coworkers
www.embopress.org/doi/full/10....
October 27, 2025 at 2:58 PM
Interactions with the nucleosome’s acidic patch and DNA entry/exit site give the chromosomal passenger complex CPC a non-catalytic role in stabilizing #centromeric chromatin
#cryoEM and biochemical, cellular data by AA Jeyaprakash and coworkers
www.embopress.org/doi/full/10....
#cryoEM and biochemical, cellular data by AA Jeyaprakash and coworkers
www.embopress.org/doi/full/10....
Reposted by Carlos Conde
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.
The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR
candidate.hr-manager.net
October 23, 2025 at 4:18 PM
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy
Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…
www.sciencedirect.com
October 23, 2025 at 7:14 AM
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Carlos Conde
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...
www.science.org
October 16, 2025 at 7:17 PM
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Carlos Conde
We’re thrilled to announce this workshop! 🌟
Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team.
👉 Check it out! There are sponsored spots available!
Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team.
👉 Check it out! There are sponsored spots available!
Starting your own lab is exciting—but challenging.
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉 gbm-online.de/de/young-inv...
Pls repost!
Join our GBM Young Investigator leadership workshop in Regensburg, April 13–16th, 2026.
Professional coaching, peer networking & practical tips for new PIs.
Apply by Nov 30, 2025.
👉 gbm-online.de/de/young-inv...
Pls repost!
October 16, 2025 at 6:13 AM
We’re thrilled to announce this workshop! 🌟
Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team.
👉 Check it out! There are sponsored spots available!
Are you a junior PI in the process of building your lab? Join us in Regensburg for an inspiring workshop where we’ll exchange ideas and strategies on how to develop a motivated and harmonious team.
👉 Check it out! There are sponsored spots available!
Reposted by Carlos Conde
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
October 15, 2025 at 4:02 PM
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
Reposted by Carlos Conde
Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
October 2, 2025 at 2:59 PM
Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
Reposted by Carlos Conde
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
October 2, 2025 at 3:49 PM
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
Good things still happen: a couple of weeks ago Nelson Leça successfully defended his PhD! 🥳 He did a fantastic job discussing his work and "wrestling" the exciting examination led by @jakedel.bsky.social and @pseudoenzyme.bsky.social.
It was a good day! 👏🎉
It was a good day! 👏🎉
September 30, 2025 at 12:17 PM
Good things still happen: a couple of weeks ago Nelson Leça successfully defended his PhD! 🥳 He did a fantastic job discussing his work and "wrestling" the exciting examination led by @jakedel.bsky.social and @pseudoenzyme.bsky.social.
It was a good day! 👏🎉
It was a good day! 👏🎉
Reposted by Carlos Conde
Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement.
Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek
www.biorxiv.org/content/10.1...
Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek
www.biorxiv.org/content/10.1...
The mitotic stopwatch limits the proliferation of whole genome doubled cells
Whole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a...
www.biorxiv.org
September 19, 2025 at 10:23 AM
Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement.
Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek
www.biorxiv.org/content/10.1...
Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek
www.biorxiv.org/content/10.1...
Reposted by Carlos Conde
Happy to share our work in @embojournal 👉 shorturl.at/zXNyn
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
September 13, 2025 at 5:14 AM
Happy to share our work in @embojournal 👉 shorturl.at/zXNyn
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
For decades, we’ve known cells dismantle & rebuild the nuclear envelope in sync with spindle poles. But why does this coordination matter? And how do pole material properties ensure error-free division?
Follow this thread to know more 👇
Fantastic seminar by Jake @jakedel.bsky.social on the wonders of the NDC80 complex, which never ceases to amaze.
September 18, 2025 at 9:55 PM
Fantastic seminar by Jake @jakedel.bsky.social on the wonders of the NDC80 complex, which never ceases to amaze.
Reposted by Carlos Conde
Our group [@i3suporto.bsky.social] is hiring a Senior Technician (tinyurl.com/3ehju86r) and a Bioinformatician (tinyurl.com/2xwatnpx).
Know someone who might be a good fit? Send them our way
Know someone who might be a good fit? Send them our way
tinyurl.com
September 18, 2025 at 2:35 PM
Our group [@i3suporto.bsky.social] is hiring a Senior Technician (tinyurl.com/3ehju86r) and a Bioinformatician (tinyurl.com/2xwatnpx).
Know someone who might be a good fit? Send them our way
Know someone who might be a good fit? Send them our way
Reposted by Carlos Conde
Looking for your next step in fly genetics? The Rajan Lab at Fred Hutch is hiring a staff scientist + postdoc for projects on fat–brain signals, immunity, and brain aging. Stable, long-term role in a collaborative lab. Apply: careers-fhcrc.icims.com/jobs/30062/j...
Fred Hutchinson Cancer Center
Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.
careers-fhcrc.icims.com
September 16, 2025 at 11:32 PM
Looking for your next step in fly genetics? The Rajan Lab at Fred Hutch is hiring a staff scientist + postdoc for projects on fat–brain signals, immunity, and brain aging. Stable, long-term role in a collaborative lab. Apply: careers-fhcrc.icims.com/jobs/30062/j...
Reposted by Carlos Conde
New cell cycle meeting starts next summer!
events.faseb.org/event/c40174...
events.faseb.org/event/c40174...
Cell Cycle Regulation in Health and Disease.
Explore breakthroughs in cell cycle regulation and its impact on disease and therapies at this new multidisciplinary scientific meeting.
events.faseb.org
September 15, 2025 at 9:19 PM
New cell cycle meeting starts next summer!
events.faseb.org/event/c40174...
events.faseb.org/event/c40174...
Reposted by Carlos Conde
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
www.science.org
September 15, 2025 at 4:50 AM
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
Reposted by Carlos Conde
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 14, 2025 at 7:36 PM
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Great seminar by Viji @viji-draviam.bsky.social at @i3suporto.bsky.social and very insightful discussions. Always a pleasure to host colleagues and brainstorm!
September 13, 2025 at 2:53 PM
Great seminar by Viji @viji-draviam.bsky.social at @i3suporto.bsky.social and very insightful discussions. Always a pleasure to host colleagues and brainstorm!
Reposted by Carlos Conde
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
September 8, 2025 at 3:15 PM
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...