Bradly Alicea
@bradly-alicea.bsky.social
Director of research and content @Orthogonal_Lab. Scientific Advisory Board @ Active Inference Institute. Lecturer, iSchool @ UIUC. Developmental biology @openworm. Bike enthusiast. Good without God. Hands off Higher-Ed. #tsundoku afficionado.
Pinned
Reposted by Bradly Alicea
Waymo privatized another public street:
Chanel approaching 4th, San Francisco
Possibly queued for a Billie Eilish show at Chase Center ~half mile away.
The light rail train on 4th seen passing in front of this roboherd has more passenger capacity than all of them combined.
OP: .tiktok.renaspam18
Chanel approaching 4th, San Francisco
Possibly queued for a Billie Eilish show at Chase Center ~half mile away.
The light rail train on 4th seen passing in front of this roboherd has more passenger capacity than all of them combined.
OP: .tiktok.renaspam18
November 24, 2025 at 3:41 PM
Waymo privatized another public street:
Chanel approaching 4th, San Francisco
Possibly queued for a Billie Eilish show at Chase Center ~half mile away.
The light rail train on 4th seen passing in front of this roboherd has more passenger capacity than all of them combined.
OP: .tiktok.renaspam18
Chanel approaching 4th, San Francisco
Possibly queued for a Billie Eilish show at Chase Center ~half mile away.
The light rail train on 4th seen passing in front of this roboherd has more passenger capacity than all of them combined.
OP: .tiktok.renaspam18
Reposted by Bradly Alicea
"Why the Future of Atheism Looks Bright (Despite Everything)" by Hemant Mehta, the @friendlyatheist.com
Join us tomorrow to see Hemant Mehta again tomorrow at 11 am in person or at www.youtube.com/@ethicalstl
Join us tomorrow to see Hemant Mehta again tomorrow at 11 am in person or at www.youtube.com/@ethicalstl
November 23, 2025 at 3:24 AM
"Why the Future of Atheism Looks Bright (Despite Everything)" by Hemant Mehta, the @friendlyatheist.com
Join us tomorrow to see Hemant Mehta again tomorrow at 11 am in person or at www.youtube.com/@ethicalstl
Join us tomorrow to see Hemant Mehta again tomorrow at 11 am in person or at www.youtube.com/@ethicalstl
Reposted by Bradly Alicea
every journalist who has been ringing the alarm bell about this for the last three years should get $10 million from any bailout, as a treat
November 24, 2025 at 11:00 PM
every journalist who has been ringing the alarm bell about this for the last three years should get $10 million from any bailout, as a treat
Reposted by Bradly Alicea
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
buff.ly/gMbJWcX
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
buff.ly/gMbJWcX
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
buff.ly
November 24, 2025 at 11:28 PM
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
buff.ly/gMbJWcX
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
buff.ly/gMbJWcX
Reposted by Bradly Alicea
The DevoWorm meeting (🪱🧬🐣🔬🧠🧫💊) for November 24 is now available on YouTube youtu.be/yPhj8WeZb90?...
DevoWorm (2025, #39): Art of the Soluable and D'Arcy Thompson (history of physical development)
YouTube video by DevoWorm
youtu.be
November 24, 2025 at 8:21 PM
The DevoWorm meeting (🪱🧬🐣🔬🧠🧫💊) for November 24 is now available on YouTube youtu.be/yPhj8WeZb90?...
Reposted by Bradly Alicea
The European Commission unveiled its plan to overhaul how the EU enforces key tech regulations as part of a ‘Digital Omnibus.’ What is it trying to achieve? Tech Policy Press associate editor Ramsha Jahangir spoke to the AI Now Institute's Leevi Saari and the Ada Lovelace Institute's Julia Smakman.
What Is Europe Trying to Achieve With Its Omnibus and Sovereignty Push? | TechPolicy.Press
Tech Policy Press associate editor Ramsha Jahangir spoke to Leevi Saari from the AI Now Institute and Julia Smakman from the Ada Lovelace Institute.
www.techpolicy.press
November 24, 2025 at 1:52 PM
The European Commission unveiled its plan to overhaul how the EU enforces key tech regulations as part of a ‘Digital Omnibus.’ What is it trying to achieve? Tech Policy Press associate editor Ramsha Jahangir spoke to the AI Now Institute's Leevi Saari and the Ada Lovelace Institute's Julia Smakman.
Reposted by Bradly Alicea
Biotic marine CO₂ removal relies on export of organic carbon from the surface ocean to the deep sea, where CO₂ will be kept out of the atmosphere even if the organic matter is remineralized.
Deep-sea mining will bring this carbon to the ocean surface and release CO₂ to the atmosphere. Not awesome.
Deep-sea mining will bring this carbon to the ocean surface and release CO₂ to the atmosphere. Not awesome.
Deep-sea mining risks harming one of the last pristine ecosystems--but if it goes ahead under Trump, it could at least be done more sustainably by smelting the metal nodules with hydrogen plasma www.newscientist.com/article/2505...
Have we found a greener way to do deep-sea mining?
There are widespread concerns that deep-sea mining for metals will damage fragile ecosystems. But if mining ever goes ahead, hydrogen plasma could shrink the carbon footprint of smelting the metal ore...
www.newscientist.com
November 24, 2025 at 1:54 PM
Biotic marine CO₂ removal relies on export of organic carbon from the surface ocean to the deep sea, where CO₂ will be kept out of the atmosphere even if the organic matter is remineralized.
Deep-sea mining will bring this carbon to the ocean surface and release CO₂ to the atmosphere. Not awesome.
Deep-sea mining will bring this carbon to the ocean surface and release CO₂ to the atmosphere. Not awesome.
Reposted by Bradly Alicea
I’m co-organizing an “AI for Science: Algorithms to Atoms” social event during #NeurIPS2025 with Yann LeCun, Anima Anandkumar, Bill Dally, and Max Welling. If you want to talk about AI Scientist, World Models, the future of AI-driven discovery, come by on Dec 5 3:30pm PT!
luma.com/AI-for-Scien...
luma.com/AI-for-Scien...
November 24, 2025 at 1:52 AM
I’m co-organizing an “AI for Science: Algorithms to Atoms” social event during #NeurIPS2025 with Yann LeCun, Anima Anandkumar, Bill Dally, and Max Welling. If you want to talk about AI Scientist, World Models, the future of AI-driven discovery, come by on Dec 5 3:30pm PT!
luma.com/AI-for-Scien...
luma.com/AI-for-Scien...
Reposted by Bradly Alicea
GPT-5 on Sudoku-Bench 🧩
GPT-5 now leads our Sudoku-Bench leaderboard with 33% solve rate, ~2x the previous best, and is the first LLM to solve a 9x9 modern Sudoku.
Still, 67% of puzzles remain unsolved.
Read more about our update here:
🔗 Blogpost → pub.sakana.ai/sudoku-gpt5/
🧵 Thread 👇
GPT-5 now leads our Sudoku-Bench leaderboard with 33% solve rate, ~2x the previous best, and is the first LLM to solve a 9x9 modern Sudoku.
Still, 67% of puzzles remain unsolved.
Read more about our update here:
🔗 Blogpost → pub.sakana.ai/sudoku-gpt5/
🧵 Thread 👇
November 11, 2025 at 8:04 AM
GPT-5 on Sudoku-Bench 🧩
GPT-5 now leads our Sudoku-Bench leaderboard with 33% solve rate, ~2x the previous best, and is the first LLM to solve a 9x9 modern Sudoku.
Still, 67% of puzzles remain unsolved.
Read more about our update here:
🔗 Blogpost → pub.sakana.ai/sudoku-gpt5/
🧵 Thread 👇
GPT-5 now leads our Sudoku-Bench leaderboard with 33% solve rate, ~2x the previous best, and is the first LLM to solve a 9x9 modern Sudoku.
Still, 67% of puzzles remain unsolved.
Read more about our update here:
🔗 Blogpost → pub.sakana.ai/sudoku-gpt5/
🧵 Thread 👇
Reposted by Bradly Alicea
Reposted by Bradly Alicea
I talked with @meghanbartels.bsky.social for her article on the ten year anniversary of the Paris Agreement. I said “Until global emissions are at net zero, the climate outcomes of tomorrow are going to be worse than today.” But: the future not yet written. www.scientificamerican.com/article/the-...
5 Charts Show Climate Progress as Paris Agreement Turns 10
The 2015 Paris Agreement forged a path for the world to stave off the worst climate change scenarios. Here’s where we stand 10 years later
www.scientificamerican.com
November 23, 2025 at 2:01 AM
I talked with @meghanbartels.bsky.social for her article on the ten year anniversary of the Paris Agreement. I said “Until global emissions are at net zero, the climate outcomes of tomorrow are going to be worse than today.” But: the future not yet written. www.scientificamerican.com/article/the-...
Reposted by Bradly Alicea
You know what was unhelpful, all the electeds and pundits back in the spring saying, "to be sure, maybe DOGE is needed to increase efficiency". That's not what it was for, it was meant for destruction and crimey stuff. Total marks.
November 24, 2025 at 12:19 AM
You know what was unhelpful, all the electeds and pundits back in the spring saying, "to be sure, maybe DOGE is needed to increase efficiency". That's not what it was for, it was meant for destruction and crimey stuff. Total marks.
Reposted by Bradly Alicea
DOGE was created for data theft and infrastructure dismantling and it wildly succeeded on both counts within the first few weeks of its existence. It will take a generation to rebuild what it destroyed and the breach of data is unprecedented.
Bye bye, “DOGE”.
It no longer exists as a “centralized entity”, according to the Office of Personnel Management.
@reuters.com
www.reuters.com/world/us/dog...
It no longer exists as a “centralized entity”, according to the Office of Personnel Management.
@reuters.com
www.reuters.com/world/us/dog...
November 23, 2025 at 3:01 PM
DOGE was created for data theft and infrastructure dismantling and it wildly succeeded on both counts within the first few weeks of its existence. It will take a generation to rebuild what it destroyed and the breach of data is unprecedented.
Reposted by Bradly Alicea
🌅 The Saturday Morning 🧠Sim for November 22 is now available on YouTube youtu.be/FDJeVwqNr1Y
Saturday Morning NeuroSim, 11-22
YouTube video by Orthogonal Research and Education Laboratory
youtu.be
November 23, 2025 at 5:35 AM
🌅 The Saturday Morning 🧠Sim for November 22 is now available on YouTube youtu.be/FDJeVwqNr1Y
Reposted by Bradly Alicea
The three of us ended up writing a paper with Simon Levin on applying these PDE models to protocell evolution, considering competition between "fast genes" and "slow genes" that were complementary for protocell-level replication.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
A PDE Model for Protocell Evolution and the Origin of Chromosomes via Multilevel Selection - Bulletin of Mathematical Biology
The evolution of complex cellular life involved two major transitions: the encapsulation of self-replicating genetic entities into cellular units and the aggregation of individual genes into a collect...
link.springer.com
November 23, 2025 at 6:30 AM
The three of us ended up writing a paper with Simon Levin on applying these PDE models to protocell evolution, considering competition between "fast genes" and "slow genes" that were complementary for protocell-level replication.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Bradly Alicea
Still posting cytoskeleton videos, it seems. Actin this time.
Sample: Lifeact-eGFP in HeLa cells.
Modality: Airyscan confocal
Timestamp is mm:ss and the scale bar is 5 µm.
Sample: Lifeact-eGFP in HeLa cells.
Modality: Airyscan confocal
Timestamp is mm:ss and the scale bar is 5 µm.
November 23, 2025 at 3:21 AM
Still posting cytoskeleton videos, it seems. Actin this time.
Sample: Lifeact-eGFP in HeLa cells.
Modality: Airyscan confocal
Timestamp is mm:ss and the scale bar is 5 µm.
Sample: Lifeact-eGFP in HeLa cells.
Modality: Airyscan confocal
Timestamp is mm:ss and the scale bar is 5 µm.
Reposted by Bradly Alicea
This is a story about how America’s world-leading cancer and dementia research system was destroyed by frauds and naifs who broke the law.
There must be consequences.
There must be consequences.
Some incredible details in this piece
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
November 22, 2025 at 10:12 PM
This is a story about how America’s world-leading cancer and dementia research system was destroyed by frauds and naifs who broke the law.
There must be consequences.
There must be consequences.
Reposted by Bradly Alicea
Someone made a clone of Gmail where you're logged in as Epstein and can see his emails. [https://jmail.world/]
November 21, 2025 at 7:50 PM
Someone made a clone of Gmail where you're logged in as Epstein and can see his emails. [https://jmail.world/]
Reposted by Bradly Alicea
“We need to start, now, to reduce CO2 emissions from fossil-fuels, by at least 5% per year. This must happen in order to have a chance to avoid unmanageable & extremely costly climate impacts affecting all people in the world.” PIKs J. Rockström @theguardian.com
www.theguardian.com/environment/...
www.theguardian.com/environment/...
Cop30: Scientists warn countries must act decisively to protect people and life or risk ‘suffering for billions’ – as it happened
As president Lula tries to find common ground between negotiating countries, planetary scientists say emissions must be urgently cut
www.theguardian.com
November 20, 2025 at 11:21 AM
“We need to start, now, to reduce CO2 emissions from fossil-fuels, by at least 5% per year. This must happen in order to have a chance to avoid unmanageable & extremely costly climate impacts affecting all people in the world.” PIKs J. Rockström @theguardian.com
www.theguardian.com/environment/...
www.theguardian.com/environment/...
Reposted by Bradly Alicea
I wrote about the exhaustion and dissonance of writing about TDOR for the past 15 years
I’m sick of writing about dead trans people | Xtra Magazine
For 15 years, I hoped my words would change something. Now I’m grieving the world that could’ve been
xtramagazine.com
November 20, 2025 at 7:33 PM
I wrote about the exhaustion and dissonance of writing about TDOR for the past 15 years
Reposted by Bradly Alicea
Stop treating neurons as passive processors... They are active controllers! 🧠 🎮
In our latest Journal Club session, Thelonious Cooper presented "The neuron as a direct data-driven controller" by Moore et al., with special commentary from Mitya Chklovskii.
🎥 www.youtube.com/watch?v=0P7k...
🧠🤖🧠📈
In our latest Journal Club session, Thelonious Cooper presented "The neuron as a direct data-driven controller" by Moore et al., with special commentary from Mitya Chklovskii.
🎥 www.youtube.com/watch?v=0P7k...
🧠🤖🧠📈
The neuron as a direct data-driven controller (Moore et al., 2024) — Sensorimotor AI Journal Club
YouTube video by Sensorimotor AI
www.youtube.com
November 21, 2025 at 6:06 AM
Stop treating neurons as passive processors... They are active controllers! 🧠 🎮
In our latest Journal Club session, Thelonious Cooper presented "The neuron as a direct data-driven controller" by Moore et al., with special commentary from Mitya Chklovskii.
🎥 www.youtube.com/watch?v=0P7k...
🧠🤖🧠📈
In our latest Journal Club session, Thelonious Cooper presented "The neuron as a direct data-driven controller" by Moore et al., with special commentary from Mitya Chklovskii.
🎥 www.youtube.com/watch?v=0P7k...
🧠🤖🧠📈
Reposted by Bradly Alicea
i once saw graffiti on the bathroom stall that said “tomorrow needs you”. i think about it every time i get into a bad headspace.
happy trans day of remembrance.
happy trans day of remembrance.
November 20, 2025 at 7:49 PM
i once saw graffiti on the bathroom stall that said “tomorrow needs you”. i think about it every time i get into a bad headspace.
happy trans day of remembrance.
happy trans day of remembrance.
Reposted by Bradly Alicea
It cannot be said enough how everyone that confirmed RFK Jr has endless blood on their hands. They should be asked why they did that every day until they acknowledge as much and beg forgiveness.
HEADS UP: CDC website now officially asserts that vaccines may cause autism.“Studies supporting a link have been ignored by health authorities.” Also says the “vaccines do not cause autism” header remains b/c of an agreement with Cassidy.
November 20, 2025 at 4:00 AM
It cannot be said enough how everyone that confirmed RFK Jr has endless blood on their hands. They should be asked why they did that every day until they acknowledge as much and beg forgiveness.
Reposted by Bradly Alicea
Billionaires are policy failures; financialization is the mechanism of enshittification.
private equity buys a company and immediately starts torturing their employees and the money
November 20, 2025 at 3:49 AM
Billionaires are policy failures; financialization is the mechanism of enshittification.
Reposted by Bradly Alicea
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
November 19, 2025 at 9:48 PM
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.