berkeleyMCB
@berkeleymcb.bsky.social
Molecular & Cell Biology (MCB) Department at UC Berkeley | curiosity driven basic research, education, training and a commitment to public service. 🧪🐻
mcb.berkeley.edu/
mcb.berkeley.edu/
Reposted by berkeleyMCB
I rarely get to give a research talk at my home institution! Looking forward to giving a talk about our latest research next Tuesday, November 18th, at 2 pm as part of the @innovativegenomics.bsky.social seminar series in Room 115 IGIB at UC Berkeley! innovativegenomics.org/events/semin...
Reimagining Druggability using Chemoproteomic Platforms
Reimagining Druggability using Chemoproteomic Platforms - Innovative Genomics Institute (IGI)
innovativegenomics.org
November 11, 2025 at 6:18 PM
I rarely get to give a research talk at my home institution! Looking forward to giving a talk about our latest research next Tuesday, November 18th, at 2 pm as part of the @innovativegenomics.bsky.social seminar series in Room 115 IGIB at UC Berkeley! innovativegenomics.org/events/semin...
Reposted by berkeleyMCB
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 8:34 PM
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Reposted by berkeleyMCB
An honor and pleasure to be at the @HKLaureatesForum, a “meeting of inspirational minds” gathering @ShawPrize recipients 🏅 and young scientists. Inspirational to hear other laureates and interact with promising researchers curious about the world around them, big 🪐 & small 🧬
November 14, 2025 at 3:24 AM
An honor and pleasure to be at the @HKLaureatesForum, a “meeting of inspirational minds” gathering @ShawPrize recipients 🏅 and young scientists. Inspirational to hear other laureates and interact with promising researchers curious about the world around them, big 🪐 & small 🧬
Reposted by berkeleyMCB
Delighted to present my trajectory and research to audiences ranging from high school students to researchers at Hong Kong Universities and Science Centers. Special thanks to my local ambassadors Zhoe and Emi for making my visit so special 🥰🥰
November 14, 2025 at 3:24 AM
Delighted to present my trajectory and research to audiences ranging from high school students to researchers at Hong Kong Universities and Science Centers. Special thanks to my local ambassadors Zhoe and Emi for making my visit so special 🥰🥰
Reposted by berkeleyMCB
New from the @doudna-lab.bsky.social and first author @owentuck.bsky.social!
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
www.science.org
November 14, 2025 at 12:27 AM
New from the @doudna-lab.bsky.social and first author @owentuck.bsky.social!
Reposted by berkeleyMCB
Azalea grew out of collaborative research conducted at the Innovative Genomics Institute in Jennifer Doudna’s lab and in Justin Eyquem’s lab as part of the Gladstone-UCSF Institute of Genomic Immunology.
@j-eyquem.bsky.social
@innovativegenomics.bsky.social
@j-eyquem.bsky.social
@innovativegenomics.bsky.social
Azalea Therapeutics Launches with $82 Million Financing to Redefine Precision Genomic Medicines by Engineering Cells Directly Inside Each Patient
Azalea Therapeutics launches with $82M to advance precision in vivo genome engineering, creating therapeutic cells directly inside patients....
www.globenewswire.com
November 14, 2025 at 9:10 PM
Azalea grew out of collaborative research conducted at the Innovative Genomics Institute in Jennifer Doudna’s lab and in Justin Eyquem’s lab as part of the Gladstone-UCSF Institute of Genomic Immunology.
@j-eyquem.bsky.social
@innovativegenomics.bsky.social
@j-eyquem.bsky.social
@innovativegenomics.bsky.social
Congrats to MCB's Evan Miller on receiving this grant from the Camille and Henry Dreyfus Foundation! 👏🎉
November 6, 2025 at 12:38 AM
Congrats to MCB's Evan Miller on receiving this grant from the Camille and Henry Dreyfus Foundation! 👏🎉
Reposted by berkeleyMCB
Coming up November 6th — join us to hear about the latest in #CRISPR for human health from IGI's Brad Ringeisen, Fyodor Urnov, and Carlotta Ronda as part of @ucberkeleyofficial.bsky.social's Basic Science Lights the Way lecture series! Register here: https://basicscience.berkeley.edu/
October 31, 2025 at 4:01 PM
Coming up November 6th — join us to hear about the latest in #CRISPR for human health from IGI's Brad Ringeisen, Fyodor Urnov, and Carlotta Ronda as part of @ucberkeleyofficial.bsky.social's Basic Science Lights the Way lecture series! Register here: https://basicscience.berkeley.edu/
Reposted by berkeleyMCB
Andrew Dillin is a professor of immunology and molecular medicine in the Department of Molecular and Cell Biology.
In his spare time, he is forming a new Center for Unmet, Rare and Emerging Diseases (CURED) that aims to discover cures other organizations are not pursuing.
gobears.me/47pCGn5
In his spare time, he is forming a new Center for Unmet, Rare and Emerging Diseases (CURED) that aims to discover cures other organizations are not pursuing.
gobears.me/47pCGn5
Introducing CURED
Driven by the motto Fiat Lux, Berkeley illuminates the world.
gobears.me
October 29, 2025 at 7:47 PM
Andrew Dillin is a professor of immunology and molecular medicine in the Department of Molecular and Cell Biology.
In his spare time, he is forming a new Center for Unmet, Rare and Emerging Diseases (CURED) that aims to discover cures other organizations are not pursuing.
gobears.me/47pCGn5
In his spare time, he is forming a new Center for Unmet, Rare and Emerging Diseases (CURED) that aims to discover cures other organizations are not pursuing.
gobears.me/47pCGn5
Reposted by berkeleyMCB
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
Reposted by berkeleyMCB
We’re thrilled to see this groundbreaking work from
@mti-ucb.bsky.social Faculty Co-director @dannomura.bsky.social! TRACERs represent a significant leap forward in targeting “undruggable” transcription factors with small molecules. We are honored to support this work!
#Epigenetics #DrugDiscovery
@mti-ucb.bsky.social Faculty Co-director @dannomura.bsky.social! TRACERs represent a significant leap forward in targeting “undruggable” transcription factors with small molecules. We are honored to support this work!
#Epigenetics #DrugDiscovery
We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Targeted Transcriptional Repression by Induced Proximity
Most cancer driving proteins remain undruggable due to the absence of ligandable pockets and their reliance on intrinsically disordered or protein-DNA/protein-protein interactions. Transcription facto...
www.biorxiv.org
October 23, 2025 at 11:16 PM
We’re thrilled to see this groundbreaking work from
@mti-ucb.bsky.social Faculty Co-director @dannomura.bsky.social! TRACERs represent a significant leap forward in targeting “undruggable” transcription factors with small molecules. We are honored to support this work!
#Epigenetics #DrugDiscovery
@mti-ucb.bsky.social Faculty Co-director @dannomura.bsky.social! TRACERs represent a significant leap forward in targeting “undruggable” transcription factors with small molecules. We are honored to support this work!
#Epigenetics #DrugDiscovery
Congrats to MCB's Professor (Affiliated) Daniel Fletcher on his election to the National Academy of Medicine! 🎉👏
October 21, 2025 at 10:26 PM
Congrats to MCB's Professor (Affiliated) Daniel Fletcher on his election to the National Academy of Medicine! 🎉👏
Reposted by berkeleyMCB
UC Berkeley PIs & collaborators: MTI invites proposals for its newly launched Parkinson’s Therapeutics Program!
Offering up to 3 awards of $90k, and additional funded access to MTI's drug-hunting infrastructure.
🗓️ Deadline: Nov 16, 2025
More info 👇
moleculartherapeutics.org/mti-launches...
Offering up to 3 awards of $90k, and additional funded access to MTI's drug-hunting infrastructure.
🗓️ Deadline: Nov 16, 2025
More info 👇
moleculartherapeutics.org/mti-launches...
MTI Launches Parkinson’s Therapeutics Program, Invites Proposals
BERKELEY — UC Berkeley’s Molecular Therapeutics Initiative (MTI) has launched a new funding program to accelerate drug discovery for Parkinson’s disease and related synucleinopathies.
moleculartherapeutics.org
October 17, 2025 at 9:27 AM
UC Berkeley PIs & collaborators: MTI invites proposals for its newly launched Parkinson’s Therapeutics Program!
Offering up to 3 awards of $90k, and additional funded access to MTI's drug-hunting infrastructure.
🗓️ Deadline: Nov 16, 2025
More info 👇
moleculartherapeutics.org/mti-launches...
Offering up to 3 awards of $90k, and additional funded access to MTI's drug-hunting infrastructure.
🗓️ Deadline: Nov 16, 2025
More info 👇
moleculartherapeutics.org/mti-launches...
Reposted by berkeleyMCB
I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
October 17, 2025 at 7:58 PM
I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
Reposted by berkeleyMCB
FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/
Systemic coagulopathy promotes host lethality in a new Drosophila tumor model - PubMed
Malignant tumors trigger a complex network of inflammatory and wound repair responses, prompting Dvorak's characterization of tumors as "wounds that never heal."<sup>1</sup> Some of these responses le...
pubmed.ncbi.nlm.nih.gov
October 18, 2025 at 2:45 PM
FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/
Reposted by berkeleyMCB
Eric Topol interviews Jennifer Doudna on the bright future of genome editing therapy in curing disease (Apple Podcasts). There’s an FDA-approved CRISPR therapy for sickle cell disease out now with others to come. [youtube.com]
Jennifer Doudna: The Exciting Future of Genome Editing
The most significant life science breakthrough of our time is just getting started.
Subscribe for more Ground Truths: https://erictopol.substack.com/
www.youtube.com
April 16, 2024 at 5:06 PM
Eric Topol interviews Jennifer Doudna on the bright future of genome editing therapy in curing disease (Apple Podcasts). There’s an FDA-approved CRISPR therapy for sickle cell disease out now with others to come. [youtube.com]
Reposted by berkeleyMCB
@mti-ucb.bsky.social is proud to have contributed to this exciting look at innovation at @ucberkeleyofficial.bsky.social.
Congrats to all involved on bringing "Startup Campus" to life!
#StartupCampus #BerkeleyInnovation #MTI
Congrats to all involved on bringing "Startup Campus" to life!
#StartupCampus #BerkeleyInnovation #MTI
🌟 SkyDeck’s latest newsletter is here!
📘 “Startup Campus” book launch - watch the powerhouse UC Berkeley innovation panel tinyurl.com/UCBPanelSC
🏅 UC’s record-breaking 5 Nobel Prizes in one week
🚀 Fundraising wins for SkyDeck alums
🔗 Read more: tinyurl.com/1017News
📘 “Startup Campus” book launch - watch the powerhouse UC Berkeley innovation panel tinyurl.com/UCBPanelSC
🏅 UC’s record-breaking 5 Nobel Prizes in one week
🚀 Fundraising wins for SkyDeck alums
🔗 Read more: tinyurl.com/1017News
October 19, 2025 at 5:15 AM
@mti-ucb.bsky.social is proud to have contributed to this exciting look at innovation at @ucberkeleyofficial.bsky.social.
Congrats to all involved on bringing "Startup Campus" to life!
#StartupCampus #BerkeleyInnovation #MTI
Congrats to all involved on bringing "Startup Campus" to life!
#StartupCampus #BerkeleyInnovation #MTI
Reposted by berkeleyMCB
The University of California just set a world record: 5 Nobel Prizes awarded to its faculty and alumni this year! 🏆🥇
A feat that underscores the impact of bold science and strong research ecosystems.
Read more here: www.universityofcalifornia.edu/news/uc-wins...
#NobelPrize #Research #Innovation
A feat that underscores the impact of bold science and strong research ecosystems.
Read more here: www.universityofcalifornia.edu/news/uc-wins...
#NobelPrize #Research #Innovation
UC wins 5 Nobel Prizes in 3 days — and sets a new world record
These discoveries span decades and disciplines, but they all have one important thing in common: They’ve all relied on competitive funding from the federal government.
www.universityofcalifornia.edu
October 19, 2025 at 5:28 AM
The University of California just set a world record: 5 Nobel Prizes awarded to its faculty and alumni this year! 🏆🥇
A feat that underscores the impact of bold science and strong research ecosystems.
Read more here: www.universityofcalifornia.edu/news/uc-wins...
#NobelPrize #Research #Innovation
A feat that underscores the impact of bold science and strong research ecosystems.
Read more here: www.universityofcalifornia.edu/news/uc-wins...
#NobelPrize #Research #Innovation
Reposted by berkeleyMCB
13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020.
On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
A prokaryotic RNA–directed targeting system can be designed to cleave any DNA sequence.
scim.ag
October 20, 2025 at 7:33 PM
13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020.
On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
Reposted by berkeleyMCB
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
October 17, 2025 at 12:30 AM
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
Welcome to Thomas Mann who will be joining the MCB department as an assistant professor of Immunology and Molecular Medicine on Jan. 1st 2026! 🎉
mcb.berkeley.edu/news-and-eve...
mcb.berkeley.edu/news-and-eve...
October 16, 2025 at 7:33 PM
Welcome to Thomas Mann who will be joining the MCB department as an assistant professor of Immunology and Molecular Medicine on Jan. 1st 2026! 🎉
mcb.berkeley.edu/news-and-eve...
mcb.berkeley.edu/news-and-eve...
Reposted by berkeleyMCB
Please join us in congratulating ASBMB member Jennifer Doudna, who has been awarded the prestigious 2026 Joseph Priestley Medal for her groundbreaking work on #RNA molecules with enzymatic functions by @acs.org.
ow.ly/8l9u50X8Sre #ASBMBMemberNews
ow.ly/8l9u50X8Sre #ASBMBMemberNews
Doudna wins Priestley Medal
She will receive a $20,000 research grant and will formally accept the honor at the ACS Spring 2026 conference.
ow.ly
October 11, 2025 at 1:41 PM
Please join us in congratulating ASBMB member Jennifer Doudna, who has been awarded the prestigious 2026 Joseph Priestley Medal for her groundbreaking work on #RNA molecules with enzymatic functions by @acs.org.
ow.ly/8l9u50X8Sre #ASBMBMemberNews
ow.ly/8l9u50X8Sre #ASBMBMemberNews
Reposted by berkeleyMCB
In advance of his November visit, @protocolsio.bsky.social prez Lenny Teytelman (@lteytelman.bsky.social) spoke to Berkeley's Leah Keiser about his path to founding a startup acquired by @springernature.com. Read the interview:
qb3.berkeley.edu/news/profess...
qb3.berkeley.edu/news/profess...
October 13, 2025 at 6:59 PM
In advance of his November visit, @protocolsio.bsky.social prez Lenny Teytelman (@lteytelman.bsky.social) spoke to Berkeley's Leah Keiser about his path to founding a startup acquired by @springernature.com. Read the interview:
qb3.berkeley.edu/news/profess...
qb3.berkeley.edu/news/profess...
Reposted by berkeleyMCB
New paper from the lab. Molecular characterization of the symbiont-containing organelle with proteomics and reverse genetics in Aiptasia and coral.
We're excited to share with everyone a preprint of our manuscript that resolves the cellular origins of the symbiosome in cnidarian-algal symbiosis through proteomics of the symbiosome, RNAi, and CRISPR/Cas9 experiments. ⬇️
www.biorxiv.org/content/10.1...
Read on below!
1/12 🧵
www.biorxiv.org/content/10.1...
Read on below!
1/12 🧵
October 13, 2025 at 10:02 PM
New paper from the lab. Molecular characterization of the symbiont-containing organelle with proteomics and reverse genetics in Aiptasia and coral.
Reposted by berkeleyMCB
Thrilled to share our new cryo-ET preprint on astrocytes, a collaboration with @mengmengfu.bsky.social here at @ucberkeleyofficial.bsky.social, revealing the nm-scale cytoskeletal architecture of ramified astrocytes reminiscing in vivo morphology. Check out the cytoskeleton compartmentalization!
Excited to share our preprint on cytoskeletal organization in astrocytes!
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
https://biorxiv.org/content/10.110…
October 13, 2025 at 11:02 PM
Thrilled to share our new cryo-ET preprint on astrocytes, a collaboration with @mengmengfu.bsky.social here at @ucberkeleyofficial.bsky.social, revealing the nm-scale cytoskeletal architecture of ramified astrocytes reminiscing in vivo morphology. Check out the cytoskeleton compartmentalization!