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innovativegenomics.bsky.social
Innovative Genomics Institute
@innovativegenomics.bsky.social
2.4K followers 600 following 230 posts
Using genome engineering to solve humanity’s greatest problems in health, climate & sustainable agriculture. UC Berkeley, UCSF, UC Davis. https://innovativegenomics.org/
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innovativegenomics.bsky.social
For the second year in a row, IGI had a booth at #NDiSTEM, the annual conference from SACNAS! More than a hundred students stopped by to learn about IGI and opportunities at the University of California.
November 26, 2025 at 4:02 PM
Reposted by Innovative Genomics Institute
erinedoherty.bsky.social
Such a privilege to see my summer mentee present her work at #ABRCMS2025!
November 23, 2025 at 2:21 AM
Reposted by Innovative Genomics Institute
jnoms.bsky.social
So happy to see this work out! Was such a pleasure to co-lead this effort with Erin. Do you like viral immune evasion, and using protein structure to study immune antagonists? Give it a read!
November 25, 2025 at 9:34 PM
innovativegenomics.bsky.social
New from @banfieldlab.bsky.social and collab Alanna Schepartz!
science.org Science Magazine @science.org · 4d
Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science.

The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
scim.ag
November 25, 2025 at 9:47 PM
innovativegenomics.bsky.social
1/2 New from co-first authors @erinedoherty.bsky.social and @jnoms.bsky.social of the @doudna-lab.bsky.social — Bacteria fight off viruses using tiny molecular “alarm signals” made of nucleotides. To survive, viruses must find ways to shut these signals down.
New Method Uncovers How Viruses Evade Immune Responses — and How We Might Fight Back
Explore how viruses evade immune responses by developing enzymes that disrupt molecular alarm signals in host cells.
innovativegenomics.org
November 25, 2025 at 9:46 PM
innovativegenomics.bsky.social
New in @natgenet.nature.com from IGI's Claire Clelland (@ucsanfrancisco.bsky.social) and @giannikopoulosp.bsky.social (@ucberkeleyofficial.bsky.social): Measurement and clinical interpretation of CRISPR off-targets

Read here: www.nature.com/articles/s41...
Measurement and clinical interpretation of CRISPR off-targets - Nature Genetics
This Perspective provides a practical and clinically relevant framework rooted in benefit–risk analyses to evaluate genomic CRISPR off-targets. Such an approach is applicable to currently available as...
www.nature.com
November 25, 2025 at 12:29 AM
innovativegenomics.bsky.social
📣 New preprint from the Doudna and Savage labs, looking at improving #CRISPR efficiency in human and plant cells!

Read here: Latent activity in TnpB revealed by mutational scanning https://ow.ly/iz4050XtHca
November 24, 2025 at 4:50 PM
Reposted by Innovative Genomics Institute
ucberkeleyofficial.bsky.social
A future without chocolate seems almost unimaginable. But according to UC Berkeley’s Brian Staskawicz, it is a very real possibility.

Learn more in this thread.🧵
November 21, 2025 at 11:27 PM
innovativegenomics.bsky.social
ICYMI: Can red seaweed reduce methane emissions from cattle? Marketplace recently featured the IGI Investigator Ermias Kebreab. Listen here: https://ow.ly/1u8o50XtGLm
November 21, 2025 at 6:45 PM
innovativegenomics.bsky.social
Out today in Science Magazine — First author Veronika Kivenson and PIs Jill Banfield (The Banfield Lab) and Alanna Schepartz team up to reveal a new genetic code in #archaea, with implications for #methane and #climate, and #bioengineering! Learn more: https://ow.ly/Kuem50Xurh0
Headshots of Veronika, Jill, and Alanna
November 20, 2025 at 7:20 PM
innovativegenomics.bsky.social
And another new one from IGI's Carlotta Ronda!
carlottaronda.bsky.social Carlotta Ronda @carlottaronda.bsky.social · 12d
🚨 A probiotic that secretes a GLP-1–triggering peptide.

By engineering E. coli Nissle to secrete a microbial peptide that stimulates host GLP-1 release, we uncovered a new connection between the microbiome, metabolism, and gut inflammation.
👉 science.org/doi/10.1126/...
Engineered probiotic restores GLP-1 signaling to ameliorate fiber-deficiency exacerbated colitis
Engineered probiotic delivers bacterial peptide that enhances GLP-1 and restores barrier integrity in diet-modulated colitis.
science.org
November 20, 2025 at 5:42 PM
innovativegenomics.bsky.social
New from IGI's Carlotta Ronda!
November 20, 2025 at 5:41 PM
innovativegenomics.bsky.social
New from IGI's @bruceconklin.bsky.social!
November 19, 2025 at 5:22 PM
Reposted by Innovative Genomics Institute
diamondlab.bsky.social
We are thrilled to announce our latest publication in the Microbiome journal in collaboration with
@thehesslab.bsky.social
Supplementation with red seaweed in cows reduces methane and induces previously uncharacterized hydrogenotropic bacteria.
microbiomejournal.biomedcentral.com/articles/10....
Red seaweed supplementation suppresses methanogenesis in the rumen, revealing potentially advantageous traits among hydrogenotrophic bacteria - Microbiome
Background Macroalgae belonging to the genus Asparagopsis have shown to reduce methane (CH4) production during rumen fermentation, while increasing feed efficiency when added to the feed of cattle. Ho...
microbiomejournal.biomedcentral.com
November 19, 2025 at 12:09 AM
Reposted by Innovative Genomics Institute
amymquinton.bsky.social
What if we could reprogram a cow's gut so it burps way less methane?🐮👏 @ucdavis.bsky.social & @innovativegenomics.bsky.social scientists found which microbes might help reduce methane w/o harming the cow. Boost that microbe & cows could become naturally cleaner for the climate! bit.ly/4oGv5YE 🧪
Three black-and-white and brown-and-white dairy cows munch on feed in a trough. Scientists may have found which microbes in a cow's gut could be used to cut methane emissions without harming the cow.
November 18, 2025 at 6:33 PM
Reposted by Innovative Genomics Institute
metaomicsnerd.bsky.social
My former UC Davis colleagues Ermias Kebreab and Paulo de Meo Filho went on Marketplace to talk about using seaweed and CRISPR to mitigate cattle enteric methane emissions!

www.marketplace.org/story/2025/1...
Could an early diet of seaweed produce climate-friendlier beef?
A UC Davis study shows promising results.
www.marketplace.org
November 7, 2025 at 8:48 PM
innovativegenomics.bsky.social
New in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: https://ow.ly/pIWQ50XtEtM
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin-like protease repeatedly acquired by multiple, ...
ow.ly
November 18, 2025 at 5:45 PM
innovativegenomics.bsky.social
Read more here: innovativegenomics.org/news/a-micro...
November 17, 2025 at 9:59 PM
Reposted by Innovative Genomics Institute
gladstoneinst.bsky.social
A new study by scientists from Gladstone, Innovative Genomics Institute, and UC Berkeley could influence how gene therapies are designed for many genetic diseases.

@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
The Genome Editing Playbook Is Different in Neurons
The striking findings of a new study could influence how gene therapies are designed for many genetic diseases.
gladstone.org
November 17, 2025 at 8:51 PM
Reposted by Innovative Genomics Institute
gladstoneinst.bsky.social
Azalea grew out of collaborative research conducted at the Innovative Genomics Institute in Jennifer Doudna’s lab and in Justin Eyquem’s lab as part of the Gladstone-UCSF Institute of Genomic Immunology.

@j-eyquem.bsky.social
@innovativegenomics.bsky.social
Azalea Therapeutics Launches with $82 Million Financing to Redefine Precision Genomic Medicines by Engineering Cells Directly Inside Each Patient
Azalea Therapeutics launches with $82M to advance precision in vivo genome engineering, creating therapeutic cells directly inside patients....
www.globenewswire.com
November 14, 2025 at 9:10 PM
innovativegenomics.bsky.social
New from IGI's @marsonlab.bsky.social!
November 14, 2025 at 8:34 PM
innovativegenomics.bsky.social
New from the @doudna-lab.bsky.social and first author @owentuck.bsky.social!
November 14, 2025 at 12:27 AM
innovativegenomics.bsky.social
New from IGI's Alex Marson!
November 13, 2025 at 9:24 PM
innovativegenomics.bsky.social
📣New preprint from IGI's Justin Eyquem and Alex Marson📣 Site-specific genome engineering of primary human natural killer cells for programmable anti-tumor function. Read here: https://ow.ly/x5k950XoACz
November 12, 2025 at 5:05 PM
innovativegenomics.bsky.social
The Edith Nourse Rogers STEM Scholarship allows eligible veterans up to 9 months or $30k of benefits for training in high-demand STEM fields. Learn more here: https://ow.ly/Zlmq50Xozcw

#VeteransDay
EDUCATION SERVICE GI BILL PROGRAMS GI BILL FAST FACTS THE EDITH NOURSE ROGERS STEM SCHOLARSHIP The STEM Scholarship can extend your GI Bill benefits up to nine months (or $30,000, whichever comes first). Scholarships are awarded on a monthly basis with decisions typically made within 30 days. Communication about your Roger STEM Scholarship benefits is available through STEMText.
November 11, 2025 at 4:25 PM