Cynthia Jones-McLellan
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balancedway.bsky.social
Cynthia Jones-McLellan
@balancedway.bsky.social
200 followers 550 following 0 posts
Neuroscience • Brain Health • MS • Myelin Repair • MH Nutrition • Trauma Recovery • Integrative Wellness • Environmental Medicine • Student • RN Ret. (she/her)
Posts Replies Media Videos
Reposted by Cynthia Jones-McLellan
euanritchie.bsky.social
When stressed & fearful, mothers will eject their joeys from their pouches. To reduce the chance of this happening, don’t approach mothers with obvious joeys/large pouches, & don’t ever let dogs chase wildlife. If a joey is ejected call a wildlife carer immediately. au.news.yahoo.com/aussie-mum-i...
Aussie mum in 'total shock' after unexpected wildlife predicament on suburban street
The mother of four has spoken to Yahoo News about her confusion following the rare encounter. Find out more.
au.news.yahoo.com
January 13, 2026 at 2:07 AM
Reposted by Cynthia Jones-McLellan
rrust.bsky.social
Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis
January 4, 2026 at 4:16 PM
Reposted by Cynthia Jones-McLellan
haoyin.bsky.social
hiPSC-derived Neural Progenitor Cells support long-term (43 dpi) graft neuronal integration & functional recovery after photothrombotic Stroke🐭

👉57% neurites extend along cc into contralateral hemisphere

Grafts▶️44% GABAergic Neurons

@rrust.bsky.social #NatComm 2025
www.nature.com/articles/s41...
January 1, 2026 at 2:21 PM
Reposted by Cynthia Jones-McLellan
neurowithmelike.bsky.social
www.cell.com/neuron/abstr...
Immune-brain plasticity underpins stress and affective behaviors
Lee and Wheeler review the interface of neuroimmune interactions, stress, and affective behaviors. They highlight anatomical and cellular mechanisms controlling immune-brain plasticity as well as ther...
www.cell.com
January 4, 2026 at 8:29 PM
Reposted by Cynthia Jones-McLellan
ruizdealmodovar.bsky.social
Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions.
@CRC1366
@erc.europa.eu @immunosens.bsky.social
October 14, 2025 at 5:16 PM
Reposted by Cynthia Jones-McLellan
biorxiv-neursci.bsky.social
Sex specific axon initial segment plasticity underlies cortical hyperexcitability in trigeminal pain https://www.biorxiv.org/content/10.1101/2025.10.11.681811v1
October 14, 2025 at 2:15 AM
Reposted by Cynthia Jones-McLellan
kevinh-phd.bsky.social
Excited to announce my new book FOOD INTELLIGENCE coauthored with brilliant journalist @juliabelluz.bsky.social‬! Cutting through the confusion about diet & health, #FoodIntelligence describes the fascinating science of how food both nourishes & harms us. www.penguinrandomhouse.com/books/671334...
Food Intelligence by Julia Belluz, Kevin Hall, PhD: 9780593332306 | PenguinRandomHouse.com: Books
The essential guide for understanding what you’re eating, and the forces that are driving you to eat it. Nutrition isn’t rocket science; it’s harder. There are new diet fads, bold...
www.penguinrandomhouse.com
July 16, 2025 at 9:53 AM
Reposted by Cynthia Jones-McLellan
profccollins.bsky.social
Ahead of #WorldMenopauseDay October 18 I ask Dr Rebecca Haslam about 10 common #nutrition questions women ask about #Menopause @nmnteatwell.bsky.social @hmriaustralia.bsky.social @menopausesociety.bsky.social Listen on Spotify shorturl.at/vBjQK
Youtube youtu.be/zPRQvYdTRpE?...
10 nutrition questions women commonly ask about menopause ...with Dr Rebecca Haslam
YouTube video by Nutrition Science Bites
youtu.be
October 14, 2025 at 2:20 AM
Reposted by Cynthia Jones-McLellan
multiplesclerosis.bsky.social
Cutting-edge review on phospholipid metabolism: A new perspective on inflammation regulation in innate immunity
www.eurekalert.org/news-release...
Cutting-edge review on phospholipid metabolism: A new perspective on inflammation regulation in innate immunity
Phospholipids, essential components of cell membranes, are increasingly recognized for their active roles in regulating innate immunity and inflammation. A new review is published to outline how phosp...
www.eurekalert.org
October 2, 2025 at 6:56 AM
Reposted by Cynthia Jones-McLellan
labwaggoner.bsky.social
Review: The relationship between genetic mutations and formation of specific amyloid fibril structures drives inheritance patterns of amyloid diseases
www.science.org/doi/10.1126/...
October 1, 2025 at 7:23 PM
Reposted by Cynthia Jones-McLellan
labwaggoner.bsky.social
Review @moltherapy.bsky.social Epigenetic networks coordinate DNA methylation across the genome
www.cell.com/molecular-th...
October 2, 2025 at 3:04 AM
Reposted by Cynthia Jones-McLellan
plosbiology.org
How do different tissues respond to mitochondrial dysfunction? @candrewfrank.bsky.social &co show that Complex I depletion triggers ROS-driven compensatory signaling in #MotorNeurons, but degeneration in muscles, with implications for #MitochondrialDisease @plosbiology.org 🧪 plos.io/4nLUIGJ
Left: Image of the Drosophila melanogaster third instar larval ventral nerve cord used to examine mitochondrial morphology. Green fluorescence labels neuronal mitochondrial clusters decorated by a transgenically expressed Mito-GFP protein. Magenta fluorescence labels the Drosophila Bruchpilot protein, a component of active zones. Image credit: Bhagaban Mallik. Right: Image of synaptic boutons at the Drosophila melanogaster third instar larval neuromuscular junction rendered into three dimensions to quantify volumes of synaptic mitochondria. Green fluorescence labels neuronal mitochondria localized to the presynaptic boutons. Mitochondria are decorated by a transgenically expressed Mito-GFP protein. Magenta fluorescence labels the Drosophila Discs Large protein, an organizer of the postsynaptic density in the muscle. Image credit: Bhagaban Mallik and Thomas Moninger.
September 23, 2025 at 8:23 AM
Reposted by Cynthia Jones-McLellan
labwaggoner.bsky.social
Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity
www.science.org/doi/10.1126/...
September 23, 2025 at 9:36 PM
Reposted by Cynthia Jones-McLellan
candrewfrank.bsky.social
We have an uncorrected proof published for Bhagaban Mallik's study on Mitochondrial Complex I and how it regulates synapse function. You can find it in @plosbiology.org. I am so proud!

H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social

journals.plos.org/plosbiology/...
Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms
How do neurons adapt to mitochondrial dysfunction in different tissues? This study shows that Mitochondrial Complex I depletion triggers ROS-driven compensatory signaling in motor neurons that preserv...
journals.plos.org
September 22, 2025 at 10:53 PM
Reposted by Cynthia Jones-McLellan
gregory-ms.com
Neonatal microglia transplantation ameliorates disability, reduces leukocyte infiltration and promotes remyelination in both inflammatory (EAE) and non-inflammatory (cuprizone) models, and reverses cognitive decline in aged mice. Neuromi...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Neonatal Microglia and Their Secretome as Mediators of Brain Repair
Neonatal microglia transplantation ameliorates disability, reduces leukocyte infiltration and promotes remyelination in both inflammatory (EAE) and non-inflammatory (cuprizone) models, and reverses co
gregory-ms.com
September 23, 2025 at 7:20 AM
Reposted by Cynthia Jones-McLellan
labwaggoner.bsky.social
Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration @cp-immunity.bsky.social @uthealthhouston.bsky.social @mayoclinic.org
www.cell.com/immunity/ful...
September 20, 2025 at 4:33 PM
Reposted by Cynthia Jones-McLellan
scinews.bsky.social
Emerging contaminants: A One Health perspective

Open Access
www.sciencedirect.com/science/arti...

#Geoscience #Science #Review #News #Pollution #AirPollution #AirContaminants #Meded #medx #Health #healthResearch #TIC2025
June 16, 2025 at 6:24 AM
Reposted by Cynthia Jones-McLellan
multiplesclerosis.bsky.social
Maintaining balance in the immune system | EurekAlert! www.eurekalert.org/news-release...
Maintaining balance in the immune system
Researchers from the Turner lab have published the first description of the role of the ZFP36 family of RNA binding proteins in regulatory T cells (Tregs). Tregs are key to maintaining balance in the...
www.eurekalert.org
June 16, 2025 at 7:18 AM
Reposted by Cynthia Jones-McLellan
jgrutzendler.bsky.social
Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...
June 14, 2025 at 4:13 PM
Reposted by Cynthia Jones-McLellan
rrust.bsky.social
A new review from our lab exploring how the blood-brain barrier (BBB) can be used as a treatment target for neurodegenerative disorders

tandfonline.com/doi/10.1080/...

TL;DR → Here are a few key highlights 👇
March 25, 2025 at 4:14 PM
Reposted by Cynthia Jones-McLellan
liisagalea.bsky.social
Our latest review on perimenopause menopause and hormone therapy. What key issues have we missed and how can we do better from education to research to clinical care. With Laura Gravelsins! www.cambridge.org/core/journal...
One size does not fit all: how type of menopause and hormone therapy matters for brain health | The British Journal of Psychiatry | Cambridge Core
One size does not fit all: how type of menopause and hormone therapy matters for brain health
www.cambridge.org
June 16, 2025 at 8:46 AM
Reposted by Cynthia Jones-McLellan
natrevneurol.nature.com
Multiple sclerosis from onset to secondary progression: a 30-year Italian register study jnnp.bmj.com/cgi/content/...
Multiple sclerosis from onset to secondary progression: a 30-year Italian register study
Background Three decades have passed since the initial approval of disease-modifying therapies (DMTs). Ongoing discussion is focused on fundamental aspects of the disease, highlighting a growing divis...
jnnp.bmj.com
June 16, 2025 at 9:44 AM
Reposted by Cynthia Jones-McLellan
bachynski.bsky.social
“All along the Southern California coastline from San Diego to Santa Barbara, hundreds of animals — sea lions, dolphins, seabirds — are washing up on the sand either dead or seriously ill. Coastal researchers & officials say it’s become a marine-life crisis that has overwhelmed rescue organizations”
Why Are Dolphins and Sea Lions Washing Up Dead on Southern California Beaches?
In recent weeks, hundreds of sea lions, dolphins and other animals have turned up in the sand dead or seriously ill, alarming rescuers and beachgoers alike.
www.nytimes.com
April 1, 2025 at 1:08 AM
Reposted by Cynthia Jones-McLellan
castltrastondrs.bsky.social
#Medsky🧪 #neurosky #IDsky #publichealth Chronic pain is often accompanied by other sx (fatigue & sleep disturbance ) these symptoms all correlate with #neuroimmune activation. cytokines in the cerebrospinal fluid (CSF) seem to be generally upregulated in patients with chronic pain vs control
Twenty-six cytokines in serum were negatively correlated with fatigue (Tables 2, S3). When queried together, we found one functional cluster of 14 cytokines, namely CCL3, CCL4, CCL25, CCL28, CXCL9, CXCL10, CXCL11, IL6, IL8, IL18, LIF-R, MCP1, MCP3, and MCP4 (Fig. 1). Twenty-five cytokines in CSF were negatively correlated with fatigue (Tables 2, S4). When queried together, we found one functional cluster of six cytokines, namely CCL3, CCL4, CCL25, CXCL9, CXCL11 and MCP1 (Fig. 2). In addition, the pairs SCF-Flt3L, TNFRSF9-CD40 and OPG-TRAIL were found to be functionally associated.
March 30, 2025 at 1:08 PM
Reposted by Cynthia Jones-McLellan
neurosexdiff.bsky.social
www.thetransmitter.org/policy/exclu...
Exclusive: NIH appears to archive policy requiring female animals in studies
Such a shift would “put us back in the dark ages in terms of our science,” says neuroscientist Anne Murphy, who helped to formulate the original policy.
www.thetransmitter.org
February 25, 2025 at 9:14 PM