Lightnews — Scholar-powered news

Wen Ding @wyd20.bsky.social · 13d

Kidney disease affects 1 in 10 of the UK population and has largely been overlooked in the UK 10 Year Health Plan. Please sign this petition by Thursday 9th October to emphasise the importance of a national strategy for kidney disease. www.ukkidney.org/prime-minist...

Add Your Name: Call on the Prime Minister to Tackle Kidney Disease

Kidney disease affects more than 7 million people in the UK, yet was largely overlooked in the Government’s new 10-year health plan for the NHS. Without action, it will place an unsustainable burden o...

www.ukkidney.org

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Wen Ding @wyd20.bsky.social · 21d

Great talk about the Hidden initiative from Kate Bramham and detecting CKD in the community in London. Absolutely inspirational @kidneyresearchuk.org

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Wen Ding @wyd20.bsky.social · 21d

Having a fantastic time listening to all the progress in kidney research in the UK @kidneyresearchuk.org driving discoveries. Fantastic talk @willkidney.bsky.social about how large well designed trials have changed our practice in nephrology

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Sampson Lab for Kidney Genomics @thesampsonlab.bsky.social · Jul 24

Your kidneys are working hard for you every day, every hour. Return the favor with these small habits that lead to lifelong health. 💬 Which of these do you already do? Which one could you start this week? #KidneyFacts #HealthyKidneys #NephrologyTips #BIGKiDsStudy #KidneyHealthAwareness #sampsonlab

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · May 29

Sibeprenlimab inches closer to approval

www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social

Phase 3 RCT next week at #ERA25 (& some journal?)

FDA Accepts, Grants Priority Review to Sibeprenlimab BLA for IgA Nephropathy

With the priority review acceptance of the Biologics License Application, the FDA has assigned a PDUFA target action date of November 28, 2025.

www.hcplive.com

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Michelle Rheault, MD @rheaultm.bsky.social · May 20

Sparsentan for FSGS?? It's alive....
ir.travere.com/press-releas...

Travere Therapeutics Announces FDA Acceptance of sNDA for FILSPARI® (sparsentan) in FSGS

PDUFA target action date of January 13, 2026 If approved, FILSPARI would be the first and only FDA-approved treatment for FSGS, a rare kidney condition and a leading cause of kidney failure Travere Th...

ir.travere.com

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WHO @who.int · Apr 24

It’s #WorldImmunizationWeek

Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute.

A reminder of what is #HumanlyPossible. Science saves lives.

#VaccinesWork
bit.ly/wiw2025

Every 10 seconds vaccination saves a life.
Immunization for all is Humanly Possible

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Chris Fell @cfell.bsky.social · Apr 9

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵

www.nature.com/articles/s41...

Reprogramming site-specific retrotransposon activity to new DNA sites - Nature

A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...

www.nature.com

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Wen Ding @wyd20.bsky.social · Apr 2

Interesting!

Cathy Quinlan ☘️ 🇦🇺 🌱 @cathyquinlan.bsky.social · Feb 17

1️⃣ Now this is amazing! 🎉 My PhD student Gráinne Butler led a groundbreaking study using Epic EMR data to detect genetic kidney disease before symptoms appeared!

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Wen Ding @wyd20.bsky.social · Mar 7

Wow! This IS dedication

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Wen Ding @wyd20.bsky.social · Mar 7

Why do you have ultrasound gel in the car? 🤔

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Eric Topol @erictopol.bsky.social · Feb 23

Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...

Design of study using sequencing of B and T cell receptor and A.I. models to unravel information about infections and autoimmune conditions

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Wen Ding @wyd20.bsky.social · Feb 10

What an exciting time to be a nephrologist. Yet another really promising therapy for IgA. Decreases proteinuria significantly, likely will be spoilt for choice soon but how will be choose the right meds for the right patient?

NEJM.org @nejm.org · Feb 10

Among patients with IgA nephropathy, treatment with iptacopan, which inhibits the alternative complement pathway, resulted in a significant reduction in proteinuria as compared with placebo. Full APPLAUSE-IgAN trial results and Research Summary: nej.md/3UmrOkh

#MedSky #Nephrology

Iptacopan in IgA Nephropathy

A Research Summary based on Perkovic V et al. | 10.1056/NEJMoa2410316 | Published on October 25, 2024

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Wen Ding @wyd20.bsky.social · Feb 10

Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design

Whitehead Institute @whiteheadinstitute.bsky.social · Feb 7

Researchers in the Young Lab at Whitehead Institute and the Barzilay Lab in MIT's CSAIL have developed ProtGPS, a machine learning model that predicts which cellular compartments a protein will reside in.

This tool could inform the development of more effective therapies. shorturl.at/5KdVE

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Di Jiang @dijiang319.bsky.social · Feb 8

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Protein codes promote selective subcellular compartmentalization

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

www.science.org

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Neil Shubin @neilshubin.bsky.social · Feb 8

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

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Wen Ding @wyd20.bsky.social · Jan 29

No idea how the academic world would cope without pubmed

Trish Greenhalgh @trishgreenhalgh.bsky.social · Jan 28

If they pull PubMed, do we have a plan B? #academicsky?

Wen Ding @wyd20.bsky.social · Jan 21

Fascinating read: history of ISKDC. Our current management of nephrotic syndrome not very different from this first nephrotic syndrome RCT. (Other than AZA which was shown not to be useful in iNS)

media.springernature.com/full/springe...

Reposted by Wen Ding

Dr Anastasia S Mihailidou PhD FAHA FCSANZ FESC @anastasiasmihaili.bsky.social · Jan 8

Why we need to start monitoring #BP before adulthood for #cardiovascular #prevention #CvPrev

Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence

evidence.nejm.org/doi/full/10....

Adolescent Blood Pressure and Early Age Stroke

Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardi...

evidence.nejm.org

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Wen Ding @wyd20.bsky.social · Jan 10

As a result sub-specialty recruitment is generally good!

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Wen Ding @wyd20.bsky.social · Jan 10

I hadn’t realised this was the case in the US, training length the same for Paediatric specialities versus general in the UK, and pay is the same on completion

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Krutika Kuppalli, MD FIDSA @krutikakuppalli.bsky.social · Jan 1

This 13-year-old received 3 antivirals and plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza— not even during H1N1.

#H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it.
www.nejm.org/doi/full/10....

Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection | NEJM

Influenza A(H5N1) viruses are an emerging zoonotic threat and have spread widely throughout birds in North America. Recently, influenza A(H5N1) infection led to serious illness in a teenager in Canada.

www.nejm.org

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Wen Ding @wyd20.bsky.social · Dec 28

Chronic Kidney Disease is rising in prevalence--I have signed this petition for the World Health Organisation to recognise kidney health as a priority, do consider signing to prioritise preventing premature death from kidney disease
#nephsky #medsky #pedsky

Fernanda Arce-Amaré @ferarceamare.bsky.social · Dec 12

Guatemala is leading a historic effort at the @who.int to recognize kidney disease as a global health priority. This will drive global strategies to improve care and reduce the burden of kidney disease.

Sign the petition: ow.ly/a7J350Tfpjp #KidneyHealthMatters #UHCDay
TY @momenabbasi.bsky.social

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Wen Ding @wyd20.bsky.social · Dec 20

😱
Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔

Altmetric @altmetric.com · Dec 19

THREAD

This Is The Story Of The The Pernicious Rise of AI-Generated Papers and their Online Impact

An Incomplete History Told In The Voice of Documentarian Adam Curtis
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Adam Curtis Title Card: We Too Are Trapped In A System. Text over a background of a large office building

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Jennifer Chen, MD FAAP @drjenchen4kids.medsky.social · Dec 16

#PedSky appreciation post: Dr. Weyand’s posts are why I now check ferritin/CRP for every anemia screen (w CBC + retic)! I’ve caught so many w single digit ferritin levels even if Hgb is “normal” 😱 It’s also an issue in “picky eaters” even if they’re not menstruating

Shematologist, MD @shematologist.medsky.social · Dec 11

Just your regular reminder that iron deficiency affects ~40% of 12-21 yo females and still no one cares.

jamanetwork.com/journals/jam...

Prevalence of Iron Deficiency and Iron-Deficiency Anemia in US Females Aged 12-21 Years, 2003-2020

This study examines prevalence of iron deficiency among females aged 12 to 21 years to inform future screening strategies for iron deficiency and iron-deficiency anemia.

jamanetwork.com

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