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NEJM.org @nejm.org · 20h

A 22-year-old woman presented with a 3-month history of bumps on the right ventral surface of her tongue. On physical examination, the bumps were observed to be pink papillomatous lesions measuring 3 to 8 mm in diameter. Read the full case details: nej.md/4mH8U2I

#MedSky #DermSky

Images in Clinical Medicine
Oral Verruciform Xanthomas

Panel A: A photo of the pink papillomatous lesions measuring 3 to 8 mm in diameter.
Panel B and inset: Histopathological analysis of an excised lesion revealing acanthotic, papillary, and parakeratinized epithelium with an accumulation of large cells with foamy cytoplasm in the connective tissue.

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NEJM.org @nejm.org · 20h

𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪 mosquitoes spread chikungunya, dengue, and Zika. In a trial in Mexico, targeted indoor residual spraying led to lower mosquito levels but not lower disease risk. Full trial results and Research Summary: nej.md/46J4e7O

#MedSky #IDSky

The New England Journal of Medicine
Targeted Indoor Spraying to Prevent Aedes-Borne Diseases
A Research Summary based on Dean NE et al. | 10.1056/NEJMoa2501069 | Published on October 9, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 1d

An AI system and a physician were given a case presentation describing a patient who was admitted to the hospital because of fever, hypoxemia, and bacteremia. Their differential diagnoses are shown in videos of slide-based presentations. Learn more: nej.md/3KYBaAE

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NEJM.org @nejm.org · 1d

A new review explores current ideas about the disease, with emphasis on the importance of dural venous sinus stenosis and new treatment options. Read the full review: nej.md/3KJlVvk

#MedSky #NeuroSky #Ophthalmology

Key points from the Review Article "Idiopathic Intracranial Hypertension"

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NEJM.org @nejm.org · 1d

In the BaxHTN phase 3 trial involving patients with uncontrolled or resistant hypertension, baxdrostat added to background therapy led to a lower seated systolic blood pressure than placebo at 12 weeks. Full trial results and Research Summary: nej.md/4my7xUZ

#MedSky #CardioSky

The New England Journal of Medicine
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension
A Research Summary based on Flack JM et al. | DOI: 10.1056/NEJMoa2507109 | Published on August 30, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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NEJM.org @nejm.org · 2d

In a 21-year-old woman who presented with a 7-day history of sore throat and cough, a chest radiograph showed two hemivertebrae at the ninth thoracic vertebral body. Read the full case details: nej.md/4pZCCCR

#MedSky #Orthopedics #Radiology

Panel A: A chest radiograph showing normal lungs and two hemivertebrae at the ninth thoracic vertebral body (T9).
Panels B–D: Subsequent computed tomography of the chest showing a sagittal cleft (axial view), anterior wedging (parasagittal view), and symmetric, triangular hemivertebrae resembling the wings of a butterfly at T9 (coronal view).

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NEJM.org @nejm.org · 2d

Presented at #OTOMTG25:

Valayannopoulos and colleagues report the outcomes of treating 12 participants who had complete inherited deafness with gene therapy. Full CHORD phase 1–2 study results: nej.md/4o7ky8f  

#MedSky #Otolaryngology

AAO-HNSF 2025 Annual Meeting & OTO EXPO

Original Article | OCT 12, 2025 | NEJM.org
DB-OTO Gene Therapy for Inherited Deafness

Figure 3. Auditory Brain-Stem Response at Week 24.

NEJM identity sits at the bottom.

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NEJM.org @nejm.org · 3d

Malaria remains a major cause of childhood death in sub-Saharan Africa. Treating the cloth wraps mothers traditionally use to carry their babies may provide additional protection. Research findings are summarized in a new Quick Take video. nej.md/430nBXE

#MedSky #IDSky

A visual representation of a trial in western Uganda that assessed whether treating the cloth wraps mothers use to carry young children might provide additional protection against malaria.

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NEJM.org @nejm.org · 3d

NEJM National Correspondent Lisa Rosenbaum, MD, shares a preview of season 3 of the “Not Otherwise Specified” podcast premiering October 15.

Listen to past episodes and subscribe to the podcast: nej.md/NOS

#MedSky

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NEJM.org @nejm.org · 3d

2️⃣ Surveillance of Health Care–Associated Infections nej.md/4h0xmuG

3️⃣ The AI Frontier in Humanitarian Aid nej.md/4pYmOR3

Subscribe to NEJM for the latest medical research: nej.md/subscribe

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NEJM.org @nejm.org · 3d

Weekend Briefing for October 11, 2025:

New Images in Clinical Medicine: Pneumococcal Sepsis in Asplenia and Hypogammaglobulinemia nej.md/4oap9GL

Three New Perspectives:

1️⃣ Digital Treatment to Reduce Global Tobacco Use nej.md/4nKq29e

#MedSky

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NEJM.org @nejm.org · 4d

Physical examination was notable for abdominal distention and mild tenderness to palpation on the left side of the abdomen. Computed tomography of the abdomen and pelvis is shown. What is the most likely diagnosis? nej.md/IC10092025 2/2

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NEJM.org @nejm.org · 4d

A 23-year-old man with autism spectrum disorder and chronic constipation presented to the emergency department with a 1-week history of abdominal pain on his left side, nausea, and vomiting. 1/2

#MedSky

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NEJM.org @nejm.org · 4d

To learn more about this term, read the editorial “Defanging the Neutrophil to Treat Bronchiectasis”: nej.md/4cANv89

Explore more terms: nej.md/glossary

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NEJM.org @nejm.org · 4d

𝐑𝐞𝐚𝐜𝐭𝐢𝐯𝐞 𝐨𝐱𝐲𝐠𝐞𝐧 𝐬𝐩𝐞𝐜𝐢𝐞𝐬 are hydroxyl radicals, produced by the metabolism of oxygen, that are extremely reactive and immediately remove electrons from any molecule with which they interact. Full definition of this NEJM Illustrated Glossary term: nej.md/48UCLRX

#MedSky #ScienceSky

A visual representation of “reactive oxygen species”

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NEJM.org @nejm.org · 4d

As more patients with sickle cell disease or β-thalassemia are treated with the gene-edited cellular drug exa-cel, there are more opportunities to test for potential off-target editing. Yen and colleagues provide an update. Read now: nej.md/4ocjWy9

#MedSky #Hematology #Genetics

A diagram of the assessment of off-target editing in clinical trial participants.

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NEJM.org @nejm.org · 5d

As aedes-borne diseases surge in the Americas, new control approaches are needed against the primary mosquito vector, 𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪. Research findings on the efficacy of targeted indoor residual spraying are summarized in a new Quick Take video. nej.md/47e9S1V

#MedSky #IDSky

Visual representation of a study that examines the effectiveness of targeted indoor residual spraying of an insecticide to reduce the incidence of aedes-borne diseases in children.

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NEJM.org @nejm.org · 5d

Case Record of the MGH: A 36-year-old man was admitted because of fever, hypoxemia, and bacteremia. Imaging revealed pulmonary opacities, thickening of the duodenal wall, and a thrombus in the right renal vein. A diagnosis was made. Full case details: nej.md/3KYBaAE

#MedSky

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NEJM.org @nejm.org · 5d

Targeted Indoor Spraying to Prevent Aedes-Borne Diseases nej.md/46J4e7O

Permethrin-Treated Wraps for Prevention of Malaria nej.md/4msFwwX

Subscribe to NEJM for the latest medical research: nej.md/subscribe

NEJM.org @nejm.org · 5d

New in the October 9, 2025, issue of NEJM:

Baxdrostat Efficacy and Safety in Uncontrolled Hypertension (BaxHTN phase 3 trial) nej.md/4my7xUZ

Nexiguran Ziclumeran in ATTR with Polyneuropathy nej.md/46Qhur7

#MedSky

Images and descriptions of what's new on NEJM.org this week

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NEJM.org @nejm.org · 6d

Idiopathic intracranial hypertension — high cerebrospinal fluid pressure most common in women of reproductive age with obesity — threatens vision. Treatment includes weight loss, medication, and surgery. Learn more in a new review: nej.md/3KJlVvk

#MedSky #NeuroSky #Ophthalmology

Panel A: Funduscopic images showing severe papilledema in the right and left eyes with hemorrhages and exudates.
Panel B: The right and left fundi 3 months later, with resolving papilledema after reduction in intracranial pressure (ICP) by venous sinus stenting followed by shunt repair.

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NEJM.org @nejm.org · 6d

𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪 mosquitoes spread chikungunya, dengue, and Zika. In a trial in Mexico, targeted indoor residual spraying led to lower mosquito levels but not lower disease risk. Full trial results: nej.md/46J4e7O

#MedSky #IDSky

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NEJM.org @nejm.org · 6d

In a national cohort of veterans, the 2024–2025 Covid-19 vaccine was linked to reduced risks of emergency department visits, hospitalizations, and deaths from Covid-19 across the overall cohort and in various subgroups. Full study results: nej.md/47anKdz

#MedSky #IDSky

A graph showing the Covid-19–associated composite outcome over 180 days in the 2024–2025 vaccination season

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NEJM.org @nejm.org · 6d

GASTROSAM trial: Many children with severe acute malnutrition have complications such as gastroenteritis, often with severe dehydration. Whether intravenous rehydration is safe in such children has been unclear. Research findings are summarized in a new Quick Take video. nej.md/4pTKHJy

A visual representation of the GASTROSAM trial, which assessed intravenous rehydration therapy for children with severe acute malnutrition with gastroenteritis and severe dehydration.

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Reposted by NEJM.org

Larry Au @larryau.bsky.social · 10d

Our new NEJM commentary argues on the need to preserve state autonomy for Emergency Medicaid, and the critical role EM plays in supporting undocumented immigrants and safety net hospitals

www.nejm.org/doi/full/10....

Emergency Medicaid at Risk — Preserving State Authority and Access to Care | NEJM

States that use federal dollars to provide health care to unauthorized immigrants, beyond narrowly defined emergency services, will now face enforcement actions and potential recoupment of funds.

www.nejm.org

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