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Follow @ai.nejm.org for medical AI content.
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Measles | NEJM
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A new Double Take video reviews evidence-based recommendations on measles prevention and management and explores commonly asked questions about the measles virus and infection. Watch on YouTube: youtu.be/PI6M680p9i0
A 39-year-old woman with obesity presented to an ophthalmology clinic with a 6-week history of a foreign-body sensation and tearing in both eyes. Symptoms were worse upon awakening. She also reported daytime fatigue, snoring, and difficulty sleeping at night. 1/2
#MedSky
#MedSky
January 30, 2026 at 8:01 PM
A 39-year-old woman with obesity presented to an ophthalmology clinic with a 6-week history of a foreign-body sensation and tearing in both eyes. Symptoms were worse upon awakening. She also reported daytime fatigue, snoring, and difficulty sleeping at night. 1/2
#MedSky
#MedSky
CORE-TIMI 72a and CORE2-TIMI 72b trials: Patients with severe hypertriglyceridemia have an increased risk of pancreatitis despite the use of lipid-lowering therapy. Research findings on the safety and efficacy of olezarsen in this population are summarized in a new video. nej.md/4bkpa7S
January 30, 2026 at 5:01 PM
CORE-TIMI 72a and CORE2-TIMI 72b trials: Patients with severe hypertriglyceridemia have an increased risk of pancreatitis despite the use of lipid-lowering therapy. Research findings on the safety and efficacy of olezarsen in this population are summarized in a new video. nej.md/4bkpa7S
A new Case Study in NEJM Catalyst Innovations in Care Delivery reports an initiative that has reduced the number of orders for vitamin D tests in the first 12 months post intervention, which supports best practice guidelines and reduces overtesting. Full study results: nej.md/4pHZ0iY
#MedSky
#MedSky
January 30, 2026 at 2:24 PM
A new Case Study in NEJM Catalyst Innovations in Care Delivery reports an initiative that has reduced the number of orders for vitamin D tests in the first 12 months post intervention, which supports best practice guidelines and reduces overtesting. Full study results: nej.md/4pHZ0iY
#MedSky
#MedSky
Physicians throughout Minnesota bear witness to the devastation that U.S. Immigration and Customs Enforcement is wreaking. They implore physicians everywhere to raise their voices.
Read “We Do Care” by Bernard E. Trappey, MD, for Minnesota Physician Voices: nej.md/4akke1G
Read “We Do Care” by Bernard E. Trappey, MD, for Minnesota Physician Voices: nej.md/4akke1G
January 29, 2026 at 10:10 PM
Physicians throughout Minnesota bear witness to the devastation that U.S. Immigration and Customs Enforcement is wreaking. They implore physicians everywhere to raise their voices.
Read “We Do Care” by Bernard E. Trappey, MD, for Minnesota Physician Voices: nej.md/4akke1G
Read “We Do Care” by Bernard E. Trappey, MD, for Minnesota Physician Voices: nej.md/4akke1G
A 63-year-old woman with psoriatic arthritis presented with a 9-month history of pain in the left knee. A nontender, palpable mass was present in the left popliteal fossa, which had a “speech bubble” shape on ultrasonography. Read the full case details: nej.md/4k8oXan
#MedSky #Rheumatology
#MedSky #Rheumatology
January 29, 2026 at 8:43 PM
A 63-year-old woman with psoriatic arthritis presented with a 9-month history of pain in the left knee. A nontender, palpable mass was present in the left popliteal fossa, which had a “speech bubble” shape on ultrasonography. Read the full case details: nej.md/4k8oXan
#MedSky #Rheumatology
#MedSky #Rheumatology
Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more: nej.md/4sZujsh
#MedSky #CardioSky
#MedSky #CardioSky
January 29, 2026 at 5:01 PM
Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more: nej.md/4sZujsh
#MedSky #CardioSky
#MedSky #CardioSky
New in the January 29, 2026, issue of NEJM:
Olezarsen for Managing Severe Hypertriglyceridemia (phase 3 CORE-TIMI 72a and CORE2-TIMI 72b trials) nej.md/491XG5V
Tenecteplase in Acute Central Retinal Artery Occlusion (phase 3 TenCRAOS trial) nej.md/3NU6BgZ
#MedSky
Olezarsen for Managing Severe Hypertriglyceridemia (phase 3 CORE-TIMI 72a and CORE2-TIMI 72b trials) nej.md/491XG5V
Tenecteplase in Acute Central Retinal Artery Occlusion (phase 3 TenCRAOS trial) nej.md/3NU6BgZ
#MedSky
January 29, 2026 at 2:22 PM
New in the January 29, 2026, issue of NEJM:
Olezarsen for Managing Severe Hypertriglyceridemia (phase 3 CORE-TIMI 72a and CORE2-TIMI 72b trials) nej.md/491XG5V
Tenecteplase in Acute Central Retinal Artery Occlusion (phase 3 TenCRAOS trial) nej.md/3NU6BgZ
#MedSky
Olezarsen for Managing Severe Hypertriglyceridemia (phase 3 CORE-TIMI 72a and CORE2-TIMI 72b trials) nej.md/491XG5V
Tenecteplase in Acute Central Retinal Artery Occlusion (phase 3 TenCRAOS trial) nej.md/3NU6BgZ
#MedSky
In a claims-based study involving 3790 affected youths, parental firearm injury was associated with increases in psychiatric diagnoses — especially trauma-related disorders — and in mental health visits among children. Full study results: nej.md/4aiAiB4
#MedSky
#MedSky
January 28, 2026 at 11:00 PM
In a claims-based study involving 3790 affected youths, parental firearm injury was associated with increases in psychiatric diagnoses — especially trauma-related disorders — and in mental health visits among children. Full study results: nej.md/4aiAiB4
#MedSky
#MedSky
In metastatic hormone-receptor–positive, HER2-positive breast cancer, maintenance palbociclib plus anti-HER2 and endocrine therapies extended progression-free survival but increased toxic effects such as neutropenia. Full phase 3 PATINA trial results: nej.md/3ZEyWdO
#MedSky #Oncology
#MedSky #Oncology
January 28, 2026 at 10:40 PM
In metastatic hormone-receptor–positive, HER2-positive breast cancer, maintenance palbociclib plus anti-HER2 and endocrine therapies extended progression-free survival but increased toxic effects such as neutropenia. Full phase 3 PATINA trial results: nej.md/3ZEyWdO
#MedSky #Oncology
#MedSky #Oncology
In acute central retinal artery occlusion treated within 4.5 hours after onset, intravenous tenecteplase did not result in greater recovery of vision at 30 days than aspirin and was associated with serious safety concerns. Full phase 3 TenCRAOS trial results: nej.md/3NU6BgZ
#MedSky
#MedSky
January 28, 2026 at 10:10 PM
In acute central retinal artery occlusion treated within 4.5 hours after onset, intravenous tenecteplase did not result in greater recovery of vision at 30 days than aspirin and was associated with serious safety concerns. Full phase 3 TenCRAOS trial results: nej.md/3NU6BgZ
#MedSky
#MedSky
A 58-year-old woman was admitted to Mass. General Hospital because of diplopia and fever. MRI of the head (seen in figure) showed no infarct or mass, but enhancement was noted along cranial nerves III, V, VI, and VII on the right side. Full case details: nej.md/4qtKPiz
January 28, 2026 at 8:03 PM
A 58-year-old woman was admitted to Mass. General Hospital because of diplopia and fever. MRI of the head (seen in figure) showed no infarct or mass, but enhancement was noted along cranial nerves III, V, VI, and VII on the right side. Full case details: nej.md/4qtKPiz
Cardiac physiologic pacing is a cornerstone therapy for the management of heart failure with reduced ejection fraction and concomitant conduction. Developments in physiologic pacing are anticipated to fundamentally change the approach to this disease. Learn more: nej.md/4qqjSfI
January 28, 2026 at 5:03 PM
Cardiac physiologic pacing is a cornerstone therapy for the management of heart failure with reduced ejection fraction and concomitant conduction. Developments in physiologic pacing are anticipated to fundamentally change the approach to this disease. Learn more: nej.md/4qqjSfI
ASCENT-04/KEYNOTE-D19: In patients with previously untreated, PD-L1–positive, advanced triple-negative breast cancer, sacituzumab govitecan + pembrolizumab led to significantly longer progression-free survival than chemotherapy + pembrolizumab. Full phase 3 trial results: nej.md/49MoXaW
January 28, 2026 at 2:03 PM
ASCENT-04/KEYNOTE-D19: In patients with previously untreated, PD-L1–positive, advanced triple-negative breast cancer, sacituzumab govitecan + pembrolizumab led to significantly longer progression-free survival than chemotherapy + pembrolizumab. Full phase 3 trial results: nej.md/49MoXaW
A 𝐫𝐞𝐭𝐢𝐧𝐚𝐥 𝐩𝐢𝐠𝐦𝐞𝐧𝐭 𝐞𝐩𝐢𝐭𝐡𝐞𝐥𝐢𝐮𝐦 (𝐑𝐏𝐄) is a pigmented cuboidal layer of epithelial cells between the choriocapillaris blood supply and photoreceptor outer segments of the retina. Full definition of this NEJM Illustrated Glossary term: nej.md/45pZ5Rb
#MedSky #Ophthalmology
#MedSky #Ophthalmology
January 27, 2026 at 6:42 PM
A 𝐫𝐞𝐭𝐢𝐧𝐚𝐥 𝐩𝐢𝐠𝐦𝐞𝐧𝐭 𝐞𝐩𝐢𝐭𝐡𝐞𝐥𝐢𝐮𝐦 (𝐑𝐏𝐄) is a pigmented cuboidal layer of epithelial cells between the choriocapillaris blood supply and photoreceptor outer segments of the retina. Full definition of this NEJM Illustrated Glossary term: nej.md/45pZ5Rb
#MedSky #Ophthalmology
#MedSky #Ophthalmology
Tobevibart plus elebsiran and tobevibart alone both lowered HDV RNA and ALT levels. The combination resulted in a high incidence of undetectable HDV RNA and an HBsAg level below 10 IU/ml at week 48. Full phase 2 SOLSTICE trial results and Research Summary: nej.md/4qIXpuM
#MedSky
#MedSky
January 27, 2026 at 2:02 PM
Tobevibart plus elebsiran and tobevibart alone both lowered HDV RNA and ALT levels. The combination resulted in a high incidence of undetectable HDV RNA and an HBsAg level below 10 IU/ml at week 48. Full phase 2 SOLSTICE trial results and Research Summary: nej.md/4qIXpuM
#MedSky
#MedSky
As a gastroenterologist, would you recommend single-use duodenoscopes or reusable duodenoscopes for patients undergoing endoscopic retrograde cholangiopancreatography?
Vote on the best option: nej.md/3LtDssq
#MedSky #MedEd
Vote on the best option: nej.md/3LtDssq
#MedSky #MedEd
January 26, 2026 at 8:02 PM
As a gastroenterologist, would you recommend single-use duodenoscopes or reusable duodenoscopes for patients undergoing endoscopic retrograde cholangiopancreatography?
Vote on the best option: nej.md/3LtDssq
#MedSky #MedEd
Vote on the best option: nej.md/3LtDssq
#MedSky #MedEd
ASCENT-04/KEYNOTE-D19 trial: Treatment options for advanced triple-negative breast cancer remain limited despite recent advances. Research evaluating sacituzumab govitecan plus pembrolizumab as first-line therapy for PD-L1–positive disease is summarized in a new video. nej.md/49OtXMz
January 26, 2026 at 5:01 PM
ASCENT-04/KEYNOTE-D19 trial: Treatment options for advanced triple-negative breast cancer remain limited despite recent advances. Research evaluating sacituzumab govitecan plus pembrolizumab as first-line therapy for PD-L1–positive disease is summarized in a new video. nej.md/49OtXMz
In resected stage III or IV melanoma, nivolumab improved 9-year recurrence-free survival as compared with ipilimumab (44% vs. 37%), with no new late adverse events and fewer subsequent therapies needed. Full phase 3 CheckMate 238 trial results and Research Summary: nej.md/46R7RZs
#MedSky
#MedSky
January 26, 2026 at 2:01 PM
In resected stage III or IV melanoma, nivolumab improved 9-year recurrence-free survival as compared with ipilimumab (44% vs. 37%), with no new late adverse events and fewer subsequent therapies needed. Full phase 3 CheckMate 238 trial results and Research Summary: nej.md/46R7RZs
#MedSky
#MedSky
A new review summarizes cardiac physiologic pacing for heart failure, highlighting benefits of biventricular pacing and emerging evidence for His-bundle and left bundle-branch pacing to improve function and outcomes. Read the full review: nej.md/4qqjSfI
#MedSky #CardioSky
#MedSky #CardioSky
January 25, 2026 at 8:01 PM
A new review summarizes cardiac physiologic pacing for heart failure, highlighting benefits of biventricular pacing and emerging evidence for His-bundle and left bundle-branch pacing to improve function and outcomes. Read the full review: nej.md/4qqjSfI
#MedSky #CardioSky
#MedSky #CardioSky
Phase 2 SOLSTICE trial: Limited treatment options are available for chronic hepatitis D virus infection. Research findings on the efficacy and safety of tobevibart and elebsiran are summarized in a new Quick Take video. nej.md/4jO9hZr
#MedSky #Hepatology
#MedSky #Hepatology
January 25, 2026 at 5:02 PM
Phase 2 SOLSTICE trial: Limited treatment options are available for chronic hepatitis D virus infection. Research findings on the efficacy and safety of tobevibart and elebsiran are summarized in a new Quick Take video. nej.md/4jO9hZr
#MedSky #Hepatology
#MedSky #Hepatology
In patients with atrial fibrillation after successful ablation, rivaroxaban therapy did not lead to a significantly lower incidence of a composite of stroke, systemic embolism, or new covert embolic stroke than aspirin therapy. Full OCEAN trial results and Research Summary: nej.md/3LsRJ86
January 25, 2026 at 2:00 PM
In patients with atrial fibrillation after successful ablation, rivaroxaban therapy did not lead to a significantly lower incidence of a composite of stroke, systemic embolism, or new covert embolic stroke than aspirin therapy. Full OCEAN trial results and Research Summary: nej.md/3LsRJ86
A 20-year-old man presented with an itchy rash 2 months after starting a ketogenic diet. Examination showed symmetric, erythematous papules and underlying reticulated hyperpigmentation on the chest, neck, and shoulders. Read the full case details: nej.md/3YPCxWk
#MedSky #DermSky #Immunology
#MedSky #DermSky #Immunology
January 24, 2026 at 8:00 PM
A 20-year-old man presented with an itchy rash 2 months after starting a ketogenic diet. Examination showed symmetric, erythematous papules and underlying reticulated hyperpigmentation on the chest, neck, and shoulders. Read the full case details: nej.md/3YPCxWk
#MedSky #DermSky #Immunology
#MedSky #DermSky #Immunology
Patients with high-risk resected melanoma remain vulnerable to disease recurrence. Long-term findings on adjuvant nivolumab from the phase 3 CheckMate 238 trial are summarized in a new Quick Take video. nej.md/4sP4UBp
#MedSky #Oncology
#MedSky #Oncology
January 24, 2026 at 5:02 PM
Patients with high-risk resected melanoma remain vulnerable to disease recurrence. Long-term findings on adjuvant nivolumab from the phase 3 CheckMate 238 trial are summarized in a new Quick Take video. nej.md/4sP4UBp
#MedSky #Oncology
#MedSky #Oncology
Case Record of the Massachusetts General Hospital: A 58-year-old woman was admitted to the hospital 3 weeks after lumbar surgery because of diplopia and fever. Left leg pain and a rash had preceded the fever and diplopia. A diagnosis was made. Full case details: nej.md/4qtKPiz
January 24, 2026 at 2:00 PM
Case Record of the Massachusetts General Hospital: A 58-year-old woman was admitted to the hospital 3 weeks after lumbar surgery because of diplopia and fever. Left leg pain and a rash had preceded the fever and diplopia. A diagnosis was made. Full case details: nej.md/4qtKPiz
A 63-year-old woman with psoriatic arthritis involving her knees presented for evaluation of 9-months of pain in the left knee. Physical examination was notable for a nontender, palpable mass in the left popliteal fossa. 1/2
#MedSky
#MedSky
January 23, 2026 at 8:04 PM
A 63-year-old woman with psoriatic arthritis involving her knees presented for evaluation of 9-months of pain in the left knee. Physical examination was notable for a nontender, palpable mass in the left popliteal fossa. 1/2
#MedSky
#MedSky