Omer Dushek
@tcell.bsky.social
Professor of Molecular Immunology at the University of Oxford.
Experiments & Math(s) to understand and exploit T cells.
Founder & Director of MatchBio Ltd
Experiments & Math(s) to understand and exploit T cells.
Founder & Director of MatchBio Ltd
Pinned
Omer Dushek
@tcell.bsky.social
· Jan 8
Our new work on optimising CAR-T cell sensitivity is now on bioRxiv!
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
biorxiv.org/cgi/content/...
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
biorxiv.org/cgi/content/...
Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal.
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
November 27, 2025 at 9:24 AM
Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal.
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....
Reposted by Omer Dushek
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
November 27, 2025 at 9:12 AM
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Reposted by Omer Dushek
UK NK 2026 in Cardiff.
January 9th. Be there.
eventbrite.co.uk/e/uk-nk-confer…
Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
January 9th. Be there.
eventbrite.co.uk/e/uk-nk-confer…
Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
https://eventbrite.co.uk/e/uk-nk-confer…
October 23, 2025 at 8:53 AM
UK NK 2026 in Cardiff.
January 9th. Be there.
eventbrite.co.uk/e/uk-nk-confer…
Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
January 9th. Be there.
eventbrite.co.uk/e/uk-nk-confer…
Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
Reposted by Omer Dushek
I was Chair of @biologists.bsky.social when we started this initiative, the brainwave of the @stevenkelly.bsky.social
It was an imaginative idea and I am thrilled to see this landmark
Remember: @biologists.bsky.social are the goodies in scientific publishing!
It was an imaginative idea and I am thrilled to see this landmark
Remember: @biologists.bsky.social are the goodies in scientific publishing!
In our Forest of Biologists we fund the restoration and preservation of ancient woodland and dedicate these trees to our peer reviewers.
There are now over 10,000 trees for peer reviews!
Thank you to all our peer reviewers. Find out more:
forest.biologists.com
#PRW2025 @peerreviewweek.bsky.social
There are now over 10,000 trees for peer reviews!
Thank you to all our peer reviewers. Find out more:
forest.biologists.com
#PRW2025 @peerreviewweek.bsky.social
September 22, 2025 at 7:21 PM
I was Chair of @biologists.bsky.social when we started this initiative, the brainwave of the @stevenkelly.bsky.social
It was an imaginative idea and I am thrilled to see this landmark
Remember: @biologists.bsky.social are the goodies in scientific publishing!
It was an imaginative idea and I am thrilled to see this landmark
Remember: @biologists.bsky.social are the goodies in scientific publishing!
Reposted by Omer Dushek
We can make the flexibility of a model match the hypothesis being tested -- more flexibility is not always better, if it prohibits rejection of the hypothesis. Here is one simple case involving T cells where it made a difference!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 8, 2025 at 6:07 PM
We can make the flexibility of a model match the hypothesis being tested -- more flexibility is not always better, if it prohibits rejection of the hypothesis. Here is one simple case involving T cells where it made a difference!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
If you're a postdoc interested in starting your own group, please consider the Dunn School at Oxford, UK.
It's a fantastic department and university for molecular immunology and all aspects of immune research!
It's a fantastic department and university for molecular immunology and all aspects of immune research!
📣 Applications now open 📣
We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!
Please share!
www.path.ox.ac.uk/work-with-us...
We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!
Please share!
www.path.ox.ac.uk/work-with-us...
August 4, 2025 at 5:58 PM
If you're a postdoc interested in starting your own group, please consider the Dunn School at Oxford, UK.
It's a fantastic department and university for molecular immunology and all aspects of immune research!
It's a fantastic department and university for molecular immunology and all aspects of immune research!
Reposted by Omer Dushek
Temporal control of cytokine production is lost in 2nd-gen CAR-T cells, says Patel et al. This could be key to understanding their efficacy and toxicity in cancer immunotherapy. 🧬
🔗 https://bit.ly/4lOLicw
##CancerImmunotherapy
🔗 https://bit.ly/4lOLicw
##CancerImmunotherapy
July 17, 2025 at 2:25 PM
Temporal control of cytokine production is lost in 2nd-gen CAR-T cells, says Patel et al. This could be key to understanding their efficacy and toxicity in cancer immunotherapy. 🧬
🔗 https://bit.ly/4lOLicw
##CancerImmunotherapy
🔗 https://bit.ly/4lOLicw
##CancerImmunotherapy
Our new review article led by Jordan Kramer:
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
May 31, 2025 at 8:54 AM
Our new review article led by Jordan Kramer:
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Platforms for studying cell–cell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Omer Dushek
📢 Registration is open for the Biomembrane Days 2025!
🔗 biomembrane-days-2025.mpikg.mpg.de
A top-notch lineup of speakers, 120 posters, 200 scientists.
📜Submit an abstract by July 14
🏆3 Poster prizes
⚠️Limited spots-previous events were fully booked!
#BiomembraneDays2025 #Biophysics #CellMembranes
🔗 biomembrane-days-2025.mpikg.mpg.de
A top-notch lineup of speakers, 120 posters, 200 scientists.
📜Submit an abstract by July 14
🏆3 Poster prizes
⚠️Limited spots-previous events were fully booked!
#BiomembraneDays2025 #Biophysics #CellMembranes
May 9, 2025 at 9:10 AM
📢 Registration is open for the Biomembrane Days 2025!
🔗 biomembrane-days-2025.mpikg.mpg.de
A top-notch lineup of speakers, 120 posters, 200 scientists.
📜Submit an abstract by July 14
🏆3 Poster prizes
⚠️Limited spots-previous events were fully booked!
#BiomembraneDays2025 #Biophysics #CellMembranes
🔗 biomembrane-days-2025.mpikg.mpg.de
A top-notch lineup of speakers, 120 posters, 200 scientists.
📜Submit an abstract by July 14
🏆3 Poster prizes
⚠️Limited spots-previous events were fully booked!
#BiomembraneDays2025 #Biophysics #CellMembranes
CombiCells allow combinatorial display of cell surface ligands
www.nature.com/articles/s41...
A new Tools of the Trade article from Nature Reviews Immunology by Sofía Bustamante Eguiguren in our lab highlights the CombiCell platform to combinatorially display and titrate many cell surface ligands
www.nature.com/articles/s41...
A new Tools of the Trade article from Nature Reviews Immunology by Sofía Bustamante Eguiguren in our lab highlights the CombiCell platform to combinatorially display and titrate many cell surface ligands
April 1, 2025 at 4:45 PM
CombiCells allow combinatorial display of cell surface ligands
www.nature.com/articles/s41...
A new Tools of the Trade article from Nature Reviews Immunology by Sofía Bustamante Eguiguren in our lab highlights the CombiCell platform to combinatorially display and titrate many cell surface ligands
www.nature.com/articles/s41...
A new Tools of the Trade article from Nature Reviews Immunology by Sofía Bustamante Eguiguren in our lab highlights the CombiCell platform to combinatorially display and titrate many cell surface ligands
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
Our work on measuring and understanding the role of molecular reach on antibody function is now part of a list of editor's pick manuscripts:
www.nature.com/collections/...
Our work on measuring and understanding the role of molecular reach on antibody function is now part of a list of editor's pick manuscripts:
www.nature.com/collections/...
March 6, 2025 at 7:28 AM
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
Our work on measuring and understanding the role of molecular reach on antibody function is now part of a list of editor's pick manuscripts:
www.nature.com/collections/...
Our work on measuring and understanding the role of molecular reach on antibody function is now part of a list of editor's pick manuscripts:
www.nature.com/collections/...
A fantastic EACR conference that focuses on all aspects of immune responses to cancer!
Barcelona - May 2025
Barcelona - May 2025
There's a month left for you to submit an abstract or apply for a Travel Grant to attend the next edition of Defence is the Best Attack, taking place in Barcelona in May! ☀️
Join us for an overview of the most recent advances in the field of immunotherapy:
eacr.org/conference/d...
Join us for an overview of the most recent advances in the field of immunotherapy:
eacr.org/conference/d...
February 22, 2025 at 7:31 AM
A fantastic EACR conference that focuses on all aspects of immune responses to cancer!
Barcelona - May 2025
Barcelona - May 2025
Reposted by Omer Dushek
🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…
sciencedirect.com
February 4, 2025 at 8:50 PM
🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
Reposted by Omer Dushek
📢 LAST CHANCE to submit your abstracts for BSI Oxford and
@immunologyoxford.bsky.social's #OIS25 Symposium
This is your opportunity to take part in this celebration Oxford's outstanding #immunology research 🔬
Submissions are open until midnight on Friday 7th Feb 👉 bit.ly/4elJmnG
@immunologyoxford.bsky.social's #OIS25 Symposium
This is your opportunity to take part in this celebration Oxford's outstanding #immunology research 🔬
Submissions are open until midnight on Friday 7th Feb 👉 bit.ly/4elJmnG
February 6, 2025 at 1:45 PM
📢 LAST CHANCE to submit your abstracts for BSI Oxford and
@immunologyoxford.bsky.social's #OIS25 Symposium
This is your opportunity to take part in this celebration Oxford's outstanding #immunology research 🔬
Submissions are open until midnight on Friday 7th Feb 👉 bit.ly/4elJmnG
@immunologyoxford.bsky.social's #OIS25 Symposium
This is your opportunity to take part in this celebration Oxford's outstanding #immunology research 🔬
Submissions are open until midnight on Friday 7th Feb 👉 bit.ly/4elJmnG
Reposted by Omer Dushek
📢 Abstract submission for BSI Oxford and @immunologyoxford.bsky.social 's #OIS25 Symposium closes NEXT WEEK (7 Feb)
Don't miss your chance to take part in this celebration of the outstanding #immunology research happening across Oxford 💫
Submit your abstract here 👉 bit.ly/4elJmnG
Don't miss your chance to take part in this celebration of the outstanding #immunology research happening across Oxford 💫
Submit your abstract here 👉 bit.ly/4elJmnG
January 30, 2025 at 2:53 PM
📢 Abstract submission for BSI Oxford and @immunologyoxford.bsky.social 's #OIS25 Symposium closes NEXT WEEK (7 Feb)
Don't miss your chance to take part in this celebration of the outstanding #immunology research happening across Oxford 💫
Submit your abstract here 👉 bit.ly/4elJmnG
Don't miss your chance to take part in this celebration of the outstanding #immunology research happening across Oxford 💫
Submit your abstract here 👉 bit.ly/4elJmnG
Reposted by Omer Dushek
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.
How to Apply and Funding
iles.web.ox.ac.uk
January 16, 2025 at 2:10 PM
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.
Reposted by Omer Dushek
We just can't stop recruiting!
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
January 14, 2025 at 4:52 PM
We just can't stop recruiting!
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
Reposted by Omer Dushek
The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
January 16, 2025 at 10:34 AM
The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
January 16, 2025 at 8:10 AM
Our new work!
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
www.biorxiv.org/content/10.1...
Reposted by Omer Dushek
A new paper by @tcell.bsky.social and team makes important advances towards improving CAR-T technology!
Read the paper here: www.biorxiv.org/content/10.1...
Listen to Omer talking about the paper and his spin-out company MatchBio here: podcasts.ox.ac.uk/series/immun...
Read the paper here: www.biorxiv.org/content/10.1...
Listen to Omer talking about the paper and his spin-out company MatchBio here: podcasts.ox.ac.uk/series/immun...
January 13, 2025 at 10:42 AM
A new paper by @tcell.bsky.social and team makes important advances towards improving CAR-T technology!
Read the paper here: www.biorxiv.org/content/10.1...
Listen to Omer talking about the paper and his spin-out company MatchBio here: podcasts.ox.ac.uk/series/immun...
Read the paper here: www.biorxiv.org/content/10.1...
Listen to Omer talking about the paper and his spin-out company MatchBio here: podcasts.ox.ac.uk/series/immun...
Our new work on optimising CAR-T cell sensitivity is now on bioRxiv!
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
biorxiv.org/cgi/content/...
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
biorxiv.org/cgi/content/...
January 8, 2025 at 12:19 PM
Our new work on optimising CAR-T cell sensitivity is now on bioRxiv!
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
biorxiv.org/cgi/content/...
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
biorxiv.org/cgi/content/...
Reposted by Omer Dushek
🧵 My former office mate and esteemed colleague Anna Huhn has co-authored a groundbreaking study in @naturecomms.bsky.social.
🦠 We're talking viruses and antibodies!
1/5
🦠 We're talking viruses and antibodies!
1/5
January 7, 2025 at 7:01 AM
🧵 My former office mate and esteemed colleague Anna Huhn has co-authored a groundbreaking study in @naturecomms.bsky.social.
🦠 We're talking viruses and antibodies!
1/5
🦠 We're talking viruses and antibodies!
1/5
Our work led by Anna Huhn is now published!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
January 4, 2025 at 4:28 PM
Our work led by Anna Huhn is now published!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
lnkd.in/epe8YZPm
Thank you to the reviewers for constructive feedback!
Reposted by Omer Dushek
The molecular reach of antibodies crucially underpins their viral neutralization capacity
www.nature.com/articles/s41...
@naturecomms.bsky.social @tcell.bsky.social
www.nature.com/articles/s41...
@naturecomms.bsky.social @tcell.bsky.social
January 3, 2025 at 6:27 PM
The molecular reach of antibodies crucially underpins their viral neutralization capacity
www.nature.com/articles/s41...
@naturecomms.bsky.social @tcell.bsky.social
www.nature.com/articles/s41...
@naturecomms.bsky.social @tcell.bsky.social
Reposted by Omer Dushek
Pre-print time!
This time our lab tackled the enigmatic "autoinflammation of unknown origin". This is a cluster of rare patients with #autoinflammatory disease, which don't fit the criteria of other syndromes. It's not even clear its a single #disease, to be honest
www.biorxiv.org/content/10.1...
This time our lab tackled the enigmatic "autoinflammation of unknown origin". This is a cluster of rare patients with #autoinflammatory disease, which don't fit the criteria of other syndromes. It's not even clear its a single #disease, to be honest
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 19, 2024 at 11:15 AM
Pre-print time!
This time our lab tackled the enigmatic "autoinflammation of unknown origin". This is a cluster of rare patients with #autoinflammatory disease, which don't fit the criteria of other syndromes. It's not even clear its a single #disease, to be honest
www.biorxiv.org/content/10.1...
This time our lab tackled the enigmatic "autoinflammation of unknown origin". This is a cluster of rare patients with #autoinflammatory disease, which don't fit the criteria of other syndromes. It's not even clear its a single #disease, to be honest
www.biorxiv.org/content/10.1...