Omer Dushek
@tcell.bsky.social
Professor of Molecular Immunology at the University of Oxford.
Experiments & Math(s) to understand and exploit T cells.
Founder & Director of MatchBio Ltd
Experiments & Math(s) to understand and exploit T cells.
Founder & Director of MatchBio Ltd
Thanks to our funding, collaborators, constructive reviewers, and for the very efficient process at Immunology & Cell Biology!
May 31, 2025 at 8:54 AM
Thanks to our funding, collaborators, constructive reviewers, and for the very efficient process at Immunology & Cell Biology!
By comparing the advantages and limitations of each platform, we provide a framework to choose the most suitable system to study signal integration in both basic and translational contexts.
May 31, 2025 at 8:54 AM
By comparing the advantages and limitations of each platform, we provide a framework to choose the most suitable system to study signal integration in both basic and translational contexts.
A recently developed CombiCell system enables easy manipulation of ligands while conserving key biophysical properties.
May 31, 2025 at 8:54 AM
A recently developed CombiCell system enables easy manipulation of ligands while conserving key biophysical properties.
In contrast, solid surfaces or supported lipid bilayers allow easy manipulation of ligands but lack the biophysical properties of cells, such as softness, a glycocalyx, and/or ligand mobility.
May 31, 2025 at 8:54 AM
In contrast, solid surfaces or supported lipid bilayers allow easy manipulation of ligands but lack the biophysical properties of cells, such as softness, a glycocalyx, and/or ligand mobility.
Although genetically modified antigen-presenting cells (APCs) offer the most physiological system, manipulating their ligands is difficult and slow.
May 31, 2025 at 8:54 AM
Although genetically modified antigen-presenting cells (APCs) offer the most physiological system, manipulating their ligands is difficult and slow.
We review and compare the available platforms, focusing on T-cell recognition.
May 31, 2025 at 8:54 AM
We review and compare the available platforms, focusing on T-cell recognition.
Since they encounter a huge variety of normal and abnormal cells, they experience many different combinations and concentrations of ligands.
Understanding immune responses therefore requires platforms that enable ligands to be easily manipulated.
Understanding immune responses therefore requires platforms that enable ligands to be easily manipulated.
May 31, 2025 at 8:54 AM
Since they encounter a huge variety of normal and abnormal cells, they experience many different combinations and concentrations of ligands.
Understanding immune responses therefore requires platforms that enable ligands to be easily manipulated.
Understanding immune responses therefore requires platforms that enable ligands to be easily manipulated.
Immune cells interact directly with other cells and make decisions by integrating information from many different receptor–ligand interactions at these cell–cell interfaces.
May 31, 2025 at 8:54 AM
Immune cells interact directly with other cells and make decisions by integrating information from many different receptor–ligand interactions at these cell–cell interfaces.
The original manuscript was published in @embojournal.org EMBO Journal last year
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors
www.embopress.org/doi/full/10....
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors
www.embopress.org/doi/full/10....
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors | The EMBO Journal
imageimageThe inherent difficulty in manipulating cell surface proteins limits our ability to
study cell–cell recognition. This work develops a platform for the combinatorial display
of cell surface l...
www.embopress.org
April 1, 2025 at 4:45 PM
The original manuscript was published in @embojournal.org EMBO Journal last year
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors
www.embopress.org/doi/full/10....
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors
www.embopress.org/doi/full/10....
Sofia has been exploiting the platform to study T cell signal integration by co-signalling receptor/ligand interactions.
April 1, 2025 at 4:45 PM
Sofia has been exploiting the platform to study T cell signal integration by co-signalling receptor/ligand interactions.