Chris Nickson
@precordialthump.bsky.social
Intensivist, ECMO specialist, Clinician Educator. Calm amid a #FOAMed storm: LITFL.com & INTENSIVEblog.com
Pinned
Etomidate
Pharmacology of etomidate (Critical Care Compendium entry)
litfl.com
Etomidate • LITFL Critical Care Compendium #foamed #foamcc
Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial
litfl.com/etomidate/
Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial
litfl.com/etomidate/
RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults – The Bottom Line #foamed #foamcc
www.thebottomline.org.uk/summaries/ic...
www.thebottomline.org.uk/summaries/ic...
RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults
Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Casey. NEJM. 2025. doi: 10.1056/NEJMoa2511420 Clinical Question Among adults with non‑traumatic critical illness undergoing emerg...
www.thebottomline.org.uk
December 14, 2025 at 11:33 AM
RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults – The Bottom Line #foamed #foamcc
www.thebottomline.org.uk/summaries/ic...
www.thebottomline.org.uk/summaries/ic...
Etomidate • LITFL Critical Care Compendium #foamed #foamcc
Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial
litfl.com/etomidate/
Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial
litfl.com/etomidate/
Etomidate
Pharmacology of etomidate (Critical Care Compendium entry)
litfl.com
December 13, 2025 at 12:00 AM
Etomidate • LITFL Critical Care Compendium #foamed #foamcc
Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial
litfl.com/etomidate/
Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial
litfl.com/etomidate/
Reposted by Chris Nickson
Pity they massively overdosed the ketamine arm - significant percentage > 2mg/kg / no ceiling dose ("rule of 1 ampoule") / dose per total body weight / and who gives > 0.5 mg/kg to a "sick" patient - great trial / wrong pharmacology / wrong conclusion = drugs are equivalent at equipotent doses
December 10, 2025 at 8:15 PM
Pity they massively overdosed the ketamine arm - significant percentage > 2mg/kg / no ceiling dose ("rule of 1 ampoule") / dose per total body weight / and who gives > 0.5 mg/kg to a "sick" patient - great trial / wrong pharmacology / wrong conclusion = drugs are equivalent at equipotent doses
Reposted by Chris Nickson
The Worlds Best Intensive Care Meeting is up and running -
Critical Care Reviews Down Under - triallist, editorialist, statistician, expert panel - an hour - not 10 mins - and that is the outside behind them - Naarm (Melbourne)
Critical Care Reviews Down Under - triallist, editorialist, statistician, expert panel - an hour - not 10 mins - and that is the outside behind them - Naarm (Melbourne)
December 9, 2025 at 12:07 AM
The Worlds Best Intensive Care Meeting is up and running -
Critical Care Reviews Down Under - triallist, editorialist, statistician, expert panel - an hour - not 10 mins - and that is the outside behind them - Naarm (Melbourne)
Critical Care Reviews Down Under - triallist, editorialist, statistician, expert panel - an hour - not 10 mins - and that is the outside behind them - Naarm (Melbourne)
Reposted by Chris Nickson
Reposted by Chris Nickson
Co-Chief Investigators Jonathan Casey and Matthew Semler share their insights from the #RSI trial after presenting at #CCRdownunder
Livestream -> www.criticalcarereviews.com
@jama.com
Livestream -> www.criticalcarereviews.com
@jama.com
December 10, 2025 at 5:40 AM
Co-Chief Investigators Jonathan Casey and Matthew Semler share their insights from the #RSI trial after presenting at #CCRdownunder
Livestream -> www.criticalcarereviews.com
@jama.com
Livestream -> www.criticalcarereviews.com
@jama.com
Reposted by Chris Nickson
In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB
@criticalcarereviews.com
@criticalcarereviews.com
December 10, 2025 at 12:20 AM
In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB
@criticalcarereviews.com
@criticalcarereviews.com
Reposted by Chris Nickson
Chief Investigator Arthur Kwizera shares an overview of the #ARISEAFRICA trial after presenting at #CCRdownunder and highlights what clinicians can take away from the results.
Livestream -> www.criticalcarereviews.com
@jama.com
Livestream -> www.criticalcarereviews.com
@jama.com
December 10, 2025 at 4:40 AM
Chief Investigator Arthur Kwizera shares an overview of the #ARISEAFRICA trial after presenting at #CCRdownunder and highlights what clinicians can take away from the results.
Livestream -> www.criticalcarereviews.com
@jama.com
Livestream -> www.criticalcarereviews.com
@jama.com
Reposted by Chris Nickson
Co-Chief Investigators Brenda O'Neill and Danny McAuley share the results of the #iRehab trial after presenting at #CCRdownunder
Livestream -> www.criticalcarereviews.com
@jama.com
Livestream -> www.criticalcarereviews.com
@jama.com
December 9, 2025 at 7:17 AM
Co-Chief Investigators Brenda O'Neill and Danny McAuley share the results of the #iRehab trial after presenting at #CCRdownunder
Livestream -> www.criticalcarereviews.com
@jama.com
Livestream -> www.criticalcarereviews.com
@jama.com
Reposted by Chris Nickson
#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com
The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting
#### Summary points
www.bmj.com
December 9, 2025 at 10:14 PM
#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com
Reposted by Chris Nickson
RSI trial now starting
➡️ Etomidate vs Ketamine for RSI
➡️ Jonathan Casey & Matthew Semler presenting
➡️ Chris Nickson editorialising
➡️ Join the livestream - criticalcarereviews.com
#ccrdownunder
➡️ Etomidate vs Ketamine for RSI
➡️ Jonathan Casey & Matthew Semler presenting
➡️ Chris Nickson editorialising
➡️ Join the livestream - criticalcarereviews.com
#ccrdownunder
December 10, 2025 at 12:14 AM
RSI trial now starting
➡️ Etomidate vs Ketamine for RSI
➡️ Jonathan Casey & Matthew Semler presenting
➡️ Chris Nickson editorialising
➡️ Join the livestream - criticalcarereviews.com
#ccrdownunder
➡️ Etomidate vs Ketamine for RSI
➡️ Jonathan Casey & Matthew Semler presenting
➡️ Chris Nickson editorialising
➡️ Join the livestream - criticalcarereviews.com
#ccrdownunder
Reposted by Chris Nickson
Congratulations to the RSI trial team #CCRdownunder
In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB
@criticalcarereviews.com
@criticalcarereviews.com
December 10, 2025 at 12:34 AM
Congratulations to the RSI trial team #CCRdownunder
Reposted by Chris Nickson
Wow wow wow
Beautiful trial. Nice editorial. Worth watching if you intubate patients.
Beautiful trial. Nice editorial. Worth watching if you intubate patients.
RSI trial now starting
➡️ Etomidate vs Ketamine for RSI
➡️ Jonathan Casey & Matthew Semler presenting
➡️ Chris Nickson editorialising
➡️ Join the livestream - criticalcarereviews.com
#ccrdownunder
➡️ Etomidate vs Ketamine for RSI
➡️ Jonathan Casey & Matthew Semler presenting
➡️ Chris Nickson editorialising
➡️ Join the livestream - criticalcarereviews.com
#ccrdownunder
December 10, 2025 at 12:47 AM
Wow wow wow
Beautiful trial. Nice editorial. Worth watching if you intubate patients.
Beautiful trial. Nice editorial. Worth watching if you intubate patients.
Reposted by Chris Nickson
Editorial by JAMA Senior Editor Derek Angus: The ImmunoSep RCT demonstrates the feasibility of biomarker-guided treatment, while highlighting ongoing challenges in immune classification and broader clinical application. #CCRdownunder ja.ma/3Kg3qz3
December 8, 2025 at 11:00 PM
Editorial by JAMA Senior Editor Derek Angus: The ImmunoSep RCT demonstrates the feasibility of biomarker-guided treatment, while highlighting ongoing challenges in immune classification and broader clinical application. #CCRdownunder ja.ma/3Kg3qz3
Reposted by Chris Nickson
Second at #ccrdownunder - #IREHABtrial
Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com
Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com
Home
The most up-to-date critical care website in the world
criticalcarereviews.com
December 8, 2025 at 11:59 PM
Second at #ccrdownunder - #IREHABtrial
Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com
Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com
Precision Therapy for Sepsis: The End of the Beginning? | Critical Care Medicine | JAMA | JAMA Network #ccrdownunder 2025
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Precision Therapy for Sepsis
Sepsis is a macabre dance between host and pathogen.1 With development of germ theory by Lister, Semmelweis, Pasteur, and Koch, pathogen eradication was the focus. Only in recent decades, with observa...
jamanetwork.com
December 8, 2025 at 11:29 PM
Precision Therapy for Sepsis: The End of the Beginning? | Critical Care Medicine | JAMA | JAMA Network #ccrdownunder 2025
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Chris Nickson
RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95
December 8, 2025 at 10:30 PM
RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95
Reposted by Chris Nickson
📊 Research Summary: The ImmunoSep trial demonstrates the potential for biomarker-guided immunotherapy in a subset of patients with sepsis. #CCRdownunder ja.ma/4pMi8wt
December 8, 2025 at 10:45 PM
📊 Research Summary: The ImmunoSep trial demonstrates the potential for biomarker-guided immunotherapy in a subset of patients with sepsis. #CCRdownunder ja.ma/4pMi8wt
Reposted by Chris Nickson
ImmunoSep uses a double-dummy design.
What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder
What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder
RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95
December 8, 2025 at 10:46 PM
ImmunoSep uses a double-dummy design.
What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder
What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder
IMMUNOSEP trial - JAMA jamanetwork.com/journals/jam... #ccrdownunder 2025
Precision Immunotherapy to Improve Sepsis Outcomes
This randomized trial assesses whether precision immunotherapy tailored to macrophage activation–like syndrome or sepsis-induced immunoparalysis improved organ dysfunction compared with placebo among ...
jamanetwork.com
December 8, 2025 at 10:26 PM
IMMUNOSEP trial - JAMA jamanetwork.com/journals/jam... #ccrdownunder 2025
Reposted by Chris Nickson
Looking forward to #ccrdownunder- if you are following along please include this hashtag in any posts and I can moderate your questions online- enjoy the live!!!
December 8, 2025 at 9:47 PM
Looking forward to #ccrdownunder- if you are following along please include this hashtag in any posts and I can moderate your questions online- enjoy the live!!!
Reposted by Chris Nickson
Up first at #ccrdownunder - #IMMUNOSEPtrial
Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com
Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com
Home
The most up-to-date critical care website in the world
criticalcarereviews.com
December 8, 2025 at 10:01 PM
Up first at #ccrdownunder - #IMMUNOSEPtrial
Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com
Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com
Reposted by Chris Nickson
Struggling to keep up with the critical care literature?
➡️ We search it daily & curate the best papers
➡️ Delivered to your inbox each weekend
➡️ Try our Newsletter - there's nothing else like it
Sample - criticalcarereviews.com/newsletters/...
Subscription - criticalcarereviews.com/newsletters/...
➡️ We search it daily & curate the best papers
➡️ Delivered to your inbox each weekend
➡️ Try our Newsletter - there's nothing else like it
Sample - criticalcarereviews.com/newsletters/...
Subscription - criticalcarereviews.com/newsletters/...
October 19, 2025 at 2:49 PM
Struggling to keep up with the critical care literature?
➡️ We search it daily & curate the best papers
➡️ Delivered to your inbox each weekend
➡️ Try our Newsletter - there's nothing else like it
Sample - criticalcarereviews.com/newsletters/...
Subscription - criticalcarereviews.com/newsletters/...
➡️ We search it daily & curate the best papers
➡️ Delivered to your inbox each weekend
➡️ Try our Newsletter - there's nothing else like it
Sample - criticalcarereviews.com/newsletters/...
Subscription - criticalcarereviews.com/newsletters/...
Reposted by Chris Nickson
There are now just under 50 days to CCR Down Under 2025.
The programme is out - 8 superb trial results coming up.
Join us in Melbourne, in person or virtually, to discuss the best critical care trials in the world!
criticalcarereviews.com/meetings/ccr...
The programme is out - 8 superb trial results coming up.
Join us in Melbourne, in person or virtually, to discuss the best critical care trials in the world!
criticalcarereviews.com/meetings/ccr...
October 21, 2025 at 8:11 PM
There are now just under 50 days to CCR Down Under 2025.
The programme is out - 8 superb trial results coming up.
Join us in Melbourne, in person or virtually, to discuss the best critical care trials in the world!
criticalcarereviews.com/meetings/ccr...
The programme is out - 8 superb trial results coming up.
Join us in Melbourne, in person or virtually, to discuss the best critical care trials in the world!
criticalcarereviews.com/meetings/ccr...
Reposted by Chris Nickson
The 5th trial to be announced for CCR Down Under 2025 is ACTiVE
Effect of automated closed-loop ventilation versus conventional ventilation on duration and quality of ventilation in critically ill patients
Join us in Melbourne, either in-person or online
criticalcarereviews.com/meetings/ccr...
Effect of automated closed-loop ventilation versus conventional ventilation on duration and quality of ventilation in critically ill patients
Join us in Melbourne, either in-person or online
criticalcarereviews.com/meetings/ccr...
CCR Down Under 2025
Critical Care Reviews Meeting Down Under - The Edge, Federation Square, Melbourne, December 9th - 10th, 2025
criticalcarereviews.com
August 10, 2025 at 9:53 PM
The 5th trial to be announced for CCR Down Under 2025 is ACTiVE
Effect of automated closed-loop ventilation versus conventional ventilation on duration and quality of ventilation in critically ill patients
Join us in Melbourne, either in-person or online
criticalcarereviews.com/meetings/ccr...
Effect of automated closed-loop ventilation versus conventional ventilation on duration and quality of ventilation in critically ill patients
Join us in Melbourne, either in-person or online
criticalcarereviews.com/meetings/ccr...