Paul Jenkins
@pjenkinslab.bsky.social
Associate Professor, Pharmacology, Psychiatry, Neuroscience, Sports, Occasional trouble-making. Oxford comma enthusiast. Hates cilantro. He/him. Views are my own.
Really interesting deficits in sensory coding in Scn2a heterozygous mice and rescue of these deficits with CRISPRa in adults. Implications for EEG-accessible biomarkers for Scn2a loss-of-function...
New work from @danfeldman.bsky.social's lab, exploring sensory representations in Scn2a loss of function mice. Whisker representations are blurred, akin to cortical visual impairment often seen in SCN2A kiddos. Rescuable w/ @nadavahituv.bsky.social's CRISPRa @P30!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Degraded sensory coding in a mouse model of Scn2a-related disorder and its rescue by CRISPRa gene activation
Heterozygous loss-of-function mutations in SCN2A, a sodium channel gene expressed in cortical pyramidal (PYR) cells, lead to a neurodevelopmental disorder characterized by autism, intellectual disabil...
www.biorxiv.org
December 15, 2025 at 4:49 PM
Really interesting deficits in sensory coding in Scn2a heterozygous mice and rescue of these deficits with CRISPRa in adults. Implications for EEG-accessible biomarkers for Scn2a loss-of-function...
Reposted by Paul Jenkins
Dunno who needs to hear this, but before your start writing your reviewer comments, eat a cookie. Only you can prevent rude reviews.
December 15, 2025 at 3:22 PM
Dunno who needs to hear this, but before your start writing your reviewer comments, eat a cookie. Only you can prevent rude reviews.
There is no rock bottom. So vile.
December 15, 2025 at 3:28 PM
There is no rock bottom. So vile.
ERA Commons having a totally normal one...
December 15, 2025 at 1:54 PM
ERA Commons having a totally normal one...
Reposted by Paul Jenkins
Reposted by Paul Jenkins
the snow has fallen such that it looks like a little child, standing on a pile of snow, watching the snow fall
December 13, 2025 at 1:01 PM
the snow has fallen such that it looks like a little child, standing on a pile of snow, watching the snow fall
New lab photo just dropped. This is the kind of stuff I am subjected to. 🤣 #justoneoftheladies #flowinglocks #sororitysquat
December 12, 2025 at 4:42 PM
New lab photo just dropped. This is the kind of stuff I am subjected to. 🤣 #justoneoftheladies #flowinglocks #sororitysquat
Reposted by Paul Jenkins
It's this Thursday! Register below 👇🏻
I’m giving a talk at the Cytoskeleton of Neurons & Glia seminar on Dec 11 (11am EST / 4pm UK)! I’ll chat about polarity in bulb DA neurons and what it means for release + self-inhibition.
Disclaimer: I’ve aged a bit since that pic, but spirit’s the same 😉
ncytoskeleton.wixsite.com/webinars/eve...
Disclaimer: I’ve aged a bit since that pic, but spirit’s the same 😉
ncytoskeleton.wixsite.com/webinars/eve...
Ana Dorrego-rivas | Neuron Cytoskeleton
ncytoskeleton.wixsite.com
December 9, 2025 at 10:23 AM
It's this Thursday! Register below 👇🏻
If I wanted to see what that dipshit Elon Musk was saying, I would have stayed on X. I wish people would stop posting his idiotic, racist drivel.
December 8, 2025 at 3:23 PM
If I wanted to see what that dipshit Elon Musk was saying, I would have stayed on X. I wish people would stop posting his idiotic, racist drivel.
Reposted by Paul Jenkins
*This* is what the people of Pompeii, and Herculaneum, and many other hapless souls saw—this is what a pyroclastic density current looks coming RIGHT at you.
Filmed from a CCTV camera during the Mount Semeru eruption on Java, Indonesia on 4 December 2022.
Video credit: PT United Tractors Tbk
Filmed from a CCTV camera during the Mount Semeru eruption on Java, Indonesia on 4 December 2022.
Video credit: PT United Tractors Tbk
December 7, 2025 at 3:24 AM
*This* is what the people of Pompeii, and Herculaneum, and many other hapless souls saw—this is what a pyroclastic density current looks coming RIGHT at you.
Filmed from a CCTV camera during the Mount Semeru eruption on Java, Indonesia on 4 December 2022.
Video credit: PT United Tractors Tbk
Filmed from a CCTV camera during the Mount Semeru eruption on Java, Indonesia on 4 December 2022.
Video credit: PT United Tractors Tbk
Always nice to see my friends from the FamilieSCN2A Foundation (@scn2a.bsky.social)! Catching up at the 2025 @amepilepsysoc.bsky.social annual meeting.
December 6, 2025 at 11:13 PM
Always nice to see my friends from the FamilieSCN2A Foundation (@scn2a.bsky.social)! Catching up at the 2025 @amepilepsysoc.bsky.social annual meeting.
Reposted by Paul Jenkins
The hepatitis B vaccine had been recommended for all newborns since 1991.
From 1990-2019, acute hepatitis B infections reported among children and teens fell 99 percent. www.nytimes.com/2025/09/16/w...
From 1990-2019, acute hepatitis B infections reported among children and teens fell 99 percent. www.nytimes.com/2025/09/16/w...
Breaking: After contentious debates and three failed attempts at a vote, a federal vaccine committee decided on Friday to end the decades-long recommendation that all newborns be immunized at birth against hepatitis B.
www.nytimes.com/2025/12/05/h...
www.nytimes.com/2025/12/05/h...
An End to Hepatitis B Shots for All Newborns
www.nytimes.com
December 5, 2025 at 3:47 PM
The hepatitis B vaccine had been recommended for all newborns since 1991.
From 1990-2019, acute hepatitis B infections reported among children and teens fell 99 percent. www.nytimes.com/2025/09/16/w...
From 1990-2019, acute hepatitis B infections reported among children and teens fell 99 percent. www.nytimes.com/2025/09/16/w...
Just got done reviewing applications for the Eagles Autism Foundation. Might be the closest I get to one of these, as a Detroit Lions fan.
December 2, 2025 at 11:15 PM
Just got done reviewing applications for the Eagles Autism Foundation. Might be the closest I get to one of these, as a Detroit Lions fan.
Reposted by Paul Jenkins
The recent seiche on Lake Erie, driven by strong NE winds, resulted in a remarkable tilting of lake levels. This particular seiche resulted in a lake-level difference of about 8-10 ft. Here is a plot of lake levels in Buffalo and Toledo (at either end of Lake Erie).
#LakeErie #seiche
#LakeErie #seiche
November 28, 2025 at 1:10 PM
Reposted by Paul Jenkins
i think if you want to have those disgusting LED headlights on your car, you should have to do a test where they blast you point blank with your own headlights and then you have 15 seconds to successfully complete some sort of vision-based task, and if you can't do it they push your car off a cliff
November 20, 2025 at 2:25 AM
i think if you want to have those disgusting LED headlights on your car, you should have to do a test where they blast you point blank with your own headlights and then you have 15 seconds to successfully complete some sort of vision-based task, and if you can't do it they push your car off a cliff
Reposted by Paul Jenkins
UNC's Center for Molecular Medicine has up to three open-rank positions for faculty conducting research with relevance to gene therapy, including: novel iPSC and animal models of disease and basic cell biology. Join us in beautiful Chapel Hill! Deadline 1/31/26: unc.peopleadmin.com/postings/309...
Open-Rank, Tenure-Track Faculty Positions, Center for Molecular Medicine
The Center for Molecular Medicine in partnership with Departments of Biochemistry and Biophysics, Cell Biology and Physiology, Genetics, Microbiology and Immunology and Pediatrics at the University of...
unc.peopleadmin.com
November 19, 2025 at 1:45 PM
UNC's Center for Molecular Medicine has up to three open-rank positions for faculty conducting research with relevance to gene therapy, including: novel iPSC and animal models of disease and basic cell biology. Join us in beautiful Chapel Hill! Deadline 1/31/26: unc.peopleadmin.com/postings/309...
Reposted by Paul Jenkins
NEW: An analysis finds that NIH funding cuts have disrupted at least 383 clinical trials, affecting over 74,000 participants that were enrolled in studies that were testing treatments for conditions including cancer, heart disease and brain disease.
November 17, 2025 at 7:55 PM
NEW: An analysis finds that NIH funding cuts have disrupted at least 383 clinical trials, affecting over 74,000 participants that were enrolled in studies that were testing treatments for conditions including cancer, heart disease and brain disease.
Reposted by Paul Jenkins
This is a real flight school, teaching people to fly planes!!! Like????
November 14, 2025 at 12:17 AM
This is a real flight school, teaching people to fly planes!!! Like????
Every. Accusation. Is. An. Admission.
November 13, 2025 at 7:14 PM
Every. Accusation. Is. An. Admission.
Reposted by Paul Jenkins
After 10 years, I am stepping down as chair of our department and we have an active search going on! Utah is a phenomenal place to live and work and it's been the honor of a lifetime chairing the department founded by Lou Goodman. #MedSky #Neuroskyence Repost!
jobs.chronicle.com/job/37914733...
jobs.chronicle.com/job/37914733...
Chair of Pharmacology and Toxicology - Salt Lake City, Utah job with The University of Utah | 37914733
The University of Utah seeks a Chair of Pharmacology and Toxicology
jobs.chronicle.com
November 12, 2025 at 4:28 PM
After 10 years, I am stepping down as chair of our department and we have an active search going on! Utah is a phenomenal place to live and work and it's been the honor of a lifetime chairing the department founded by Lou Goodman. #MedSky #Neuroskyence Repost!
jobs.chronicle.com/job/37914733...
jobs.chronicle.com/job/37914733...
Reposted by Paul Jenkins
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2025 at 4:20 PM
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Paul Jenkins
The Germans have a word, Backpfeifengesicht, which roughly translates to "a face in need of a fist". Just going to leave that bit of knowledge there.
November 13, 2025 at 4:36 PM
The Germans have a word, Backpfeifengesicht, which roughly translates to "a face in need of a fist". Just going to leave that bit of knowledge there.
Reposted by Paul Jenkins
The Republican president is a pedophile who has doubled my healthcare costs and let scores of violent criminals out of jail. But a Democratic mayor-elect wants to make busses free in a city I don't live in. I have never felt more politically homeless.
November 13, 2025 at 12:47 PM
The Republican president is a pedophile who has doubled my healthcare costs and let scores of violent criminals out of jail. But a Democratic mayor-elect wants to make busses free in a city I don't live in. I have never felt more politically homeless.
Reposted by Paul Jenkins
In a sense, it's anti-inflammatory nonsense
November 12, 2025 at 9:39 PM
In a sense, it's anti-inflammatory nonsense