@markesnyder.bsky.social
Transplant pulmonologist, T cell biologist
Imagine this: 20+ years from now. I’m a burnt out scientist, PI of a lab, but forced to work in an ancillary building, filled with reject scientists that have been shunned by the scientific community. Despite this, we end up lucking into groundbreaking fundamental scientific truths. -“Flow Horses”
fit.it
November 6, 2025 at 5:36 PM
Imagine this: 20+ years from now. I’m a burnt out scientist, PI of a lab, but forced to work in an ancillary building, filled with reject scientists that have been shunned by the scientific community. Despite this, we end up lucking into groundbreaking fundamental scientific truths. -“Flow Horses”
Reposted
A new mechanism helps explain idiopathic pulmonary fibrosis
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
November 6, 2025 at 2:04 PM
A new mechanism helps explain idiopathic pulmonary fibrosis
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Reposted
Thank you Congressman Neguse for laying it plain.
October 31, 2025 at 4:14 PM
Thank you Congressman Neguse for laying it plain.
Great manuscript below. Would be amazing if this could be applied to transplantation tolerance.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
www.science.org
October 23, 2025 at 11:31 PM
Great manuscript below. Would be amazing if this could be applied to transplantation tolerance.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
We need an HHS Secretary who respects science and does not make policy based on conspiracy theories.
Vaccines are safe and effective.
Kennedy is threatening the health of our kids and all Americans.
He must resign.
Vaccines are safe and effective.
Kennedy is threatening the health of our kids and all Americans.
He must resign.
September 4, 2025 at 7:59 PM
We need an HHS Secretary who respects science and does not make policy based on conspiracy theories.
Vaccines are safe and effective.
Kennedy is threatening the health of our kids and all Americans.
He must resign.
Vaccines are safe and effective.
Kennedy is threatening the health of our kids and all Americans.
He must resign.
Reposted
July 22, 2025 at 6:35 PM
Reposted
Memory CD8+ T cells have differential cytotoxic capacities across human tissues @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 18, 2025 at 7:07 PM
Memory CD8+ T cells have differential cytotoxic capacities across human tissues @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Donor-recipient SIRPα mismatch, implicated in innate allorecognition and monocyte activation, adversely affects kidney allograft survival in humans
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 17, 2025 at 2:29 PM
Donor-recipient SIRPα mismatch, implicated in innate allorecognition and monocyte activation, adversely affects kidney allograft survival in humans
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
There are a lot of terrible things happening right now, so it’s easy to lose track of page 2+ of the news, but this anti-science/anti-health/pro-idiocy move must be opposed:
www.nytimes.com/2025/06/09/h...
www.nytimes.com/2025/06/09/h...
Kennedy Removes All C.D.C. Vaccine Panel Experts
www.nytimes.com
June 9, 2025 at 11:18 PM
There are a lot of terrible things happening right now, so it’s easy to lose track of page 2+ of the news, but this anti-science/anti-health/pro-idiocy move must be opposed:
www.nytimes.com/2025/06/09/h...
www.nytimes.com/2025/06/09/h...
Reposted
Carl Sagan in 1986 on the problems with media and science literacy.
June 5, 2025 at 1:33 PM
Carl Sagan in 1986 on the problems with media and science literacy.
Run in golden state park. Barely passed this cute banana slug, we were neck and neck for a few miles.
May 18, 2025 at 11:13 PM
Run in golden state park. Barely passed this cute banana slug, we were neck and neck for a few miles.
Reposted
Promoting regenerative responses in a pulmonary fibrosis model!
Victor J. Thannickal & team discover that blocking CTLA4 in immune cells induced regeneration and reduce fibrosis in a mouse model of idiopathic pulmonary fibrosis: buff.ly/ZtmORCG
Victor J. Thannickal & team discover that blocking CTLA4 in immune cells induced regeneration and reduce fibrosis in a mouse model of idiopathic pulmonary fibrosis: buff.ly/ZtmORCG
May 16, 2025 at 1:20 PM
Promoting regenerative responses in a pulmonary fibrosis model!
Victor J. Thannickal & team discover that blocking CTLA4 in immune cells induced regeneration and reduce fibrosis in a mouse model of idiopathic pulmonary fibrosis: buff.ly/ZtmORCG
Victor J. Thannickal & team discover that blocking CTLA4 in immune cells induced regeneration and reduce fibrosis in a mouse model of idiopathic pulmonary fibrosis: buff.ly/ZtmORCG
Reposted
2023 ASCI Emerging-Generation recipient @rramonell.bsky.social identify a novel target to manage treatment-refractory asthma by describing a significant association of airway CD8+ TEMRA cells with asthma duration: buff.ly/gmsfzyQ
April 29, 2025 at 3:13 PM
2023 ASCI Emerging-Generation recipient @rramonell.bsky.social identify a novel target to manage treatment-refractory asthma by describing a significant association of airway CD8+ TEMRA cells with asthma duration: buff.ly/gmsfzyQ
Bottom right. Future scientist (or artist, or both) Liam Snyder. Grade 5!
Our current issue's special collection of Physician-Scientist Development articles includes an editorial by Editor in chief @eickelbergmd.bsky.social & is paired with a cover collage of children's drawings illustrating what a 'physician-scientist' means to them: buff.ly/kQ4fmrg
April 8, 2025 at 4:07 PM
Bottom right. Future scientist (or artist, or both) Liam Snyder. Grade 5!
Just got back from the Smokies! Felt amazing to get off the grid for a few seconds.
April 7, 2025 at 1:01 PM
Just got back from the Smokies! Felt amazing to get off the grid for a few seconds.
Reposted
De Sousa, Perkey, Le Corre, Maillard, Labrecque et al. @umontreal.ca show that fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #LymphocyteBiology
#InfectiousDisease #HostDefense #LymphocyteBiology
March 20, 2025 at 6:20 PM
De Sousa, Perkey, Le Corre, Maillard, Labrecque et al. @umontreal.ca show that fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #LymphocyteBiology
#InfectiousDisease #HostDefense #LymphocyteBiology
Reposted
Maintenance of graft tissue-resident Foxp3+ cells is necessary for lung transplant tolerance in mice
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
March 18, 2025 at 6:03 PM
Maintenance of graft tissue-resident Foxp3+ cells is necessary for lung transplant tolerance in mice
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
Reposted
@markesnyder.bsky.social et al. flip the script on our understanding of infection and rejection after transplantation– they show that systemic NKG2D blockade can impair airway-associated Tissue resident memory T cell accumulation and reduce CLAD severity: buff.ly/61mpbwk
March 6, 2025 at 4:13 PM
@markesnyder.bsky.social et al. flip the script on our understanding of infection and rejection after transplantation– they show that systemic NKG2D blockade can impair airway-associated Tissue resident memory T cell accumulation and reduce CLAD severity: buff.ly/61mpbwk
Reposted
WHERE WILL YOU BE ON MARCH 7TH!?
Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!
#standupforscience2025
Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!
#standupforscience2025
March 2, 2025 at 2:04 AM
WHERE WILL YOU BE ON MARCH 7TH!?
Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!
#standupforscience2025
Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!
#standupforscience2025
Reposted
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 12, 2025 at 5:04 PM
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Reposted
By itself, this is certainly not the most important issue we're confronting right now. But it's emblematic of the pervasive, destructive, anti-science efforts.
Gift link
www.nytimes.com/2025/02/26/c...
Gift link
www.nytimes.com/2025/02/26/c...
She Lobbied for a Carcinogen. Now She’s at the E.P.A., Approving New Chemicals. (Gift Article)
Lynn Dekleva, who recently took a senior role at the agency, once led an aggressive effort by industry to block regulations on formaldehyde.
www.nytimes.com
March 2, 2025 at 4:04 PM
By itself, this is certainly not the most important issue we're confronting right now. But it's emblematic of the pervasive, destructive, anti-science efforts.
Gift link
www.nytimes.com/2025/02/26/c...
Gift link
www.nytimes.com/2025/02/26/c...