Marco Enriquez, PhD
@marcoenriquez18.bsky.social
Postdoctoral Fellow
The University of Queensland, Australia
Soft matter | Cell Biology | Microscopy
🏡 Tweed Heads 🌱
The University of Queensland, Australia
Soft matter | Cell Biology | Microscopy
🏡 Tweed Heads 🌱
Pinned
How cells generate traction against hyaluronic acid (HA) remains largely unknown, especially in its liquid form. Join tomorrow (Dec 17) to learn more about our efforts to understand how cells move in this physical state as well as how to manipulate the mechanics of HA.
(B218; 1:30 pm) #cellbio2024
(B218; 1:30 pm) #cellbio2024
Reposted by Marco Enriquez, PhD
Reposted by Marco Enriquez, PhD
Talin-tensin3 interactions regulate fibrillar #adhesion formation and tensin3 phase separation, say Xingchen Li, Igor Barsukov, Thomas Zacharchenko, Christoph Ballestrem, @mcrcellmatrix.bsky.social and colleagues: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #StructuralBiology
#Cytoskeleton #Biochemistry #StructuralBiology
November 28, 2025 at 2:15 PM
Talin-tensin3 interactions regulate fibrillar #adhesion formation and tensin3 phase separation, say Xingchen Li, Igor Barsukov, Thomas Zacharchenko, Christoph Ballestrem, @mcrcellmatrix.bsky.social and colleagues: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #StructuralBiology
#Cytoskeleton #Biochemistry #StructuralBiology
Reposted by Marco Enriquez, PhD
Reposted by Marco Enriquez, PhD
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
November 21, 2025 at 3:54 AM
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
Reposted by Marco Enriquez, PhD
Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion, say Camilla Teng @xsciteng.bsky.social, Jeffrey Bush @jeffbush.bsky.social and colleagues @ctbatucsf.bsky.social: rupress.org/jcb/article/...
#Development #Adhesion
#Development #Adhesion
November 20, 2025 at 7:45 PM
Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion, say Camilla Teng @xsciteng.bsky.social, Jeffrey Bush @jeffbush.bsky.social and colleagues @ctbatucsf.bsky.social: rupress.org/jcb/article/...
#Development #Adhesion
#Development #Adhesion
Reposted by Marco Enriquez, PhD
Cellular structure self-organizes through an interplay between internal mechanisms and external cues. The single-celled suctorian P. collini builds a trap structure to capture large prey using microtubule feeding tentacles, creating feedback between cell morphology and prey availability.
November 18, 2025 at 4:15 PM
Cellular structure self-organizes through an interplay between internal mechanisms and external cues. The single-celled suctorian P. collini builds a trap structure to capture large prey using microtubule feeding tentacles, creating feedback between cell morphology and prey availability.
Reposted by Marco Enriquez, PhD
Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...
November 19, 2025 at 6:15 PM
Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...
Reposted by Marco Enriquez, PhD
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
July 1, 2025 at 4:46 AM
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
Reposted by Marco Enriquez, PhD
I’m super excited to share that my PhD work is now out in npj Imaging (@natureportfolio.nature.com)! 🔬
You can read the paper here: rdcu.be/eOKdU
You can read the paper here: rdcu.be/eOKdU
November 17, 2025 at 9:35 AM
I’m super excited to share that my PhD work is now out in npj Imaging (@natureportfolio.nature.com)! 🔬
You can read the paper here: rdcu.be/eOKdU
You can read the paper here: rdcu.be/eOKdU
Reposted by Marco Enriquez, PhD
Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose.
buff.ly/r3BlzFj
buff.ly/r3BlzFj
November 15, 2025 at 11:44 PM
Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose.
buff.ly/r3BlzFj
buff.ly/r3BlzFj
Reposted by Marco Enriquez, PhD
Migration of cell populations is a fundamental process in morphogenesis and disease. Researchers have identified a novel form of collective mesenchymal cell migration during chick gastrulation, where cells self-organise into a dynamic meshwork structure.
buff.ly/JDp0rUo
buff.ly/JDp0rUo
November 14, 2025 at 9:21 AM
Migration of cell populations is a fundamental process in morphogenesis and disease. Researchers have identified a novel form of collective mesenchymal cell migration during chick gastrulation, where cells self-organise into a dynamic meshwork structure.
buff.ly/JDp0rUo
buff.ly/JDp0rUo
Reposted by Marco Enriquez, PhD
Dong R, et al. A tale of two distinct actin networks underlies the entire life cycle of focal adhesion. bioRxiv posted 13 November 2025 doi:10.1101/2025.11.12.688129. www.biorxiv.org/content/10.1...
A tale of two distinct actin networks underlies the entire life cycle of focal adhesion
Cell assembles focal adhesion (FA) to transmit the stress fiber (SF)-based actomyosin contraction onto the extracellular matrix (ECM) for mesenchymal migration, essential for many physiological proces...
www.biorxiv.org
November 14, 2025 at 6:46 AM
Dong R, et al. A tale of two distinct actin networks underlies the entire life cycle of focal adhesion. bioRxiv posted 13 November 2025 doi:10.1101/2025.11.12.688129. www.biorxiv.org/content/10.1...
Reposted by Marco Enriquez, PhD
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
November 11, 2025 at 11:01 PM
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
Reposted by Marco Enriquez, PhD
Check out this sneaky lamin A knockdown cell (pink dot) swimming against the tide (migration into gap) & slithering between its sisters.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
November 7, 2025 at 4:29 PM
Check out this sneaky lamin A knockdown cell (pink dot) swimming against the tide (migration into gap) & slithering between its sisters.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
Reposted by Marco Enriquez, PhD
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM. New report from Athul Nair, Tom Kirchhausen @kirchhausenlab.bsky.social and colleagues @bostonchildrens.bsky.social: rupress.org/jcb/article/...
#Trafficking #Technology #ER_literature
#Trafficking #Technology #ER_literature
November 7, 2025 at 8:30 PM
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM. New report from Athul Nair, Tom Kirchhausen @kirchhausenlab.bsky.social and colleagues @bostonchildrens.bsky.social: rupress.org/jcb/article/...
#Trafficking #Technology #ER_literature
#Trafficking #Technology #ER_literature
Reposted by Marco Enriquez, PhD
We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...
Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state
van der Net et al. show that mechanical interactions with the stromal component collagen
I trigger reprogramming of colorectal cancer cells into a fetal-like state, through
mechanosensitive integrins ...
www.cell.com
November 7, 2025 at 4:33 PM
We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...
Reposted by Marco Enriquez, PhD
I am honnestly a bit worried by the latest fuss about qed (the IA driven review). While the results are indeed quite impressive (it is very good at listing the claim and finding potential improvement), I don't quite see how this will eventually reduce the reviewing burden or help us
November 7, 2025 at 8:33 AM
I am honnestly a bit worried by the latest fuss about qed (the IA driven review). While the results are indeed quite impressive (it is very good at listing the claim and finding potential improvement), I don't quite see how this will eventually reduce the reviewing burden or help us
Reposted by Marco Enriquez, PhD
An iPSC heart muscle cell forming sarcomeres videoed through a microscope by Emma Koory for 20 h before it dies most dramatically. This was our first try on a new microscope, and Emma now has the imaging parameters dialed in so her cells do not go POP! Alpha-actinin-2 is shown. #CellBiology
October 31, 2025 at 2:46 PM
An iPSC heart muscle cell forming sarcomeres videoed through a microscope by Emma Koory for 20 h before it dies most dramatically. This was our first try on a new microscope, and Emma now has the imaging parameters dialed in so her cells do not go POP! Alpha-actinin-2 is shown. #CellBiology
Reposted by Marco Enriquez, PhD
In @jcb.org, Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
November 6, 2025 at 5:45 PM
In @jcb.org, Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
Reposted by Marco Enriquez, PhD
In their Perspective, John Wallingford @jbwallingford.bsky.social and colleagues present their view on the assembly and potential function of DynAPs, as well as their place within the broader context of motile ciliated cells.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
October 28, 2025 at 4:35 PM
In their Perspective, John Wallingford @jbwallingford.bsky.social and colleagues present their view on the assembly and potential function of DynAPs, as well as their place within the broader context of motile ciliated cells.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Marco Enriquez, PhD
☕Vanni et al. show a role for #microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation. #mechanobiology #cytoskeleton
bit.ly/4oS2Ju3
bit.ly/4oS2Ju3
Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling - Nature Cell Biology
Vanni et al. show a role for microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and...
bit.ly
November 4, 2025 at 6:35 PM
☕Vanni et al. show a role for #microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation. #mechanobiology #cytoskeleton
bit.ly/4oS2Ju3
bit.ly/4oS2Ju3
Reposted by Marco Enriquez, PhD
Surface mechanics and compressive stress impact mammalian follicle development
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
Surface mechanics and compressive stress impact mammalian follicle development
Mice were group housed in individually ventilated cages with access to water and food under a 12-h light/12-h dark cycle. Mouse rooms were maintained at 18–25 °C and 30-70% relative humidity. C57BL/6NTac female mice, aged P25 – P28, were euthanized...
www.nature.com
November 2, 2025 at 6:55 AM
Reposted by Marco Enriquez, PhD
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
From the archives….a colony of melanoma cells expressing GFP Utrophin 🎥 🎞️
October 29, 2025 at 5:08 AM
From the archives….a colony of melanoma cells expressing GFP Utrophin 🎥 🎞️
Reposted by Marco Enriquez, PhD
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
September 15, 2025 at 8:42 AM
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens: