little john
@littlejohn.bsky.social
[he/him]
aka nhojelttil
a delightful ding dong
smpls
aka nhojelttil
a delightful ding dong
smpls
Reposted by little john
HOLY SHIT. They found the genes for fibromyalgia - and it's *not* autoimmune, it's the central nervous system. It's very cool to see some progress made on the thing that's ruined my life since late teenage years!
Medical Republic: 'Fibromyalgia finally gets a genetic fingerprint'
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
Fibromyalgia finally gets a genetic fingerprint - Medical Republic
A massive global study links the chronic pain condition to 26 genes associated with brain signalling, marking a turning point in understanding its biological roots.
www.medicalrepublic.com.au
November 14, 2025 at 4:09 AM
HOLY SHIT. They found the genes for fibromyalgia - and it's *not* autoimmune, it's the central nervous system. It's very cool to see some progress made on the thing that's ruined my life since late teenage years!
Reposted by little john
Medical Republic: 'Fibromyalgia finally gets a genetic fingerprint'
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
Fibromyalgia finally gets a genetic fingerprint - Medical Republic
A massive global study links the chronic pain condition to 26 genes associated with brain signalling, marking a turning point in understanding its biological roots.
www.medicalrepublic.com.au
November 13, 2025 at 2:28 PM
Medical Republic: 'Fibromyalgia finally gets a genetic fingerprint'
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
My mom is pre-planning her own obituary and funeral, and one of the first details she specified was the story that when she was 9 years old her dad told the librarian that she was allowed to read any book she wanted to.
We might make a bibliography for my dad's funeral
November 15, 2025 at 3:17 AM
My mom is pre-planning her own obituary and funeral, and one of the first details she specified was the story that when she was 9 years old her dad told the librarian that she was allowed to read any book she wanted to.
Get out there
If clear tonight - especially closer to sunset but after dark, tonight could be another big night of northern lights in Minnesota and elsewhere. #mnwx
Northern lights just now at Lake Harriet - and you can see reds and greens with your naked eye.
November 12, 2025 at 4:36 PM
Get out there
I'm further south now and it's even more incredible, this must be unbelievable in Minnesota
Go look for aurora, anywhere you are. I'm in central Missouri, like 400-500 miles south of MSP, but I'm a dark place, looking at the most amazing display I've ever seen
November 12, 2025 at 4:49 AM
I'm further south now and it's even more incredible, this must be unbelievable in Minnesota
Go look for aurora, anywhere you are. I'm in central Missouri, like 400-500 miles south of MSP, but I'm a dark place, looking at the most amazing display I've ever seen
November 12, 2025 at 2:38 AM
Go look for aurora, anywhere you are. I'm in central Missouri, like 400-500 miles south of MSP, but I'm a dark place, looking at the most amazing display I've ever seen
What the fuck. Just in general
November 11, 2025 at 3:01 PM
What the fuck. Just in general
Interesting convo with a friend who owns a hip NYC record shop about a sudden renewed interest in CDs, which were a negligible part of his business till recently.
November 11, 2025 at 1:15 AM
Reposted by little john
People need to understand that Chicago is a preview, not a culmination.
I have been actively watching contracts and surge funding over the last few days and what I would say to my friends in Baltimore is “be absolutely ready, right now.”
ICE poised to ramp up raids in Baltimore by Thanksgiving
The Trump administration has rush-ordered infrastructure to conduct raids, abduct residents, and detain people for months.
open.substack.com
November 9, 2025 at 1:51 PM
People need to understand that Chicago is a preview, not a culmination.
Reposted by little john
Helicopters are the leaf blowers of the sky
November 9, 2025 at 3:25 AM
Helicopters are the leaf blowers of the sky
Reposted by little john
They do not have a plan, they’ve never had a plan. They’ve also never had the votes to repeal the ACA which is *OVERWHELMINGLY* popular, nor have they been able to get the Supreme Court to overturn it, so instead they’ve just shut down the entire government to try forcing Dems to stop funding it.
November 9, 2025 at 1:53 AM
They do not have a plan, they’ve never had a plan. They’ve also never had the votes to repeal the ACA which is *OVERWHELMINGLY* popular, nor have they been able to get the Supreme Court to overturn it, so instead they’ve just shut down the entire government to try forcing Dems to stop funding it.
Reposted by little john
pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 12:55 AM
pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.
Reposted by little john
Reposted by little john
School board email has been bouncing back undelivered for me this week. (Convenient!)
Use: [email protected] and all Board + Supt emails.
See my reply for all emails.
Use: [email protected] and all Board + Supt emails.
See my reply for all emails.
If you are a parent of a kid in Minneapolis public schools, please, please, PLEASE take 2 minutes to email the school board ([email protected]) and superintendent ([email protected]) to tell them to settle with the educators' union and give them what they want. Your emails truly help!
November 7, 2025 at 4:12 PM
School board email has been bouncing back undelivered for me this week. (Convenient!)
Use: [email protected] and all Board + Supt emails.
See my reply for all emails.
Use: [email protected] and all Board + Supt emails.
See my reply for all emails.
Reposted by little john
Community members, you can do this too, even without a kid in MPS! Tell them we all do better when we all do better! It's in EVERYONE'S best interest to give city kids a great education!
If you are a parent of a kid in Minneapolis public schools, please, please, PLEASE take 2 minutes to email the school board ([email protected]) and superintendent ([email protected]) to tell them to settle with the educators' union and give them what they want. Your emails truly help!
November 7, 2025 at 4:23 PM
Community members, you can do this too, even without a kid in MPS! Tell them we all do better when we all do better! It's in EVERYONE'S best interest to give city kids a great education!
Reposted by little john
If you're a taxpayer in Minneapolis without kids, you can still do this too.
If you are a parent of a kid in Minneapolis public schools, please, please, PLEASE take 2 minutes to email the school board ([email protected]) and superintendent ([email protected]) to tell them to settle with the educators' union and give them what they want. Your emails truly help!
November 7, 2025 at 4:25 PM
If you're a taxpayer in Minneapolis without kids, you can still do this too.
Reposted by little john
No one wants a strike. We all want to keep kids in school. Family pressure on the district TRULY HELPS. A 2 sentence email saying you support MFE and want the district to give them what they're asking for to avoid a strike can help ensure your kids are in school next week!
November 7, 2025 at 3:44 PM
No one wants a strike. We all want to keep kids in school. Family pressure on the district TRULY HELPS. A 2 sentence email saying you support MFE and want the district to give them what they're asking for to avoid a strike can help ensure your kids are in school next week!
Reposted by little john
If you are a parent of a kid in Minneapolis public schools, please, please, PLEASE take 2 minutes to email the school board ([email protected]) and superintendent ([email protected]) to tell them to settle with the educators' union and give them what they want. Your emails truly help!
November 7, 2025 at 3:44 PM
If you are a parent of a kid in Minneapolis public schools, please, please, PLEASE take 2 minutes to email the school board ([email protected]) and superintendent ([email protected]) to tell them to settle with the educators' union and give them what they want. Your emails truly help!
Re: MPS/MFE, slide #2 is the thing www.instagram.com/p/DQu67YegZf3/
November 7, 2025 at 2:17 PM
Re: MPS/MFE, slide #2 is the thing www.instagram.com/p/DQu67YegZf3/
Reposted by little john
This means if you are in the habit of saying things like "fuck Trump" or "I hope Cheney burns in hell", probably a good amount of your feed isn't seeing those posts because, unbeknownst to them, Bsky has shielded grown adults from "rude" "threats" like this.
November 6, 2025 at 6:36 PM
This means if you are in the habit of saying things like "fuck Trump" or "I hope Cheney burns in hell", probably a good amount of your feed isn't seeing those posts because, unbeknownst to them, Bsky has shielded grown adults from "rude" "threats" like this.
Reposted by little john
"your passport says you're 5'7" but you were 1'8" when you were born so that's what we're listing" this is what that sounds like
I spit on the reputation of the U.S. Supreme Court, not that it can get much more degraded than it has already become by the repulsive actions of its disgusting GOP members.
You can hear the transphobic sneer in these words.
You can hear the transphobic sneer in these words.
November 6, 2025 at 11:02 PM
"your passport says you're 5'7" but you were 1'8" when you were born so that's what we're listing" this is what that sounds like
Reposted by little john
This reminds me: A few CBP agents were recently overheard complaining about how much they *hate* the whistles. Apparently, in addition to the obvious, the racket makes it harder for them to communicate with each other.
Listening to CPD radio traffic from something last month and can hear the whistles in the background.
November 6, 2025 at 6:13 PM
This reminds me: A few CBP agents were recently overheard complaining about how much they *hate* the whistles. Apparently, in addition to the obvious, the racket makes it harder for them to communicate with each other.
Reposted by little john
In which Lewis Hamilton, eloquently and devastatingly, goes full Red Hand Files mode about Roscoe, loss and the way we share grief.
Thanks to the fantastic Elizabeth Blackstock for manifesting and documenting this moment with one of our greatest champions!
Thanks to the fantastic Elizabeth Blackstock for manifesting and documenting this moment with one of our greatest champions!
In Mexico, I asked Lewis Hamilton about what pet ownership taught him about himself. A simple question... but one with a LOT of baggage in the #F1 paddock.
This is your sign to ask your questions, no matter what others think.
open.substack.com/pub/deadlypa...
This is your sign to ask your questions, no matter what others think.
open.substack.com/pub/deadlypa...
November 6, 2025 at 3:32 PM
In which Lewis Hamilton, eloquently and devastatingly, goes full Red Hand Files mode about Roscoe, loss and the way we share grief.
Thanks to the fantastic Elizabeth Blackstock for manifesting and documenting this moment with one of our greatest champions!
Thanks to the fantastic Elizabeth Blackstock for manifesting and documenting this moment with one of our greatest champions!
Reposted by little john
If you’re ever desperate for a Times article, there’s a 90% chance your local library offers free digital access to the Times with a library card. it’s their job to do that for you. you do not have to pay for it yourself. Cancel your sub
one thing that's nice about canceling your New York Times sub is every week you get at least one or two stories shared on here that make you say, "yeah, it rocks that I did that, I only wish I could do it again." highly recommend you cancel yours if you haven't already
November 6, 2025 at 12:43 PM
If you’re ever desperate for a Times article, there’s a 90% chance your local library offers free digital access to the Times with a library card. it’s their job to do that for you. you do not have to pay for it yourself. Cancel your sub